Works by Trotti, Davide

Results: 29

Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01547-2

By:

Antoniani, Francesco;
Cimino, Marco;
Mediani, Laura;
Vinet, Jonathan;
Verde, Enza M.;
Secco, Valentina;
Yamoah, Alfred;
Tripathi, Priyanka;
Aronica, Eleonora;
Cicardi, Maria E.;
Trotti, Davide;
Sterneckert, Jared;
Goswami, Anand;
Carra, Serena

Publication type:

Article

EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.89298

By:

Urban, Mark W.;
Charsar, Brittany A.;
Heinsinger, Nicolette M.;
Markandaiah, Shashirekha S.;
Sprimont, Lindsay;
Wei Zhou;
Brown, Eric V.;
Henderson, Nathan T.;
Thomas, Samantha J.;
Ghosh, Biswarup;
Cain, Rachel E.;
Trotti, Davide;
Pasinelli, Piera;
Wright, Megan C.;
Dalva, Matthew B.;
Lepore, Angelo C.

Publication type:

Article

JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43728-8

By:

Scopa, Chiara;
Barnada, Samantha M.;
Cicardi, Maria E.;
Singer, Mo;
Trotti, Davide;
Trizzino, Marco

Publication type:

Article

Sumoylation of Critical Proteins in Amyotrophic Lateral Sclerosis: Emerging Pathways of Pathogenesis.

Published in:

NeuroMolecular Medicine, 2013, v. 15, n. 4, p. 760, doi. 10.1007/s12017-013-8262-x

By:

Foran, Emily;
Rosenblum, Lauren;
Bogush, Alexey I.;
Trotti, Davide

Publication type:

Article

Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha.

Published in:

Glia (0894-1491), 2018, v. 66, n. 5, p. 1016, doi. 10.1002/glia.23298

By:

Kia, Azadeh;
McAvoy, Kevin;
Krishnamurthy, Karthik;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.

Published in:

Glia (0894-1491), 2016, v. 64, n. 8, p. 1298, doi. 10.1002/glia.23003

By:

Qosa, Hisham;
Lichter, Jessica;
Sarlo, Mark;
Markandaiah, Shashirekha S.;
McAvoy, Kevin;
Richard, Jean‐Philippe;
Jablonski, Michael R.;
Maragakis, Nicholas J.;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.

Published in:

Glia (0894-1491), 2011, v. 59, n. 11, p. 1719, doi. 10.1002/glia.21218

By:

Foran, Emily;
Bogush, Alexey;
Goffredo, Michael;
Roncaglia, Paola;
Gustincich, Stefano;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress.

Published in:

EMBO Molecular Medicine, 2019, v. 11, n. 2, p. 1, doi. 10.15252/emmm.201809423

By:

Westergard, Thomas;
McAvoy, Kevin;
Russell, Katelyn;
Wen, Xinmei;
Pang, Yu;
Morris, Brandie;
Pasinelli, Piera;
Trotti, Davide;
Haeusler, Aaron

Publication type:

Article

Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis.

Published in:

2021

By:

Cicardi, Maria Elena;
Marrone, Lara;
Azzouz, Mimoun;
Trotti, Davide

Publication type:

Literature Review

NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-024-07412-x

By:

Kim, Kevin M.;
Girdhar, Amandeep;
Cicardi, Maria E.;
Kankate, Vaishnavi;
Hayashi, Miyuki;
Yang, Ruoyu;
Carey, Jenny L.;
Fare, Charlotte M.;
Shorter, James;
Cingolani, Gino;
Trotti, Davide;
Guo, Lin

Publication type:

Article

Differential Modulation of the Uptake Currents by Redox Interconversion of Cysteine Residues in the Human Neuronal Glutamate Transporter EAAC1.

Published in:

European Journal of Neuroscience, 1997, v. 9, n. 10, p. 2207, doi. 10.1111/j.1460-9568.1997.tb01388.x

By:

Trotti, Davide;
Nussberger, Stephan;
Volterra, Andrea;
Hedger, Matthias A.

