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γ-aminobutyric acid stimulates β-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel γ-aminobutyric acid type A receptor positive allosteric modulator.
- Published in:
- Diabetes, Obesity & Metabolism, 2020, v. 22, n. 11, p. 2021, doi. 10.1111/dom.14118
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- Article
GABA promotes ß-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.
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- FASEB Journal, 2019, v. 33, n. 3, p. 3968, doi. 10.1096/fj.201801397R
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- Article
Increased Renal Methylglyoxal Formation with Down-Regulation of PGC-1α-FBPase Pathway in Cystathionine γ-Lyase Knockout Mice.
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- PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0029592
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- Article
Oxidative stress and aging: Is methylglyoxal the hidden enemy?
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- Canadian Journal of Physiology & Pharmacology, 2010, v. 88, n. 3, p. 273, doi. 10.1139/Y10-001
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- Article
Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept.
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- Biomolecules (2218-273X), 2021, v. 11, n. 8, p. 1073, doi. 10.3390/biom11081073
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- Article