Works by Troconiz, Iñaki F.

Results: 79

Population pharmacokinetic analysis of lanreotide Autogel in healthy subjects : evidence for injection interval of up to 2 months.

Published in:

2009

By:

Trocóniz, Iñaki F.;
Cendrós, Josep-María;
Peraire, Concepción;
Ramis, Joaquim;
Garrido, Maria J.;
Boscani, Paolo F.;
Obach, Rosendo;
Trocóniz, Iñaki F;
Cendrós, Josep-María;
Peraire, Concepción

Publication type:

journal article

Modelling the anti-migraine effects of BIBN 4096 BS: a new calcitonin gene-related peptide receptor antagonist.

Published in:

2006

By:

Trocóniz, Iñaki F.;
Wolters, Jan-Markus;
Tillmann, Christiane;
Schaefer, Hans G.;
Roth, Willy;
Trocóniz, Iñaki F

Publication type:

journal article

Bringing Model-Based Prediction to Oncology Clinical Practice: A Review of Pharmacometrics Principles and Applications.

Published in:

Oncologist, 2016, v. 21, n. 2, p. 220, doi. 10.1634/theoncologist.2015-0322

By:

Buil‐Bruna, Núria;
López‐Picazo, José‐María;
Martín‐Algarra, Salvador;
Trocóniz, Iñaki F.

Publication type:

Article

Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.

Published in:

2010

By:

Vásquez-Bahena, DA;
Salazar-Morales, UE;
Ortiz, MI;
Castañeda-Hernández, G;
Trocóniz, IF;
Vásquez-Bahena, D A;
Salazar-Morales, U E;
Ortiz, M I;
Castañeda-Hernández, G;
Trocóniz, Iñaki F

Publication type:

journal article

Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1.

Published in:

2021

By:

Zalba, Sara;
Belsúe, Virginia;
Topp, Brian;
de Alwis, Dinesh;
Alvarez, Maite;
Trocóniz, Iñaki F.;
Berraondo, Pedro;
Garrido, María J.

Publication type:

journal article

Disentangling Anti‐Tumor Response of Immunotherapy Combinations: A Physiologically Based Framework for V937 Oncolytic Virus and Pembrolizumab.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 5, p. 1304, doi. 10.1002/cpt.3379

By:

Sancho‐Araiz, Aymara;
Parra‐Guillen, Zinnia P.;
Troconiz, Iñaki F.;
Freshwater, Tomoko

Publication type:

Article

Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically‐Based Modeling.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 623, doi. 10.1002/cpt.2937

By:

Parra‐Guillen, Zinnia P.;
Sancho‐Araiz, Aymara;
Mayawala, Kapil;
Zalba, Sara;
Garrido, Maria J.;
de Alwis, Dinesh;
Troconiz, Iñaki F.;
Freshwater, Tomoko

Publication type:

Article

Model‐Informed Dose Selection for Xentuzumab, a Dual Insulin‐Like Growth Factor‐I/II—Neutralizing Antibody.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 3, p. 597, doi. 10.1002/cpt.1648

By:

Parra‐Guillen, Zinnia P.;
Schmid, Ulrike;
Janda, Alvaro;
Freiwald, Matthias;
Troconiz, Iñaki F.

Publication type:

Article

Pharmacokinetic–pharmacodynamic modeling of the influence of chronic phenytoin therapy on the rocuronium bromide response in patients undergoing brain surgery.

Published in:

European Journal of Clinical Pharmacology, 2008, v. 64, n. 8, p. 795, doi. 10.1007/s00228-008-0485-7

By:

Fernández-Candil, Juan;
Gambús, Pedro L.;
Trocóniz, Iñaki F.;
Valero, Ricard;
Carrero, Enrique;
Bueno, Lorea;
Fábregas, Neus

Publication type:

Article

Development and Application of Physiologically-Based Pharmacokinetic Model to Predict Systemic and Organ Exposure of Colorectal Cancer Drugs.

