Works matching AU Tuszynski, Jack A.

Results: 199

Biophysical insights into cancer transformation and treatment.

Published in:

2013

By:

Pokorny, Jií;
Foletti, Alberto;
Kobilková, Jitka;
Jandová, Anna;
Vrba, Jan;
Vrba Jr, Jan;
Nedbalová, Martina;
Cocek, Ales;
Danani, Andrea;
Tuszynski, Jack A;
Pokorný, Jiří;
Vrba, Jan Jr;
Čoček, Aleš;
Tuszyński, Jack A

Publication type:

journal article

Design and evaluation of albumin nanoparticles for the delivery of a novel β-tubulin polymerization inhibitor.

Published in:

2021

By:

Spada, Alessandra;
Emam, Jaber;
Sanaee, Forough;
Aminpour, Maral;
Paiva, Igor M.;
Tuszynski, Jack A.;
Lavasanifar, Afsaneh;
Emami, Jaber;
Sanaee, Foroughalsadat;
Tuszynski, Jack

Publication type:

journal article

Computational Search for Inhibitors of SOD1 Mutant Infectivity as Potential Therapeutics for ALS Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4660, doi. 10.3390/ijms26104660

By:

Carnaroli, Marco;
Deriu, Marco Agostino;
Tuszynski, Jack Adam

Publication type:

Article

Gibbs free energy as a measure of complexity correlates with time within C. elegans embryonic development.

Published in:

Journal of Biological Physics, 2017, v. 43, n. 4, p. 551, doi. 10.1007/s10867-017-9469-0

By:

McGuire, Samuel;
Rietman, Edward;
Siegelmann, Hava;
Tuszynski, Jack

Publication type:

Article

Thermodynamic measures of cancer: Gibbs free energy and entropy of protein-protein interactions.

Published in:

Journal of Biological Physics, 2016, v. 42, n. 3, p. 339, doi. 10.1007/s10867-016-9410-y

By:

Rietman, Edward;
Platig, John;
Tuszynski, Jack;
Lakka Klement, Giannoula

Publication type:

Article

Boundaries of brain information processing.

Published in:

2010

By:

Velazquez, Jose Luis Perez;
Tuszynski, Jack;
Dominguez, Luis Garcia

Publication type:

Editorial

Neural cytoskeleton capabilities for learning and memory.

Published in:

Journal of Biological Physics, 2010, v. 36, n. 1, p. 3, doi. 10.1007/s10867-009-9153-0

By:

Priel, Avner;
Tuszynski, Jack A.;
Woolf, Nancy J.

Publication type:

Article

A critical assessment of the information processing capabilities of neuronal microtubules using coherent excitations.

Published in:

Journal of Biological Physics, 2010, v. 36, n. 1, p. 53, doi. 10.1007/s10867-009-9158-8

By:

Craddock, Travis John Adrian;
Tuszynski, Jack A.

Publication type:

Article

Effect of Calcium on Electrical Energy Transfer by Microtubules.

Published in:

Journal of Biological Physics, 2008, v. 34, n. 5, p. 475, doi. 10.1007/s10867-008-9106-z

By:

Priel, Avner;
Ramos, Arnolt;
Tuszynski, Jack;
Cantiello, Horacio

Publication type:

Article

The physiological concentration of ferrous iron (II) alters the inhibitory effect of hydrogen peroxide on CD45, LAR and PTP1B phosphatases.

Published in:

BioMetals, 2015, v. 28, n. 6, p. 975, doi. 10.1007/s10534-015-9882-4

By:

Kuban-Jankowska, Alicja;
Gorska, Magdalena;
Jaremko, Lukasz;
Jaremko, Mariusz;
Tuszynski, Jack;
Wozniak, Michal

Publication type:

Article

Dual continuum upscaling of liver lobule flow and metabolism to the full organ scale.

Published in:

Frontiers in Systems Biology, 2022, v. 2, p. 1, doi. 10.3389/fsysb.2022.926923

By:

Coombe, Dennis;
Rezania, Vahid;
Tuszynski, Jack Adam

Publication type:

Article

Renormalization in Quantum Brain Dynamics.

Published in:

AppliedMath, 2023, v. 3, n. 1, p. 117, doi. 10.3390/appliedmath3010009

By:

Nishiyama, Akihiro;
Tanaka, Shigenori;
Tuszynski, Jack A.

Publication type:

Article

Cancer Metabolism as a Therapeutic Target and Review of Interventions.

Published in:

Nutrients, 2023, v. 15, n. 19, p. 4245, doi. 10.3390/nu15194245

By:

Halma, Matthew T. J.;
Tuszynski, Jack A.;
Marik, Paul E.

