Works by Tumber, Anthony
Results: 40
Human Oxygenase Variants Employing a Single Protein Fe<sup>II</sup> Ligand Are Catalytically Active.
- Published in:
- Angewandte Chemie, 2021, v. 133, n. 26, p. 14778, doi. 10.1002/ange.202103711
- By:
- Publication type:
- Article
JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships.
- Published in:
- Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07183-5
- By:
- Publication type:
- Article
Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colony-stimulating factor.
- Published in:
- International Journal of Cancer, 2004, v. 109, n. 5, p. 653, doi. 10.1002/ijc.20056
- By:
- Publication type:
- Article
Human breast-cancer cells stimulate the fusion, migration and resorptive activity of osteoclasts in bone explants.
- Published in:
- International Journal of Cancer, 2001, v. 91, n. 5, p. 650, doi. 10.1002/1097-0215(200002)9999:9999<::AID-IJC1101>3.0.CO;2-0
- By:
- Publication type:
- Article
Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains.
- Published in:
- ChemBioChem, 2023, v. 24, n. 4, p. 1, doi. 10.1002/cbic.202200576
- By:
- Publication type:
- Article
Innenrücktitelbild: A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity (Angew. Chem. 40/2024).
- Published in:
- Angewandte Chemie, 2024, v. 136, n. 40, p. 1, doi. 10.1002/ange.202414504
- By:
- Publication type:
- Article
A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity.
- Published in:
- Angewandte Chemie, 2024, v. 136, n. 40, p. 1, doi. 10.1002/ange.202410438
- By:
- Publication type:
- Article
Lessons from LIMK1 enzymology and their impact on inhibitor design.
- Published in:
- Biochemical Journal, 2019, v. 476, n. 21, p. 3197, doi. 10.1042/BCJ20190517
- By:
- Publication type:
- Article
Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
- Published in:
- Angewandte Chemie International Edition, 2012, v. 51, n. 7, p. 1631, doi. 10.1002/anie.201107833
- By:
- Publication type:
- Article
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26673-2
- By:
- Publication type:
- Article
Inside Back Cover: A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity (Angew. Chem. Int. Ed. 40/2024).
- Published in:
- Angewandte Chemie International Edition, 2024, v. 63, n. 40, p. 1, doi. 10.1002/anie.202414504
- By:
- Publication type:
- Article
A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity.
- Published in:
- Angewandte Chemie International Edition, 2024, v. 63, n. 40, p. 1, doi. 10.1002/anie.202410438
- By:
- Publication type:
- Article
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
- Published in:
- Nature Communications, 2017, v. 8, n. 4, p. 14773, doi. 10.1038/ncomms14773
- By:
- Publication type:
- Article
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
- Published in:
- Nature Communications, 2016, v. 7, n. 9, p. 12700, doi. 10.1038/ncomms12700
- By:
- Publication type:
- Article
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
- Published in:
- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132004
- By:
- Publication type:
- Article
Stromelysin (MMP-3) Synthesis Is Up-Regulated in Estrogen-Deficient Mouse Osteoblasts In Vivo and In Vitro.
- Published in:
- Journal of Bone & Mineral Research, 1999, v. 14, n. 11, p. 1880, doi. 10.1359/jbmr.1999.14.11.1880
- By:
- Publication type:
- Article
Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-10028-y
- By:
- Publication type:
- Article
Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat.
- Published in:
- ChemMedChem, 2024, v. 19, n. 24, p. 1, doi. 10.1002/cmdc.202400504
- By:
- Publication type:
- Article
Human Oxygenase Variants Employing a Single Protein Fe<sup>II</sup> Ligand Are Catalytically Active.
- Published in:
- Angewandte Chemie International Edition, 2021, v. 60, n. 26, p. 14657, doi. 10.1002/anie.202103711
- By:
- Publication type:
- Article
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease.
- Published in:
- ChemMedChem, 2022, v. 17, n. 9, p. 1, doi. 10.1002/cmdc.202200016
- By:
- Publication type:
- Article
Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease.
- Published in:
- ChemMedChem, 2022, v. 17, n. 4, p. 1, doi. 10.1002/cmdc.202100582
- By:
- Publication type:
- Article
Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase.
- Published in:
- ChemMedChem, 2020, v. 15, n. 13, p. 1139, doi. 10.1002/cmdc.202000147
- By:
- Publication type:
- Article
Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
- Published in:
- ChemMedChem, 2020, v. 15, n. 3, p. 270, doi. 10.1002/cmdc.201900557
- By:
- Publication type:
- Article
A Fluorescent Benzo[g]isoquinoline‐Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.
- Published in:
- ChemMedChem, 2019, v. 14, n. 1, p. 94, doi. 10.1002/cmdc.201800483
- By:
- Publication type:
- Article
A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1.
- Published in:
- ChemMedChem, 2014, v. 9, n. 3, p. 566, doi. 10.1002/cmdc.201300428
- By:
- Publication type:
- Article
Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds.
- Published in:
- ChemMedChem, 2011, v. 6, n. 5, p. 759, doi. 10.1002/cmdc.201100026
- By:
- Publication type:
- Article
Cyclic β²,³-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.
- Published in:
- Bulletin of the Chemical Society of Japan, 2024, v. 97, n. 5, p. 1, doi. 10.1093/bulcsj/uoae018
- By:
- Publication type:
- Article
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.
- Published in:
- Chemistry - A European Journal, 2019, v. 25, n. 8, p. 2019, doi. 10.1002/chem.201804790
- By:
- Publication type:
- Article
Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
- Published in:
- Angewandte Chemie, 2012, v. 124, n. 7, p. 1663, doi. 10.1002/ange.201107833
- By:
- Publication type:
- Article
The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2007, v. 60, n. 2, p. 275, doi. 10.1007/s00280-006-0374-7
- By:
- Publication type:
- Article
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.
- Published in:
- Angewandte Chemie, 2017, v. 129, n. 49, p. 15761, doi. 10.1002/ange.201706788
- By:
- Publication type:
- Article
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction.
- Published in:
- Angewandte Chemie, 2014, v. 126, n. 24, p. 6240, doi. 10.1002/ange.201402750
- By:
- Publication type:
- Article
Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.
- Published in:
- 2020
- By:
- Publication type:
- Correction Notice
Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.
- Published in:
- 2020
- By:
- Publication type:
- Correction Notice
Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65123-9
- By:
- Publication type:
- Article
Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2.
- Published in:
- Proteins, 2023, v. 91, n. 11, p. 1510, doi. 10.1002/prot.26541
- By:
- Publication type:
- Article
Assessing histone demethylase inhibitors in cells: lessons learned.
- Published in:
- Epigenetics & Chromatin, 2017, v. 10, p. 1, doi. 10.1186/s13072-017-0116-6
- By:
- Publication type:
- Article
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 49, p. 15555, doi. 10.1002/anie.201706788
- By:
- Publication type:
- Article
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction.
- Published in:
- Angewandte Chemie International Edition, 2014, v. 53, n. 24, p. 6126, doi. 10.1002/anie.201402750
- By:
- Publication type:
- Article
Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7.
- Published in:
- Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 10, p. 1, doi. 10.1002/pro.5162
- By:
- Publication type:
- Article