Works by Tucker, Stephen J

Results: 39

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 158, doi. 10.1038/nsmb.2208

By:

Bavro, Vassiliy N;
De Zorzi, Rita;
Schmidt, Matthias R;
Muniz, João R C;
Zubcevic, Lejla;
Sansom, Mark S P;
Vénien-Bryan, Catherine;
Tucker, Stephen J

Publication type:

Article

Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.

Published in:

Journal of Physiology, 2001, v. 532, n. 2, p. 359, doi. 10.1111/j.1469-7793.2001.0359f.x

By:

Pessia, Mauro;
Imbrici, Paola;
D'Adamo, Maria Cristina;
Salvatore, Lorena;
Tucker, Stephen J.

Publication type:

Article

The role of lysine 185 in the Kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.

Published in:

Journal of Physiology, 1999, v. 520, n. 3, p. 661, doi. 10.1111/j.1469-7793.1999.00661.x

By:

Reimann, Frank;
Ryder, Timothy J.;
Tucker, Stephen J.;
Ashcroft, Frances M.

Publication type:

Article

Involvement of the N-terminus of Kir6.2 in coupling to the sulphonylurea receptor.

Published in:

Journal of Physiology, 1999, v. 518, n. 2, p. 325, doi. 10.1111/j.1469-7793.1999.0325p.x

By:

Reimann, Frank;
Tucker, Stephen J.;
Proks, Peter;
Ashcroft, Frances M.

Publication type:

Article

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

Published in:

Journal of Physiology, 1999, v. 514, n. 1, p. 19, doi. 10.1111/j.1469-7793.1999.019af.x

By:

Proks, Peter;
Gribble, Fiona M.;
Adhikari, Raju;
Tucker, Stephen J.;
Ashcroft, Frances M.

Publication type:

Article

The Interaction of nucleotides with the tolbutamide block of cloned atp-sensitive k+ channel currents expressed in xenopus oocytes: a reinterpretation.

Published in:

Journal of Physiology, 1997, v. 504, n. 1, p. 35, doi. 10.1111/j.1469-7793.1997.00035.x

By:

Gribble, Fiona M.;
Tucker, Stephen J.;
Ashcroft, Frances M.

Publication type:

Article

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 ( Kcnj16).

Published in:

Experimental Physiology, 2011, v. 96, n. 4, p. 451, doi. 10.1113/expphysiol.2010.055848

By:

Trapp, Stefan;
Tucker, Stephen J.;
Gourine, Alexander V.

Publication type:

Article

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

Published in:

Nature Medicine, 2010, v. 16, n. 10, p. 1157, doi. 10.1038/nm.2216

By:

Lafrenière, Ronald G.;
Cader, M. Zameel;
Poulin, Jean-François;
Andres-Enguix, Isabelle;
Simoneau, Maryse;
Gupta, Namrata;
Boisvert, Karine;
Lafrenière, François;
McLaughlan, Shannon;
Dubé, Marie-Pierre;
Marcinkiewicz, Martin M.;
Ramagopalan, Sreeram;
Ansorge, Olaf;
Brais, Bernard;
Sequeiros, Jorge;
Pereira-Monteiro, Jose Maria;
Griffiths, Lyn R.;
Tucker, Stephen J.;
Ebers, George;
Rouleau, Guy A.

Publication type:

Article

Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability.

Published in:

Pflügers Archiv: European Journal of Physiology, 2020, v. 472, n. 7, p. 923, doi. 10.1007/s00424-020-02382-5

By:

Imbrici, Paola;
Nematian-Ardestani, Ehsan;
Hasan, Sonia;
Pessia, Mauro;
Tucker, Stephen J.;
D'Adamo, Maria Cristina

Publication type:

Article

Structural basis for proton coupled cystine transport by cystinosin.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32589-2

By:

Löbel, Mark;
Salphati, Sacha P.;
El Omari, Kamel;
Wagner, Armin;
Tucker, Stephen J.;
Parker, Joanne L.;
Newstead, Simon

Publication type:

Article

Tissue specificity of sulfonylureas.

Published in:

Diabetes, 1998, v. 47, n. 9, p. 1412, doi. 10.2337/diabetes.47.9.1412

By:

Gribble, Fiona M.;
Tucker, Stephen J.;
Seino, Susumu;
Ashcroft, Frances M.

Publication type:

Article

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K channel.