Publication type:

Article

ALGEBRAIC AND TOPOLOGICAL INDICES OF MOLECULAR PATHWAY NETWORKS IN HUMAN CANCERS.

Published in:

Mathematical Biosciences & Engineering, 2015, v. 12, n. 6, p. 1289, doi. 10.3934/mbe.2015.12.1289

By:

HINOW, PETER;
RIETMAN, EDWARD A.;
OMAR, SARA IBRAHIM;
TUSZYNSKI, JACK A.

Publication type:

Article

Tubulin's response to external electric fields by molecular dynamics simulations.

Published in:

PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0202141

By:

Timmons, Joshua J.;
Preto, Jordane;
Tuszynski, Jack A.;
Wong, Eric T.

Publication type:

Article

Virtual screening using covalent docking to find activators for G245S mutant p53.

Published in:

PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0200769

By:

Omar, Sara Ibrahim;
Lepre, Marco Gaetano;
Morbiducci, Umberto;
Deriu, Marco Agostino;
Tuszynski, Jack A.

Publication type:

Article

Analysis of Protein Three-Dimension Structure Using Amino Acids Depths.

Published in:

Protein Journal, 2007, v. 26, n. 3, p. 183, doi. 10.1007/s10930-006-9060-1

By:

Shiyi Shen;
Gang Hu;
Jack Tuszynski

Publication type:

Article

Recent Update on siRNA Therapeutics.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 8, p. 3456, doi. 10.3390/ijms26083456

By:

Ebenezer, Oluwakemi;
Oyebamiji, Abel Kolawole;
Olanlokun, John Oludele;
Tuszynski, Jack A.;
Wong, Gane Ka-Shu

Publication type:

Article

Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers.

Published in:

PLoS Computational Biology, 2021, v. 17, n. 1, p. 1, doi. 10.1371/journal.pcbi.1008603

By:

Omar, Sara Ibrahim;
Zhao, Meng;
Sekar, Rohith Vedhthaanth;
Moghadam, Sahar Arbabi;
Tuszynski, Jack A.;
Woodside, Michael T.

Publication type:

Article

A Systems Biology Analysis of Chronic Lymphocytic Leukemia.

Published in:

Onco, 2024, v. 4, n. 3, p. 163, doi. 10.3390/onco4030013

By:

Pozzati, Giulia;
Zhou, Jinrui;
Hazan, Hananel;
Klement, Giannoula Lakka;
Siegelmann, Hava T.;
Tuszynski, Jack A.;
Rietman, Edward A.

Publication type:

Article

An Accurate Method for Prediction of Protein-Ligand Binding Site on Protein Surface Using SVM and Statistical Depth Function.

Published in:

BioMed Research International, 2013, v. 2013, p. 1, doi. 10.1155/2013/409658

By:

Kui Wang;
Jianzhao Gao;
Shiyi Shen;
Tuszynski, Jack A.;
Jishou Ruan;
Gang Hu

Publication type:

Article

Tubulin: Structure, Functions and Roles in Disease.

Published in:

2019

By:

Binarová, Pavla;
Tuszynski, Jack

Publication type:

Editorial

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents.

Published in:

Cells (2073-4409), 2018, v. 7, n. 11, p. 216, doi. 10.3390/cells7110216

By:

Majcher, Urszula;
Klejborowska, Greta;
Kaik, Magdalena;
Maj, Ewa;
Wietrzyk, Joanna;
Moshari, Mahshad;
Preto, Jordane;
Tuszynski, Jack A.;
Huczyński, Adam

Publication type:

Article

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

Published in:

Cells (2073-4409), 2018, v. 7, n. 11, p. 192, doi. 10.3390/cells7110192

By:

Majcher, Urszula;
Klejborowska, Greta;
Moshari, Mahshad;
Maj, Ewa;
Wietrzyk, Joanna;
Bartl, Franz;
Tuszynski, Jack A.;
Huczyński, Adam

Publication type:

Article

Phase transitions and structure analysis in wild-type, A30P, E46K, and A53T mutants of α-synuclein.

Published in:

European Biophysics Journal, 2016, v. 45, n. 4, p. 355, doi. 10.1007/s00249-015-1103-0

By:

Healey, Mark;
Woodside, Michael;
Tuszynski, Jack

Publication type:

Article

Vibrational dynamics of bio- and nano-filaments in viscous solution subjected to ultrasound: implications for microtubules.

