Works by Tulkens, Paul M.

Results: 80

Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).

Published in:

2008

By:

Maritza Barcia-Macay;
Fatima Mouaden;
Marie-Paule Mingeot-Leclercq;
Paul M. Tulkens;
Françoise Van Bambeke;
Barcia-Macay, Maritza;
Mouaden, Fatima;
Mingeot-Leclercq, Marie-Paule;
Tulkens, Paul M;
Van Bambeke, Françoise

Publication type:

journal article

Activity of Moxifloxacin Against Biofilms Formed by Clinical Isolates of Staphylococcus aureus Differing by Their Resistant or Persister Character to Fluoroquinolones.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.785573

By:

Nguyen, Tiep K.;
Peyrusson, Frédéric;
Siala, Wafi;
Pham, Nhung H.;
Nguyen, Hoang A.;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Multidrug-Resistant Streptococcus pneumoniae Infections:Current and Future Therapeutic Options.

Published in:

Drugs, 2007, v. 67, n. 16, p. 2355, doi. 10.2165/00003495-200767160-00005

By:

Van Bambeke, Françoise;
Reinert, René R.;
Appelbaum, Peter C.;
Tulkens, Paul M.;
Peetermans, Willy E.

Publication type:

Article

Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.

Published in:

2019

By:

Pokem, Perrin Ngougni;
Capron, Arnaud;
Wallemacq, Pierre;
Tulkens, Paul M;
Bambeke, Françoise Van;
Laterre, Pierre-François;
Ngougni Pokem, Perrin;
Van Bambeke, Françoise

Publication type:

Case Study

Temocillin dosing in haemodialysis patients based on population pharmacokinetics of total and unbound concentrations and Monte Carlo simulations.

Published in:

2018

By:

Bastos, Ana C Miranda;
Vandecasteele, Stefaan J;
Spinewine, Anne;
Tulkens, Paul M;
Bambeke, Françoise Van;
Miranda Bastos, Ana C;
Van Bambeke, Françoise

Publication type:

journal article

Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 6, p. 1713, doi. 10.1093/jac/dkv032

By:

Vandevelde, Nathalie M.;
Tulkens, Paul M.;
Muccioli, Giulio G.;
Van Bambeke, Françoise

Publication type:

Article

Avibactam confers susceptibility to a large proportion of ceftazidime-resistant Pseudomonas aeruginosa isolates recovered from cystic fibrosis patients.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 5, p. 1596, doi. 10.1093/jac/dku551

By:

Chalhoub, Hussein;
Tunney, Michael;
Elborn, J. Stuart;
Vergison, Anne;
Denis, Olivier;
Plésiat, Patrick;
Kahl, Barbara C.;
Van Bambeke, Françoise;
Tulkens, Paul M.

Publication type:

Article

Temocillin (6 g daily) in critically ill patients: continuous infusion versus three times daily administration.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 3, p. 891, doi. 10.1093/jac/dku465

By:

Laterre, Pierre-François;
Wittebole, Xavier;
Van de Velde, Sebastien;
Muller, Anouk E.;
Mouton, Johan W.;
Carryn, Stéphane;
Tulkens, Paul M.;
Dugernier, Thierry

Publication type:

Article

Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 7, p. 1455, doi. 10.1093/jac/dkt072

By:

Garcia, Laetitia G.;
Lemaire, Sandrine;
Kahl, Barbara C.;
Becker, Karsten;
Proctor, Richard A.;
Denis, Olivier;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Stability and compatibility of vancomycin for administration by continuous infusion.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 5, p. 1179, doi. 10.1093/jac/dks510

By:

Raverdy, Violeta;
Ampe, Els;
Hecq, Jean-Daniel;
Tulkens, Paul M.

Publication type:

Article

Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 3, p. 648

By:

Mélard, Aurélie;
Garcia, Laetitia G.;
Das, Debaditya;
Rozenberg, Raoul;
Tulkens, Paul M.;
Van Bambeke, Françoise;
Lemaire, Sandrine

Publication type:

Article

Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to β-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2012, v. 67, n. 12, p. 2873, doi. 10.1093/jac/dks325

By:

Garcia, Laetitia G.;
Lemaire, Sandrine;
Kahl, Barbara C.;
Becker, Karsten;
Proctor, Richard A.;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2012, v. 67, n. 3, p. 771, doi. 10.1093/jac/dkr543

By:

Buyck, Julien M.;
Guénard, Sophie;
Plésiat, Patrick;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Hepatic safety of antibiotics used in primary care.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2011, v. 66, n. 7, p. 1431, doi. 10.1093/jac/dkr159

By:

Andrade, Raúl J.;
Tulkens, Paul M.

