Works by Vaara, Martti

Results: 32

New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin.

Published in:

Medicinal Research Reviews, 2018, v. 38, n. 5, p. 1661, doi. 10.1002/med.21494

By:

Vaara, Martti

Publication type:

Article

Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis.

Published in:

2018

By:

Vaara, Timo;
Vaara, Martti;
Lundberg, Carina Vingsbo;
Vingsbo Lundberg, Carina

Publication type:

journal article

Novel derivatives of polymyxins.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 6, p. 1213, doi. 10.1093/jac/dkt039

By:

Vaara, Martti

Publication type:

Article

Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 3, p. 636, doi. 10.1093/jac/dks438

By:

Vaara, Martti;
Sader, Helio S.;
Rhomberg, Paul R.;
Jones, Ronald N.;
Vaara, Timo

Publication type:

Article

Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008–11).

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2012, v. 67, n. 12, p. 2860, doi. 10.1093/jac/dks299

By:

Österblad, Monica;
Kirveskari, Juha;
Hakanen, Antti J.;
Tissari, Päivi;
Vaara, Martti;
Jalava, Jari

Publication type:

Article

Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 5, p. 981, doi. 10.1093/jac/dkq072

By:

Vingsbo Lundberg, Carina;
Vaara, Timo;
Frimodt-Möller, Niels;
Vaara, Martti

Publication type:

Article

Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 5, p. 942, doi. 10.1093/jac/dkq040

By:

Vaara, Martti;
Siikanen, Osmo;
Apajalahti, Juha;
Frimodt-Möller, Niels;
Vaara, Timo

Publication type:

Article

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2009, v. 64, n. 5, p. 1067, doi. 10.1093/jac/dkp331

By:

Atta Ali, Feda' Emad;
Cao, Guoying;
Poudyal, Anima;
Vaara, Timo;
Nation, Roger L.;
Vaara, Martti;
Jian Li

Publication type:

Article

Excretion of the Polymyxin Derivative NAB739 in Murine Urine.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 4, p. 143, doi. 10.3390/antibiotics9040143

By:

Vaara, Martti;
Vaara, Timo;
Kuka, Janis;
Sevostjanovs, Eduards;
Grinberga, Solveiga;
Dambrova, Maija;
Liepinsh, Edgars

Publication type:

Article

Rapid Molecular Characterization of Acinetobacter baumannii Clones with rep-PCR and Evaluation of Carbapenemase Genes by New Multiplex PCR in Hospital District of Helsinki and Uusimaa.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085854

By:

Pasanen, Tanja;
Koskela, Suvi;
Mero, Sointu;
Tarkka, Eveliina;
Tissari, Päivi;
Vaara, Martti;
Kirveskari, Juha

Publication type:

Article

Efficacy of a novel PCR- and microarray-based method in diagnosis of a prosthetic joint infection.

Published in:

Acta Orthopaedica, 2014, v. 85, n. 2, p. 165, doi. 10.3109/17453674.2014.889978

By:

Metso, Leena;
Mäki, Minna;
Tissari, Päivi;
Remes, Ville;
Piiparinen, Pasi;
Kirveskari, Juha;
Tarkka, Eveliina;
Anttila, Veli-Jukka;
Vaara, Martti;
Huotari, Kaisa

Publication type:

Article

Corrigendum: Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics.

Published in:

2019

By:

Vaara, Martti

Publication type:

Correction Notice

Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics.

Published in:

Frontiers in Microbiology, 2019, p. 1, doi. 10.3389/fmicb.2019.01689

By:

Vaara, Martti

Publication type:

Article

Shiga Toxin-Producing Escherichia coli O100:H: stx in Drinking Water Contaminated by Waste Water in Finland.

Published in:

Current Microbiology, 2011, v. 62, n. 4, p. 1239, doi. 10.1007/s00284-010-9832-x

By:

Lienemann, Taru;
Pitkänen, Tarja;
Antikainen, Jenni;
Mölsä, Elina;
Miettinen, Ilkka;
Haukka, Kaisa;
Vaara, Martti;
Siitonen, Anja

Publication type:

Article

A selective broth enrichment combined with real-time nuc-mecA-PCR in the exclusion of MRSA.

Published in:

APMIS, 2010, v. 118, n. 1, p. 74, doi. 10.1111/j.1600-0463.2009.02562.x

By:

PASANEN, TANJA;
KORKEILA, MAIJA;
MERO, SOINTU;
TARKKA, EVELIINA;
PIIPARINEN, HELI;
VUOPIO-VARKILA, JAANA;
VAARA, MARTTI;
TISSARI, PÄIVI

Publication type:

Article

Detection of virulence genes of Clostridium difficile by multiplex PCR.