Published in:

Pharmaceutics, 2025, v. 17, n. 1, p. 57, doi. 10.3390/pharmaceutics17010057

By:

Peribañez-Dominguez, Sara;
Parra-Guillen, Zinnia;
Troconiz, Iñaki F.

Publication type:

Article

Pharmacodynamic Model of the Hemodynamic Effects of Propofol and Remifentanil and Their Interaction with Noxious Stimulation †.

Published in:

Pharmaceutics, 2024, v. 16, n. 12, p. 1615, doi. 10.3390/pharmaceutics16121615

By:

Garraza-Obaldia, Maite;
Jaramillo, Sebastian;
Parra-Guillen, Zinnia P.;
Valencia, José F.;
Gambús, Pedro L.;
Trocóniz, Iñaki F.

Publication type:

Article

Quantitative Approach to Explore Regulatory T Cell Activity in Immuno-Oncology.

Published in:

Pharmaceutics, 2024, v. 16, n. 11, p. 1461, doi. 10.3390/pharmaceutics16111461

By:

Serrano, Alejandro;
Zalba, Sara;
Lasarte, Juan Jose;
Troconiz, Iñaki F.;
Riva, Natalia;
Garrido, Maria J.

Publication type:

Article

Population Pharmacodynamic Modelling of the CD19+ Suppression Effects of Rituximab in Paediatric Patients with Neurological and Autoimmune Diseases.

Published in:

Pharmaceutics, 2023, v. 15, n. 11, p. 2534, doi. 10.3390/pharmaceutics15112534

By:

Riva, Natalia;
Brstilo, Lucas;
Sancho-Araiz, Aymara;
Molina, Manuel;
Savransky, Andrea;
Roffé, Georgina;
Sanz, Marianela;
Tenembaum, Silvia;
Katsicas, Maria M.;
Trocóniz, Iñaki F.;
Schaiquevich, Paula

Publication type:

Article

The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives.

Published in:

Pharmaceutics, 2021, v. 13, n. 7, p. 1016, doi. 10.3390/pharmaceutics13071016

By:

Sancho-Araiz, Aymara;
Mangas-Sanjuan, Victor;
Trocóniz, Iñaki F.

Publication type:

Article

Untangling Absorption Mechanisms and Variability in Bioequivalence Studies Using Population Analysis.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 12, p. 2047, doi. 10.1007/s11095-021-03136-3

By:

Ameijeiras Rodríguez, Carolina;
Henriques, Sara Carolina;
Sancho-Araiz, Aymara;
Trocóniz, Iñaki F.;
Almeida, Luis;
Silva, Nuno Elvas

Publication type:

Article

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).

Published in:

2021

By:

Mouraux, André;
Bloms-Funke, Petra;
Boesl, Irmgard;
Caspani, Ombretta;
Chapman, Sonya C.;
Di Stefano, Giulia;
Finnerup, Nanna Brix;
Garcia-Larrea, Luis;
Goetz, Marcus;
Kostenko, Anna;
Pelz, Bernhard;
Pogatzki-Zahn, Esther;
Schubart, Karin;
Stouffs, Alexandre;
Truini, Andrea;
Tracey, Irene;
Troconiz, Iñaki F.;
Van Niel, Johannes;
Vela, Jose Miguel;
Vincent, Katy

Publication type:

journal article

Mechanism-based modeling of the clinical effects of bevacizumab and everolimus on vestibular schwannomas of patients with neurofibromatosis type 2.

Published in:

2016

By:

Ouerdani, Aziz;
Goutagny, Stéphane;
Kalamarides, Michel;
Trocóniz, Iñaki;
Ribba, Benjamin;
Goutagny, Stéphane;
Trocóniz, Iñaki F

Publication type:

journal article

Semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the Plk-1 inhibitor BI 2536 and its application in clinical development.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 4, p. 785, doi. 10.1007/s00280-009-1223-2

By:

Soto, Elena;
Staab, Alexander;
Tillmann, Christiane;
Trommeshauser, Dirk;
Fritsch, Holger;
Munzert, Gerd;
Trocóniz, Iñaki F.