Publication type:

Article

Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae.

Published in:

2011

By:

El Garch, Farid;
Lismond, Ann;
Piddock, Laura J. V.;
Courvalin, Patrice;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Correction Notice

Efflux of novel quinolones in contemporary Streptococcus pneumoniae isolates from community-acquired pneumonia.

Published in:

2011

By:

Lismond, Ann;
Carbonnelle, Sylviane;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Letter

Activity of moxifloxacin against intracellular community-acquired methicillin-resistant Staphylococcus aureus: comparison with clindamycin, linezolid and co-trimoxazole and attempt at defining an intracellular susceptibility breakpoint.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2011, v. 66, n. 3, p. 596, doi. 10.1093/jac/dkq478

By:

Lemaire, Sandrine;
Kosowska-Shick, Klaudia;
Appelbaum, Peter C.;
Glupczynski, Y.;
Van Bambeke, Françoise;
Tulkens, Paul M.

Publication type:

Article

Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 10, p. 2076, doi. 10.1093/jac/dkq287

By:

Garch, Farid El;
Lismond, Ann;
Piddock, Laura J. V.;
Courvalin, Patrice;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Long-term stability of temocillin in elastomeric pumps for outpatient antibiotic therapy in cystic fibrosis patients.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 9, p. 2045, doi. 10.1093/jac/dkq229

By:

Carryn, Stéphane;
Couwenbergh, Nathalie;
Tulkens, Paul M.

Publication type:

Article

Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 8, p. 1720, doi. 10.1093/jac/dkq159

By:

Brinch, Karoline Sidelmann;
Tulkens, Paul M.;
Van Bambeke, Francoise;
Frimodt-Møller, Niels;
Høiby, Niels;
Kristensen, Hans-Henrik

Publication type:

Article

Activity of quinupristin/dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 6, p. 1228, doi. 10.1093/jac/dkq110

By:

Baudoux, Pierre;
Lemaire, Sandrine;
Denis, Olivier;
Tulkens, Paul M.;
Van Bambeke, Françoise;
Glupczynski, Youri

Publication type:

Article

Stability of meropenem and doripenem solutions for administration by continuous infusion.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 5, p. 1073, doi. 10.1093/jac/dkq044

By:

Berthoin, Karine;
Le Duff, Cécile S.;
Marchand-Brynaert, Jacqueline;
Carryn, Stéphane;
Tulkens, Paul M.

Publication type:

Article

Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 5, p. 962, doi. 10.1093/jac/dkq052

By:

Sandberg, Anne;
Jensen, Klaus Skovbo;
Baudoux, Pierre;
Van Bambeke, Françoise;
Tulkens, Paul M.;
Frimodt-Möller, Niels

Publication type:

Article

Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2009, v. 64, n. 5, p. 1035, doi. 10.1093/jac/dkp267

By:

Lemaire, Sandrine;
Van Bambeke, Françoise;
Appelbaum, Peter C.;
Tulkens, Paul M.

Publication type:

Article

Temocillin revived.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2009, v. 63, n. 2, p. 243

By:

David M. Livermore;
Paul M. Tulkens

Publication type:

Article

Contrasting effects of human THP-1 cell differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2008, v. 62, n. 3, p. 518, doi. 10.1093/jac/dkn232

By:

Sébastien Van de Velde;
Hoang Anh Nguyen;
Françoise Van Bambeke;
Paul M. Tulkens;
Jean Grellet;
Véronique Dubois;
Claudine Quentin;
Marie-Claude Saux

Publication type:

Article

Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2008, v. 61, n. 2, p. 382, doi. 10.1093/jac/dkm467

By:

Raf De Jongh;
Ria Hens;
Violetta Basma;
Johan W. Mouton;
Paul M. Tulkens;
Stéphane Carryn

Publication type:

Article

Tissue concentrations: do we ever learn?

