Works matching AU Tsai, Li-Huei

Results: 89

Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2012, v. 67, n. 7, p. 741, doi. 10.1093/gerona/gls110

By:

Kosik, Kenneth S.;
Rapp, Peter R.;
Raz, Naftali;
Small, Scott A.;
Sweatt, J. David;
Tsai, Li-Huei

Publication type:

Article

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Published in:

2012

By:

Kosik KS;
Rapp PR;
Raz N;
Small SA;
Sweatt JD;
Tsai LH;
Kosik, Kenneth S;
Rapp, Peter R;
Raz, Naftali;
Small, Scott A;
Sweatt, J David;
Tsai, Li-Huei

Publication type:

journal article

Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56641-z

By:

Shin, Tay Won;
Wang, Hao;
Zhang, Chi;
An, Bobae;
Lu, Yangning;
Zhang, Elizabeth;
Lu, Xiaotang;
Karagiannis, Emmanouil D.;
Kang, Jeong Seuk;
Emenari, Amauche;
Symvoulidis, Panagiotis;
Asano, Shoh;
Lin, Leanne;
Costa, Emma K.;
Marblestone, Adam H.;
Kasthuri, Narayanan;
Tsai, Li-Huei;
Boyden, Edward S.

Publication type:

Article

Callosal axon guidance defects in p35<sup>−/−</sup> mice.

Published in:

Journal of Comparative Neurology, 1999, v. 415, n. 2, p. 218, doi. 10.1002/(SICI)1096-9861(19991213)415:2<218::AID-CNE6>3.0.CO;2-F

By:

Kwon, Young T.;
Tsai, Li-Huei;
Crandall, James E.

Publication type:

Article

A novel disruption of cortical development in p35<sup>−/−</sup> mice distinct from reeler.

Published in:

Journal of Comparative Neurology, 1998, v. 395, n. 4, p. 510, doi. 10.1002/(SICI)1096-9861(19980615)395:4<510::AID-CNE7>3.0.CO;2-4

By:

Kwon, Young T.;
Tsai, Li-Huei

Publication type:

Article

Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 6, p. 2372, doi. 10.1523/JNEUROSCI.0969-14.2015

By:

Rudenko, Andrii;
Seo, Jinsoo;
Hu, Ji;
Su, Susan C.;
de Anda, Froylan Calderon;
Durak, Omer;
Ericsson, Maria;
Carlén, Marie;
Tsai, Li-Huei

Publication type:

Article

Proteomics analysis characterizing new markers related to Aβ plaques and tau tangles pathologies.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.091288

By:

Binette, Alexa Pichet;
Wennström, Malin;
Strandberg, Olof;
Mathys, Hansruedi;
Tsai, Li‐Huei;
Mattsson‐Carlgren, Niklas;
Stomrud, Erik;
Janelidze, Shorena;
Vogel, Jacob W.;
Hansson, Oskar

Publication type:

Article

Deciphering the molecular and cellular underpinnings of cognitive resilience in Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.090374

By:

Castanho, Isabel;
Yeganeh, Pourya Naderi;
Boix, Carles A;
Mathys, Hansruedi;
Prokopenko, Dmitry;
White, Bartholomew;
Morgan, Sarah;
Lange, Christoph;
Bennett, David A.;
Bertram, Lars;
Tanzi, Rudolph E.;
Tsai, Li‐Huei;
Kellis, Manolis;
Hide, Winston

Publication type:

Article

Lithium protects against ApoE4 mediated calcium dysregulation and mitochondrial dysfunction and cell damage in iPSCs from a sporadic Alzheimer's disease patient.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082765

By:

Liang, Ge;
Anchipolovsky, Samuel;
Zhang, Roland;
Das, Ipsita;
Ayala, Benjamin;
Xu, Xandro;
Tsai, Li‐Huei;
Wei, Huafeng

Publication type:

Article

HDAC2 negatively regulates memory formation and synaptic plasticity.

Published in:

Nature, 2009, v. 459, n. 7243, p. 55, doi. 10.1038/nature07925

By:

Guan, Ji-Song;
Haggarty, Stephen J.;
Giacometti, Emanuela;
Dannenberg, Jan-Hermen;
Joseph, Nadine;
Gao, Jun;
Nieland, Thomas J. F.;
Zhou, Ying;
Wang, Xinyu;
Mazitschek, Ralph;
Bradner, James E.;
DePinho, Ronald A.;
Jaenisch, Rudolf;
Tsai, Li-Huei

Publication type:

Article

Three decades of Cdk5.

Published in:

Journal of Biomedical Science, 2021, v. 28, n. 1, p. 1, doi. 10.1186/s12929-021-00774-y

By:

Pao, Ping-Chieh;
Tsai, Li-Huei

Publication type:

Article

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics.

