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Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.
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- Angewandte Chemie, 2015, v. 127, n. 24, p. 7250, doi. 10.1002/ange.201501575
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- Article
Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
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- BMC Structural Biology, 2012, v. 12, n. 1, p. 32, doi. 10.1186/1472-6807-12-32
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- Article
Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.
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- Nature Communications, 2017, v. 8, n. 1, p. 14132, doi. 10.1038/ncomms14132
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- Article
Synthesis of Benzothiophene-Containing 10- and 11-Membered Cyclic Phostones.
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- European Journal of Organic Chemistry, 2016, v. 2016, n. 22, p. 3728, doi. 10.1002/ejoc.201600333
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The design of a potent inhibitor of the hepatitis C virus NS3 protease: BILN 2061-From the NMR tube to the clinic.
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- Biopolymers, 2004, v. 76, n. 4, p. 309, doi. 10.1002/bip.20127
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- Article
Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase.
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- FEBS Open Bio, 2024, v. 14, n. 8, p. 1320, doi. 10.1002/2211-5463.13853
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- Article
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.
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- Angewandte Chemie International Edition, 2015, v. 54, n. 24, p. 7144, doi. 10.1002/anie.201501575
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- Article
Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics StrategyWe are grateful to Dr. Michael Bös, Dr. Michael Cordingley, and Dr. Paul Anderson for encouragement and support. We also thank Dr. Timothy Stammers, Dr. Nathalie Goudreau, Dr. Marc-André Poupart, Dr. Dale Cameron, and Mr. Jeff O'Meara for comments or critical reading of the manuscript, as well as Ginette McKercher for determining inhibition constants.
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- Angewandte Chemie, 2004, v. 116, n. 33, p. 4406, doi. 10.1002/ange.200460326
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- Article
ISOPRENOIDS PATHWAY, TAU PHOSPHORYLATION AND ALZHEIMER’S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1314, doi. 10.1016/j.jalz.2017.06.2013
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BRAIN ISOPRENOIDS AND ALZHEIMER'S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P659, doi. 10.1016/j.jalz.2016.06.1494
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- Article
Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.
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- Acta Crystallographica: Section F, Structural Biology Communications, 2014, v. 70, n. 3, p. 299, doi. 10.1107/S2053230X14002106
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Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
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- PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0186447
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A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.
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- ChemBioChem, 2016, v. 17, n. 9, p. 843, doi. 10.1002/cbic.201500485
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- Article
Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics StrategyWe are grateful to Dr. Michael Bös, Dr. Michael Cordingley, and Dr. Paul Anderson for encouragement and support. We also thank Dr. Timothy Stammers, Dr. Nathalie Goudreau, Dr. Marc-André Poupart, Dr. Dale Cameron, and Mr. Jeff O'Meara for comments or critical reading of the manuscript, as well as Ginette McKercher for determining inhibition constants.
- Published in:
- Angewandte Chemie International Edition, 2004, v. 43, n. 33, p. 4306, doi. 10.1002/anie.200460326
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- Article
Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection.
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- Angewandte Chemie International Edition, 2003, v. 42, n. 12, p. 1356, doi. 10.1002/anie.200390347
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- Article