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Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets.
Published in:
Journal of Hematology & Oncology, 2017, v. 10, p. 1, doi. 10.1186/s13045-017-0540-x
By:
- Kanojia, Deepika;
- Garg, Manoj;
- Martinez, Jacqueline;
- M. T., Anand;
- Luty, Samuel B.;
- Doan, Ngan B.;
- Said, Jonathan W.;
- Forscher, Charles;
- Tyner, Jeffrey W.;
- Koeffler, H. Phillip
Publication type:
Article
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.
Published in:
Journal of Clinical Investigation, 2006, v. 116, n. 2, p. 309, doi. 10.1172/JCI25167
By:
- Tyner, Jeffrey W.;
- Kim, Edy Y.;
- Ide, Kyotaro;
- Pelletier, Mark R.;
- Roswit, William T.;
- Morton, Jeffrey D.;
- Battaile, John T.;
- Patel, Anand C.;
- Patterson, G. Alexander;
- Castro, Mario;
- Spoor, Melanie S.;
- You, Yingjian;
- Brody, Steven L.;
- Holtzman, Michael J.
Publication type:
Article
Immune cell proportions correlate with clinicogenomic features and ex vivo drug responses in acute myeloid leukemia.
Published in:
Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1192829
By:
- Romine, Kyle A.;
- Bottomly, Daniel;
- Yashar, William;
- Long, Nicola;
- Viehdorfer, Matthew;
- McWeeney, Shannon K.;
- Tyner, Jeffrey W.
Publication type:
Article
Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.
Published in:
Science Signaling, 2018, v. 11, n. 539, p. 1, doi. 10.1126/scisignal.aao5617
By:
- Jenkins, Chelsea;
- Luty, Samuel B.;
- Maxson, Julia E.;
- Eide, Christopher A.;
- Abel, Melissa L.;
- Togiai, Corinne;
- Nemecek, Eneida R.;
- Bottomly, Daniel;
- McWeeney, Shannon K.;
- Wilmot, Beth;
- Loriaux, Marc;
- Chang, Bill H.;
- Tyner, Jeffrey W.
Publication type:
Article
Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR.
Published in:
Journal of Ovarian Research, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13048-023-01160-y
By:
- Chien, Wenwen;
- Tyner, Jeffrey W.;
- Gery, Sigal;
- Zheng, Yueyuan;
- Li, Li-Yan;
- Gopinatha Pillai, Mohan Shankar;
- Nam, Chehyun;
- Bhowmick, Neil A.;
- Lin, De-Chen;
- Koeffler, H. Phillip
Publication type:
Article
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
Published in:
Nature Medicine, 2008, v. 14, n. 6, p. 633, doi. 10.1038/nm1770
By:
- Kim, Edy Y.;
- Battaile, John T.;
- Patel, Anand C.;
- Yingjian You;
- Agapov, Eugene;
- Grayson, Mitchell H.;
- Benoit, Loralyn A.;
- Byers, Derek E.;
- Alevy, Yael;
- Tucker, Jennifer;
- Swanson, Suzanne;
- Tidwell, Rose;
- Tyner, Jeffrey W.;
- Morton, Jeffrey D.;
- Castro, Mario;
- Polineni, Deepika;
- Patterson, Alexander G.;
- Schwendener, Reto A.;
- Allard, John D.;
- Peltz, Gary
Publication type:
Article
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.
Published in:
Nature Medicine, 2005, v. 11, n. 11, p. 1180, doi. 10.1038/nm1303
By:
- Tyner, Jeffrey W.;
- Uchida, Osamu;
- Kajiwara, Naohiro;
- Kim, Edy Y.;
- Patel, Anand C.;
- O'Sullivan, Mary P.;
- Walter, Michael J.;
- Schwendener, Reto A.;
- Cook, Donald N.;
- Danoff, Theodore M.;
- Holtzman, Michael J.
Publication type:
Article
CDK12/13 dual inhibitors are potential therapeutics for acute myeloid leukemia.
Published in:
British Journal of Haematology, 2023, v. 202, n. 1, p. 195, doi. 10.1111/bjh.18843
By:
- Savoy, Lindsey;
- Long, Nicola;
- Lee, Hyunjung;
- Chen, Reid;
- Allen, Basil;
- Lin, Hsin‐Yun;
- Tognon, Cristina;
- V. Malhotra, Sanjay;
- Tyner, Jeffrey W.;
- Zhang, Haijiao
Publication type:
Article
Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance.