Published in:

Channels (19336950), 2017, v. 11, n. 5, p. 482, doi. 10.1080/19336950.2017.1356955

By:

Nematian-Ardestani, Ehsan;
Jarerattanachat, Viwan;
Aryal, Prafulla;
Sansom, Mark S. P.;
Tucker, Stephen J.

Publication type:

Article

A BEST example of channel structure annotation by molecular simulation.

Published in:

Channels (19336950), 2017, v. 11, n. 4, p. 347, doi. 10.1080/19336950.2017.1306163

By:

Rao, Shanlin;
Klesse, Gianni;
Stansfeld, Phillip J.;
Tucker, Stephen J.;
Sansom, Mark S. P.

Publication type:

Article

Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel.

Published in:

Channels (19336950), 2015, v. 9, n. 1, p. 44, doi. 10.4161/19336950.2014.981987

By:

Aryal, Prafulla;
Abd-Wahab, Firdaus;
Bucci, Giovanna;
Sansom, Mark SP;
Tucker, Stephen J

Publication type:

Article

Insights into the structural nature of the transition state in the Kir channel gating pathway.

Published in:

Channels (19336950), 2014, v. 8, n. 6, p. 551, doi. 10.4161/19336950.2014.962371

By:

Fowler, Philip W;
Bollepalli, Murali K;
Rapedius, Markus;
Nematian-Ardestani, Ehsan;
Shang, Lijun;
Sansom, Mark SP;
Tucker, Stephen J;
Baukrowitz, Thomas

Publication type:

Article

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.

Published in:

Channels (19336950), 2012, v. 6, n. 6, p. 1, doi. 10.4161/chan.22153

By:

Rapedius, Markus;
Schmidt, Matthias R.;
Sharma, Chetan;
Stansfeld, Phillip J.;
Sansom, Mark S.P.;
Baukrowitz, Thomas;
Tucker, Stephen J.

Publication type:

Article

Random mutagenesis screening indicates the absence of a separate H+-sensor in the pH-sensitive Kir channels.

Published in:

Channels (19336950), 2010, v. 4, n. 5, p. 390, doi. 10.4161/chan.4.5.13006

By:

Paynter, Jennifer J.;
Shang, Lijun;
Bollepalli, Murali K.;
Baukrowitz, Thomas;
Tucker, Stephen J.

Publication type:

Article

De novo point mutations in patients diagnosed with ataxic cerebral palsy.

Published in:

2015

By:

Schnekenberg, Ricardo Parolin;
Perkins, Emma M.;
Miller, Jack W.;
Davies, Wayne I. L.;
D'Adamo, Maria Cristina;
Pessia, Mauro;
Fawcett, Katherine A.;
Sims, David;
Gillard, Elodie;
Hudspith, Karl;
Skehel, Paul;
Williams, Jonathan;
O'Regan, Mary;
Jayawant, Sandeep;
Jefferson, Rosalind;
Hughes, Sarah;
Lustenberger, Andrea;
Ragoussis, Jiannis;
Jackson, Mandy;
Tucker, Stephen J.

Publication type:

journal article

Identification and developmental expression of the Xenopus laevis cystic fibrosis transmembrane conductance regulator gene.

Published in:

Human Molecular Genetics, 1992, v. 1, n. 2, p. 77

By:

Tucker, Stephen J.;
Tannahill, David;
Higgins, Christopher F.

Publication type:

Article

Peptide Backbone Mutagenesis of Putative Gating Hinges in a Potassium Ion Channel.

Published in:

ChemBioChem, 2008, v. 9, n. 11, p. 1725, doi. 10.1002/cbic.200800133

By:

Nagaoka, Yasuo;
Shang, Lijun;
Banerjee, Arijit;
Bayley, Hagan;
Tucker, Stephen J.

Publication type:

Article

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

Published in:

Nature, 1997, v. 387, n. 6629, p. 179, doi. 10.1038/387179a0

By:

Tucker, Stephen J.;
Gribble, Fiona M.

Publication type:

Article

Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.

Published in:

EMBO Reports, 2006, v. 7, n. 6, p. 611, doi. 10.1038/sj.embor.7400678

By:

Rapedius, Markus;
Haider, Shozeb;
Browne, Katharine F.;
Lijun Shang;
Sansom, Mark S. P.;
Baukrowitz, Thomas;
Tucker, Stephen J.

Publication type:

Article

Molecular simulation studies of hydrophobic gating in nanopores and ion channels.