Publication type:

Article

Phase I dose-finding study and a pharmacokinetic/pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumours.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 6, p. 727, doi. 10.1007/s00280-005-0112-6

By:

Trocòniz, Iñaki F.;
Garrido, María J.;
Segura, Cristina;
Cendrós, Josep-María;
Principe, Paola;
Peraire, Concepción;
Obach, Rosendo

Publication type:

Article

Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 12, p. 887, doi. 10.3390/antibiotics9120887

By:

Butragueño-Laiseca, Laura;
Troconiz, Iñaki F.;
Grau, Santiago;
Campillo, Nuria;
García, Xandra;
Padilla, Belén;
Fernández, Sarah N.;
Santiago, María José

Publication type:

Article

Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?

Published in:

Pain & Therapy, 2024, v. 13, n. 1, p. 145, doi. 10.1007/s40122-023-00569-z

By:

Sethi, Vidhu;
Qin, Li;
Cox, Eugène;
Trocóniz, Iñaki F.;
Della Pasqua, Oscar

Publication type:

Article

Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Pain.

Published in:

Pain & Therapy, 2024, v. 13, n. 1, p. 127, doi. 10.1007/s40122-023-00566-2

By:

Sethi, Vidhu;
Qin, Li;
Trocóniz, Iñaki F.;
Van der Laan, Luke;
Cox, Eugène;
Della Pasqua, Oscar

Publication type:

Article

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8295, doi. 10.3390/ijms23158295

By:

van Niel, Johannes;
Bloms-Funke, Petra;
Caspani, Ombretta;
Cendros, Jose Maria;
Garcia-Larrea, Luis;
Truini, Andrea;
Tracey, Irene;
Chapman, Sonya C.;
Marco-Ariño, Nicolás;
Troconiz, Iñaki F.;
Phillips, Keith;
Finnerup, Nanna Brix;
Mouraux, André;
Treede, Rolf-Detlef

Publication type:

Article

Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 3, p. 1115, doi. 10.1111/bcp.15563

By:

Riva, Natalia;
Ibarra, Manuel;
Parra‐Guillen, Zinnia P.;
Galván, Maria Eugenia;
Pérez, Erika;
Trezeguet Renatti, Guido;
Cáceres Guido, Paulo;
Lopez, Clarisa;
Licciardone, Nieves;
Halac, Esteban;
Dip, Marcelo;
Cruz, Alejandro;
Imventarza, Oscar;
Buamscha, Daniel;
Troconiz, Iñaki F.;
Schaiquevich, Paula

Publication type:

Article

Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 1, p. 166, doi. 10.1111/bcp.14937

By:

Vera‐Yunca, Diego;
Parra‐Guillen, Zinnia P.;
Girard, Pascal;
Trocóniz, Iñaki F.;
Terranova, Nadia

Publication type:

Article

Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning.

Published in:

British Journal of Clinical Pharmacology, 2020, v. 86, n. 8, p. 1537, doi. 10.1111/bcp.14260

By:

Solans, Belén P.;
Chiesa, Robert;
Doncheva, Bilyana;
Prunty, Helen;
Veys, Paul;
Trocóniz, Iñaki F.;
Standing, Joseph F.

Publication type:

Article

Assessing the impact of the addition of dendritic cell vaccination to neoadjuvant chemotherapy in breast cancer patients: A model‐based characterization approach.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 8, p. 1670, doi. 10.1111/bcp.13947

By:

Solans, Belén P.;
López‐Díaz de Cerio, Ascensión;
Elizalde, Arlette;
Pina, Luis Javier;
Inogés, Susana;
Espinós, Jaime;
Salgado, Esteban;
Mejías, Luis Daniel;
Trocóniz, Iñaki F.;
Santisteban, Marta

Publication type:

Article

Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.

Published in:

British Journal of Clinical Pharmacology, 2016, v. 82, n. 1, p. 92, doi. 10.1111/bcp.12921

By:

Mangas‐Sanjuan, Víctor;
Pastor, José Martín;
Rengelshausen, Jens;
Bursi, Roberta;
Troconiz, Iñaki F.

