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Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.
Published in:
BioMetals, 2018, v. 31, n. 2, p. 267, doi. 10.1007/s10534-018-0089-3
By:
- Jingshu Xu;
- Church, Stephanie J.;
- Patassini, Stefano;
- Begley, Paul;
- Kellett, Katherine A. B.;
- Vardy, Emma R. L. C.;
- Unwin, Richard D.;
- Hooper, Nigel M.;
- Cooper, Garth J. S.
Publication type:
Article
Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis.
Published in:
Scientific Data, 2021, v. 8, n. 1, p. 1, doi. 10.1038/s41597-021-01090-8
By:
- Haytural, Hazal;
- Benfeitas, Rui;
- Schedin-Weiss, Sophia;
- Bereczki, Erika;
- Rezeli, Melinda;
- Unwin, Richard D.;
- Wang, Xusheng;
- Dammer, Eric B.;
- Johnson, Erik C. B.;
- Seyfried, Nicholas T.;
- Winblad, Bengt;
- Tijms, Betty M.;
- Visser, Pieter Jelle;
- Frykman, Susanne;
- Tjernberg, Lars O.
Publication type:
Article
Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na<sup>+</sup>/K<sup>+</sup>-ATPase Dysfunction in Vascular Dementia.
Published in:
Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.822787
By:
- Philbert, Sasha A.;
- Xu, Jingshu;
- Scholefield, Melissa;
- Church, Stephanie J.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial.
Published in:
Schizophrenia Bulletin, 2023, v. 49, n. 4, p. 893, doi. 10.1093/schbul/sbac201
By:
- Susai, Subash Raj;
- Föcking, Melanie;
- Mongan, David;
- Heurich, Meike;
- Coutts, Fiona;
- Egerton, Alice;
- Whetton, Tony;
- Rossum, Inge Winter-van;
- Unwin, Richard D;
- Pollak, Thomas A;
- Weiser, Mark;
- Leboyer, Marion;
- Rujescu, Dan;
- Byrne, Jonah F;
- Gifford, George W;
- Dazzan, Paola;
- Koutsouleris, Nikolaos;
- Kahn, René S;
- Cotter, David R;
- McGuire, Philip
Publication type:
Article
Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson's Disease Dementia.
Published in:
Metabolites (2218-1989), 2021, v. 11, n. 9, p. 569, doi. 10.3390/metabo11090569
By:
- Scholefield, Melissa;
- Church, Stephanie J.;
- Xu, Jingshu;
- Patassini, Stefano;
- Hooper, Nigel M.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain.
Published in:
Metabolites (2218-1989), 2020, v. 10, n. 11, p. 438, doi. 10.3390/metabo10110438
By:
- Scholefield, Melissa;
- Church, Stephanie J.;
- Xu, Jingshu;
- Robinson, Andrew C.;
- Gardiner, Natalie J.;
- Roncaroli, Federico;
- Hooper, Nigel M.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease.
Published in:
Metabolites (2218-1989), 2019, v. 9, n. 6, p. 113, doi. 10.3390/metabo9060113
By:
- Patassini, Stefano;
- Begley, Paul;
- Xu, Jingshu;
- Church, Stephanie J.;
- Kureishy, Nina;
- Reid, Suzanne J.;
- Waldvogel, Henry J.;
- Faull, Richard L. M.;
- Snell, Russell G.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066510
By:
- White, Daniel J.;
- Unwin, Richard D.;
- Bindels, Eric;
- Pierce, Andrew;
- Teng, Hsiang-Ying;
- Muter, Joanne;
- Greystoke, Brigit;
- Somerville, Tim D.;
- Griffiths, John;
- Lovell, Simon;
- Somervaille, Tim C. P.;
- Delwel, Ruud;
- Whetton, Anthony D.;
- Meyer, Stefan
Publication type:
Article
Identification of Nuclear Protein Targets for Six Leukemogenic Tyrosine Kinases Governed by Post-Translational Regulation.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038928
By:
- Pierce, Andrew;
- Williamson, Andrew;
- Jaworska, Ewa;
- Griffiths, John R.;
- Taylor, Sam;
- Walker, Michael;
- O'Dea, Mark Aspinall;
- Spooncer, Elaine;
- Unwin, Richard D.;
- Poolman, Toryn;
- Ray, David;
- Whetton, Anthony D.
