Works by Umehara, Ken

Results: 19

Dysphagia following C1 laminectomy and posterior atlantoaxial fixation for retro-odontoid pseudotumor: a case report.

Published in:

British Journal of Neurosurgery, 2020, v. 34, n. 5, p. 508, doi. 10.1080/02688697.2018.1538485

By:

Tanioka, Satoru;
Kuraishi, Keita;
Mizuno, Masaki;
Ishida, Fujimaro;
Fuse, Ikuko;
Umehara, Ken;
Suzuki, Hidenori

Publication type:

Article

Hemodialysis clearance of iosimenol, a novel iso-osmolar radiographic contrast medium.

Published in:

2014

By:

Hirao, Yukihiro;
Kashiyama, Eiji;
Umehara, Ken;
Kohno, Makoto;
Ikei, Nobuhiro;
Hogstrom, Barry

Publication type:

Journal Article

Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.

Published in:

Journal of Toxicological Sciences, 2015, v. 40, n. 2, p. 181, doi. 10.2131/jts.40.181

By:

Kenji Takeuchi;
Hirohiko Goto;
Yuko Ito;
Makoto Sato;
Satoshi Matsumoto;
Tadashi Senba;
Hideyuki Yamada;
Ken Umehara

Publication type:

Article

Nonclinical Pharmacokinetics of a New Nonpeptide V2 Receptor Antagonist, Tolvaptan.

Published in:

Cardiovascular Drugs & Therapy, 2011, v. 25, p. 83, doi. 10.1007/s10557-011-6357-x

By:

Furukawa, Masayuki;
Umehara, Ken;
Kashiyama, Eiji

Publication type:

Article

Novel In Vitro-In Vivo Extrapolation (IVIVE) Method to Predict Hepatic Organ Clearance in Rat.

Published in:

Pharmaceutical Research, 2012, v. 29, n. 2, p. 603, doi. 10.1007/s11095-011-0607-2

By:

Umehara, Ken-ichi;
Camenisch, Gian

Publication type:

Article

Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 5, p. 1082, doi. 10.1002/cpt.1693

By:

Taskar, Kunal S.;
Pilla Reddy, Venkatesh;
Burt, Howard;
Posada, Maria M.;
Varma, Manthena;
Zheng, Ming;
Ullah, Mohammed;
Emami Riedmaier, Arian;
Umehara, Ken‐ichi;
Snoeys, Jan;
Nakakariya, Masanori;
Chu, Xiaoyan;
Beneton, Maud;
Chen, Yuan;
Huth, Felix;
Narayanan, Rangaraj;
Mukherjee, Dwaipayan;
Dixit, Vaishali;
Sugiyama, Yuichi;
Neuhoff, Sibylle

Publication type:

Article

Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug–drug interaction potential of CYP3A4 substrates.

Published in:

Biopharmaceutics & Drug Disposition, 2018, v. 39, n. 3, p. 152, doi. 10.1002/bdd.2122

By:

Umehara, Ken‐ichi;
Huth, Felix;
Won, Christina S.;
Heimbach, Tycho;
He, Handan

Publication type:

Article

Absorption, distribution and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis.

Published in:

Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 4, p. 301, doi. 10.1002/bdd.2064

By:

Shibata, Masakazu;
Shimokawa, Yoshihiko;
Sasahara, Katsunori;
Yoda, Noriaki;
Sasabe, Hiroyuki;
Suzuki, Mitsunari;
Umehara, Ken

Publication type:

Article

Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions.

Published in:

Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 4, p. 179, doi. 10.1002/bdd.1784

By:

Camenisch, Gian;
Umehara, Ken-ichi

Publication type:

Article

Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.

Published in:

Drug Metabolism & Personalized Therapy, 2017, v. 32, n. 4, p. 191, doi. 10.1515/dmpt-2017-0024

By:

Umehara, Ken-ichi;
Huth, Felix;
Gu, Helen;
Schiller, Hilmar;
Heimbach, Tycho;
He, Handan

Publication type:

Article

Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.