Published in:

APMIS, 2009, v. 117, n. 8, p. 607, doi. 10.1111/j.1600-0463.2009.02509.x

By:

ANTIKAINEN, JENNI;
PASANEN, TANJA;
MERO, SOINTU;
TARKKA, EVELIINA;
KIRVESKARI, JUHA;
KOTILA, SAARA;
MENTULA, SILJA;
KÖNÖNEN, EIJA;
VIROLAINEN-JULKUNEN, ANNI-RIITTA;
VAARA, MARTTI;
TISSARI, PÄIVI

Publication type:

Article

Real-time multiplex PCR assay for detection of Yersinia pestis and Yersinia pseudotuberculosis.

Published in:

APMIS, 2009, v. 117, n. 1, p. 34, doi. 10.1111/j.1600-0463.2008.00013.x

By:

MATERO, PIRJO;
PASANEN, TANJA;
LAUKKANEN, RIIKKA;
TISSARI, PÄIVI;
TARKKA, EVELIINA;
VAARA, MARTTI;
SKURNIK, MIKAEL

Publication type:

Article

Lactobacillus Bacteremia during a Rapid Increase in Probiotic Use of Lactobacillus rhamnosus GG in Finland.

Published in:

Clinical Infectious Diseases, 2002, v. 35, n. 10, p. 1155, doi. 10.1086/342912

By:

Salminen, Minna K.;
Tynkkynen, Soile;
Rautelin, Hilpi;
Saxelin, Maija;
Vaara, Martti;
Ruutu, Petri;
Sarna, Seppo;
Valtonen, Ville;
Järvinen, Asko

Publication type:

Article

Etiological Diagnosis of Childhood Pneumonia by Use of Transthoracic Needle Aspiration and Modern Microbiological Methods.

Published in:

Clinical Infectious Diseases, 2002, v. 34, n. 5, p. 583, doi. 10.1086/338642

By:

Vuori-Holopainen, Elina;
Salo, Eeva;
Sax é n, Harri;
Hedman, Klaus;
Hyypi ä, Timo;
Lahdenper ä, Raija;
Leinonen, Maija;
Tarkka, Eveliina;
Vaara, Martti;
Peltola, Heikki

Publication type:

Article

Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics.

Published in:

Molecules, 2019, v. 24, n. 2, p. 249, doi. 10.3390/molecules24020249

By:

Vaara, Martti

Publication type:

Article

Comparative activity of rifabutin and rifampicin against gram-negative bacteria that have damaged or defective outer membranes.

Published in:

1993

By:

VAARA, MARTTI;
Vaara, M

Publication type:

research

Quantitative antimicrobial susceptibility testing of outer membrane-altered mutant bacteria by the E test.

Published in:

1993

By:

VAARA, MARTTI;
Vaara, M

Publication type:

research

The outer membrane as the penetration barrier against mupirocin in gram-negative enteric bacteria.

Published in:

1992

By:

VAARA, MARTTI;
Vaara, M

Publication type:

research

Lipopolysaccharides of polymyxin B-resistant mutants of Escherichia coli are extensively substituted by 2-aminoethyl pyrophosphate and contain aminoarabinose in lipid A.

Published in:

Molecular Microbiology, 1995, v. 16, n. 2, p. 271, doi. 10.1111/j.1365-2958.1995.tb02299.x

By:

Nummila, Kim;
Helander, Ilkka M.;
Kilpeläinen, Ilkka;
Zähringer, Ulrich;
Vaara, Martti

Publication type:

Article

Increased substitution of phosphate groups in lipopolysaccharides and lipid A of the polymyxin- resistant pmrA mutants of Salmonella typhimurium: a 31P--NMR study.

Published in:

Molecular Microbiology, 1994, v. 11, n. 3, p. 481, doi. 10.1111/j.1365-2958.1994.tb00329.x

By:

Helander, Ilkka M.;
Kilpelainen, Ilkka;
Vaara, Martti

Publication type:

Article

Evaluation of Antimicrobial Therapy of Blood Culture Positive Healthcare-Associated Infections in Children.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0141555

By:

Laine, Niina;
Vaara, Martti;
Anttila, Veli-Jukka;
Hoppu, Kalle;
Laaksonen, Raisa;
Airaksinen, Marja;
Saxen, Harri

Publication type:

Article

Distribution of Streptoccocal Inhibitor of Complement Variants in Pharyngitis and Invasive Isolates in an Epidemic of Serotype M1 Group A.

Published in:

Journal of Infectious Diseases, 2001, v. 183, n. 4, p. 633, doi. 10.1086/318543

By:

Hoe, Nancy P.;
Musser, James M.;
Vuopio-Varkila, Jaana;
Vaara, Martti;
Grigsby, Diana;
Nakashima, Kazumitsu;
Dou, Shu-Jun;
Pan, Xi;
De Lorenzo, David;
Fu, Yun-Xin

Publication type:

Article

Isolation and characterization of Streptococcus mitis from blood of child with osteomyelitis.

