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Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.
- Published in:
- Diabetologia, 2016, v. 59, n. 7, p. 1503, doi. 10.1007/s00125-016-3963-y
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- Article
PI3K in lymphocyte development, differentiation and activation.
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- Nature Reviews Immunology, 2003, v. 3, n. 4, p. 317, doi. 10.1038/nri1056
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- Article
NFκB-Mediated Expression of Phosphoinositide 3-Kinase δ Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells.
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- Cells (2073-4409), 2023, v. 12, n. 2, p. 207, doi. 10.3390/cells12020207
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- Article
PI3K-C2β limits mTORC1 signaling and angiogenic growth.
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- Science Signaling, 2023, v. 16, n. 813, p. 1, doi. 10.1126/scisignal.adg1913
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- Article
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors.
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- Genome Biology, 2013, v. 14, n. 4, p. 1, doi. 10.1186/gb-2013-14-4-r37
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- Article
High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation.
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- FASEB Journal, 2012, v. 26, n. 6, p. 2498, doi. 10.1096/fj.11-198192
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- Article
Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase.
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- FASEB Journal, 2012, v. 26, n. 2, p. 691, doi. 10.1096/fj.11-189753
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- Article
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation.
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- Nature, 2006, v. 441, n. 7091, p. 366, doi. 10.1038/nature04694
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- Article
Essential role for the p110dphosphoinositide 3-kinase in the allergic response.
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- Nature, 2004, v. 431, n. 7011, p. 1007, doi. 10.1038/nature02991
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- Article
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion.
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- Journal of Cell Biology, 2010, v. 190, n. 6, p. 1053, doi. 10.1083/jcb.201001028
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- Article
The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
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- Journal of Cell Biology, 2010, v. 188, n. 6, p. 863, doi. 10.1083/jcb.200907135
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- Article
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.
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- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-32389-z
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- Article
Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization.
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- Nature Communications, 2015, v. 6, n. 1, p. 5937, doi. 10.1038/ncomms6937
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- Article
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model.
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- Nature Communications, 2014, v. 5, n. 3, p. 3450, doi. 10.1038/ncomms4450
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- Article
Cracking the context-specific PI3K signaling code.
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- Science Signaling, 2020, v. 13, n. 613, p. 1, doi. 10.1126/scisignal.aay2940
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- Article
Autophosphorylation of p110d phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.
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- EMBO Journal, 1999, v. 18, n. 5, p. 1292, doi. 10.1093/emboj/18.5.1292
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- Article
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis.
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- 2020
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- journal article
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration.
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- 2008
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- Letter
Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion.
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- 2022
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- Publication type:
- journal article
Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach.
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- 2021
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- Publication type:
- journal article
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.
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- PLoS Genetics, 2015, v. 11, n. 7, p. 1, doi. 10.1371/journal.pgen.1005304
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- Article
Michael D. Waterfield.
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- Biochemical Journal, 2023, v. 480, n. 18, p. 1475, doi. 10.1042/BCJ20230368
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- Article
Phosphoinositide lipids in primary cilia biology.
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- Biochemical Journal, 2020, v. 477, n. 18, p. 3541, doi. 10.1042/BCJ20200277
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- Article
Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection.
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- Biochemical Journal, 2014, v. 464, n. 2, p. e7, doi. 10.1042/BJ20141218
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- Article
The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice.
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- 2014
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- Publication type:
- Journal Article
The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice.
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- Arthritis & Rheumatology, 2014, v. 66, n. 8, p. 2210, doi. 10.1002/art.38660
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- Article
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07812-8
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- Article
The PI3K Isoforms p110α and p110δ Are Essential for Pre-B Cell Receptor Signaling and B Cell Development.
- Published in:
- Science Signaling, 2010, v. 3, n. 134, p. 1, doi. 10.1126/scisignal.2001104
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- Article
PI3K signalling: the path to discovery and understanding.
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- Nature Reviews Molecular Cell Biology, 2012, v. 13, n. 3, p. 195, doi. 10.1038/nrm3290
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- Article
The emerging mechanisms of isoform-specific PI3K signalling.
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- Nature Reviews Molecular Cell Biology, 2010, v. 11, n. 5, p. 329, doi. 10.1038/nrm2882
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- Publication type:
- Article
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages.
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- Nature Cell Biology, 1999, v. 1, n. 1, p. 69, doi. 10.1038/9045
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- Publication type:
- Article
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.
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- EMBO Molecular Medicine, 2013, v. 5, n. 4, p. 563, doi. 10.1002/emmm.201201953
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- Article
Regulation of p110δ PI 3-Kinase Gene Expression.
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- PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005145
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- Article
Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury.
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- Bioscience Reports, 2017, v. 37, n. 5, p. 1, doi. 10.1042/BSR20171112
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- Article
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development.
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- Journal of Pathology, 2022, v. 258, n. 4, p. 382, doi. 10.1002/path.6009
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- Article
Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies.
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- Journal of Pathology, 2016, v. 240, n. 4, p. 387, doi. 10.1002/path.4802
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- Article
The role of PI3Kα isoform in cardioprotection.
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- Basic Research in Cardiology, 2017, v. 112, n. 6, p. 1, doi. 10.1007/s00395-017-0657-7
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- Article
Inactivation of PI(3)K p110? breaks regulatory T-cell-mediated immune tolerance to cancer.
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- Nature, 2014, v. 510, n. 7505, p. 407, doi. 10.1038/nature13444
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- Article
Corrigendum: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
- Published in:
- Nature Immunology, 2014, v. 15, n. 2, p. 205, doi. 10.1038/ni0214-205b
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- Article
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
- Published in:
- Nature Immunology, 2013, v. 14, n. 11, p. 1127, doi. 10.1038/ni.2708
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- Article
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
- Published in:
- Nature Immunology, 2013, v. 14, n. 8, p. 877, doi. 10.1038/ni0813-877d
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- Article
Class III Phosphoinositide 3-Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling.
- Published in:
- Traffic, 2013, v. 14, n. 8, p. 933, doi. 10.1111/tra.12079
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- Article
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate.
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- Scientific Reports, 2017, p. 39985, doi. 10.1038/srep39985
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- Article
Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.
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- Biomolecules (2218-273X), 2019, v. 9, n. 8, p. 331, doi. 10.3390/biom9080331
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- Article
The mouse made easy.
- Published in:
- Nature Cell Biology, 2005, v. 7, n. 5, p. 461, doi. 10.1038/ncb0505-461
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- Publication type:
- Article
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition.
- Published in:
- 2005
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- Publication type:
- Letter
p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model.
- Published in:
- Journal of Neuroscience, 2019, v. 39, n. 40, p. 7976, doi. 10.1523/JNEUROSCI.0674-19.2019
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- Publication type:
- Article
The p110δ isoform of PI 3-kinase negatively controls RhoA and PTEN.
- Published in:
- EMBO Journal, 2007, v. 26, n. 13, p. 3050, doi. 10.1038/sj.emboj.7601763
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- Article
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.
- Published in:
- EMBO Journal, 2002, v. 21, n. 19, p. 5097, doi. 10.1093/emboj/cdf512
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- Publication type:
- Article
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.
- Published in:
- PLoS Genetics, 2021, v. 17, n. 11, p. 1, doi. 10.1371/journal.pgen.1009876
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- Publication type:
- Article