Found: 2

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  • The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

    Published in:
    Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26526-y
    By:
    • Gebregiworgis, Teklab;
    • Kano, Yoshihito;
    • St-Germain, Jonathan;
    • Radulovich, Nikolina;
    • Udaskin, Molly L.;
    • Mentes, Ahmet;
    • Huang, Richard;
    • Poon, Betty P. K.;
    • He, Wenguang;
    • Valencia-Sama, Ivette;
    • Robinson, Claire M.;
    • Huestis, Melissa;
    • Miao, Jinmin;
    • Yeh, Jen Jen;
    • Zhang, Zhong-Yin;
    • Irwin, Meredith S.;
    • Lee, Jeffrey E.;
    • Tsao, Ming-Sound;
    • Raught, Brian;
    • Marshall, Christopher B.
    Publication type:
    Article

  • Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08115-8
    By:
    • Kano, Yoshihito;
    • Gebregiworgis, Teklab;
    • Marshall, Christopher B.;
    • Radulovich, Nikolina;
    • Poon, Betty P. K.;
    • St-Germain, Jonathan;
    • Cook, Jonathan D.;
    • Valencia-Sama, Ivette;
    • Grant, Benjamin M. M.;
    • Herrera, Silvia Gabriela;
    • Miao, Jinmin;
    • Raught, Brian;
    • Irwin, Meredith S.;
    • Lee, Jeffrey E.;
    • Yeh, Jen Jen;
    • Zhang, Zhong-Yin;
    • Tsao, Ming-Sound;
    • Ikura, Mitsuhiko;
    • Ohh, Michael
    Publication type:
    Article