Published in:

International Journal of Paediatric Dentistry, 2011, v. 21, n. 3, p. 192, doi. 10.1111/j.1365-263X.2010.01110.x

By:

NOMURA, RYOTA;
NAKANO, KAZUHIKO;
MÄKELÄ, KATRIINA;
VAARA, MARTTI;
SALO, EEVA;
ALALUUSUA, SATU;
OOSHIMA, TAKASHI

Publication type:

Article

Dual-light photodynamic therapy administered daily provides a sustained antibacterial effect on biofilm and prevents Streptococcus mutans adaptation.

Published in:

PLoS ONE, 2020, v. 15, n. 5, p. 1, doi. 10.1371/journal.pone.0232775

By:

Nikinmaa, Sakari;
Alapulli, Heikki;
Auvinen, Petri;
Vaara, Martti;
Rantala, Juha;
Kankuri, Esko;
Sorsa, Timo;
Meurman, Jukka;
Pätilä, Tommi

Publication type:

Article

Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes.

Published in:

Annals of Clinical Microbiology & Antimicrobials, 2004, v. 3, p. 1

By:

Jalava, Jari;
Vaara, Martti;
Huovinen, Pentti

Publication type:

Article

Overgrowth of Enterococcus faecium in the Feces of Patients with Hematologic Malignancies.

Published in:

Clinical Infectious Diseases, 1996, v. 23, n. 4, p. 694, doi. 10.1093/clinids/23.4.694

By:

Suppola, Juhana P.;
Volin, Liisa;
Valtonen, Ville V.;
Vaara, Martti

Publication type:

Article

Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.

Published in:

ChemMedChem, 2016, v. 11, n. 22, p. 2511, doi. 10.1002/cmdc.201600421

By:

Jin, Jinshan;
Hsieh, Ying‐Hsin;
Cui, Jianmei;
Damera, Krishna;
Dai, Chaofeng;
Chaudhary, Arpana S.;
Zhang, Hao;
Yang, Hsiuchin;
Cao, Nannan;
Jiang, Chun;
Vaara, Martti;
Wang, Binghe;
Tai, Phang C.

Publication type:

Article

Works by Vaara, Martti

New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin.

Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis.

Novel derivatives of polymyxins.

Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens.

Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008–11).

Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice.

Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin.

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration.

Excretion of the Polymyxin Derivative NAB739 in Murine Urine.

Rapid Molecular Characterization of <i>Acinetobacter baumannii</i> Clones with rep-PCR and Evaluation of Carbapenemase Genes by New Multiplex PCR in Hospital District of Helsinki and Uusimaa.

Efficacy of a novel PCR- and microarray-based method in diagnosis of a prosthetic joint infection.

Corrigendum: Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics.

Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics.

Shiga Toxin-Producing Escherichia coli O100:H: stx in Drinking Water Contaminated by Waste Water in Finland.

A selective broth enrichment combined with real-time nuc-mecA-PCR in the exclusion of MRSA.

Detection of virulence genes of Clostridium difficile by multiplex PCR.

Real-time multiplex PCR assay for detection of Yersinia pestis and Yersinia pseudotuberculosis.

Lactobacillus Bacteremia during a Rapid Increase in Probiotic Use of Lactobacillus rhamnosus GG in Finland.

Etiological Diagnosis of Childhood Pneumonia by Use of Transthoracic Needle Aspiration and Modern Microbiological Methods.

Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics.

Comparative activity of rifabutin and rifampicin against gram-negative bacteria that have damaged or defective outer membranes.

Quantitative antimicrobial susceptibility testing of outer membrane-altered mutant bacteria by the E test.

The outer membrane as the penetration barrier against mupirocin in gram-negative enteric bacteria.

Lipopolysaccharides of polymyxin B-resistant mutants of Escherichia coli are extensively substituted by 2-aminoethyl pyrophosphate and contain aminoarabinose in lipid A.

Increased substitution of phosphate groups in lipopolysaccharides and lipid A of the polymyxin- resistant pmrA mutants of <em>Salmonella typhimurium</em>: a <sup>31</sup>P--NMR study.

Evaluation of Antimicrobial Therapy of Blood Culture Positive Healthcare-Associated Infections in Children.

Distribution of Streptoccocal Inhibitor of Complement Variants in Pharyngitis and Invasive Isolates in an Epidemic of Serotype M1 Group A.

Isolation and characterization of Streptococcus mitis from blood of child with osteomyelitis.

Dual-light photodynamic therapy administered daily provides a sustained antibacterial effect on biofilm and prevents Streptococcus mutans adaptation.

Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes.

Overgrowth of Enterococcus faecium in the Feces of Patients with Hematologic Malignancies.

Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.