Works by Tsigelny, Igor

Results: 65

MODELING OF GLYCEROL-3-PHOSPHATE TRANSPORTER SUGGESTS A POTENTIAL 'TILT' MECHANISM INVOLVED IN ITS FUNCTION.

Published in:

Journal of Bioinformatics & Computational Biology, 2008, v. 6, n. 5, p. 885, doi. 10.1142/S0219720008003801

By:

TSIGELNY, IGOR F.;
GREENBERG, JERRY;
KOUZNETSOVA, VALENTINA;
NIGAM, SANJAY K.

Publication type:

Article

Analysis of Metagene Portraits Reveals Distinct Transitions During Kidney Organogenesis.

Published in:

Science Signaling, 2008, v. 1, n. 49, p. 1, doi. 10.1126/scisignal.1163630

By:

Tsigelny, Igor F.;
Kouznetsova, Valentina L.;
Sweeney, Derina E.;
Wei Wu;
Bush, Kevin T.;
Nigam, Sanjay K.

Publication type:

Article

BRAF mutation as a novel driver of eosinophilic cystitis.

Published in:

Cancer Biology & Therapy, 2017, v. 18, n. 9, p. 655, doi. 10.1080/15384047.2017.1360449

By:

Choi, Michael Y.;
Tsigelny, Igor F.;
Boichard, Amelie;
Skjevik, Åge A.;
Shabaik, Ahmed;
Kurzrock, Razelle

Publication type:

Article

Modeling of mutant superoxide dismutase 1 octamers with cross-linked disulfide bonds.

Published in:

Journal of Molecular Modeling, 2022, v. 28, n. 4, p. 1, doi. 10.1007/s00894-022-05072-4

By:

Zhang, Aidan;
Teigen, Knut;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.

Publication type:

Article

Polycomb repressive 2 complex—Molecular mechanisms of function.

Published in:

Protein Science: A Publication of the Protein Society, 2019, v. 28, n. 8, p. 1387, doi. 10.1002/pro.3647

By:

Kouznetsova, Valentina L.;
Tchekanov, Alex;
Li, Xiaoming;
Yan, Xiaowen;
Tsigelny, Igor F.

Publication type:

Article

Cripto stabilizes GRP78 on the cell membrane.

Published in:

Protein Science: A Publication of the Protein Society, 2018, v. 27, n. 3, p. 653, doi. 10.1002/pro.3358

By:

Kouznetsova, Valentina L.;
Hu, Hannah;
Teigen, Knut;
Zanetti, Maurizio;
Tsigelny, Igor F.

Publication type:

Article

Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

Published in:

PLoS Pathogens, 2022, v. 18, n. 7, p. 1, doi. 10.1371/journal.ppat.1010686

By:

Almanza, Gonzalo;
Clark, Alex E.;
Kouznetsova, Valentina;
Olmedillas, Eduardo;
Castro, Andrea;
Tsigelny, Igor F.;
Wu, Yan;
Gao, George F.;
Leibel, Sandra L.;
Bray, William;
Ollmann Saphire, Erica;
Carlin, Aaron F.;
Zanetti, Maurizio

Publication type:

Article

An All-Atom Model of the Structure of Human Copper Transporter 1.

Published in:

Cell Biochemistry & Biophysics, 2012, v. 63, n. 3, p. 223, doi. 10.1007/s12013-012-9358-x

By:

Tsigelny, Igor;
Sharikov, Yuriy;
Greenberg, Jerry;
Miller, Mark;
Kouznetsova, Valentina;
Larson, Christopher;
Howell, Stephen

Publication type:

Article

Conformational Changes of the Multispecific Transporter Organic Anion Transporter 1 (OAT1/SLC22A6) Suggests a Molecular Mechanism for Initial Stages of Drug and Metabolite Transport.

Published in:

Cell Biochemistry & Biophysics, 2011, v. 61, n. 2, p. 251, doi. 10.1007/s12013-011-9191-7

By:

Tsigelny, Igor;
Kovalskyy, Dmytro;
Kouznetsova, Valentina;
Balinskyi, Oleksii;
Sharikov, Yuriy;
Bhatnagar, Vibha;
Nigam, Sanjay

Publication type:

Article

Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy Using Machine Learning.

