Works by Tumber, Anthony

Results: 40
    1

    A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction.

    Published in:
    Angewandte Chemie, 2014, v. 126, n. 24, p. 6240, doi. 10.1002/ange.201402750
    By:
    • Rooney, Timothy P. C.;
    • Filippakopoulos, Panagis;
    • Fedorov, Oleg;
    • Picaud, Sarah;
    • Cortopassi, Wilian A.;
    • Hay, Duncan A.;
    • Martin, Sarah;
    • Tumber, Anthony;
    • Rogers, Catherine M.;
    • Philpott, Martin;
    • Wang, Minghua;
    • Thompson, Amber L.;
    • Heightman, Tom D.;
    • Pryde, David C.;
    • Cook, Andrew;
    • Paton, Robert S.;
    • Müller, Susanne;
    • Knapp, Stefan;
    • Brennan, Paul E.;
    • Conway, Stuart J.
    Publication type:
    Article
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    Assessing histone demethylase inhibitors in cells: lessons learned.

    Published in:
    Epigenetics & Chromatin, 2017, v. 10, p. 1, doi. 10.1186/s13072-017-0116-6
    By:
    • Hatch, Stephanie B.;
    • Yapp, Clarence;
    • Montenegro, Raquel C.;
    • Savitsky, Pavel;
    • Gamble, Vicki;
    • Tumber, Anthony;
    • Ruda, Gian Filippo;
    • Bavetsias, Vassilios;
    • Fedorov, Oleg;
    • Atrash, Butrus;
    • Raynaud, Florence;
    • Lanigan, Rachel;
    • Carmichael, LeAnne;
    • Tomlin, Kathy;
    • Burke, Rosemary;
    • Westaway, Susan M.;
    • Brown, Jack A.;
    • Prinjha, Rab K.;
    • Martinez, Elisabeth D.;
    • Oppermann, Udo
    Publication type:
    Article
    7

    Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.

    Published in:
    PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0132004
    By:
    • Chan, Mun Chiang;
    • Atasoylu, Onur;
    • Hodson, Emma;
    • Tumber, Anthony;
    • Leung, Ivanhoe K. H.;
    • Chowdhury, Rasheduzzaman;
    • Gómez-Pérez, Verónica;
    • Demetriades, Marina;
    • Rydzik, Anna M.;
    • Holt-Martyn, James;
    • Tian, Ya-Min;
    • Bishop, Tammie;
    • Claridge, Timothy D. W.;
    • Kawamura, Akane;
    • Pugh, Christopher W.;
    • Ratcliffe, Peter J.;
    • Schofield, Christopher J.
    Publication type:
    Article
    8
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    Cyclic β²,³-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.

    Published in:
    Bulletin of the Chemical Society of Japan, 2024, v. 97, n. 5, p. 1, doi. 10.1093/bulcsj/uoae018
    By:
    • Takashi Miura;
    • Malla, Tika R.;
    • Brewitz, Lennart;
    • Tumber, Anthony;
    • Salah, Eidarus;
    • Kang Ju Lee;
    • Naohiro Terasaka;
    • Owen, C. David;
    • Damerell, Claire Strain;
    • Lukacik, Petra;
    • Walsh, Martin A.;
    • Akane Kawamura;
    • Schofield, Christopher J.;
    • Takayuki Katoh;
    • Hiroaki Suga
    Publication type:
    Article
    10

    Inside Back Cover: A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity (Angew. Chem. Int. Ed. 40/2024).

    Published in:
    Angewandte Chemie International Edition, 2024, v. 63, n. 40, p. 1, doi. 10.1002/anie.202414504
    By:
    • Wu, Yue;
    • Chen, Yafen;
    • Corner, Thomas P.;
    • Nakashima, Yu;
    • Salah, Eidarus;
    • Li, Zhihong;
    • Zhang, Linjian;
    • Yang, Le;
    • Tumber, Anthony;
    • Sun, Zhuoli;
    • Wen, Yukang;
    • Zhong, Ailin;
    • Yang, Fulai;
    • Li, Xiang;
    • Zhang, Zhihong;
    • Schofield, Christopher J.;
    • Zhang, Xiaojin
    Publication type:
    Article
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    Innenrücktitelbild: A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity (Angew. Chem. 40/2024).