Publication type:
Article
Streaming visualisation of quantitative mass spectrometry data based on a novel raw signal decomposition method.
Published in:
Proteomics, 2015, v. 15, n. 8, p. 1419, doi. 10.1002/pmic.201400428
By:
- Zhang, Yan;
- Bhamber, Ranjeet;
- Riba ‐ Garcia, Isabel;
- Liao, Hanqing;
- Unwin, Richard D.;
- Dowsey, Andrew W.
Publication type:
Article
Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.
Published in:
Proteomics, 2010, v. 10, n. 18, p. 3321, doi. 10.1002/pmic.201000176
By:
- Lee, Chia Fang;
- Griffiths, Stephen;
- Rodríguez-Suárez, Eva;
- Pierce, Andrew;
- Unwin, Richard D.;
- Jaworska, Ewa;
- Evans, Caroline A.;
- J. Gaskell, Simon;
- Whetton, Anthony D.
Publication type:
Article
Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect.
Published in:
Proteomics, 2003, v. 3, n. 8, p. 1620, doi. 10.1002/pmic.200300464
By:
- Richard D. Unwin;
- Rachel A. Craven;
- Patricia Harnden;
- Sarah Hanrahan;
- Nick Totty;
- Margaret Knowles;
- Ian Eardley;
- Peter J. Selby;
- Rosamonde E. Banks
Publication type:
Article
Serological and proteomic evaluation of antibody responses in the identification of tumor antigens in renal cell carcinoma.
Published in:
Proteomics, 2003, v. 3, n. 1, p. 45, doi. 10.1002/pmic.200390008
By:
- Unwin, Richard D.;
- Harnden, Patricia;
- Pappin, Darryl;
- Rahman, Dinah;
- Whelan, Peter;
- Craven, Rachel A.;
- Selby, Peter J.;
- Banks, Rosamonde E.
Publication type:
Article
Adipocyte NR1D1 dictates adipose tissue expansion during obesity.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.63324
By:
- Hunter, Ann Louise;
- Pelekanou, Charlotte E.;
- Barron, Nichola J.;
- Northeast, Rebecca C.;
- Grudzien, Magdalena;
- Adamson, Antony D.;
- Downton, Polly;
- Cornfield, Thomas;
- Cunningham, Peter S.;
- Billaud, Jean-Noel;
- Hodson, Leanne;
- Loudon, Andrew SI.;
- Unwin, Richard D.;
- Iqbal, Mudassar;
- Ray, David W.;
- Bechtold, David A.
Publication type:
Article
Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer's Disease Consistent With Cerebral Pantothenate Deficiency.
Published in:
Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.893159
By:
- Sang, Crystal;
- Philbert, Sasha A.;
- Hartland, Danielle;
- Unwin, Richard. D;
- Dowsey, Andrew W.;
- Xu, Jingshu;
- Cooper, Garth J. S.
Publication type:
Article
Epithelial cadherin regulates transition between the naïve and primed pluripotent states in mouse embryonic stem cells.
Published in:
Stem Cells, 2020, v. 38, n. 10, p. 1292, doi. 10.1002/stem.3249
By:
- Sharaireh, Aseel M.;
- Fitzpatrick, Lorna M.;
- Ward, Chris M.;
- McKay, Tristan R.;
- Unwin, Richard D.
Publication type:
Article
Urological malignancies and the proteomic-genomic interface.
Published in:
Electrophoresis, 1999, v. 20, n. 18, p. 3629, doi. 10.1002/(SICI)1522-2683(19991201)20:18<3629::AID-ELPS3629>3.0.CO;2-S
By:
- Unwin, Richard D.;
- Knowles, Margaret A.;
- Selby, Peter J.;
- Banks, Rosamonde E.