Published in:

European Biophysics Journal, 2011, v. 40, n. 8, p. 937, doi. 10.1007/s00249-011-0709-0

By:

Samarbakhsh, Abdorreza;
Tuszynski, Jack

Publication type:

Article

Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129168

By:

St. George, Marc;
Ayoub, Ahmed T.;
Banerjee, Asok;
Churchill, Cassandra D. M.;
Winter, Philip;
Klobukowski, Mariusz;
Cass, Carol E.;
Ludueña, Richard F.;
Tuszynski, Jack A.;
Damaraju, Sambasivarao

Publication type:

Article

A Computational Strategy to Select Optimized Protein Targets for Drug Development toward the Control of Cancer Diseases.

Published in:

PLoS ONE, 2015, v. 10, n. 1, p. 1, doi. 10.1371/journal.pone.0115054

By:

Carels, Nicolas;
Tilli, Tatiana;
Tuszynski, Jack A.

Publication type:

Article

Investigation of the Josephin Domain Protein-Protein Interaction by Molecular Dynamics.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0108677

By:

Deriu, Marco A.;
Grasso, Gianvito;
Licandro, Ginevra;
Danani, Andrea;
Gallo, Diego;
Tuszynski, Jack A.;
Morbiducci, Umberto

Publication type:

Article

Systematic Identification and Evolutionary Analysis of Catalytically Versatile Cytochrome P450 Monooxygenase Families Enriched in Model Basidiomycete Fungi.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0086683

By:

Syed, Khajamohiddin;
Shale, Karabo;
Pagadala, Nataraj Sekhar;
Tuszynski, Jack

Publication type:

Article

Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0052495

By:

Kuban-Jankowska, Alicja;
Tuszynski, Jack A.;
Winter, Philip;
Gorska, Magdalena;
Knap, Narcyz;
Wozniak, Michal

Publication type:

Article

Virtual Screening and Biological Evaluation of Inhibitors Targeting the XPA-ERCC1 Interaction.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051329

By:

Barakat, Khaled H.;
Jordheim, Lars P.;
Perez-Pineiro, Rolando;
Wishart, David;
Dumontet, Charles;
Tuszynski, Jack A.

Publication type:

Article

Computational Predictions of Volatile Anesthetic Interactions with the Microtubule Cytoskeleton: Implications for Side Effects of General Anesthesia.

Published in:

PLoS ONE, 2012, v. 7, n. 6, p. e37251, doi. 10.1371/journal.pone.0037251

By:

Craddock, Travis J. A.;
George, Marc St.;
Freedman, Holly;
Barakat, Khaled H.;
Damaraju, Sambasivarao;
Hameroff, Stuart;
Tuszynski, Jack A.

Publication type:

Article

The Molecular Mechanism of Action of the CR6261- Azichromycin Combination Found through Computational Analysis.

Published in:

PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037790

By:

Wei Cui;
Kui Wang;
Ruan, Jishou;
Zhi Qi;
Yi Feng;
Yiming Shao;
Tuszynski, Jack A.

Publication type:

Article

Computable Features Required to Evaluate the Efficacy of Drugs and a Universal Algorithm to Find Optimally Effective Drug in a Drug Complex.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0033709

By:

Kui Wang;
Wei Cui;
Gang Hu;
Jianzhao Gao;
Zhonghua Wu;
Xingye Qiu;
Jishou Ruan;
Yi Feng;
Zhi Qi;
Yiming Shao;
Tuszynski, Jack A.

Publication type:

Article

The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0033552

By:

Craddock, Travis J. A.;
Tuszynski, Jack A.;
Chopra, Deepak;
Casey, Noel;
Goldstein, Lee E.;
Hameroff, Stuart R.;
Tanzi, Rudolph E.

Publication type:

Article

Effects of Temperature on the p53-DNA Binding Interactions and Their Dynamical Behavior: Comparing the Wild Type to the R248Q Mutant.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027651

By:

Barakat, Khaled;
Issack, Bilkiss B.;
Stepanova, Maria;
Tuszynski, Jack

Publication type:

Article

Near death experiences: a multidisciplinary hypothesis.

Published in:

Frontiers in Human Neuroscience, 2013, v. 7, p. 1, doi. 10.3389/fnhum.2013.00533

By:

Bókkon, István;
Mallick, Birendra N.;
Tuszynski, Jack A.

Publication type:

Article

Tubulin electrostatics and isotype specific drug binding.

Published in:

Canadian Journal of Physics, 2008, v. 86, n. 4, p. 635, doi. 10.1139/P07-199

By:

Tuszyński, Jack A.;
Malinski, Wojtek;
Carpenter, Eric J.;
Luchko, Tyler;
Huzil, J. Torin;
Ludeña, Richard F.

Publication type:

Article

Issue Information.