Published in:

Biochemical Society Transactions, 2015, v. 43, n. 2, p. 146, doi. 10.1042/BST20140256

By:

Trick, Jemma L.;
Aryal, Prafulla;
Tucker, Stephen J.;
Sansom, Mark S. P.

Publication type:

Article

Inward rectification in KATP channels: a pH switch in the pore.

Published in:

EMBO Journal, 1999, v. 18, n. 4, p. 847, doi. 10.1093/emboj/18.4.847

By:

Baukrowitz, Thomas;
Tucker, Stephen J.;
Schulte, Uwe;
Benndorf, K.;
Peter, Ruppersberg, J.;
Fakler, Bernd

Publication type:

Article

Molecular determinants of KATP channel inhibition by ATP.

Published in:

EMBO Journal, 1998, v. 17, n. 12, p. 3290, doi. 10.1093/emboj/17.12.3290

By:

Tucker, Stephen J.;
Gribble, Fiona M.;
Proks, Peter;
Trapp, Stefan;
Ryder, Timothy J.;
Haug, Trude;
Reimann, Frank;
Ashcroft, Frances M.

Publication type:

Article

The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.

Published in:

EMBO Journal, 1997, v. 16, n. 6, p. 1145, doi. 10.1093/emboj/16.6.1145

By:

Gribble, Fiona M.;
Tucker, Stephen J.;
Ashcroft, Frances M.

Publication type:

Article

Role of receptor protein tyrosine phosphatase α (RPTPα) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels.

Published in:

Pflügers Archiv: European Journal of Physiology, 2000, v. 441, n. 2/3, p. 257, doi. 10.1007/s004240000406

By:

Imbrici, Paola;
Tucker, Stephen J.;
D'Adamo, Maria Cristina;
Pessia, Mauro

Publication type:

Article

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.

Published in:

European Biophysics Journal, 2008, v. 37, n. 2, p. 165, doi. 10.1007/s00249-007-0206-7

By:

Lijun Shang;
Tucker, Stephen J.

Publication type:

Article

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.

Published in:

Nature Communications, 2014, v. 5, n. 7, p. 4377, doi. 10.1038/ncomms5377

By:

Aryal, Prafulla;
Abd-Wahab, Firdaus;
Bucci, Giovanna;
Sansom, Mark S. P.;
Tucker, Stephen J.

Publication type:

Article

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene.

Published in:

Frontiers in Physiology, 2015, v. 5, p. 1, doi. 10.3389/fphys.2014.00525

By:

D'Adamo, Maria C.;
Gallenmüller, Constanze;
Servettini, Ilenio;
Hartl, Elisabeth;
Tucker, Stephen J.;
Arning, Larissa;
Biskup, Saskia;
Grottesi, Alessandro;
Guglielmi, Luca;
Imbrici, Paola;
Bernasconi, Pia;
Di Giovanni, Giuseppe;
Franciolini, Fabio;
Catacuzzeno, Luigi;
Pessia, Mauro;
Klopstock, Thomas

Publication type:

Article

Correction: Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.

Published in:

2016

By:

Reed, Alan P.;
Bucci, Giovanna;
Abd-Wahab, Firdaus;
Tucker, Stephen J.

Publication type:

Correction Notice

Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.

Published in:

PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0156456

By:

Reed, Alan P.;
Bucci, Giovanna;
Abd-Wahab, Firdaus;
Tucker, Stephen J.

Publication type:

Article

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.

Published in:

Diabetes, 2021, v. 70, n. 5, p. 1145, doi. 10.2337/db20-0691

By:

Sachse, Gregor;
Haythorne, Elizabeth;
Hill, Thomas;
Proks, Peter;
Joynson, Russell;
Terrón-Expósito, Raul;
Bentley, Liz;
Tucker, Stephen J.;
Cox, Roger D.;
Ashcroft, Frances M.