Publication type:

Article

Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 4, p. 630, doi. 10.1111/bcp.12649

By:

Jacobo‐Cabral, Carlos Orlando;
García‐Roca, Pilar;
Romero‐Tejeda, Elba Margarita;
Reyes, Herlinda;
Medeiros, Mara;
Castañeda‐Hernández, Gilberto;
Trocóniz, Iñaki F.

Publication type:

Article

Pharmacokinetic-pharmacodynamic modelling in anaesthesia.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 79, n. 1, p. 72, doi. 10.1111/bcp.12286

By:

Gambús, Pedro L.;
Trocóniz, Iñaki F.

Publication type:

Article

Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 14, p. 3815, doi. 10.1111/bph.15821

By:

Vera‐Yunca, Diego;
Córdoba, Karol M.;
Parra‐Guillen, Zinnia P.;
Jericó, Daniel;
Fontanellas, Antonio;
Trocóniz, Iñaki F.

Publication type:

Article

Disease pharmacokinetic-pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA-based therapies.

Published in:

2020

By:

Parra‐Guillen, Zinnia P.;
Fontanellas, Antonio;
Jiang, Lei;
Jericó, Daniel;
Martini, Paolo;
Vera‐Yunca, Diego;
Hard, Marjie;
Guey, Lin T.;
Troconiz, Iñaki F.;
Parra-Guillen, Zinnia P;
Vera-Yunca, Diego

Publication type:

journal article

Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival.

Published in:

AAPS Journal, 2020, v. 22, n. 3, p. 1, doi. 10.1208/s12248-020-0434-7

By:

Vera-Yunca, Diego;
Girard, Pascal;
Parra-Guillen, Zinnia P.;
Munafo, Alain;
Trocóniz, Iñaki F.;
Terranova, Nadia

Publication type:

Article

Translational Framework Predicting Tumour Response in Gemcitabine-Treated Patients with Advanced Pancreatic and Ovarian Cancer from Xenograft Studies.

Published in:

AAPS Journal, 2019, v. 21, n. 2, p. 1, doi. 10.1208/s12248-018-0291-9

By:

Garcia-Cremades, Maria;
Pitou, Celine;
Iversen, Philip W.;
Troconiz, Iñaki F.

Publication type:

Article

A Population Pharmacodynamic Model for Lactate Dehydrogenase and Neuron Specific Enolase to Predict Tumor Progression in Small Cell Lung Cancer Patients.

Published in:

AAPS Journal, 2014, v. 16, n. 3, p. 609, doi. 10.1208/s12248-014-9600-0

By:

Buil-Bruna, Núria;
López-Picazo, José-María;
Moreno-Jiménez, Marta;
Martín-Algarra, Salvador;
Ribba, Benjamin;
Trocóniz, Iñaki F.

Publication type:

Article

Target-Mediated Disposition Model Describing the Dynamics of IL12 and IFN<sub>γ</sub> after Administration of a Mifepristone-Inducible Adenoviral Vector for IL-12 Expression in Mice.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 183, doi. 10.1208/s12248-012-9423-9

By:

Parra-Guillen, Zinnia Patricia;
Janda, Alvaro;
Alzuguren, Pilar;
Berraondo, Pedro;
Hernandez-Alcoceba, Ruben;
Troconiz, Iñaki F.

Publication type:

Article

Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 904, doi. 10.1208/s12248-012-9405-y

By:

de Mendizábal, Nieves Vélez;
Vásquez-Bahena, Dalia;
Jiménez-Andrade, Juan M.;
Ortiz, Mario I.;
Castañeda-Hernández, Gilberto;
Trocóniz, Iñaki F.

Publication type:

Article

A systems pharmacology model for inflammatory bowel disease.

Published in:

PLoS ONE, 2018, v. 13, n. 3, p. 1, doi. 10.1371/journal.pone.0192949

By:

Balbas-Martinez, Violeta;
Ruiz-Cerdá, Leire;
Irurzun-Arana, Itziar;
González-García, Ignacio;
Vermeulen, An;
Gómez-Mantilla, José David;
Trocóniz, Iñaki F.