Publication type:
Article
Systems-level dynamic analyses of fate change in murine embryonic stem cells.
Published in:
Nature, 2009, v. 462, n. 7271, p. 358, doi. 10.1038/nature08575
By:
- Lu, Rong;
- Markowetz, Florian;
- Unwin, Richard D.;
- Leek, Jeffrey T.;
- Airoldi, Edoardo M.;
- MacArthur, Ben D.;
- Lachmann, Alexander;
- Rozov, Roye;
- Ma'ayan, Avi;
- Boyer, Laurie A.;
- Troyanskaya, Olga G.;
- Whetton, Anthony D.;
- Lemischka, Ihor R.
Publication type:
Article
Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-42592-1
By:
- Lawless, Michael;
- Caldwell, Jessica L.;
- Radcliffe, Emma J.;
- Smith, Charlotte E. R.;
- Madders, George W. P.;
- Hutchings, David C.;
- Woods, Lori S.;
- Church, Stephanie J.;
- Unwin, Richard D.;
- Kirkwood, Graeme J.;
- Becker, Lorenz K.;
- Pearman, Charles M.;
- Taylor, Rebecca F.;
- Eisner, David A.;
- Dibb, Katharine M.;
- Trafford, Andrew. W.
Publication type:
Article
Multi-regional alterations in glucose and purine metabolic pathways in the Parkinson's disease dementia brain.
Published in:
NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00488-y
By:
- Scholefield, Melissa;
- Church, Stephanie J.;
- Taylor, George;
- Knight, David;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location.
Published in:
Metallomics, 2020, v. 12, n. 6, p. 952, doi. 10.1039/d0mt00048e
By:
- Scholefield, Melissa;
- Church, Stephanie J.;
- Xu, Jingshu;
- Kassab, Sarah;
- Gardiner, Natalie J.;
- Roncaroli, Federico;
- Hooper, Nigel M.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.
Published in:
Metallomics, 2017, v. 9, n. 8, p. 1106, doi. 10.1039/c7mt00074j
By:
- Xu, Jingshu;
- Church, Stephanie J.;
- Patassini, Stefano;
- Begley, Paul;
- Waldvogel, Henry J.;
- Curtis, Maurice A.;
- Faull, Richard L. M.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation.
Published in:
NAR Cancer, 2024, v. 6, n. 3, p. 1, doi. 10.1093/narcan/zcae030
By:
- Coulson-Gilmer, Camilla;
- Littler, Samantha;
- Barnes, Bethany M;
- Brady, Rosie M;
- Anagho, Holda A;
- Pillay, Nisha;
- Dey, Malini;
- Macmorland, William;
- Bronder, Daniel;
- Nelson, Louisa;
- Tighe, Anthony;
- Lin, Wei-Hsiang;
- Morgan, Robert D;
- Unwin, Richard D;
- Nielsen, Michael L;
- McGrail, Joanne C;
- Taylor, Stephen S
Publication type:
Article
Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia.
Published in:
Frontiers in Aging Neuroscience, 2021, v. 13, p. N.PAG, doi. 10.3389/fnagi.2021.641222
By:
- Scholefield, Melissa;
- Church, Stephanie J.;
- Xu, Jingshu;
- Patassini, Stefano;
- Roncaroli, Federico;
- Hooper, Nigel M.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson's Disease Dementia.
Published in:
Frontiers in Molecular Neuroscience, 2021, v. 14, p. 1, doi. 10.3389/fnmol.2021.711396
By:
- Scholefield, Melissa;
- Church, Stephanie J.;
- Xu, Jingshu;
- Patassini, Stefano;
- Roncaroli, Federico;
- Hooper, Nigel M.;
- Unwin, Richard D.;
- Cooper, Garth J. S.
Publication type:
Article
Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure.
