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3,4-Dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I.
- Published in:
- Journal of Antimicrobial Chemotherapy (JAC), 2012, v. 67, n. 12, p. 2882, doi. 10.1093/jac/dks322
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- Article
Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8709, doi. 10.3390/ijms23158709
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- Article
Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation.
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- International Journal of Molecular Sciences, 2018, v. 19, n. 5, p. 1439, doi. 10.3390/ijms19051439
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- Article
Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site.
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- Nucleic Acids Research, 2018, v. 46, n. 14, p. 7296, doi. 10.1093/nar/gky492
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- Article
Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage.
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- Nucleic Acids Research, 2012, v. 40, n. 18, p. 9233, doi. 10.1093/nar/gks688
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- Article
Bacterial topoisomerase I as a target for discovery of antibacterial compounds.
- Published in:
- Nucleic Acids Research, 2009, v. 37, n. 3, p. 731, doi. 10.1093/nar/gkn936
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- Publication type:
- Article
Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region.
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- Nucleic Acids Research, 2008, v. 36, n. 14, p. 4788, doi. 10.1093/nar/gkn460
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- Publication type:
- Article
Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.
- Published in:
- Nucleic Acids Research, 2008, v. 36, n. 3, p. 1017, doi. 10.1093/nar/gkm1126
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- Publication type:
- Article
Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives.
- Published in:
- ChemMedChem, 2022, v. 17, n. 23, p. 1, doi. 10.1002/cmdc.202200301
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- Article
Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development.
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- ChemMedChem, 2020, v. 15, n. 7, p. 623, doi. 10.1002/cmdc.201900721
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- Publication type:
- Article
RNase HI overproduction is required for efficient full-length RNA synthesis in the absence of topoisomerase I inEscherichia coli.
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- Molecular Microbiology, 2004, v. 54, n. 1, p. 198, doi. 10.1111/j.1365-2958.2004.04258.x
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- Article
Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II).
- Published in:
- PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0120022
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- Publication type:
- Article
Identification of Anziaic Acid, a Lichen Depside from <i>Hypotrachyna</i> sp., as a New Topoisomerase Poison Inhibitor.
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- PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0060770
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- Article
Changes in lipid distribution in E. coli strains in response to norfloxacin.
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- Journal of Mass Spectrometry, 2015, v. 50, n. 1, p. 88, doi. 10.1002/jms.3500
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- Publication type:
- Article
Virus- and cell-encoded tyrosine protein kinases inactivate DNA topoisomerases in vitro.
- Published in:
- Nature, 1984, v. 312, n. 5996, p. 785, doi. 10.1038/312785a0
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- Publication type:
- Article
Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents.
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- Cancers, 2019, v. 11, n. 10, p. 1416, doi. 10.3390/cancers11101416
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- Article
Type IA Topoisomerases as Targets for Infectious Disease Treatments.
- Published in:
- Microorganisms, 2021, v. 9, n. 1, p. 86, doi. 10.3390/microorganisms9010086
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- Article
Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I.
- Published in:
- Nucleic Acids Research, 2006, v. 34, n. 6, p. 1785, doi. 10.1093/nar/gkl109
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- Article
The carboxyl terminal domain of Escherichia coli DNA topoisomerase I confers higher affinity to DNA.
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- Proteins, 1989, v. 6, n. 3, p. 249, doi. 10.1002/prot.340060307
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- Article
Evaluation of topotecan and etoposide for non-Hodgkin lymphoma: correlation of topoisomerase-DNA complex formation with clinical response.
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- 2001
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- Publication type:
- journal article
Interaction in the interface between domain 3 (D3) and domain 4 (D4) regulate the conformational changes in type IA topoisomerases.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02072
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- Publication type:
- Article
Microbial resistance: Novel screens for a contemporary problem.
- Published in:
- Medicinal Research Reviews, 1999, v. 19, n. 6, p. 559, doi. 10.1002/(SICI)1098-1128(199911)19:6<559::AID-MED6>3.0.CO;2-D
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- Publication type:
- Article
Synthesizing topological structures containing RNA.
- Published in:
- Nature Communications, 2017, v. 8, n. 3, p. 14936, doi. 10.1038/ncomms14936
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- Article
Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life.
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- Cells (2073-4409), 2024, v. 13, n. 6, p. 553, doi. 10.3390/cells13060553
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- Publication type:
- Article
The interaction between transport-segment DNA and topoisomerase IA—crystal structure of MtbTOP1 in complex with both G- and T-segments.
- Published in:
- Nucleic Acids Research, 2023, v. 51, n. 1, p. 349, doi. 10.1093/nar/gkac1205
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- Publication type:
- Article
Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains.
- Published in:
- Nucleic Acids Research, 2020, v. 48, n. 8, p. 4448, doi. 10.1093/nar/gkaa201
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- Publication type:
- Article
Isolation and Characterization of Fungal Endophytes from Petiveria alliacea and Their Antimicrobial Activities in South Florida.
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- Microbiology Research, 2023, v. 14, n. 3, p. 1470, doi. 10.3390/microbiolres14030100
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- Publication type:
- Article
Identification of proximal sites for unwound DNA substrate in Escherichia coli topoisomerase I with oxidative crosslinking.
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- FEBS Letters, 2017, v. 591, n. 1, p. 28, doi. 10.1002/1873-3468.12517
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- Article
Characterization of molecular interactions between Escherichia coli RNA polymerase and topoisomerase I by molecular simulations.
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- FEBS Letters, 2016, v. 590, n. 17, p. 2844, doi. 10.1002/1873-3468.12321
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- Article
Mechanism of Type IA Topoisomerases.
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- Molecules, 2020, v. 25, n. 20, p. 4769, doi. 10.3390/molecules25204769
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- Article
Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound.
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- PLoS ONE, 2019, v. 14, n. 2, p. 1, doi. 10.1371/journal.pone.0207733
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- Publication type:
- Article
Characterization and antimicrobial activity of endophytic fungi from medicinal plant Agave americana.
- Published in:
- Letters in Applied Microbiology, 2024, v. 77, n. 3, p. 1, doi. 10.1093/lambio/ovae025
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- Publication type:
- Article