Publication type:

Article

Non-synaptic Localization of the Glutamate Transporter EAACI in Cultured Hippocampal Neurons.

Published in:

European Journal of Neuroscience, 1997, v. 9, n. 9, p. 1902, doi. 10.1111/j.1460-9568.1997.tb00757.x

By:

Coco, Silvia;
Verderio, Claudia;
Trotti, Davide;
Rothstein, Jeffrey D.;
Volterra, Andrea;
Matteoli, Michela

Publication type:

Article

miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 24, p. 5478, doi. 10.1523/JNEUROSCI.3037-17.2018

By:

Maimon, Roy;
Ionescu, Ariel;
Bonnie, Avichai;
Gradus, Tal;
Perlson, Eran;
Sweetat, Sahar;
Behar, Oded;
Wald-Altman, Shane;
Inbar, Shani;
Weil, Miguel;
Trotti, Davide

Publication type:

Article

Small Peptides against the Mutant SOD1/Bcl-2 Toxic Mitochondrial Complex Restore Mitochondrial Function and Cell Viability in Mutant SOD1-Mediated ALS.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 28, p. 11588, doi. 10.1523/JNEUROSCI.5385-12.2013

By:

Wenzhi Tan;
Naniche, Nicole;
Bogush, Alexey;
Pedrini, Steve;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.

Published in:

EMBO Reports, 2024, v. 25, n. 5, p. 2479, doi. 10.1038/s44319-024-00140-7

By:

Nelson, Andrew T;
Cicardi, Maria Elena;
Markandaiah, Shashirekha S;
Han, John YS;
Philp, Nancy J;
Welebob, Emily;
Haeusler, Aaron R;
Pasinelli, Piera;
Manfredi, Giovanni;
Kawamata, Hibiki;
Trotti, Davide

Publication type:

Article

Reactive Oxygen Species Inhibit High-Affinity Glutamate Uptake: Molecular Mechanism and Neuropathological Implications.

Published in:

Annals of the New York Academy of Sciences, 1994, v. 738, n. 1, p. 153, doi. 10.1111/j.1749-6632.1994.tb21800.x

By:

VOLTERRA, ANDREA;
TROTTI, DAVIDE;
FLORIDI, STEFANO;
RACAGNI, GIORGIO

Publication type:

Article

Inhibiting drug efflux transporters improves efficacy of ALS therapeutics.

Published in:

Annals of Clinical & Translational Neurology, 2014, v. 1, n. 12, p. 996, doi. 10.1002/acn3.141

By:

Jablonski, Michael R.;
Markandaiah, Shashirekha S.;
Jacob, Dena;
Meng, Ni J.;
Li, Ke;
Gennaro, Victoria;
Lepore, Angelo C.;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-09593-z

By:

Verdone, Brandie Morris;
Cicardi, Maria Elena;
Wen, Xinmei;
Sriramoji, Sindhu;
Russell, Katelyn;
Markandaiah, Shashirekha S.;
Jensen, Brigid K.;
Krishnamurthy, Karthik;
Haeusler, Aaron R.;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

Published in:

1999

By:

Trotti, Davide;
Rolfs, Andreas;
Danbolt, Niels C.;
Brown, Robert H.;
Hediger, Matthias A.

Publication type:

Correction Notice

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

Published in:

Nature Neuroscience, 1999, v. 2, n. 5, p. 427, doi. 10.1038/8091

By:

Trotti, Davide;
Rolfs, Andreas;
Danbolt, Niels C.;
Brown, Robert H.;
Hediger, Matthias A.

Publication type:

Article

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

Published in:

Human Molecular Genetics, 2010, v. 19, n. 15, p. 2974, doi. 10.1093/hmg/ddq202

By:

Pedrini, Steve;
Sau, Daniela;
Guareschi, Stefania;
Bogush, Marina;
Brown, Robert H.;
Naniche, Nicole;
Kia, Azadeh;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ALS/FTD is rescued by SV2 replenishment.