    Published in:
    Angewandte Chemie, 2024, v. 136, n. 40, p. 1, doi. 10.1002/ange.202414504
    By:
    • Wu, Yue;
    • Chen, Yafen;
    • Corner, Thomas P.;
    • Nakashima, Yu;
    • Salah, Eidarus;
    • Li, Zhihong;
    • Zhang, Linjian;
    • Yang, Le;
    • Tumber, Anthony;
    • Sun, Zhuoli;
    • Wen, Yukang;
    • Zhong, Ailin;
    • Yang, Fulai;
    • Li, Xiang;
    • Zhang, Zhihong;
    • Schofield, Christopher J.;
    • Zhang, Xiaojin
    Publication type:
    Article
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    Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

    Published in:
    Angewandte Chemie, 2017, v. 129, n. 49, p. 15761, doi. 10.1002/ange.201706788
    By:
    • Gerken, Philip A.;
    • Wolstenhulme, Jamie R.;
    • Tumber, Anthony;
    • Hatch, Stephanie B.;
    • Zhang, Yijia;
    • Müller, Susanne;
    • Chandler, Shane A.;
    • Mair, Barbara;
    • Li, Fengling;
    • Nijman, Sebastian M. B.;
    • Konietzny, Rebecca;
    • Szommer, Tamas;
    • Yapp, Clarence;
    • Fedorov, Oleg;
    • Benesch, Justin L. P.;
    • Vedadi, Masoud;
    • Kessler, Benedikt M.;
    • Kawamura, Akane;
    • Brennan, Paul E.;
    • Smith, Martin D.
    Publication type:
    Article
    22

    Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.

    Published in:
    Nature Communications, 2017, v. 8, n. 4, p. 14773, doi. 10.1038/ncomms14773
    By:
    • Kawamura, Akane;
    • Münzel, Martin;
    • Kojima, Tatsuya;
    • Yapp, Clarence;
    • Bhushan, Bhaskar;
    • Goto, Yuki;
    • Tumber, Anthony;
    • Katoh, Takayuki;
    • King, Oliver N. F.;
    • Passioura, Toby;
    • Walport, Louise J.;
    • Hatch, Stephanie B.;
    • Madden, Sarah;
    • Müller, Susanne;
    • Brennan, Paul E.;
    • Chowdhury, Rasheduzzaman;
    • Hopkinson, Richard J.;
    • Suga, Hiroaki;
    • Schofield, Christopher J.
    Publication type:
    Article
    23

    The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.

    Published in:
    Nature Communications, 2016, v. 7, n. 9, p. 12700, doi. 10.1038/ncomms12700
    By:
    • Carbonneau, Mélissa;
    • M. Gagné, Laurence;
    • Lalonde, Marie-Eve;
    • Germain, Marie-Anne;
    • Motorina, Alena;
    • Guiot, Marie-Christine;
    • Secco, Blandine;
    • Vincent, Emma E.;
    • Tumber, Anthony;
    • Hulea, Laura;
    • Bergeman, Jonathan;
    • Oppermann, Udo;
    • Jones, Russell G.;
    • Laplante, Mathieu;
    • Topisirovic, Ivan;
    • Petrecca, Kevin;
    • Huot, Marc-Étienne;
    • Mallette, Frédérick A.
    Publication type:
    Article
    24
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    Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.

