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Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
Published in:
Biochemical Journal, 2014, v. 458, n. 2, p. 395, doi. 10.1042/BJ20131516
By:
- VARGHESE, Leila N.;
- UNGUREANU, Daniela;
- LIAU, Nicholas P. D.;
- YOUNG, Samuel N.;
- LAKTYUSHIN, Artem;
- HAMMAREN, Henrik;
- LUCET, Isabelle S.;
- NICOLA, Nicos A.;
- SILVENNOINEN, Olli;
- BABON, Jeffrey J.;
- MURPHY, James M.
Publication type:
Article
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Published in:
Biochemical Journal, 2014, v. 457, n. 2, p. 323, doi. 10.1042/BJ20131174
By:
- MURPHY, James M.;
- Qingwei ZHANG;
- YOUNG, Samuel N.;
- REESE, Michael L.;
- BAILEY, Fiona P.;
- EYERS, Patrick A.;
- UNGUREANU, Daniela;
- HAMMAREN, Henrik;
- SILVENNOINEN, Olli;
- VARGHESE, Leila N.;
- CHEN, Kelan;
- TRIPAYDONIS, Anne;
- JURA, Natalia;
- FUKUDA, Koichi;
- QIN, Jun;
- NIMCHUK, Zachary;
- MUDGETT, Mary Beth;
- ELOWE, Sabine;
- GEE, Christine L.;
- Ling LIU
Publication type:
Article
Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1.
Published in:
BMC Biochemistry, 2012, v. 13, n. 1, p. 20, doi. 10.1186/1471-2091-13-20
By:
- Grnholm, Juha;
- Vanhatupa, Sari;
- Ungureanu, Daniela;
- Vliaho, Jouni;
- Laitinen, Tuomo;
- Valjakka, Jarkko;
- Silvennoinen, Olli
Publication type:
Article
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.
Published in:
Nature Structural & Molecular Biology, 2014, v. 21, n. 7, p. 579, doi. 10.1038/nsmb.2849
By:
- Shan, Yibing;
- Gnanasambandan, Kavitha;
- Ungureanu, Daniela;
- Kim, Eric T;
- Hammarén, Henrik;
- Yamashita, Kazuo;
- Silvennoinen, Olli;
- Shaw, David E;
- Hubbard, Stevan R
Publication type:
Article
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Published in:
Nature Structural & Molecular Biology, 2012, v. 19, n. 8, p. 754, doi. 10.1038/nsmb.2348
By:
- Bandaranayake, Rajintha M;
- Ungureanu, Daniela;
- Shan, Yibing;
- Shaw, David E;
- Silvennoinen, Olli;
- Hubbard, Stevan R
Publication type:
Article
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.
Published in:
Nature Structural & Molecular Biology, 2011, v. 18, n. 9, p. 971, doi. 10.1038/nsmb.2099
By:
- Ungureanu, Daniela;
- Jinhua Wu;
- Pekkala, Tuija;
- Niranjan, Yashavanthi;
- Young, Clifford;
- Jensen, Ole N.;
- Chong-Feng Xu;
- Neubert, Thomas A.;
- Skoda, Radek C.;
- Hubbard, Stevan R.;
- Silvennoinen, Olli
Publication type:
Article
ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity.
Published in:
Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01527-6
By:
- Piki, Emilia;
- Dini, Alice;
- Raivola, Juuli;
- Salokas, Kari;
- Zhang, Kaiyang;
- Varjosalo, Markku;
- Pellinen, Teijo;
- Välimäki, Katja;
- Veskimäe, Kristina Tabor;
- Staff, Synnöve;
- Hautaniemi, Sampsa;
- Murumägi, Astrid;
- Ungureanu, Daniela
Publication type:
Article
Analysis of Jak2 Catalytic Function by Peptide Microarrays: The Role of the JH2 Domain and V617F Mutation.
Published in:
PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018522
By:
- Sanz, Arturo;
- Ungureanu, Daniela;
- Pekkala, Tuija;
- Ruijtenbeek, Rob;
- Touw, Ivo P.;
- Hilhorst, Riet;
- Silvennoinen, Olli
Publication type:
Article
Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors.
Published in:
Cancers, 2021, v. 13, n. 15, p. 3727, doi. 10.3390/cancers13153727
By:
- Jacome Sanz, Dafne;
- Raivola, Juuli;
- Karvonen, Hanna;
- Arjama, Mariliina;
- Barker, Harlan;
- Murumägi, Astrid;
- Ungureanu, Daniela
Publication type:
Article
Transanal Total Mesorectal Excision - A Case Report.
Published in:
Chirurgia, 2019, v. 114, n. 2, p. 278, doi. 10.21614/chirurgia.114.2.278
By:
- Tudor, Ştefan;
- Minciună, Corina;
- Lăcătuş, Monica;
- Gavrilă, Daniel;
- Manciu, Simona;
- Ungureanu, Daniela;
- Cordun, Mihai;
- Vasilescu, Cătălin
Publication type:
Article
Liver Resections in a High-Volume Center: Form Standard Procedures to Extreme Surgery and Ultrasound-guided Resections.