Published in:

Frontiers in Molecular Neuroscience, 2023, v. 15, p. 1, doi. 10.3389/fnmol.2022.948456

By:

Ramamurthy, Easwaran;
Welch, Gwyneth;
Cheng, Jemmie;
Yixin Yuan;
Gunsalus, Laura;
Bennett, David A.;
Tsai, Li-Huei;
Pfenning, Andreas R.

Publication type:

Article

Reelin and Cyclin-Dependent Kinase 5-Dependent Signals Cooperate in Regulating Neuronal Migration and Synaptic Transmission.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 8, p. 1897, doi. 10.1523/JNEUROSCI.4084-03.2004

By:

Beffert, Uwe;
Weeber, Edwin J.;
Morfini, Gerardo;
Ko, Jane;
Brady, Scott T.;
Tsai, Li-Huei;
Sweatt, J. David;
Herz, Joachim

Publication type:

Article

Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms.

Published in:

Neurodegenerative Diseases, 2012, v. 10, n. 1-4, p. 191, doi. 10.1159/000334602

By:

Mungenast, Alison E.;
Tsai, Li-Huei

Publication type:

Article

14-3-3e is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.

Published in:

Nature Genetics, 2003, v. 34, n. 3, p. 274, doi. 10.1038/ng1169

By:

Toyo-oka, Kazuhito;
Shionoya, Aki;
Gambello, Michael J;
Cardoso, Carlos;
Leventer, Richard;
Ward, Heather L;
Ayala, Ramses;
Tsai, Li-Huei;
Dobyns, William;
Ledbetter, David;
Hirotsune, Shinji;
Wynshaw-Boris, Anthony

Publication type:

Article

Innovations in noninvasive sensory stimulation treatments to combat Alzheimer's disease.

Published in:

PLoS Biology, 2025, v. 23, n. 2, p. 1, doi. 10.1371/journal.pbio.3003046

By:

Park, Jung M.;
Tsai, Li-Huei

Publication type:

Article

3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0599-8

By:

Gail Canter, Rebecca;
Huang, Wen-Chin;
Choi, Heejin;
Wang, Jun;
Ashley Watson, Lauren;
Yao, Christine G.;
Abdurrob, Fatema;
Bousleiman, Stephanie M.;
Young, Jennie Z.;
Bennett, David A.;
Delalle, Ivana;
Chung, Kwanghun;
Tsai, Li-Huei

Publication type:

Article

A DECADE OF CDK5.

Published in:

Nature Reviews Molecular Cell Biology, 2001, v. 2, n. 10, p. 749, doi. 10.1038/35096019

By:

Dhavan, Rani;
Tsai, Li-Huei

Publication type:

Article

How MicroRNAs Are Involved in Splitting the Mind.

Published in:

2016

By:

Tsai, Li-Huei;
Siegert, Sandra

Publication type:

journal article

S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.

Published in:

Translational Psychiatry, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41398-019-0388-7

By:

Amal, Haitham;
Gong, Guanyu;
Gjoneska, Elizabeta;
Lewis, Sarah M.;
Wishnok, John S.;
Tsai, Li-Huei;
Tannenbaum, Steven R.

Publication type:

Article

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes.

Published in:

PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0161969

By:

Raja, Waseem K.;
Mungenast, Alison E.;
Lin, Yuan-Ta;
Ko, Tak;
Abdurrob, Fatema;
Seo, Jinsoo;
Tsai, Li-Huei

Publication type:

Article

Axon selection.

Published in:

Communicative & Integrative Biology, 2011, v. 4, n. 3, p. 304, doi. 10.4161/cib.4.3.14781

By:

Calderon de Anda, Froylan;
Tsai, Li-Huei

Publication type:

Article

Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load.

Published in:

Nature Protocols, 2018, v. 13, n. 8, p. 1850, doi. 10.1038/s41596-018-0021-x

By:

Singer, Annabelle C.;
Martorell, Anthony J.;
Douglas, J. Miller;
Abdurrob, Fatema;
Attokaren, Matthew K.;
Tipton, John;
Mathys, Hansruedi;
Adaikkan, Chinnakkaruppan;
Tsai, Li-Huei

Publication type:

Article

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 21, p. 8951, doi. 10.1523/JNEUROSCI.5657-12.2013

By:

Graff, Johannes;
Kahn, Martin;
Samiei, Alireza;
Jun Gao;
Ota, Kristie T.;
Rei, Damien;
Tsai, Li-Huei

Publication type:

Article

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1).

Published in:

Journal of Neuroscience, 2011, v. 31, n. 44, p. 15751, doi. 10.1523/JNEUROSCI.3588-11.2011

By:

Giusti-Rodríguez, Paola;
Gao, Jun;
Gräff, Johannes;
Rei, Damien;
Soda, Takahiro;
Tsai, Li-Huei

Publication type:

Article

Life is a journey: a genetic look at neocortical development.