    Published in:
    Angewandte Chemie International Edition, 2017, v. 56, n. 49, p. 15555, doi. 10.1002/anie.201706788
    By:
    • Gerken, Philip A.;
    • Wolstenhulme, Jamie R.;
    • Tumber, Anthony;
    • Hatch, Stephanie B.;
    • Zhang, Yijia;
    • Müller, Susanne;
    • Chandler, Shane A.;
    • Mair, Barbara;
    • Li, Fengling;
    • Nijman, Sebastian M. B.;
    • Konietzny, Rebecca;
    • Szommer, Tamas;
    • Yapp, Clarence;
    • Fedorov, Oleg;
    • Benesch, Justin L. P.;
    • Vedadi, Masoud;
    • Kessler, Benedikt M.;
    • Kawamura, Akane;
    • Brennan, Paul E.;
    • Smith, Martin D.
    Publication type:
    Article
    26

    Lessons from LIMK1 enzymology and their impact on inhibitor design.

    Published in:
    Biochemical Journal, 2019, v. 476, n. 21, p. 3197, doi. 10.1042/BCJ20190517
    By:
    • Salah, Eidarus;
    • Chatterjee, Deep;
    • Beltrami, Alessandra;
    • Tumber, Anthony;
    • Preuss, Franziska;
    • Canning, Peter;
    • Chaikuad, Apirat;
    • Knaus, Petra;
    • Knapp, Stefan;
    • Bullock, Alex N.;
    • Mathea, Sebastian
    Publication type:
    Article
    27

    Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7.

    Published in:
    Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 10, p. 1, doi. 10.1002/pro.5162
    By:
    • Bilgin, Nurgül;
    • Tumber, Anthony;
    • Dhingra, Siddhant;
    • Salah, Eidarus;
    • Al‐Salmy, Aziza;
    • Martín, Sandra Pinzón;
    • Wang, Yicheng;
    • Schofield, Christopher J.;
    • Mecinović, Jasmin
    Publication type:
    Article
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    A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1.

    Published in:
    ChemMedChem, 2014, v. 9, n. 3, p. 566, doi. 10.1002/cmdc.201300428
    By:
    • Schiller, Rachel;
    • Scozzafava, Giuseppe;
    • Tumber, Anthony;
    • Wickens, James R.;
    • Bush, Jacob T.;
    • Rai, Ganesha;
    • Lejeune, Clarisse;
    • Choi, Hwanho;
    • Yeh, Tzu‐Lan;
    • Chan, Mun Chiang;
    • Mott, Bryan T.;
    • McCullagh, James S. O.;
    • Maloney, David J.;
    • Schofield, Christopher J.;
    • Kawamura, Akane
    Publication type:
    Article
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    A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction.

    Published in:
    Angewandte Chemie International Edition, 2014, v. 53, n. 24, p. 6126, doi. 10.1002/anie.201402750
    By:
    • Rooney, Timothy P. C.;
    • Filippakopoulos, Panagis;
    • Fedorov, Oleg;
    • Picaud, Sarah;
    • Cortopassi, Wilian A.;
    • Hay, Duncan A.;
    • Martin, Sarah;
    • Tumber, Anthony;
    • Rogers, Catherine M.;
    • Philpott, Martin;
    • Wang, Minghua;
    • Thompson, Amber L.;
    • Heightman, Tom D.;
    • Pryde, David C.;
    • Cook, Andrew;
    • Paton, Robert S.;
    • Müller, Susanne;
    • Knapp, Stefan;
    • Brennan, Paul E.;
    • Conway, Stuart J.
    Publication type:
    Article
    39

    Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.

    Published in:
    Angewandte Chemie International Edition, 2012, v. 51, n. 7, p. 1631, doi. 10.1002/anie.201107833
    By:
    • Woon, Esther C. Y.;
    • Tumber, Anthony;
    • Kawamura, Akane;
    • Hillringhaus, Lars;
    • Ge, Wei;
    • Rose, Nathan R.;
    • Ma, Jerome H. Y.;
    • Chan, Mun Chiang;
    • Walport, Louise J.;
    • Che, Ka Hing;
    • Ng, Stanley S.;
    • Marsden, Brian D.;
    • Oppermann, Udo;
    • McDonough, Michael A.;
    • Schofield, Christopher J.
    Publication type:
    Article
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