Published in:
Chirurgia, 2017, v. 112, n. 3, p. 259, doi. 10.21614/chirurgia.112.3.259
By:
- Botea, Florin;
- Ionescu, Mihnea;
- Braşoveanu, Vladislav;
- Hrehoreţ, Doina;
- Alexandrescu, Sorin;
- Grigorie, Mihai;
- Stanciulea, Oana;
- Nicolaescu, Diana;
- Tomescu, Dana;
- Droc, Gabriela;
- Ungureanu, Daniela;
- Fota, Ruxandra;
- Croitoru, Adina;
- Gheorghe, Liana;
- Gheorghe, Cristian;
- Lupescu, Ioana;
- Grasu, Mugur;
- Boroş, Mirela;
- Dumitru, Radu;
- Toma, Mihai
Publication type:
Article
The Romanian National Program for Liver Transplantation - 852 Procedures in 815 Patients over 17 Years (2000-2017): A Continuous Evolution to Success.
Published in:
Chirurgia, 2017, v. 112, n. 3, p. 229, doi. 10.21614/chirurgia.112.3.229
By:
- Popescu, Irinel;
- Ionescu, Mihnea;
- Braşoveanu, Vladislav;
- Hrehoreţ, Doina;
- Copca, Narcis;
- Lupaşcu, Cristian;
- Botea, Florin;
- Dorobanţu, Bogdan;
- Alexandrescu, Sorin;
- Grigorie, Mihai;
- Matei, Emil;
- Zamfir, Radu;
- Lungu, Vasile;
- Tomescu, Dana;
- Droc, Gabriela;
- Ungureanu, Daniela;
- Fota, Ruxandra;
- Manga, Graţiela;
- Popescu, Mihai;
- Popa, Laura
Publication type:
Article
Targeting Wnt signaling pseudokinases in hematological cancers.
Published in:
European Journal of Haematology, 2018, v. 101, n. 4, p. 457, doi. 10.1111/ejh.13137
By:
- Karvonen, Hanna;
- Perttilä, Robert;
- Niininen, Wilhelmiina;
- Barker, Harlan;
- Ungureanu, Daniela
Publication type:
Article
First report of cytokine removal using CytoSorb® in severe noninfectious inflammatory syndrome after liver transplantation.
Published in:
2016
By:
- Tomescu, Dana R.;
- Dima, Simona Olimpia;
- Ungureanu, Daniela;
- Popescu, Mihai;
- Tulbure, Dan;
- Popescu, Irinel;
- Olimpia Dima, Simona
Publication type:
journal article
New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome.
Published in:
Cellular & Molecular Life Sciences, 2022, v. 79, n. 5, p. 1, doi. 10.1007/s00018-022-04301-6
By:
- Raivola, Juuli;
- Dini, Alice;
- Salokas, Kari;
- Karvonen, Hanna;
- Niininen, Wilhelmiina;
- Piki, Emilia;
- Varjosalo, Markku;
- Ungureanu, Daniela
Publication type:
Article
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02446
By:
- Sheetz, Joshua;
- Mathea, Sebastian;
- Karvonen, Hanna;
- Malhotra, Ketan;
- Chatterjee, Deep;
- Niininen, Wilhelmiina;
- Perttila, Robert;
- Preuss, Franziska;
- Suresh, Krishna;
- Stayrook, Steven;
- Tsutsui, Yuko;
- Radhakrishnan, Ravi;
- Ungureanu, Daniela;
- Knapp, Stefan;
- Lemmon, Mark
Publication type:
Article
A Combined Program of Cadaveric and Living-Related Liver Transplantation in a Single Center: An Experience of 1,000 Operations.
Published in:
Surgery, Gastroenterology & Oncology, 2021, v. 26, n. 1, p. 30, doi. 10.21614/sgo-26-328
By:
- Botea, Florin;
- Dorobantu, Bogdan;
- Alexandrescu, Sorin;
- Grigorie, Mihai;
- Matei, Emil;
- Zamfir, Radu;
- Lungu, Vasile;
- Zamfirescu, Dragos;
- Tomescu, Dana;
- Droc, Gabriela;
- Ungureanu, Daniela;
- Fota, Ruxandra;
- Manga, Gratiela;
- Popescu, Mihai;
- Gheorghe, Liana;
- Iacob, Speranta;
- Pietrareanu, Corina;
- Mihaila, Mariana;
- Micu, Laurentiu;
- Gheorghe, Cristian
Publication type:
Article
Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention.
Published in:
Cell Death & Disease, 2022, v. 13, n. 8, p. 1, doi. 10.1038/s41419-022-05161-5
By:
- Raivola, Juuli;
- Dini, Alice;
- Karvonen, Hanna;
- Piki, Emilia;
- Salokas, Kari;
- Niininen, Wilhelmiina;
- Kaleva, Laura;
- Zhang, Kaiyang;
- Arjama, Mariliina;
- Gudoityte, Greta;
- Seashore-Ludlow, Brinton;
- Varjosalo, Markku;
- Kallioniemi, Olli;
- Hautaniemi, Sampsa;
- Murumägi, Astrid;
- Ungureanu, Daniela
Publication type:
Article
Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness.
