Works by Vadolas, Jim

Results: 25

Animal models of β-hemoglobinopathies: utility and limitations.

Published in:

Journal of Blood Medicine, 2016, v. 7, p. 263, doi. 10.2147/JBM.S87955

By:

McColl, Bradley;
Vadolas, Jim

Publication type:

Article

Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-024-84395-z

By:

Jamrus, Parinda;
Pholngam, Nuttanan;
Kiatpakdee, Benjaporn;
Viwatpinyo, Kittikun;
Vadolas, Jim;
Ngampramuan, Sukonthar;
Svasti, Saovaros;
Chaichompoo, Pornthip

Publication type:

Article

Cognitive impairment and hippocampal neuronal damage in β-thalassaemia mice.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-60459-y

By:

Pholngam, Nuttanan;
Jamrus, Parinda;
Viwatpinyo, Kittikun;
Kiatpakdee, Benjaporn;
Vadolas, Jim;
Chaichompoo, Pornthip;
Ngampramuan, Sukonthar;
Svasti, Saovaros

Publication type:

Article

Intranasal immunization with yeast-expressed 19 kD carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (yMSP1[sub 19]) induces protective immunity to blood stage malaria infection in mice.

Published in:

Parasite Immunology, 1998, v. 20, n. 9, p. 413, doi. 10.1046/j.1365-3024.1998.00161.x

By:

HIRUNPETCHARAT, CHAKRIT;
STANISIC, DANIELLE;
LIU, XUE QIN;
VADOLAS, JIM;
STRUGNELL, RICHARD A.;
LEE, ROGAN;
MILLER, LOUIS H.;
KASLOW, DAVID C.;
GOOD, MICHAEL F.

Publication type:

Article

Interplay between α‐thalassemia and β‐hemoglobinopathies: Translating genotype–phenotype relationships into therapies.

Published in:

HemaSphere, 2024, v. 8, n. 5, p. 1, doi. 10.1002/hem3.78

By:

Vadolas, Jim;
Nualkaew, Tiwaporn;
Voon, Hsiao P. J.;
Vilcassim, Shahla;
Grigoriadis, George

Publication type:

Article

Cellular genomic reporter assays for screening and evaluation of inducers of fetal hemoglobin.

Published in:

Human Molecular Genetics, 2004, v. 13, n. 2, p. 223, doi. 10.1093/hmg/ddh023

By:

Vadolas, Jim;
Wardan, Hady;
Orford, Michael;
Williamson, Robert;
Ioannou, Panayiotis A.

Publication type:

Article

Engineering EGFP reporter constructs into a 200 kb human β-globin BAC clone using GET Recombination.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 18, p. e84, doi. 10.1093/nar/28.18.e84

By:

Orford, Michael;
Nefedov, Mikhail;
Vadolas, Jim;
Zaibak, Faten;
Williamson, Robert;
Ioannou, Panayiotis A.

Publication type:

Article

Gene induction for the treatment of methylmalonic aciduria.

Published in:

Journal of Gene Medicine, 2009, v. 11, n. 4, p. 361, doi. 10.1002/jgm.1297

By:

Hu, Ruimei;
Buck, Nicole E.;
Khaniani, Mahmoud S.;
Wood, Leonie;
Wardan, Hady;
Benoist, Jean-Francois;
Li, Lingli;
Vadolas, Jim;
Sarsero, Joseph P.;
Ioannou, Panos A.;
Peters, Heidi L.

Publication type:

Article

Accumulation of lipid peroxidation-derived DNA lesions in iron-overloaded thalassemic mouse livers: Comparison with levels in the lymphocytes of thalassemia patients.

Published in:

International Journal of Cancer, 2009, v. 125, n. 4, p. 759, doi. 10.1002/ijc.24412

By:

Meerang, Mayura;
Nair, Jagadeesan;
Sirankapracha, Pornpan;
Thephinlap, Chonthida;
Srichairatanakool, Somdet;
Arab, Khelifa;
Kalpravidh, Ruchaneekorn;
Vadolas, Jim;
Fucharoen, Suthat;
Bartsch, Helmut

Publication type:

Article

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.

Published in:

Nature Communications, 2015, v. 6, n. 5, p. 7085, doi. 10.1038/ncomms8085

By:

Wienert, Beeke;
Funnell, Alister P. W.;
Norton, Laura J.;
Pearson, Richard C. M.;
Wilkinson-White, Lorna E.;
Lester, Krystal;
Vadolas, Jim;
Porteus, Matthew H.;
Matthews, Jacqueline M.;
Quinlan, Kate G. R.;
Crossley, Merlin

Publication type:

Article

A comprehensive study of immune function and immunophenotyping of white blood cells from β‐thalassaemia/HbE patients on hydroxyurea supports the safety of the drug.

Published in:

British Journal of Haematology, 2023, v. 200, n. 3, p. 367, doi. 10.1111/bjh.18508

By:

Siriworadetkun, Sirikwan;
Thiengtavor, Chayada;
Thubthed, Rattanawan;
Paiboonsukwong, Kittiphong;
Fucharoen, Suthat;
Pattanapanyasat, Kovit;
Vadolas, Jim;
Svasti, Saovaros;
Chaichompoo, Pornthip

Publication type:

Article

SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia.

Published in:

British Journal of Haematology, 2021, v. 194, n. 1, p. 200, doi. 10.1111/bjh.17428

By:

Vadolas, Jim;
Ng, Garrett Z.;
Kysenius, Kai;
Crouch, Peter J.;
Dames, Sibylle;
Eisermann, Mona;
Nualkaew, Tiwaporn;
Vilcassim, Shahla;
Schaeper, Ute;
Grigoriadis, George

Publication type:

Article

Elevated levels of circulating monocytic myeloid derived suppressor cells in splenectomised β‐thalassaemia/HbE patients.