Published in:
British Journal of Haematology, 2016, v. 172, n. 6, p. 983, doi. 10.1111/bjh.13551
By:
- Viola, Shelton;
- Traer, Elie;
- Huan, Jianya;
- Hornick, Noah I.;
- Tyner, Jeffrey W.;
- Agarwal, Anupriya;
- Loriaux, Marc;
- Johnstone, Brian;
- Kurre, Peter
Publication type:
Article
The FLT3<sup>N701K</sup> mutation causes clinical AML resistance to gilteritinib and triggers TKI sensitivity switch to quizartinib.
Published in:
American Journal of Hematology, 2023, v. 98, n. 12, p. E364, doi. 10.1002/ajh.27096
By:
- Joshi, Sunil K.;
- Pittsenbarger, Janét;
- Kennedy, Vanessa E.;
- Peretz, Cheryl A. C.;
- Perl, Alexander E.;
- Smith, Catherine C.;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Traer, Elie
Publication type:
Article
Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting.
Published in:
Scientific Reports, 2016, p. 28163, doi. 10.1038/srep28163
By:
- Jacob, Thomas;
- Agarwal, Anupriya;
- Ramunno-Johnson, Damien;
- O'Hare, Thomas;
- Gönen, Mehmet;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Vu, Tania Q.
Publication type:
Article
Growth Arrest of BCR-ABL Positive Cells with a Sequence-Specific Polyamide-Chlorambucil Conjugate.
Published in:
PLoS ONE, 2008, v. 3, n. 10, p. 1, doi. 10.1371/journal.pone.0003593
By:
- Chou, C. James;
- O'Hare, Thomas;
- Lefebvre, Sophie;
- Alvarez, David;
- Tyner, Jeffrey W.;
- Eide, Christopher A.;
- Druker, Brian J.;
- Gottesfeld, Joel M.
Publication type:
Article
Apoptosis in the Airways.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2003, v. 29, n. 1, p. 3, doi. 10.1165/rcmb.F273
By:
- O'Sullivan, Mary P.;
- Tyner, Jeffrey W.;
- Holtzman, Michael J.
Publication type:
Article
Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia.
Published in:
Cancers, 2022, v. 14, n. 24, p. 6142, doi. 10.3390/cancers14246142
By:
- Summers, Ryan J.;
- Jain, Juhi;
- Vasileiadi, Eleana;
- Smith, Brittany;
- Chimenti, Madison L.;
- Yeung, Tsz Y.;
- Kelvin, James;
- Wang, Xiaodong;
- Frye, Stephen V.;
- Earp, H. Shelton;
- Tyner, Jeffrey W.;
- Dreaden, Erik C.;
- DeRyckere, Deborah;
- Graham, Douglas K.
Publication type:
Article
TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.
Published in:
Database: The Journal of Biological Databases & Curation, 2014, v. 2014, p. 1, doi. 10.1093/database/bau007
By:
- Jun Zhong;
- Sharma, Jyoti;
- Raju, Rajesh;
- Palapetta, Shyam Mohan;
- Prasad, T. S. Keshava;
- Tai-Chung Huang;
- Yoda, Akinori;
- Tyner, Jeffrey W.;
- van Bodegom, Diederik;
- Weinstock, David M.;
- Ziegler, Steven F.;
- Pandey, Akhilesh
Publication type:
Article
The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.
Published in:
Nature Cell Biology, 2015, v. 17, n. 5, p. 665, doi. 10.1038/ncb3158
By:
- Kang, Xunlei;
- Lu, Zhigang;
- Cui, Changhao;
- Deng, Mi;
- Fan, Yuqi;
- Dong, Baijun;
- Han, Xin;
- Xie, Fuchun;
- Tyner, Jeffrey W.;
- Coligan, John E.;
- Collins, Robert H.;
- Xiao, Xiangshu;
- You, M. James;
- Zhang, Cheng Cheng
Publication type:
Article
Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma.
