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Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45167-5
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- Publication type:
- Article
A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability.
- Published in:
- Molecular Systems Biology, 2023, v. 19, n. 7, p. 1, doi. 10.15252/msb.202211267
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- Publication type:
- Article
Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43790-2
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- Publication type:
- Article
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29730-6
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- Publication type:
- Article
Differential substrate use in EGF‐ and oncogenic KRAS‐stimulated human mammary epithelial cells.
- Published in:
- FEBS Journal, 2021, v. 288, n. 19, p. 5629, doi. 10.1111/febs.15858
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- Publication type:
- Article
Metabolomics in cancer research and emerging applications in clinical oncology.
- Published in:
- CA: A Cancer Journal for Clinicians, 2021, v. 71, n. 4, p. 333, doi. 10.3322/caac.21670
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- Publication type:
- Article
The CAT-SIR is out of the bag: tumors prefer host rather than dietary nutrients.
- Published in:
- 2021
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- Publication type:
- Letter
Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22490-9
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- Publication type:
- Article
Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis.
- Published in:
- Cancer & Metabolism, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40170-020-00232-7
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- Publication type:
- Article
Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18769-y
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- Publication type:
- Article
MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18607-1
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- Publication type:
- Article
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.
- Published in:
- 2020
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- Publication type:
- Correction Notice
A Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up Study.
- Published in:
- Metabolites (2218-1989), 2020, v. 10, n. 3, p. 99, doi. 10.3390/metabo10030099
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- Publication type:
- Article
Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity.
- Published in:
- FEBS Letters, 2020, v. 594, n. 4, p. 646, doi. 10.1002/1873-3468.13648
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- Publication type:
- Article
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.
- Published in:
- Nature Communications, 2019, p. 1, doi. 10.1038/s41467-019-13419-4
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- Publication type:
- Article
Identification of DHODH as a therapeutic target in small cell lung cancer.
- Published in:
- Science Translational Medicine, 2019, v. 11, n. 517, p. 1, doi. 10.1126/scitranslmed.aaw7852
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- Publication type:
- Article
Increased PHGDH expression promotes aberrant melanin accumulation.
- Published in:
- 2019
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- Publication type:
- journal article
Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1.
- Published in:
- PLoS Biology, 2019, v. 17, n. 6, p. 1, doi. 10.1371/journal.pbio.2004413
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- Publication type:
- Article
PKM2 is not required for pancreatic ductal adenocarcinoma.
- Published in:
- Cancer & Metabolism, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40170-018-0188-1
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- Publication type:
- Article
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.
- Published in:
- Cancer & Metabolism, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40170-018-0179-2
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- Publication type:
- Article
PKM2 is not required for colon cancer initiated by APC loss.
- Published in:
- Cancer & Metabolism, 2017, v. 5, p. 1, doi. 10.1186/s40170-017-0172-1
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- Publication type:
- Article
Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer.
- Published in:
- 2017
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- Publication type:
- journal article
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
- Published in:
- eLife, 2017, p. 1, doi. 10.7554/eLife.28083
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- Publication type:
- Article
Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.
- Published in:
- eLife, 2017, p. 1, doi. 10.7554/eLife.27713.001
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- Publication type:
- Article
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
- Published in:
- Nature Communications, 2017, v. 8, n. 7, p. 16031, doi. 10.1038/ncomms16031
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- Publication type:
- Article
PKM2, cancer metabolism, and the road ahead.
- Published in:
- EMBO Reports, 2016, v. 17, n. 12, p. 1721, doi. 10.15252/embr.201643300
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- Publication type:
- Article
Metabolic requirements for cancer cell proliferation.
- Published in:
- Cancer & Metabolism, 2016, v. 4, p. 1, doi. 10.1186/s40170-016-0156-6
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- Publication type:
- Article
Association between very small tumour size and increased cancer-specific mortality after radical prostatectomy in lymph node-positive prostate cancer.