Published in:
Journal of Vascular Research, 2016, v. 52, n. 5, p. 299, doi. 10.1159/000443885
By:
- aghamohammadzadeh, Reza;
- Unwin, Richard D.;
- Greenstein, adam S.;
- Heagerty, anthony M.
Publication type:
Article
The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications.
Published in:
Mass Spectrometry Reviews, 2015, v. 34, n. 6, p. 595, doi. 10.1002/mas.21421
By:
- Chicooree, Navin;
- Unwin, Richard D.;
- Griffiths, John R.
Publication type:
Article
Regional protein expression in human Alzheimer's brain correlates with disease severity.
Published in:
Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0254-9
By:
- Xu, Jingshu;
- Patassini, Stefano;
- Rustogi, Nitin;
- Riba-Garcia, Isabel;
- Hale, Benjamin D.;
- Phillips, Alexander M;
- Waldvogel, Henry;
- Haines, Robert;
- Bradbury, Phil;
- Stevens, Adam;
- Faull, Richard L. M.;
- Dowsey, Andrew W.;
- Cooper, Garth J. S.;
- Unwin, Richard D.
Publication type:
Article
Extensive multiregional urea elevations in a case-control study of vascular dementia point toward a novel shared mechanism of disease amongst the age-related dementias.
Published in:
Frontiers in Molecular Neuroscience, 2023, p. 1, doi. 10.3389/fnmol.2023.1215637
By:
- Philbert, Sasha A.;
- Jingshu Xu;
- Scholefield, Melissa;
- Patassini, Stefano;
- Church, Stephanie J.;
- Unwin, Richard D.;
- Roncaroli, Federico;
- Cooper, Garth J. S.
Publication type:
Article
Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia.
Published in:
British Journal of Haematology, 2010, v. 148, n. 4, p. 534, doi. 10.1111/j.1365-2141.2009.07979.x
By:
- Rees-Unwin, Karen S.;
- Faragher, Robin;
- Unwin, Richard D.;
- Adams, Julie;
- Brown, Philip J.;
- Buckle, Ann-Marie;
- Pettitt, Andrew;
- Hutchinson, Claire V.;
- Johnson, Suzanne M.;
- Pulford, Karen;
- Banham, Alison H.;
- Whetton, Anthony D.;
- Lucas, Guy;
- Mason, David Y.;
- Burthem, John
Publication type:
Article
The use of missing values in proteomic data-independent acquisition mass spectrometry to enable disease activity discrimination.
Published in:
Bioinformatics, 2020, v. 36, n. 7, p. 2217, doi. 10.1093/bioinformatics/btz898
By:
- McGurk, Kathryn A;
- Dagliati, Arianna;
- Chiasserini, Davide;
- Lee, Dave;
- Plant, Darren;
- Baricevic-Jones, Ivona;
- Kelsall, Janet;
- Eineman, Rachael;
- Reed, Rachel;
- Geary, Bethany;
- Unwin, Richard D;
- Nicolaou, Anna;
- Keavney, Bernard D;
- Barton, Anne;
- Whetton, Anthony D;
- Geifman, Nophar
Publication type:
Article
Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.
Published in:
Proteomics - Clinical Applications, 2010, v. 4, n. 12, p. 969, doi. 10.1002/prca.201090108
By:
- Lee, Chia Fang;
- Griffiths, Stephen;
- Rodríguez-Suárez, Eva;
- Pierce, Andrew;
- Unwin, Richard D.;
- Jaworska, Ewa;
- Evans, Caroline A.;
- J. Gaskell, Simon;
- Whetton, Anthony D.
Publication type:
Article
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Published in:
2016
By:
- Freeman, Oliver J.;
- Unwin, Richard D.;
- Dowsey, Andrew W.;
- Begley, Paul;
- Ali, Sumia;
- Hollywood, Katherine A.;
- Rustogi, Nitin;
- Petersen, Rasmus S.;
- Dunn, Warwick B.;
- Cooper, Garth J. S.;
- Gardiner, Natalie J.
Publication type:
journal article

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