Published in:
PLoS ONE, 2019, v. 14, n. 10, p. 1, doi. 10.1371/journal.pone.0223639
By:
- Choonoo, Gabrielle;
- Blucher, Aurora S.;
- Higgins, Samuel;
- Boardman, Mitzi;
- Jeng, Sophia;
- Zheng, Christina;
- Jacobs, James;
- Anderson, Ashley;
- Chamberlin, Steven;
- Evans, Nathaniel;
- Vigoda, Myles;
- Cordier, Benjamin;
- Tyner, Jeffrey W.;
- Kulesz-Martin, Molly;
- McWeeney, Shannon K.;
- Laderas, Ted
Publication type:
Article
TNK1 is a ubiquitin‐sensing kinase that can be targeted to block tumor growth.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5508
By:
- Andersen, Joshua L.;
- Chan, Tsz‐Yin;
- Egbert, Christina M.;
- Lopez‐Palacios, Tania;
- Maxson, Julia E.;
- Tyner, Jeffrey W.;
- Warner, Steven L.
Publication type:
Article
Targeting BCL-2 and ABL/LYN in Philadelphia chromosome–positive acute lymphoblastic leukemia.
Published in:
Science Translational Medicine, 2016, v. 8, n. 354, p. 1, doi. 10.1126/scitranslmed.aaf5309
By:
- Leonard, Jessica T.;
- Rowley, Joelle S. J.;
- Eide, Christopher A.;
- Traer, Elie;
- Hayes-Lattin, Brandon;
- Loriaux, Marc;
- Spurgeon, Stephen E.;
- Druker, Brian J.;
- Tyner, Jeffrey W.;
- Chang, Bill H.
Publication type:
Article
Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma.
Published in:
Cell Death & Disease, 2022, v. 13, n. 3, p. 1, doi. 10.1038/s41419-022-04684-1
By:
- Thieme, Elana;
- Liu, Tingting;
- Bruss, Nur;
- Roleder, Carly;
- Lam, Vi;
- Wang, Xiaoguang;
- Nechiporuk, Tamilla;
- Shouse, Geoffrey;
- Danilova, Olga V.;
- Bottomly, Daniel;
- McWeeney, Shannon K.;
- Tyner, Jeffrey W.;
- Kurtz, Stephen E.;
- Danilov, Alexey V.
Publication type:
Article
Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism.
Published in:
American Journal of Hematology, 2016, v. 91, n. 2, p. 211, doi. 10.1002/ajh.24245
By:
- Garbati, Michael R.;
- Welgan, Catherine A.;
- Landefeld, Sally H.;
- Newell, Laura F.;
- Agarwal, Anupriya;
- Dunlap, Jennifer B.;
- Chourasia, Tapan K.;
- Lee, Hyunjung;
- Elferich, Johannes;
- Traer, Elie;
- Rattray, Rogan;
- Cascio, Michael J.;
- Press, Richard D.;
- Bagby, Grover C.;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Dao, Kim-Hien T.
Publication type:
Article
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia.
Published in:
NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00209-9
By:
- White, Brian S.;
- Khan, Suleiman A.;
- Mason, Mike J.;
- Ammad-ud-din, Muhammad;
- Potdar, Swapnil;
- Malani, Disha;
- Kuusanmäki, Heikki;
- Druker, Brian J.;
- Heckman, Caroline;
- Kallioniemi, Olli;
- Kurtz, Stephen E.;
- Porkka, Kimmo;
- Tognon, Cristina E.;
- Tyner, Jeffrey W.;
- Aittokallio, Tero;
- Wennerberg, Krister;
- Guinney, Justin
Publication type:
Article
Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent.
Published in:
Journal of Hematology & Oncology, 2016, v. 9, p. 1, doi. 10.1186/s13045-016-0258-1
By:
- Leonard, Jessica T.;
- Raess, Philipp W.;
- Dunlap, Jennifer;
- Hayes-Lattin, Brandon;
- Tyner, Jeffrey W.;
- Traer, Elie
Publication type:
Article
YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway.
Published in:
Journal of Hematology & Oncology, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13045-015-0132-6
By:
- Chang, Bill H.;
- Johnson, Kara;
- LaTocha, Dorian;
- Rowley, Joelle S. J.;
- Bryant, Jade;
- Burke, Russell;
- Smith, Rebecca L.;
- Loriaux, Marc;
- Müschen, Markus;
- Mullighan, Charles;
- Druker, Brian J.;
- Tyner, Jeffrey W.
Publication type:
Article
A case study of personalized therapy for osteosarcoma.