Published in:

2002

By:

Gupta, Amitabh;
Tsai, Li-Huei;
Wynshaw-Boris, Anthony

Publication type:

journal article

The schizophrenia risk gene product miR-137 alters presynaptic plasticity.

Published in:

Nature Neuroscience, 2015, v. 18, n. 7, p. 1008, doi. 10.1038/nn.4023

By:

Siegert, Sandra;
Seo, Jinsoo;
Kwon, Ester J;
Rudenko, Andrii;
Cho, Sukhee;
Wang, Wenyuan;
Flood, Zachary;
Martorell, Anthony J;
Ericsson, Maria;
Mungenast, Alison E;
Tsai, Li-Huei

Publication type:

Article

Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

Published in:

Nature Neuroscience, 2014, v. 17, n. 12, p. 1840, doi. 10.1038/nn1214-1840a

By:

de Anda, Froylan Calderon;
Rosario, Ana Lucia;
Durak, Omer;
Tran, Tracy;
Gräff, Johannes;
Meletis, Konstantinos;
Rei, Damien;
Soda, Takahiro;
Madabhushi, Ram;
Ginty, David D;
Kolodkin, Alex L;
Tsai, Li-Huei

Publication type:

Article

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.

Published in:

Nature Neuroscience, 2013, v. 16, n. 10, p. 1383, doi. 10.1038/nn.3514

By:

Wang, Wen-Yuan;
Pan, Ling;
Su, Susan C;
Quinn, Emma J;
Sasaki, Megumi;
Jimenez, Jessica C;
Mackenzie, Ian R A;
Huang, Eric J;
Tsai, Li-Huei

Publication type:

Article

The Top3β way to untangle RNA.

Published in:

Nature Neuroscience, 2013, v. 16, n. 9, p. 1163, doi. 10.1038/nn.3506

By:

Nott, Alexi;
Tsai, Li-Huei

Publication type:

Article

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.

Published in:

Nature Neuroscience, 2013, v. 16, n. 8, p. 1008, doi. 10.1038/nn.3460

By:

Dobbin, Matthew M;
Madabhushi, Ram;
Pan, Ling;
Chen, Yue;
Kim, Dohoon;
Gao, Jun;
Ahanonu, Biafra;
Pao, Ping-Chieh;
Qiu, Yi;
Zhao, Yingming;
Tsai, Li-Huei

Publication type:

Article

DNA methylation in cognition comes of age.

Published in:

Nature Neuroscience, 2012, v. 15, n. 8, p. 1061, doi. 10.1038/nn.3169

By:

Su, Susan C;
Tsai, Li-Huei

Publication type:

Article

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

Published in:

Nature Neuroscience, 2012, v. 15, n. 7, p. 1022, doi. 10.1038/nn.3141

By:

Calderon de Anda, Froylan;
Rosario, Ana Lucia;
Durak, Omer;
Tran, Tracy;
Gräff, Johannes;
Meletis, Konstantinos;
Rei, Damien;
Soda, Takahiro;
Madabhushi, Ram;
Ginty, David D;
Kolodkin, Alex L;
Tsai, Li-Huei

Publication type:

Article

Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46478-3

By:

Adaikkan, Chinnakkaruppan;
Joseph, Justin;
Foustoukos, Georgios;
Wang, Jun;
Polygalov, Denis;
Boehringer, Roman;
Middleton, Steven J.;
Huang, Arthur J. Y.;
Tsai, Li-Huei;
McHugh, Thomas J.

Publication type:

Article

Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome.

Published in:

PLoS ONE, 2025, v. 20, n. 4, p. 1, doi. 10.1371/journal.pone.0317428

By:

Islam, Md Rezaul;
Jackson, Brennan;
Naomi, Maeesha Tasnim;
Schatz, Brooke;
Tan, Noah;
Murdock, Mitchell;
Park, Dong Shin;
Amorim, Daniela Rodrigues;
Jiang, Xueqiao;
Pineda, S. Sebastian;
Adaikkan, Chinnakkaruppan;
Fernandez Avalos, Vanesa;
Geigenmuller, Ute;
Firenze, Rosalind Mott;
Kellis, Manolis;
Boyden, Edward S.;
Tsai, Li-Huei

Publication type:

Article

P35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.

Published in:

Nature, 1994, v. 371, n. 6496, p. 419, doi. 10.1038/371419a0

By:

Tsai, Li-Huei;
Delalle, Ivana

Publication type:

Article

Cyclin-Dependent Kinase 5 Permits Efficient Cytoskeletal Remodeling—a Hypothesis on Neuronal Migration.

Published in:

Cerebral Cortex, 2006, v. 16, n. suppl_1, p. i64, doi. 10.1093/cercor/bhj170

By:

Xie, Zhigang;
Samuels, Benjamin Adam;
Tsai, Li-Huei

Publication type:

Article

Cyclin-Dependent Kinase 5 Permits Efficient Cytoskeletal Remodeling—a Hypothesis on Neuronal Migration.