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2008, v. 61, n. 2, p. 235

By:

Johan W. Mouton;
Ursula Theuretzbacher;
William A. Craig;
Paul M. Tulkens;
Hartmut Derendorf;
Otto Cars

Publication type:

Article

Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2007, v. 60, n. 5, p. 965, doi. 10.1093/jac/dkm292

By:

Laetitia Avrain;
Mark Garvey;
Narcisa Mesaros;
Youri Glupczynski;
Marie-Paule Mingeot-Leclercq;
Laura J. V. Piddock;
Paul M. Tulkens;
Raymond Vanhoof;
FranÃ§oise Van Bambeke

Publication type:

Article

A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2007, v. 59, n. 3, p. 378, doi. 10.1093/jac/dkl504

By:

Narcisa Mesaros;
Youri Glupczynski;
Laëtitia Avrain;
Nancy E. Caceres;
Paul M. Tulkens;
Françoise Van Bambeke

Publication type:

Article

Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2007, v. 59, n. 2, p. 246

By:

Pierre Baudoux;
Nathalie Bles;
Sandrine Lemaire;
Marie-Paule Mingeot-Leclercq;
Paul M. Tulkens;
Françoise Van Bambeke

Publication type:

Article

Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2006, v. 58, n. 6, p. 1177, doi. 10.1093/jac/dkl424

By:

Barcia-Macay, Maritza;
Lemaire, Sandrine;
Mingeot-Leclercq, Marie-Paule;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Water-soluble amphotericin B–polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2006, v. 57, n. 2, p. 236, doi. 10.1093/jac/dki455

By:

Ekatherina Charvalos;
Manolis N. Tzatzarakis;
Françoise Van Bambeke;
Paul M. Tulkens;
Aristidis M. Tsatsakis;
George N. Tzanakakis;
Marie-Paule Mingeot-Leclercq

Publication type:

Article

Activity of three β-lactams (ertapenem, meropenem and ampicillin) against intraphagocytic <it>Listeria monocytogenes</it> and <it>Staphylococcus aureus</it>.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2005, v. 55, n. 6, p. 897

By:

Paul M. Tulkens

Publication type:

Article

Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2003, v. 51, n. 5, p. 1167, doi. 10.1093/jac/dkg223

By:

Cristina Seral;
Stéphane Carryn;
Paul M. Tulkens;
Françoise Van Bambeke

Publication type:

Article

Stability and compatibility study of cefepime in comparison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units.

Published in:

2003

By:

Baririan, Nariné;
Chanteux, Hugues;
Viaene, Eric;
Servais, Hélène;
Tulkens, Paul M.;
Baririan, Nariné;
Servais, Hélène

Publication type:

journal article

Editorial for the Special Issue "A Themed Issue in Honor of Professor Hartmut Derendorf—Outstanding Contributions in the Fields of Quantitative Clinical Pharmacology".

Published in:

2023

By:

Van Bambeke, Françoise;
Wicha, Sebastian;
Tulkens, Paul M.;
Zeitlinger, Markus

Publication type:

Editorial

Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion.

Published in:

Antibiotics (2079-6382), 2022, v. 11, n. 7, p. 898, doi. 10.3390/antibiotics11070898

By:

Ngougni Pokem, Perrin;
Wittebole, Xavier;
Collienne, Christine;
Rodriguez-Villalobos, Hector;
Tulkens, Paul M.;
Elens, Laure;
Van Bambeke, Françoise;
Laterre, Pierre-François

Publication type:

Article

Clinical Use and Adverse Drug Reactions of Linezolid: A Retrospective Study in Four Belgian Hospital Centers.

Published in:

Antibiotics (2079-6382), 2021, v. 10, n. 5, p. 530, doi. 10.3390/antibiotics10050530

By:

Thirot, Hélène;
Briquet, Caroline;
Frippiat, Frédéric;
Jacobs, Frédérique;
Holemans, Xavier;
Henrard, Séverine;
Tulkens, Paul M.;
Spinewine, Anne;
Van Bambeke, Françoise;
Figueras, Albert

Publication type:

Article

Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1310309

By:

Thirot, Hélène;
Fage, David;
Leonhardt, Antonia;
Clevenbergh, Philippe;
Besse-Hammer, Tatiana;
Yombi, Jean Cyr;
Cornu, Olivier;
Briquet, Caroline;
Hites, Maya;
Jacobs, Frédérique;
Wijnant, Gert-Jan;
Wicha, Sebastian G.;
Cotton, Frédéric;
Tulkens, Paul M.;
Spinewine, Anne;
Van Bambeke, Françoise

Publication type:

Article

Analysis of the Membrane Proteome of Ciprofloxacin-Resistant Macrophages by Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC).