Published in:

Chemical Biology & Drug Design, 2020, v. 95, n. 4, p. i, doi. 10.1111/cbdd.13541

By:

Gentile, Francesco;
Elmenoufy, Ahmed H.;
Ciniero, Gloria;
Jay, David;
Karimi‐Busheri, Feridoun;
Barakat, Khaled H.;
Weinfeld, Michael;
West, Frederick G.;
Tuszynski, Jack A.

Publication type:

Article

Computer‐aided drug design of small molecule inhibitors of the ERCC1‐XPF protein–protein interaction.

Published in:

Chemical Biology & Drug Design, 2020, v. 95, n. 4, p. 460, doi. 10.1111/cbdd.13660

By:

Gentile, Francesco;
Elmenoufy, Ahmed H.;
Ciniero, Gloria;
Jay, David;
Karimi‐Busheri, Feridoun;
Barakat, Khaled H.;
Weinfeld, Michael;
West, Frederick G.;
Tuszynski, Jack A.

Publication type:

Article

Synthesis, antiproliferative activity, and molecular docking studies of 4‐chlorothiocolchicine analogues.

Published in:

Chemical Biology & Drug Design, 2020, v. 95, n. 1, p. 182, doi. 10.1111/cbdd.13618

By:

Klejborowska, Greta;
Moshari, Mahshad;
Maj, Ewa;
Majcher, Urszula;
Preto, Jordane;
Wietrzyk, Joanna;
Tuszynski, Jack A.;
Huczyński, Adam

Publication type:

Article

Elucidating the Mechanism of Action of the Clinically Approved Taxanes: A Comprehensive Comparison of Local and Allosteric Effects.

Published in:

Chemical Biology & Drug Design, 2015, v. 86, n. 5, p. 1253, doi. 10.1111/cbdd.12595

By:

Churchill, Cassandra D. M.;
Klobukowski, Mariusz;
Tuszynski, Jack A.

Publication type:

Article

The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.

Published in:

Chemical Biology & Drug Design, 2015, v. 86, n. 2, p. 190, doi. 10.1111/cbdd.12475

By:

Churchill, Cassandra D. M.;
Klobukowski, Mariusz;
Tuszynski, Jack A.

Publication type:

Article

Ranking the Binding Energies of p53 Mutant Activators and Their ADMET Properties.

Published in:

Chemical Biology & Drug Design, 2015, v. 86, n. 2, p. 163, doi. 10.1111/cbdd.12480

By:

Omar, Sara Ibrahim;
Tuszynski, Jack

Publication type:

Article

Homology and Molecular Dynamics Models of Toll-Like Receptor 7 Protein and Its Dimerization.

Published in:

Chemical Biology & Drug Design, 2014, v. 83, n. 6, p. 656, doi. 10.1111/cbdd.12278

By:

Tseng, Chih ‐ Yuan;
Gajewski, Melissa;
Danani, Andrea;
Tuszynski, Jack A.

Publication type:

Article

Experimental and Computational Study of the Interaction of Novel Colchicinoids with a Recombinant Human α I/β I-Tubulin Heterodimer.

Published in:

Chemical Biology & Drug Design, 2013, v. 82, n. 1, p. 60, doi. 10.1111/cbdd.12132

By:

Mane, Jonathan Y.;
Semenchenko, Valentyna;
Perez ‐ Pineiro, Rolando;
Winter, Philip;
Wishart, David;
Tuszynski, Jack A.

Publication type:

Article

Dynamic Change of Heme Environment in Soluble Guanylate Cyclase and Complexation of NO-Independent Drug Agents with H-NOX Domain.

Published in:

Chemical Biology & Drug Design, 2013, v. 81, n. 3, p. 359, doi. 10.1111/cbdd.12082

By:

Alisaraie, Laleh;
Fu, Yangxin;
Tuszynski, Jack A.

Publication type:

Article

Chemotherapy Drugs Form Ion Pores in Membranes Due to Physical Interactions with Lipids.

Published in:

Chemical Biology & Drug Design, 2012, v. 80, n. 6, p. 992, doi. 10.1111/cbdd.12060

By:

Ashrafuzzaman, Mohammad;
Tseng, Chih-Yuan;
Duszyk, Marek;
Tuszynski, Jack A.

Publication type:

Article

Discovery of Small Molecule Inhibitors that Interact with γ-Tubulin.

Published in:

Chemical Biology & Drug Design, 2012, v. 79, n. 5, p. 639, doi. 10.1111/j.1747-0285.2012.01340.x

By:

Friesen, Douglas E.;
Barakat, Khaled H.;
Semenchenko, Valentyna;
Perez-Pineiro, Rolando;
Fenske, Bruce W.;
Mane, Jonathan;
Wishart, David S.;
Tuszynski, Jack A.

Publication type:

Article