Published in:

Molecules, 2020, v. 25, n. 17, p. 3886, doi. 10.3390/molecules25173886

By:

Wang, Kate;
Romm, Eden L.;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.;
Maigret, Bernard;
Gentili, Pier Luigi

Publication type:

Article

A Pilot Study of Multi-Input Recurrent Neural Networks for Drug-Kinase Binding Prediction.

Published in:

Molecules, 2020, v. 25, n. 15, p. 3372, doi. 10.3390/molecules25153372

By:

Carpenter, Kristy;
Pilozzi, Alexander;
Huang, Xudong;
Tsigelny, Igor F.

Publication type:

Article

Relevant Applications of Generative Adversarial Networks in Drug Design and Discovery: Molecular De Novo Design, Dimensionality Reduction, and De Novo Peptide and Protein Design.

Published in:

Molecules, 2020, v. 25, n. 14, p. 3250, doi. 10.3390/molecules25143250

By:

Lin, Eugene;
Lin, Chieh-Hsin;
Lane, Hsien-Yuan;
Tsigelny, Igor F.

Publication type:

Article

Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach.

Published in:

Molecules, 2020, v. 25, n. 9, p. 2155, doi. 10.3390/molecules25092155

By:

Kubick, Norwin;
Pajares, Marta;
Enache, Ioana;
Manda, Gina;
Mickael, Michel-Edwar;
Tsigelny, Igor F.

Publication type:

Article

How Sure Can We Be about ML Methods-Based Evaluation of Compound Activity: Incorporation of Information about Prediction Uncertainty Using Deep Learning Techniques.

Published in:

Molecules, 2020, v. 25, n. 6, p. 1452, doi. 10.3390/molecules25061452

By:

Sieradzki, Igor;
Leśniak, Damian;
Podlewska, Sabina;
Tsigelny, Igor F.;
Maigret, Bernard

Publication type:

Article

miRNA in Machine-Learning-Based Diagnostics of Oral Cancer.

Published in:

Biomedicines, 2024, v. 12, n. 10, p. 2404, doi. 10.3390/biomedicines12102404

By:

Li, Xinghang;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.

Publication type:

Article

Machine‐learning‐based virtual screening to repurpose drugs for treatment of Candida albicans infection.

Published in:

Mycoses, 2022, v. 65, n. 8, p. 794, doi. 10.1111/myc.13475

By:

Gao, Andrew;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.

Publication type:

Article

The Arg451Cys-Neuroligin-3 Mutation Associated with Autism Reveals a Defect in Protein Processing.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 20, p. 4889, doi. 10.1523/JNEUROSCI.0468-04.2004

By:

Comoletti, Davide;
De Jaco, Antonella;
Jennings, Lori L.;
Flynn, Robyn E.;
Gaietta, Guido;
Tsigelny, Igor;
Ellisman, Mark H.;
Taylor, Palmer

Publication type:

Article

Interactions of large T-Antigen (LT) protein of polyomaviruses with p53 unfold their cancerogenic potential.

Published in:

Journal of Biomolecular Structure & Dynamics, 2022, v. 40, n. 11, p. 5243, doi. 10.1080/07391102.2020.1869097

By:

Kellogg, Caroline;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.

Publication type:

Article

p75 Neurotrophin Receptor Is a Clock Gene That Regulates Oscillatory Components of Circadian and Metabolic Networks.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 25, p. 10221, doi. 10.1523/JNEUROSCI.2757-12.2013

By:

Baeza-Raja, Bernat;
Eckel-Mahan, Kristin;
Zhang, Luoying;
Vagena, Eirini;
Tsigelny, Igor F.;
Sassone-Corsi, Paolo;
Ptacek, Louis J.;
Akassoglou, Katerina

Publication type:

Article

Anelloviruses and Cancer.

Published in:

2025

By:

Tang, Jason Y;
Chen, Trevor B;
Kouznetsova, Valentina L;
Tsigelny, Igor F

Publication type:

Literature Review

DEVELOPMENT OF NOVEL SMALL MOLECULES THAT TARGET GLIOBLASTOMA STEM CELLS.