Published in:

EMBO Molecular Medicine, 2020, v. 12, n. 5, p. 1, doi. 10.15252/emmm.201910722

By:

Jensen, Brigid K;
Schuldi, Martin H;
McAvoy, Kevin;
Russell, Katelyn A;
Boehringer, Ashley;
Curran, Bridget M;
Krishnamurthy, Karthik;
Wen, Xinmei;
Westergard, Thomas;
Ma, Le;
Haeusler, Aaron R;
Edbauer, Dieter;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1600, doi. 10.1208/s12248-017-0120-6

By:

Mohamed, Loqman;
Markandaiah, Shashirekha;
Bonanno, Silvia;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

High Sensitivity of Glutamate Uptake to Extracellular Free Arachidonic Acid Levels in Rat Cortical Synaptosomes and Astrocytes.

Published in:

Journal of Neurochemistry, 1992, v. 59, n. 2, p. 600, doi. 10.1111/j.1471-4159.1992.tb09411.x

By:

Volterra, Andrea;
Trotti, Davide;
Cassutti, Paola;
Tromba, Cinzia;
Salvaggio, Antonino;
Melcangi, Roberto C.;
Racagni, Giorgio

Publication type:

Article

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31098-6

By:

Gleixner, Amanda M.;
Verdone, Brandie Morris;
Otte, Charlton G.;
Anderson, Eric N.;
Ramesh, Nandini;
Shapiro, Olivia R.;
Gale, Jenna R.;
Mauna, Jocelyn C.;
Mann, Jacob R.;
Copley, Katie E.;
Daley, Elizabeth L.;
Ortega, Juan A.;
Cicardi, Maria Elena;
Kiskinis, Evangelos;
Kofler, Julia;
Pandey, Udai B.;
Trotti, Davide;
Donnelly, Christopher J.

Publication type:

Article

Neuronal and Glial Glutamate Transporters Possess an SH-based Redox Regulatory Mechanism.

Published in:

European Journal of Neuroscience, 1997, v. 9, n. 6, p. 1236, doi. 10.1111/j.1460-9568.1997.tb01478.x

By:

Trotti, Davide;
Rizzini, Barbara Lodi;
Rossi, Daniela;
Haugeto, Oyvind;
Racagni, Giorgio;
Danbolt, Niels C.;
Volterra, Andrea

Publication type:

Article

The Competitive Transport Inhibitor L- trans-pyrrolidine-2,4-dicarboxylate Triggers Excitotoxicity in Rat Cortical Neuron-Astrocyte Co-cultures via Glutamate Release rather than Uptake Inhibition.

Published in:

European Journal of Neuroscience, 1996, v. 8, n. 9, p. 2019, doi. 10.1111/j.1460-9568.1996.tb01345.x

By:

Volterra, Andrea;
Bezzi, Paola;
Rizzini, Barbara Lodi;
Trotti, Davide;
Ullensvang, Kyrre;
Danbolt, Niels C.;
Racagni, Giorgio

Publication type:

Article

Breakdown of the central synapses in C9orf72-linked ALS/FTD.

Published in:

Frontiers in Molecular Neuroscience, 2022, v. 15, p. 1, doi. 10.3389/fnmol.2022.1005112

By:

Ghaffari, Layla T.;
Trotti, Davide;
Haeusler, Aaron R.;
Jensen, Brigid K.

Publication type:

Article

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis‐linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.

Published in:

Glia (0894-1491), 2022, v. 70, n. 7, p. 1426, doi. 10.1002/glia.24183

By:

Jensen, Brigid K.;
McAvoy, Kevin J.;
Heinsinger, Nicolette M.;
Lepore, Angelo C.;
Ilieva, Hristelina;
Haeusler, Aaron R.;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article