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058285

By:

Caceres, Nancy E.;
Aerts, Maarten;
Marquez, Béatrice;
Mingeot-Leclercq, Marie-Paule;
Tulkens, Paul M.;
Devreese, Bart;
Van Bambeke, Françoise

Publication type:

Article

Characterization of Abcc4 Gene Amplification in Stepwise-Selected Mouse J774 Macrophages Resistant to the Topoisomerase II Inhibitor Ciprofloxacin.

Published in:

PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0028368

By:

Marquez, Bé atrice;
Ameye, Geneviève;
Vallet, Coralie M.;
Tulkens, Paul M.;
Poirel, Hé lène A.;
Bambeke, Françoise Van

Publication type:

Article

Adverse Drug Reactions to Antiretroviral Therapy: Frequency, Type, and Risk Factors in Children in Mali.

Published in:

Journal of Pediatric Pharmacology & Therapeutics, 2023, v. 28, n. 3, p. 197, doi. 10.5863/1551-6776-28.3.197

By:

Oumar, Aboubacar Alassane;
Seydou, Alassane;
Fofana, Souleymane;
Diarra, Zoumana;
Mariko, Djeneba;
Diallo, Abdallah;
Coulibaly, Sanata;
Sidibe, Lala N.;
Togo, Boubacar;
Sounkalo Dao;
Doumbia, Seydou;
Tulkens, Paul M.

Publication type:

Article

The Persister Character of Clinical Isolates of Staphylococcus aureus Contributes to Faster Evolution to Resistance and Higher Survival in THP-1 Monocytes: A Study With Moxifloxacin.

Published in:

Frontiers in Microbiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fmicb.2020.587364

By:

Nguyen, Tiep K.;
Peyrusson, Frédéric;
Dodémont, Magali;
Pham, Nhung H.;
Nguyen, Hoang A.;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Profile of a Novel Anionic Fluoroquinolone—Delafloxacin.

Published in:

Clinical Infectious Diseases, 2019, v. 68, p. S213, doi. 10.1093/cid/ciy1079

By:

Tulkens, Paul M;
Bambeke, Françoise Van;
Zinner, Stephen H

Publication type:

Article

Colistin and a New Paradigm in Drug Development.

Published in:

Clinical Infectious Diseases, 2016, v. 62, n. 5, p. 559, doi. 10.1093/cid/civ968

By:

Van Bambeke, Françoise;
Tulkens, Paul M.

Publication type:

Article

Tedizolid Phosphate for the Management of Acute Bacterial Skin and Skin Structure Infections: Safety Summary.

Published in:

Clinical Infectious Diseases, 2014, v. 58, n. suppl_1, p. S51, doi. 10.1093/cid/cit618

By:

Das, Debaditya;
Tulkens, Paul M.;
Mehra, Purvi;
Fang, Edward;
Prokocimer, Philippe

Publication type:

Article

Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability.

Published in:

Clinical Infectious Diseases, 2012, v. 55, n. 4, p. 534, doi. 10.1093/cid/cis473

By:

Buyck, Julien M.;
Plésiat, Patrick;
Traore, H.;
Vanderbist, F.;
Tulkens, Paul M.;
Van Bambeke, Françoise

Publication type:

Article

Macrophage Killing of Bacterial and Fungal Pathogens Is Not Inhibited by Intense Intracellular Accumulation of the Lipoglycopeptide Antibiotic Oritavancin.

Published in:

Clinical Infectious Diseases, 2012, v. 54, p. S229, doi. 10.1093/cid/cir921

By:

Baquir, Beverlie;
Lemaire, Sandrine;
Van Bambeke, Francxoise;
Tulkens, Paul M.;
Lin Lin;
Spellberg, Brad

Publication type:

Article

Activity of Fusidic Acid Against Extracellular and Intracellular Staphylococcus aureus: Influence of pH and Comparison With Linezolid and Clindamycin.

Published in:

Clinical Infectious Diseases, 2011, v. 52, n. Suppl 7, p. S493, doi. 10.1093/cid/cir165

By:

Lemaire, Sandrine;
Van Bambeke, Francoise;
Pierard, Denis;
Appelbaum, Peter C.;
Tulkens, Paul M.

Publication type:

Article