- Published in:
- BJU International, 2016, v. 118, n. 2, p. 279, doi. 10.1111/bju.13248
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- Publication type:
- Article
Cooperative nutrient accumulation sustains growth of mammalian cells.
- Published in:
- Scientific Reports, 2015, v. 5, n. 1, p. 17401, doi. 10.1038/srep17401
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- Publication type:
- Article
The Role of Pyruvate Kinase M2 in Cancer Metabolism.
- Published in:
- 2015
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- Publication type:
- Other
An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.
- Published in:
- Cancer & Metabolism, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40170-015-0131-7
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- Publication type:
- Article
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
- Published in:
- Nature, 2015, v. 520, n. 7547, p. 363, doi. 10.1038/nature14363
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- Publication type:
- Article
Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy.
- Published in:
- BMC Biology, 2014, v. 12, n. 1, p. 82, doi. 10.1186/s12915-014-0082-4
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- Publication type:
- Article
Metabolic targets for cancer therapy.
- Published in:
- Nature Reviews Drug Discovery, 2013, v. 12, n. 12, p. 963, doi. 10.1038/nrd4191
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- Publication type:
- Article
Metabolic targets for cancer therapy.
- Published in:
- Nature Reviews Drug Discovery, 2013, v. 12, n. 11, p. 829, doi. 10.1038/nrd4145
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- Publication type:
- Article
Exploiting tumor metabolism: challenges for clinical translation.
- Published in:
- Journal of Clinical Investigation, 2013, v. 123, n. 9, p. 3648, doi. 10.1172/JCI72391
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- Publication type:
- Article
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.
- Published in:
- Nature Communications, 2013, v. 4, n. 7, p. 2236, doi. 10.1038/ncomms3236
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- Publication type:
- Article
BCAT1 defines gliomas by IDH status.
- Published in:
- Nature Medicine, 2013, v. 19, n. 7, p. 816, doi. 10.1038/nm.3263
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- Publication type:
- Article
Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
- Published in:
- Nature Biotechnology, 2013, v. 31, n. 6, p. 522, doi. 10.1038/nbt.2530
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- Publication type:
- Article
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
- Published in:
- Nature, 2013, v. 497, n. 7451, p. 633, doi. 10.1038/nature12138
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- Publication type:
- Article
Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States.
- Published in:
- Science Signaling, 2013, v. 6, n. 263, p. 1, doi. 10.1126/scisignal.2003925
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- Publication type:
- Article
Seeing the Warburg effect in the developing retina.
- Published in:
- Nature Cell Biology, 2012, v. 14, n. 8, p. 790, doi. 10.1038/ncb2554
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- Publication type:
- Article
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons.
- Published in:
- Journal of Molecular Cell Biology, 2012, v. 4, n. 2, p. 79, doi. 10.1093/jmcb/mjr030
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- Publication type:
- Article
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
- Published in:
- Nature, 2012, v. 481, n. 7381, p. 380, doi. 10.1038/nature10602
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- Publication type:
- Article
Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy.
- Published in:
- Science Translational Medicine, 2012, v. 4, n. 116, p. 1, doi. 10.1126/scitranslmed.3002693
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- Publication type:
- Article
Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
- Published in:
- 2012
- By:
- Publication type:
- Abstract
PHGDH amplification and altered glucose metabolism in human melanoma.
- Published in:
- Pigment Cell & Melanoma Research, 2011, v. 24, n. 6, p. 1112, doi. 10.1111/j.1755-148X.2011.00919.x
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- Publication type:
- Article
Targeting cancer metabolism: a therapeutic window opens.
- Published in:
- 2011
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- Publication type:
- journal article
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
- Published in:
- Nature, 2010, v. 465, n. 7300, p. 966, doi. 10.1038/nature09132
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- Publication type:
- Article
Targeting Cell Metabolism in Cancer Patients.
- Published in:
- Science Translational Medicine, 2010, v. 2, n. 31, p. 1, doi. 10.1126/scitranslmed.3001210
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- Publication type:
- Article