Works by Van Hoecke, Lien

Results: 25

Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1283711

By:

Claeys, Wouter;
Verhaege, Daan;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Van Acker, Lore;
Amelinck, Laura;
De Ponti, Federico F.;
Scott, Charlotte;
Geerts, Anja;
Van Steenkiste, Christophe;
Van Hoecke, Lien;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

mRNA in cancer immunotherapy: beyond a source of antigen.

Published in:

2021

By:

Van Hoecke, Lien;
Verbeke, Rein;
Dewitte, Heleen;
Lentacker, Ine;
Vermaelen, Karim;
Breckpot, Karine;
Van Lint, Sandra

Publication type:

Literature Review

Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann–Pick Type C Disease.

Published in:

Biomedicines, 2021, v. 9, n. 12, p. 1864, doi. 10.3390/biomedicines9121864

By:

Van Hoecke, Lien;
Van Cauwenberghe, Caroline;
Börger, Verena;
Bruggeman, Arnout;
Castelein, Jonas;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Dittrich, Robin;
Claeys, Wouter;
Xie, Junhua;
Giebel, Bernd;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-22423-6

By:

Claeys, Wouter;
Van Hoecke, Lien;
Geerts, Anja;
Van Vlierberghe, Hans;
Lefere, Sander;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Ghesquière, Bart;
Vandenbroucke, Roosmarijn E.;
Van Steenkiste, Christophe

Publication type:

Article

Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.

Published in:

Frontiers in Cellular Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fncel.2021.757482

By:

Van Hoecke, Lien;
Van Cauwenberghe, Caroline;
Dominko, Kristina;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Castelein, Jonas;
Xie, Junhua;
Claeys, Wouter;
Vandendriessche, Charysse;
Kremer, Anna;
Borghgraef, Peter;
De Rycke, Riet;
Hecimovic, Silva;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 17, p. 4254, doi. 10.3390/ijms20174254

By:

Van Hoecke, Lien;
Raes, Laurens;
Stremersch, Stephan;
Brans, Toon;
Fraire, Juan C.;
Roelandt, Ria;
Declercq, Wim;
Vandenabeele, Peter;
Raemdonck, Koen;
Braeckmans, Kevin;
Saelens, Xavier

Publication type:

Article

Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling.

Published in:

Journal of Extracellular Vesicles, 2023, v. 12, n. 2, p. 1, doi. 10.1002/jev2.12306

By:

Xie, Junhua;
Cools, Lien;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Pauwels, Marie J.;
Vlaeminck, Ine;
De Witte, Chloë;
EL Andaloussi, Samir;
Wierda, Keimpe;
De Groef, Lies;
Haesebrouck, Freddy;
Van Hoecke, Lien;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice.

Published in:

OncoImmunology, 2020, v. 9, n. 1, p. 1, doi. 10.1080/2162402X.2020.1802968

By:

Van Hoecke, Lien;
Riederer, Stephanie;
Saelens, Xavier;
Sutter, Gerd;
Rojas, Juan J.

Publication type:

Article

Intracellular Delivery of mRNA in Adherent and Suspension Cells by Vapor Nanobubble Photoporation.

Published in:

Nano-Micro Letters, 2020, v. 12, n. 1, p. N.PAG, doi. 10.1007/s40820-020-00523-0

By:

Raes, Laurens;
Stremersch, Stephan;
Fraire, Juan C.;
Brans, Toon;
Goetgeluk, Glenn;
De Munter, Stijn;
Van Hoecke, Lien;
Verbeke, Rein;
Van Hoeck, Jelter;
Xiong, Ranhua;
Saelens, Xavier;
Vandekerckhove, Bart;
De Smedt, Stefaan;
Raemdonck, Koen;
Braeckmans, Kevin

Publication type:

Article

Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer's disease.

Published in:

Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01747-6

By:

Van Hoecke, Lien;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies.

Published in:

Neural Regeneration Research, 2025, v. 20, n. 12, p. 3461, doi. 10.4103/NRR.NRR-D-24-00600

By:

Claeys, Wouter;
Geerts, Anja;
Van Hoecke, Lien;
Van Steenkiste, Christophe;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02814-w

By:

Claeys, Wouter;
Van Hoecke, Lien;
Lernout, Hannah;
De Nolf, Clint;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Verhaege, Daan;
Castelein, Jonas;
Geerts, Anja;
Van Steenkiste, Christophe;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice.

Published in:

2019

By:

Joe, Patrick Tjok;
Christopoulou, Ioanna;
van Hoecke, Lien;
Schepens, Bert;
Ysenbaert, Tine;
Heirman, Carlo;
Thielemans, Kris;
Saelens, Xavier;
Aerts, Joeri L.

Publication type:

journal article

How mRNA therapeutics are entering the monoclonal antibody field.