Published in:
Cell Death & Disease, 2020, v. 11, n. 9, p. 1, doi. 10.1038/s41419-020-03009-4
By:
- Karvonen, Hanna;
- Arjama, Mariliina;
- Kaleva, Laura;
- Niininen, Wilhelmiina;
- Barker, Harlan;
- Koivisto-Korander, Riitta;
- Tapper, Johanna;
- Pakarinen, Päivi;
- Lassus, Heini;
- Loukovaara, Mikko;
- Bützow, Ralf;
- Kallioniemi, Olli;
- Murumägi, Astrid;
- Ungureanu, Daniela
Publication type:
Article
Targeting ROR1 identifies new treatment strategies in hematological cancers.
Published in:
Biochemical Society Transactions, 2017, v. 45, n. 2, p. 457, doi. 10.1042/BST20160272
By:
- Karvonen, Hanna;
- Niininen, Wilhelmiina;
- Murumägi, Astrid;
- Ungureanu, Daniela
Publication type:
Article
New insights into the structure and function of the pseudokinase domain in JAK2.
Published in:
Biochemical Society Transactions, 2013, v. 41, n. 4, p. 1002, doi. 10.1042/BST20130005
By:
- Silvennoinen, Olli;
- Ungureanu, Daniela;
- Niranjan, Yashavanthi;
- Hammaren, Henrik;
- Bandaranayake, Rajintha;
- Hubbard, Stevan R.
Publication type:
Article
Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma.
Published in:
British Journal of Cancer, 2023, v. 128, n. 4, p. 678, doi. 10.1038/s41416-022-02067-z
By:
- Murumägi, Astrid;
- Ungureanu, Daniela;
- Khan, Suleiman;
- Arjama, Mariliina;
- Välimäki, Katja;
- Ianevski, Aleksandr;
- Ianevski, Philipp;
- Bergström, Rebecka;
- Dini, Alice;
- Kanerva, Anna;
- Koivisto-Korander, Riitta;
- Tapper, Johanna;
- Lassus, Heini;
- Loukovaara, Mikko;
- Mägi, Andrus;
- Hirasawa, Akira;
- Aoki, Daisuke;
- Pietiäinen, Vilja;
- Pellinen, Teijo;
- Bützow, Ralf
Publication type:
Article
Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways.
Published in:
Cells (2073-4409), 2019, v. 8, n. 8, p. 812, doi. 10.3390/cells8080812
By:
- Karvonen, Hanna;
- Barker, Harlan;
- Kaleva, Laura;
- Niininen, Wilhelmiina;
- Ungureanu, Daniela
Publication type:
Article
Sumoylation of Drosophila Transcription Factor STAT92E.
Published in:
Journal of Innate Immunity, 2010, v. 2, n. 6, p. 618, doi. 10.1159/000318676
By:
- Grönholm, Juha;
- Ungureanu, Daniela;
- Vanhatupa, Sari;
- Rämet, Mika;
- Silvennoinen, Olli
Publication type:
Article
Interaction between ROR1 and MuSK activation complex in myogenic cells.
Published in:
FEBS Letters, 2018, v. 592, n. 3, p. 434, doi. 10.1002/1873-3468.12966
By:
- Karvonen, Hanna;
- Summala, Katja;
- Niininen, Wilhelmiina;
- Barker, Harlan R.;
- Ungureanu, Daniela
Publication type:
Article
Nasal permeability after endoscopic surgical treatment in children with chronic and recurrent rhinosinusitis.
Published in:
ORL.ro, 2016, v. 9, n. 31, p. 57
By:
- Maniuc, M.;
- Ababii, Polina;
- Chiaburu, Angela;
- Chirtoca, Diana;
- Diacova, Svetlana;
- Didencu, A.;
- Rusu-Ungureanu, Daniela
Publication type:
Article
Endoscopic surgical treatment of rhinosinusitis in children.
Published in:
2016
By:
- Maniuc, Mihail;
- Ababii, Polina;
- Danilov, L.;
- Chirtoca, Diana;
- Didencu, Alexandru;
- Rusu-Ungureanu, Daniela
Publication type:
Abstract
IL-15-IgG2b fusion protein accelerates and enhances a Th2 but not a Th1 immune response in vivo, while IL-2-IgG2b fusion protein inhibits both.
Published in:
European Journal of Immunology, 1998, v. 28, n. 10, p. 3312, doi. 10.1002/(SICI)1521-4141(199810)28:10<3312::AID-IMMU3312>3.0.CO;2-I
By:
- Rückert, René;
- Herz, Udo;
- Paus, Ralf;
- Ungureanu, Daniela;
- Pohl, Thomas;
- Renz, Harald;
- Bulfone-Paus, Silvia
Publication type:
Article

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