Published in:

Neuro-Oncology, 2014, v. 16, n. suppl_3, p. iii17, doi. 10.1093/neuonc/nou206.61

By:

Kesari, Santosh;
Tsigelny, Igor F.;
Mukthavaram, Rajesh;
Kouznetsova, Valentina L.;
Chao, Ying;
Pastorino, Sandra;
Jiang, Pengfei;
Pingle, Sandeep C.;
Wrasidlo, Wolf;
Makale, Milan

Publication type:

Article

Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials.

Published in:

International Journal of Cancer, 2020, v. 147, n. 9, p. 2537, doi. 10.1002/ijc.33240

By:

Schperberg, Alexander V.;
Boichard, Amélie;
Tsigelny, Igor F.;
Richard, Stéphane B.;
Kurzrock, Razelle

Publication type:

Article

The role of BAG3 in dilated cardiomyopathy and its association with Charcot-Marie-Tooth disease type 2.

Published in:

Acta Myologica, 2022, v. 41, n. 2, p. 59, doi. 10.36185/2532-1900-071

By:

Nitya Yerabandi;
Kouznetsova, Valentina L.;
Kesari, Santosh;
Tsigelny, Igor F.

Publication type:

Article

A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.

Published in:

2016

By:

Wrasidlo, Wolfgang;
Tsigelny, Igor F.;
Price, Diana L.;
Dutta, Garima;
Rockenstein, Edward;
Schwarz, Thomas C.;
Ledolter, Karin;
Bonhaus, Douglas;
Paulino, Amy;
Eleuteri, Simona;
Skjevik, Åge A.;
Kouznetsova, Valentina L.;
Spencer, Brian;
Desplats, Paula;
Gonzalez-Ruelas, Tania;
Trejo-Morales, Margarita;
Overk, Cassia R.;
Winter, Stefan;
Chunni Zhu;
Chesselet, Marie-Francoise

Publication type:

journal article

Laryngeal cancer diagnosis via miRNA-based decision tree model.

Published in:

European Archives of Oto-Rhino-Laryngology, 2024, v. 281, n. 3, p. 1391, doi. 10.1007/s00405-023-08383-1

By:

Arora, Aarav;
Tsigelny, Igor F.;
Kouznetsova, Valentina L.

Publication type:

Article

Development of a Diagnostic Model for Pancreatic Ductal Adenocarcinoma Using Machine Learning and Blood-Based miRNAs.

Published in:

Oncology, 2025, v. 103, n. 3, p. 209, doi. 10.1159/000540329

By:

Tang, Jason Y.;
Kouznetsova, Valentina L.;
Kesari, Santosh;
Tsigelny, Igor F.

Publication type:

Article

Machine-learning diagnostics of breast cancer using piRNA biomarkers.

Published in:

Biomarkers, 2025, v. 30, n. 2, p. 167, doi. 10.1080/1354750X.2025.2461067

By:

Zhao, Amy R.;
Kouznetsova, Valentina L.;
Kesari, Santosh;
Tsigelny, Igor F.

Publication type:

Article

Hidden Markov Models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information.

Published in:

Protein Engineering, 2002, v. 15, n. 5, p. 347, doi. 10.1093/protein/15.5.347

By:

Tsigelny, Igor;
Sharikov, Yuriy;
Ten Eyck, Lynn F.

Publication type:

Article

Protein docking using continuum electrostatics and geometric fit.

Published in:

Protein Engineering, 2001, v. 14, n. 2, p. 105, doi. 10.1093/protein/14.2.105

By:

Mandell, Jeffrey G.;
Roberts, Victoria A.;
Pique, Michael E.;
Kotlovyi, Vladimir;
Mitchell, Julie C.;
Nelson, Erik;
Tsigelny, Igor;
Ten Eyck, Lynn F.

Publication type:

Article

Targeting Epigenetic Regulators Using Machine Learning: Potential Sirtuin 2 Inhibitors.

Published in:

Journal of Computational Biophysics & Chemistry, 2021, v. 20, n. 8, p. 841, doi. 10.1142/S2737416521500526

By:

Kessler, Andrew;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.

Publication type:

Article

Using Machine Learning and miRNA for the Diagnosis of Esophageal Cancer.