Published in:

British Journal of Haematology, 2020, v. 191, n. 3, p. e72, doi. 10.1111/bjh.17012

By:

Siriworadetkun, Sirikwan;
Thubthed, Rattanawan;
Thiengtavor, Chayada;
Paiboonsukwong, Kittiphong;
Khuhapinant, Archrob;
Fucharoen, Suthat;
Pattanapanyasat, Kovit;
Vadolas, Jim;
Svasti, Saovaros;
Chaichompoo, Pornthip

Publication type:

Article

Increased ferritin levels in non‐transfusion‐dependent β°‐thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration.

Published in:

British Journal of Haematology, 2020, v. 189, n. 1, p. 187, doi. 10.1111/bjh.16295

By:

Thiengtavor, Chayada;
Siriworadetkun, Sirikwan;
Paiboonsukwong, Kittiphong;
Fucharoen, Suthat;
Pattanapanyasat, Kovit;
Vadolas, Jim;
Svasti, Saovaros;
Chaichompoo, Pornthip

Publication type:

Article

An in vivo model for analysis of developmental erythropoiesis and globin gene regulation.

Published in:

FASEB Journal, 2014, v. 28, n. 5, p. 2306, doi. 10.1096/fj.13-246637

By:

McColl, Bradley;
Kao, Betty R.;
Lourthai, Preeyachan;
Chan, Kasey;
Wardan, Hady;
Roosjen, Mark;
Delagneau, Orane;
Gearing, Linden J.;
Blewitt, Mamie E.;
Svasti, Saovaros;
Fucharoen, Suthat;
Vadolas, Jim

Publication type:

Article

Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β‐like globin genes.

Published in:

FASEB Journal, 2014, v. 28, n. 4, p. 1610, doi. 10.1096/fj.13-242669

By:

Roosjen, Mark;
McColl, Bradley;
Kao, Betty;
Gearing, Linden J.;
Blewitt, Marnie E.;
Vadolas, Jim

Publication type:

Article

Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.

Published in:

FASEB Journal, 2012, v. 26, n. 4, p. 1736, doi. 10.1096/fj.11-199356

By:

Chan, Kasey S. K.;
Jian Xu;
Wardan, Hady;
McColl, Bradley;
Orkin, Stuart;
Vadolas, Jim

Publication type:

Article

ErythRED, a hESC line enabling identification of erythroid cells.

Published in:

Nature Methods, 2009, v. 6, n. 9, p. 659, doi. 10.1038/nmeth.1364

By:

Hatzistavrou, Tanya;
Micallef, Suzanne J.;
Ng, Elizabeth S.;
Vadolas, Jim;
Stanley, Edouard G.;
Elefanty, Andrew G.

Publication type:

Article

Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at Gγ-globin gene promoter.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-87738-2

By:

Nuamsee, Khanita;
Chuprajob, Thipphawan;
Pabuprapap, Wachirachai;
Jintaridth, Pornrutsami;
Munkongdee, Thongperm;
Phannasil, Phatchariya;
Vadolas, Jim;
Chaichompoo, Pornthip;
Suksamrarn, Apichart;
Svasti, Saovaros

Publication type:

Article

Development of model systems for β-thalassaemia.

Published in:

Thalassemia Reports, 2013, v. 3, n. 1s, p. 102, doi. 10.4081/thal.2013.s1.e41

By:

Vadolas, Jim

Publication type:

Article

A 191-kb genomic fragment containing the human α-globin locus can rescue α-thalassemic mice.

Published in:

Mammalian Genome, 2005, v. 16, n. 11, p. 847, doi. 10.1007/s00335-005-0089-9

By:

Al-Hasani, Keith;
Vadolas, Jim;
Knaupp, Anja S.;
Wardan, Hady;
Voullaire, Lucille;
Williamson, Robert;
Ioannou, Panayiotis A.

Publication type:

Article

Impaired neutrophil extracellular trap formation in β-thalassaemia/HbE.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06036-7

By:

Thubthed, Rattanawan;
Siriworadetkun, Sirikwan;
Paiboonsukwong, Kittiphong;
Fucharoen, Suthat;
Pattanapanyasat, Kovit;
Vadolas, Jim;
Svasti, Saovaros;
Chaichompoo, Pornthip

Publication type:

Article

The role of macrophages in the induction and regulation of immunity elicited by exogenous antigens.

Published in:

European Journal of Immunology, 1998, v. 28, n. 2, p. 479, doi. 10.1002/(SICI)1521-4141(199802)28:02<479::AID-IMMU479>3.0.CO;2-R

By:

Wijburg, Odilia L. C.;
van den Dobbelsteen, Germie P. J. M.;
Vadolas, Jim;
Sanders, Annemarie;
Strugnell, Richard A.;
van Rooijen, Nico

Publication type:

Article

Intranasal immunization with liposomes induces strong mucosal immune responses in mice.

Published in:

European Journal of Immunology, 1995, v. 25, n. 4, p. 969, doi. 10.1002/eji.1830250417

By:

Vadolas, Jim;
Davies, John K.;
Wright, Peter J.;
Strugnell, Richard A.

Publication type:

Article

A reduced curcuminoid analog as a novel inducer of fetal hemoglobin.

Published in:

Annals of Hematology, 2013, v. 92, n. 3, p. 379, doi. 10.1007/s00277-012-1604-1

By:

Chaneiam, Nattawara;
Changtam, Chatchawan;
Mungkongdee, Thongperm;
Suthatvoravut, Umaporn;
Winichagoon, Pranee;
Vadolas, Jim;
Suksamrarn, Apichart;
Fucharoen, Suthat;
Svasti, Saovaros

Publication type:

Article