Published in:
Pediatric Blood & Cancer, 2013, v. 60, n. 8, p. 1313, doi. 10.1002/pbc.24512
By:
- Davis, Lara E.;
- Hofmann, Nicolle E.;
- Li, Guangheng;
- Huang, Elaine T.;
- Loriaux, Marc M.;
- Bracha, Shay;
- Helfand, Stuart C.;
- Mata, John E.;
- Marley, Kevin;
- Mansoor, Atiya;
- Tyner, Jeffrey W.;
- Abraham, Jinu;
- Séguin, Bernard;
- Keller, Charles
Publication type:
Article
In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia.
Published in:
Pediatric Blood & Cancer, 2012, v. 59, n. 3, p. 576, doi. 10.1002/pbc.23383
By:
- Glover, Jason M.;
- Loriaux, Marc;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Chang, Bill H.
Publication type:
Article
Comprehensive molecular characterization of a rare case of Philadelphia chromosome--positive acute myeloid leukemia.
Published in:
Cold Spring Harbor Molecular Case Studies, 2022, v. 8, n. 6, p. 1, doi. 10.1101/mcs.a006218
By:
- Rosenberg, Mara W.;
- Savage, Samantha L.;
- Eide, Christopher A.;
- Schultz, Anna Reister;
- Cook, Rachel J.;
- Press, Richard D.;
- Rempfer, Carole;
- Eickelberg, Garrett;
- Wilmot, Beth;
- McWeeney, Shannon K.;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Tognon, Cristina E.
Publication type:
Article
Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma.
Published in:
Cold Spring Harbor Molecular Case Studies, 2020, v. 6, n. 4, p. 1, doi. 10.1101/mcs.a005439
By:
- Anderson, Ashley N.;
- McClanahan, Danielle;
- Jacobs, James;
- Jeng, Sophia;
- Vigoda, Myles;
- Blucher, Aurora S.;
- Zheng, Christina;
- Yeon Jung Yoo;
- Hale, Carolyn;
- Xiaoming Ouyang;
- Clayburgh, Daniel;
- Andersen, Peter;
- Tyner, Jeffrey W.;
- Bar, Anna;
- Lucero, Olivia M.;
- Leitenberger, Justin J.;
- McWeeney, Shannon K.;
- Kulesz-Martin, Molly
Publication type:
Article
Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine.
Published in:
Genome Medicine, 2013, v. 5, n. 11, p. 1, doi. 10.1186/gm509
By:
- Bottomly, Daniel;
- Ryabinin, Peter A.;
- Tyner, Jeffrey W.;
- Chang, Bill H.;
- Loriaux, Marc M.;
- Druker, Brian J.;
- McWeeney, Shannon K.;
- Wilmot, Beth
Publication type:
Article
Pl GF enhances TLR-dependent inflammatory responses in human mononuclear phagocytes.
Published in:
American Journal of Reproductive Immunology, 2017, v. 78, n. 4, p. n/a, doi. 10.1111/aji.12709
By:
- Newell, Laura F.;
- Holtan, Shernan G.;
- Yates, Jane E.;
- Pereira, Leonardo;
- Tyner, Jeffrey W.;
- Burd, Irina;
- Bagby, Grover C.
Publication type:
Article
HitWalker: variant prioritization for personalized functional cancer genomics.
Published in:
Bioinformatics, 2013, v. 29, n. 4, p. 509, doi. 10.1093/bioinformatics/btt003
By:
- Bottomly, Daniel;
- Wilmot, Beth;
- Tyner, Jeffrey W.;
- Eide, Christopher A.;
- Loriaux, Marc M.;
- Druker, Brian J.;
- McWeeney, Shannon K.
Publication type:
Article
Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia.
Published in:
PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0179558
By:
- Bandyopadhyay, Shovik;
- Li, Junjie;
- Traer, Elie;
- Tyner, Jeffrey W.;
- Zhou, Amy;
- Oh, Stephen T.;
- Cheng, Ji-Xin
Publication type:
Article
Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer.
Published in:
Molecular Oncology, 2015, v. 9, n. 4, p. 889, doi. 10.1016/j.molonc.2015.01.002
By:
- Chien, Wenwen;
- Sun, Qiao-Yang;
- Lee, Kian Leong;
- Ding, Ling-Wen;
- Wuensche, Peer;
- Torres-Fernandez, Lucia A.;
- Tan, Siew Zhuan;
- Tokatly, Itay;
- Zaiden, Norazean;
- Poellinger, Lorenz;
- Mori, Seiichi;
- Yang, Henry;
- Tyner, Jeffrey W.;
- Koeffler, H. Phillip
Publication type:
Article

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