Published in:

2019

By:

Van Hoecke, Lien;
Roose, Kenny

Publication type:

journal article

Low-grade peripheral inflammation affects brain pathology in the App<sup>NL-G-F</sup>mouse model of Alzheimer's disease.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01253-z

By:

Xie, Junhua;
Gorlé, Nina;
Vandendriessche, Charysse;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Van Cauwenberghe, Caroline;
Parthoens, Eef;
Van Hamme, Evelien;
Lippens, Saskia;
Van Hoecke, Lien;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05979-8

By:

Van Hoecke, Lien;
Van Lint, Sandra;
Roose, Kenny;
Van Parys, Alexander;
Vandenabeele, Peter;
Grooten, Johan;
Tavernier, Jan;
De Koker, Stefaan;
Saelens, Xavier

Publication type:

Article

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.

Published in:

NPJ Vaccines, 2020, v. 5, n. 1, p. 1, doi. 10.1038/s41541-020-00211-5

By:

Van Den Eeckhout, Bram;
Van Hoecke, Lien;
Burg, Elianne;
Van Lint, Sandra;
Peelman, Frank;
Kley, Niko;
Uzé, Gilles;
Saelens, Xavier;
Tavernier, Jan;
Gerlo, Sarah

Publication type:

Article

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide.

Published in:

Advanced Healthcare Materials, 2017, v. 6, n. 13, p. n/a, doi. 10.1002/adhm.201601412

By:

Udhayakumar, Vimal K.;
De Beuckelaer, Ans;
McCaffrey, Joanne;
McCrudden, Cian M.;
Kirschman, Jonathan L.;
Vanover, Daryll;
Van Hoecke, Lien;
Roose, Kenny;
Deswarte, Kim;
De Geest, Bruno G.;
Lienenklaus, Stefan;
Santangelo, Philip J.;
Grooten, Johan;
McCarthy, Helen O.;
De Koker, Stefaan

Publication type:

Article

Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis.

Published in:

Journal of Extracellular Biology, 2024, v. 3, n. 11, p. 1, doi. 10.1002/jex2.70015

By:

Burgelman, Marlies;
Dujardin, Pieter;
Willems, Anthony;
Hochepied, Tino;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Van Hoecke, Lien;
Vandendriessche, Charysse;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection.

Published in:

Frontiers in Immunology, 2019, v. 10, p. 1, doi. 10.3389/fimmu.2019.02920

By:

De Vlieger, Dorien;
Hoffmann, Katja;
Van Molle, Inge;
Nerinckx, Wim;
Van Hoecke, Lien;
Ballegeer, Marlies;
Creytens, Sarah;
Remaut, Han;
Hengel, Hartmut;
Schepens, Bert;
Saelens, Xavier

Publication type:

Article

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59377-y

By:

Liang, Xiuming;
Gupta, Dhanu;
Xie, Junhua;
Van Wonterghem, Elien;
Van Hoecke, Lien;
Hean, Justin;
Niu, Zheyu;
Ghaeidamini, Marziyeh;
Wiklander, Oscar P. B.;
Zheng, Wenyi;
Wiklander, Rim Jawad;
He, Rui;
Mamand, Doste R.;
Bost, Jeremy;
Zhou, Guannan;
Zhou, Houze;
Roudi, Samantha;
Estupiñán, H. Yesid;
Rädler, Julia;
Zickler, Antje M.

Publication type:

Article

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59377-y

By:

Liang, Xiuming;
Gupta, Dhanu;
Xie, Junhua;
Van Wonterghem, Elien;
Van Hoecke, Lien;
Hean, Justin;
Niu, Zheyu;
Ghaeidamini, Marziyeh;
Wiklander, Oscar P. B.;
Zheng, Wenyi;
Wiklander, Rim Jawad;
He, Rui;
Mamand, Doste R.;
Bost, Jeremy;
Zhou, Guannan;
Zhou, Houze;
Roudi, Samantha;
Estupiñán, H. Yesid;
Rädler, Julia;
Zickler, Antje M.

Publication type:

Article

The Spreading and Effects of Human Recombinant a-Synuclein Preformed Fibrils in the Cerebrospinal Fluid of Mice.

Published in:

eNeuro, 2024, v. 11, n. 3, p. 1, doi. 10.1523/ENEURO.0024-23.2024

By:

Vandendriessche, Charysse;
Bruggeman, Arnout;
Foroozandeh, Joyce;
Van Hoecke, Lien;
Dujardin, Pieter;
Junhua Xie;
Van Imschoot, Griet;
Van Wonterghem, Elien;
Castelein, Jonas;
Lucci, Cristiano;
De Groef, Lies;
Vandenbroucke, Roosmarijn E.

Publication type:

Article

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice.

Published in:

Immunity, Inflammation & Disease, 2016, v. 4, n. 3, p. 350, doi. 10.1002/iid3.118

By:

Smet, Muriel;
Van Hoecke, Lien;
De Beuckelaer, Ans;
Vander Beken, Seppe;
Naessens, Thomas;
Vergote, Karl;
Willart, Monique;
Lambrecht, Bart N.;
Gustafsson, Jan‐Åke;
Steffensen, Knut R.;
Grooten, Johan

Publication type:

Article

The Impact of Systemic Inflammation on Alzheimer's Disease Pathology.

Published in:

Frontiers in Immunology, 2022, v. 12, p. 1, doi. 10.3389/fimmu.2021.796867

By:

Xie, Junhua;
Van Hoecke, Lien;
Vandenbroucke, Roosmarijn E.

Publication type:

Article