Published in:

Journal of Applied Laboratory Medicine, 2024, v. 9, n. 4, p. 684, doi. 10.1093/jalm/jfae037

By:

Aravind, Vishnu A.;
Kouznetsova, Valentina L.;
Kesari, Santosh;
Tsigelny, Igor F.

Publication type:

Article

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.

Published in:

Journal of Cell Biology, 2007, v. 177, n. 6, p. 1119, doi. 10.1083/jcb.200701040

By:

Sachs, Benjamin D.;
Baillie, George S.;
McCall, Julianne R.;
Passino, Melissa A.;
Schachtrup, Christian;
Wallace, Derek A.;
Dunlop, Allan J.;
MacKenzie, Kirsty F.;
Klussmann, Enno;
Lynch, Martin J.;
Sikorski, Shoana L.;
Nuriel, Tal;
Tsigelny, Igor;
Jin Zhang;
Houslay, Miles D.;
Chao, Moses V.;
Akassoglou, Katerina

Publication type:

Article

The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).

Published in:

Metallomics, 2015, v. 7, n. 11, p. 1477, doi. 10.1039/c5mt00131e

By:

Tsai, Cheng-Yu;
Liebig, Janika K.;
Tsigelny, Igor F.;
Howell, Stephen B.

Publication type:

Article

Colorectal Cancer Detection via Metabolites and Machine Learning.

Published in:

Current Issues in Molecular Biology, 2024, v. 46, n. 5, p. 4133, doi. 10.3390/cimb46050254

By:

Yang, Rachel;
Tsigelny, Igor F.;
Kesari, Santosh;
Kouznetsova, Valentina L.

Publication type:

Article

miRNA-Based Diagnosis of Schizophrenia Using Machine Learning.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 5, p. 2280, doi. 10.3390/ijms26052280

By:

Heda, Vishrut;
Dogra, Saanvi;
Kouznetsova, Valentina L.;
Kumar, Alex;
Kesari, Santosh;
Tsigelny, Igor F.

Publication type:

Article

600 ps Molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase.

Published in:

Biopolymers, 1999, v. 50, n. 5, p. 513, doi. 10.1002/(SICI)1097-0282(19991015)50:5<513::AID-BIP5>3.0.CO;2-I

By:

Tsigelny, Igor;
Greenberg, Jerry P.;
Cox, Sarah;
Nichols, William L.;
Taylor, Susan S.;
Ten Eyck, Lynn F.

Publication type:

Article

Catalytic subunit of cAMP-dependent protein kinase: Electrostatic features and peptide recognition.

Published in:

Biopolymers, 1996, v. 39, n. 3, p. 353, doi. 10.1002/(SICI)1097-0282(199609)39:3<353::AID-BIP7>3.0.CO;2-N

By:

Tsigelny, Igor;
Grant, Bruce D.;
Taylor, Susan S.;
Ten Eyck, Lynn F.

Publication type:

Article

Implementation of Machine Learning-Based System for Early Diagnosis of Feline Mammary Carcinomas through Blood Metabolite Profiling.

Published in:

Metabolites (2218-1989), 2024, v. 14, n. 9, p. 501, doi. 10.3390/metabo14090501

By:

Kulkarni, Vidhi;
Tsigelny, Igor F.;
Kouznetsova, Valentina L.

Publication type:

Article

Diagnostics of Thyroid Cancer Using Machine Learning and Metabolomics.

Published in:

Metabolites (2218-1989), 2024, v. 14, n. 1, p. 11, doi. 10.3390/metabo14010011

By:

Kuang, Alyssa;
Kouznetsova, Valentina L.;
Kesari, Santosh;
Tsigelny, Igor F.

Publication type:

Article

Two-Stage Deep-Learning Classifier for Diagnostics of Lung Cancer Using Metabolites.

Published in:

Metabolites (2218-1989), 2023, v. 13, n. 10, p. 1055, doi. 10.3390/metabo13101055

By:

Choudhary, Ashvin;
Yu, Jianpeng;
Kouznetsova, Valentina L.;
Kesari, Santosh;
Tsigelny, Igor F.

Publication type:

Article

Finding distinctions between oral cancer and periodontitis using saliva metabolites and machine learning.