Published in:

Cerebral Cortex, 2006, v. 16, n. 1, p. i64, doi. 10.1093/cercor/bhj170

By:

Xie, Zhigang;
Samuels, Benjamin Adam;
Tsai, Li-Huei

Publication type:

Article

Differential Cellular Phosphorylation of Neurofilament Heavy Side-Arms by Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinase-5.

Published in:

Journal of Neurochemistry, 1996, v. 66, n. 4, p. 1698, doi. 10.1046/j.1471-4159.1996.66041698.x

By:

Guidato, Sonia;
Tsai, Li-Huei;
Woodgett, Jim;
Miller, Christopher C. J.

Publication type:

Article

Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration.

Published in:

Annals of the New York Academy of Sciences, 2009, v. 1170, p. 674, doi. 10.1111/j.1749-6632.2009.04105.x

By:

Kim, Dohoon;
Tsai, Li‐Huei

Publication type:

Article

iPSC‐derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss.

Published in:

Glia (0894-1491), 2024, v. 72, n. 2, p. 452, doi. 10.1002/glia.24485

By:

Penney, Jay;
Ralvenius, William T.;
Loon, Anjanet;
Cerit, Oyku;
Dileep, Vishnu;
Milo, Blerta;
Pao, Ping‐Chieh;
Woolf, Hannah;
Tsai, Li‐Huei

Publication type:

Article

Histone acetylation: molecular mnemonics on the chromatin.

Published in:

2013

By:

Gräff J;
Tsai LH;
Gräff, Johannes;
Tsai, Li-Huei

Publication type:

journal article

Histone acetylation: molecular mnemonics on the chromatin.

Published in:

Nature Reviews Neuroscience, 2013, v. 14, n. 2, p. 97, doi. 10.1038/nrn3427

By:

Gräff, Johannes;
Tsai, Li-Huei

Publication type:

Article

Spindle regulation in neural precursors of flies and mammals.

Published in:

Nature Reviews Neuroscience, 2007, v. 8, n. 2, p. 89, doi. 10.1038/nrn2058

By:

Buchman, Joshua J.;
Tsai, Li-Huei

Publication type:

Article

Cdk5: One of the links between senile plaques and neurofibrillary tangles?

Published in:

Journal of Alzheimer's Disease, 2003, v. 5, n. 2, p. 127, doi. 10.3233/JAD-2003-5207

By:

Lee, Ming-Sum;
Tsai, Li-Huei

Publication type:

Article

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.

Published in:

Annals of Neurology, 2024, v. 95, n. 4, p. 625, doi. 10.1002/ana.26864

By:

Vance, Jeffery M.;
Farrer, Lindsay A.;
Huang, Yadong;
Cruchaga, Carlos;
Hyman, Bradley T.;
Pericak‐Vance, Margaret A.;
Goate, Alison M.;
Greicius, Michael D.;
Griswold, Anthony J.;
Haines, Jonathan L.;
TCW, Julia;
Schellenberg, Gerard D.;
Tsai, Li‐Huei;
Herz, Joachim;
Holtzman, David M.

Publication type:

Article

Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration.

Published in:

Molecular Systems Biology, 2020, v. 16, n. 12, p. 1, doi. 10.15252/msb.20209819

By:

Morshed, Nader;
Ralvenius, William T;
Nott, Alexi;
Watson, L Ashley;
Rodriguez, Felicia H;
Akay, Leyla A;
Joughin, Brian A;
Pao, Ping‐Chieh;
Penney, Jay;
LaRocque, Lauren;
Mastroeni, Diego;
Tsai, Li‐Huei;
White, Forest M

Publication type:

Article

Nanoparticle‐Mediated Delivery of Anti‐PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation.

Published in:

Advanced Materials, 2024, v. 36, n. 8, p. 1, doi. 10.1002/adma.202309225

By:

Ralvenius, William T.;
Andresen, Jason L.;
Huston, Margaret M.;
Penney, Jay;
Bonner, Julia Maeve;
Fenton, Owen S.;
Langer, Robert;
Tsai, Li‐Huei

Publication type:

Article

Editorial.

Published in:

NeuroSignals (Karger AG), 2003, v. 12, n. 4/5, p. 163, doi. 10.1159/000074616

By:

Tsai, Li-Huei;
Wang, Jerry H.C.

Publication type:

Article

Cyclin-Dependent Kinase 5 and Neuronal Migration in the Neocortex.

Published in:

NeuroSignals (Karger AG), 2003, v. 12, n. 4/5, p. 173, doi. 10.1159/000074618

By:

Gupta, Amitabh;
Tsai, Li-Huei

Publication type:

Article