Published in:

Drug Metabolism & Personalized Therapy, 2016, v. 31, n. 4, p. 221, doi. 10.1515/dmpt-2016-0028

By:

Njuguna, Nicholas M.;
Umehara, Ken-ichi;
Huth, Felix;
Schiller, Hilmar;
Chibale, Kelly;
Camenisch, Gian

Publication type:

Article

Effect of physical frailty on maximum phonation time in community‐dwelling older individuals who visited a neurology outpatient clinic.

Published in:

Journal of Oral Rehabilitation, 2024, v. 51, n. 7, p. 1221, doi. 10.1111/joor.13698

By:

Umehara, Ken;
Yamamoto, Akio;
Kitagawa, Takeo;
Yoshimaru, Kimiko;
Ishikawa, Akira

Publication type:

Article

Measurement of laryngeal elevation time using a flexible surface stretch sensor.

Published in:

Journal of Oral Rehabilitation, 2020, v. 47, n. 12, p. 1489, doi. 10.1111/joor.13082

By:

Hanaie, Kaoru;
Yamamoto, Akio;
Umehara, Ken;
Bessho, Yusuke;
Nakamoto, Hiroyuki;
Nakayama, Kimiko;
Sawada, Kaku;
Osawa, Satoshi;
Ogasawara, Takeshi;
Tsuneishi, Syuichi;
Wakasugi, Yoko;
Ishikawa, Akira

Publication type:

Article

Liquid chromatography-tandem mass spectrometry method for determining tolvaptan and its nine metabolites in rat serum: application to a pharmacokinetic study.

Published in:

Archives of Pharmacal Research, 2014, v. 37, n. 12, p. 1578, doi. 10.1007/s12272-014-0352-2

By:

Furukawa, Masayuki;
Miyata, Kenichi;
Kawasome, Chie;
Himeda, Yoshiko;
Takeuchi, Kenji;
Koga, Toshihisa;
Hirao, Yukihiro;
Umehara, Ken

Publication type:

Article

Possible nonimmunological toxicological mechanisms of vesnarinone-associated agranulocytosis in HL-60 cells: role of reduced glutathione as cytotoxic defense.

Published in:

Journal of Toxicological Sciences, 2024, v. 49, n. 3, p. 95, doi. 10.2131/jts.49.95

By:

Toshihisa Koga;
Yuko Sahara;
Tadaaki Ohtani;
Kaneko Yosuke;
Ken Umehara

Publication type:

Article

In vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole.

Published in:

Xenobiotica, 2021, v. 51, n. 5, p. 522, doi. 10.1080/00498254.2021.1897898

By:

Sasabe, Hiroyuki;
Koga, Toshihisa;
Furukawa, Masayuki;
Matsunaga, Masayuki;
Sasahara, Katsunori;
Hashizume, Kenta;
Oozone, Yoshihiro;
Amunom, Immaculate;
Torii, Mikako;
Umehara, Ken;
Kashiyama, Eiji;
Takeuchi, Kenji

Publication type:

Article

Esterase phenotyping in human liver in vitro : specificity of carboxylesterase inhibitors.

Published in:

Xenobiotica, 2016, v. 46, n. 10, p. 862, doi. 10.3109/00498254.2015.1133867

By:

Umehara, Ken-Ichi;
Zollinger, Markus;
Kigondu, Elizabeth;
Witschi, Marc;
Juif, Claire;
Huth, Felix;
Schiller, Hilmar;
Chibale, Kelly;
Camenisch, Gian

Publication type:

Article

Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies.

Published in:

Xenobiotica, 2015, v. 45, n. 4, p. 353, doi. 10.3109/00498254.2014.985760

By:

Yamamura, Yoshiya;
Koyama, Noriyuki;
Umehara, Ken

Publication type:

Article

Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.

Published in:

Xenobiotica, 2012, v. 42, n. 8, p. 719, doi. 10.3109/00498254.2012.656732

By:

Yoda, Noriaki;
Emoto, Chie;
Date, Shoichi;
Kondo, Satoshi;
Miyake, Masateru;
Nakazato, Satoru;
Umehara, Ken;
Kashiyama, Eiji

Publication type:

Article