Publication type:

Article

KCNK18 Biallelic Variants Associated with Intellectual Disability and Neurodevelopmental Disorders Alter TRESK Channel Activity.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 6064, doi. 10.3390/ijms22116064

By:

Pavinato, Lisa;
Nematian-Ardestani, Ehsan;
Zonta, Andrea;
De Rubeis, Silvia;
Buxbaum, Joseph;
Mancini, Cecilia;
Bruselles, Alessandro;
Tartaglia, Marco;
Pessia, Mauro;
Tucker, Stephen J.;
D'Adamo, Maria Cristina;
Brusco, Alfredo

Publication type:

Article

Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 5972, doi. 10.3390/ijms22115972

By:

Poli, Giulia;
Hasan, Sonia;
Belia, Silvia;
Cenciarini, Marta;
Tucker, Stephen J.;
Imbrici, Paola;
Shehab, Safa;
Pessia, Mauro;
Brancorsini, Stefano;
D'Adamo, Maria Cristina

Publication type:

Article

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48536-2

By:

Rödström, Karin E. J.;
Cloake, Alexander;
Sörmann, Janina;
Baronina, Agnese;
Smith, Kathryn H. M.;
Pike, Ashley C. W.;
Ang, Jackie;
Proks, Peter;
Schewe, Marcus;
Holland-Kaye, Ingelise;
Bushell, Simon R.;
Elliott, Jenna;
Pardon, Els;
Baukrowitz, Thomas;
Owens, Raymond J.;
Newstead, Simon;
Steyaert, Jan;
Carpenter, Elisabeth P.;
Tucker, Stephen J.

Publication type:

Article

Effects of ionic strength on gating and permeation of TREK-2 K2P channels.

Published in:

PLoS ONE, 2021, v. 16, n. 10, p. 1, doi. 10.1371/journal.pone.0258275

By:

Conrad, Linus J.;
Proks, Peter;
Tucker, Stephen J.

Publication type:

Article

Ion channels as convergence points in the pathology of pulmonary arterial hypertension.

Published in:

Biochemical Society Transactions, 2021, v. 49, n. 4, p. 1855, doi. 10.1042/BST20210538

By:

Jouen-Tachoire, Thibault R. H.;
Tucker, Stephen J.;
Tammaro, Paolo

Publication type:

Article

The pore structure and gating mechanism of K2P channels.

Published in:

EMBO Journal, 2011, v. 30, n. 21, p. 4515, doi. 10.1038/emboj.2011.369

By:

Piechotta, Paula L;
Rapedius, Markus;
Stansfeld, Phillip J;
Bollepalli, Murali K;
Ehrlich, Gunter;
Andres-Enguix, Isabelle;
Fritzenschaft, Hariolf;
Decher, Niels;
Sansom, Mark S P;
Tucker, Stephen J;
Baukrowitz, Thomas

Publication type:

Article

Works by Tucker, Stephen J

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.

Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.

The role of lysine 185 in the Kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.

Involvement of the N-terminus of Kir6.2 in coupling to the sulphonylurea receptor.

Involvement of the N-terminus of Kir6.2 in the inhibition of the K<sub>ATP</sub> channel by ATP.

The Interaction of nucleotides with the tolbutamide block of cloned atp-sensitive k<sup>+</sup> channel currents expressed in xenopus oocytes: a reinterpretation.

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 ( Kcnj16).

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability.

Structural basis for proton coupled cystine transport by cystinosin.

Tissue specificity of sulfonylureas.

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K channel.

A BEST example of channel structure annotation by molecular simulation.

Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel.

Insights into the structural nature of the transition state in the Kir channel gating pathway.

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.

Random mutagenesis screening indicates the absence of a separate H<sup>+</sup>-sensor in the pH-sensitive Kir channels.

De novo point mutations in patients diagnosed with ataxic cerebral palsy.

Identification and developmental expression of the Xenopus laevis cystic fibrosis transmembrane conductance regulator gene.

Peptide Backbone Mutagenesis of Putative Gating Hinges in a Potassium Ion Channel.

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.

Molecular simulation studies of hydrophobic gating in nanopores and ion channels.

Inward rectification in K<sub>ATP</sub> channels: a pH switch in the pore.

Molecular determinants of K<sub>ATP</sub> channel inhibition by ATP.

The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.

Role of receptor protein tyrosine phosphatase α (RPTPα) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels.

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene.

Correction: Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K<sup>+</sup> Channel Associated with Balkan Endemic Nephropathy.

Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K<sup>+</sup> Channel Associated with Balkan Endemic Nephropathy.

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.

KCNK18 Biallelic Variants Associated with Intellectual Disability and Neurodevelopmental Disorders Alter TRESK Channel Activity.

Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa.

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.

Effects of ionic strength on gating and permeation of TREK-2 K2P channels.

Ion channels as convergence points in the pathology of pulmonary arterial hypertension.

The pore structure and gating mechanism of K2P channels.