Published in:

Oral Diseases, 2021, v. 27, n. 3, p. 484, doi. 10.1111/odi.13591

By:

Kouznetsova, Valentina L.;
Li, Jeremy;
Romm, Eden;
Tsigelny, Igor F.

Publication type:

Article

Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.

Published in:

British Journal of Pharmacology, 2014, v. 171, n. 24, p. 5757, doi. 10.1111/bph.12875

By:

Wrasidlo, Wolf;
Crews, Leslie A;
Tsigelny, Igor F;
Stocking, Emily;
Kouznetsova, Valentina L;
Price, Diana;
Paulino, Amy;
Gonzales, Tania;
Overk, Cassia R;
Patrick, Christina;
Rockenstein, Edward;
Masliah, Eliezer

Publication type:

Article

Diagnostics of ovarian cancer via metabolite analysis and machine learning.

Published in:

Integrative Biology, 2023, v. 15, p. 1, doi. 10.1093/intbio/zyad005

By:

Yao, Jerry Z;
Tsigelny, Igor F;
Kesari, Santosh;
Kouznetsova, Valentina L

Publication type:

Article

Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseas.

Published in:

PLoS ONE, 2008, v. 3, n. 9, p. 1, doi. 10.1371/journal.pone.0003135

By:

Tsigelny, Igor F.;
Crews, Leslie;
Desplats, Paula;
Shaked, Gideon M.;
Sharikov, Yuriy;
Mizuno, Hideya;
Spencer, Brian;
Rockenstein, Edward;
Trejo, Margarita;
Platoshyn, Oleksandr;
Yuan, Jason X.-J.;
Masliah, Eliezer

Publication type:

Article

Small molecular decoys in Alzheimer's disease.

Published in:

Neural Regeneration Research, 2024, v. 19, n. 8, p. 1658, doi. 10.4103/1673-5374.389643

By:

Sho Oasa;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.;
Terenius, Lars

Publication type:

Article

Recognition of early and late stages of bladder cancer using metabolites and machine learning.

Published in:

Metabolomics, 2019, v. 15, n. 7, p. N.PAG, doi. 10.1007/s11306-019-1555-9

By:

Kouznetsova, Valentina L.;
Kim, Elliot;
Romm, Eden L.;
Zhu, Alan;
Tsigelny, Igor F.

Publication type:

Article

Finding needles in haystacks: Reranking DOT results by using shape complementarity, cluster analysis, and biological information.

Published in:

Proteins, 2003, v. 52, n. 1, p. 33, doi. 10.1002/prot.10395

By:

Dennis S. Law;
Lynn F. Ten Eyck;
Omer Katzenelson;
Igor Tsigelny;
Victoria A. Roberts;
Mike E. Pique;
Julie C. Mitchell

Publication type:

Article

Neuroprotective effects of a novel Aß-protein stabilizer in APP transgenic mouse model of Alzheimer's disease

Published in:

2012

By:

Price, Diana;
Wrasidlo, Wolfgang;
Tsigelny, Igor;
Bonhaus, Douglas;
Paulino, Amy;
Mante, Michael;
Inglis, Chandra;
Adame, Anthony;
Moessler, Herbert;
Rockenstein, Edward;
Masliah, Eliezer

Publication type:

Abstract

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

Published in:

FEBS Journal, 2012, v. 279, n. 6, p. 1000, doi. 10.1111/j.1742-4658.2012.08489.x

By:

Tsigelny, Igor F.;
Sharikov, Yuriy;
Wrasidlo, Wolfgang;
Gonzalez, Tania;
Desplats, Paula A.;
Crews, Leslie;
Spencer, Brian;
Masliah, Eliezer

Publication type:

Article

Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide.

Published in:

FEBS Journal, 2008, v. 275, n. 6, p. 1309, doi. 10.1111/j.1742-4658.2008.06292.x

By:

Frederick, Adam;
Tsigelny, Igor;
Cohenour, Frances;
Spiker, Christopher;
Krejci, Eric;
Chatonnet, Arnaud;
Bourgoin, Stefan;
Richards, Greg;
Allen, Tessa;
Whitlock, Mary H.;
Pezzementi, Leo

Publication type:

Article