Publication type:

Article

Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 8, p. 1487, doi. 10.1007/s11095-010-0136-4

By:

Parra-Guillén, Zinnia P.;
González-Aseguinolaza, Gloria;
Berraondo, Pedro;
Trocóniz, Iñaki F.

Publication type:

Article

A Semi-physiological-Based Pharmacokinetic/Pharmacodynamic Model to Describe the Effects of Topotecan on B-Lymphocyte Lineage Cells.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 3, p. 431, doi. 10.1007/s11095-009-0025-x

By:

De Mendizábal, Nieves Vélez;
Martínez-Forero, Iván;
Garrido, María J.;
Bandrés, Eva;
García-Foncillas, Jesús;
Segura, Cristina;
Trocóniz, Iñaki F.

Publication type:

Article

Population In Vitro- In Vivo Correlation Model for Pramipexole Slow-Release Oral Formulations.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 2, p. 340, doi. 10.1007/s11095-009-0027-8

By:

Soto, Elena;
Haertter, Sebastian;
Koenen-Bergmann, Michael;
Staab, Alexander;
Trocóniz, Iñaki F.

Publication type:

Article

Recovery time after oral and maxillofacial ambulatory surgery with dexmedetomidine: an observational study.

Published in:

Clinical Oral Investigations, 2019, v. 23, n. 1, p. 391, doi. 10.1007/s00784-018-2447-5

By:

Hernando, Belen;
Martinez-Simon, Antonio;
Cacho-Asenjo, Elena;
Troconiz, Iñaki F.;
Honorato-Cia, Cristina;
Panadero, Alfredo;
Naval, Luis L.;
Nuñez-Cordoba, Jorge M.

Publication type:

Article

Advanced Boolean modeling of biological networks applied to systems pharmacology.

Published in:

Bioinformatics, 2017, v. 33, n. 7, p. 1040, doi. 10.1093/bioinformatics/btw747

By:

Irurzun-Arana, Itziar;
Martín Pastor, José;
Trocóniz, Iñaki F.;
Gómez-Mantilla, José David

Publication type:

Article

Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.705443

By:

Parra-Guillen, Zinnia P.;
Freshwater, Tomoko;
Cao, Youfang;
Mayawala, Kapil;
Zalba, Sara;
Garrido, Maria J.;
de Alwis, Dinesh;
Troconiz, Iñaki F.

Publication type:

Article

Drug Exposure to Establish Pharmacokinetic-Response Relationships in Oncology.

Published in:

2020

By:

Solans, Belén P.;
Garrido, María Jesús;
Trocóniz, Iñaki F.

Publication type:

journal article

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors.

Published in:

2019

By:

Centanni, Maddalena;
Moes, Dirk Jan A. R.;
Trocóniz, Iñaki F.;
Ciccolini, Joseph;
van Hasselt, J. G. Coen

Publication type:

journal article

Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.

Published in:

2019

By:

Fernandez-Teruel, Carlos;
Gonzalez, Ignacio;
Trocóniz, Iñaki F.;
Lubomirov, Rubin;
Soto, Arturo;
Fudio, Salvador

Publication type:

journal article

Population Pharmacokinetics of Volasertib Administered in Patients with Acute Myeloid Leukaemia as a Single Agent or in Combination with Cytarabine.

Published in:

2018

By:

P. Solans, Belén;
Fleury, Angèle;
Freiwald, Matthias;
Fritsch, Holger;
Haug, Karin;
Trocóniz, Iñaki F.

Publication type:

journal article

Population Pharmacokinetic Analysis of Lanreotide Autogel/Depot in the Treatment of Neuroendocrine Tumors: Pooled Analysis of Four Clinical Trials.

Published in:

2016

By:

Buil-Bruna, Núria;
Garrido, María;
Dehez, Marion;
Manon, Amandine;
Nguyen, Thi;
Gomez-Panzani, Edda;
Trocóniz, Iñaki;
Buil-Bruna, Núria;
Garrido, María Jesús;
Nguyen, Thi Xuan Quyen;
Gomez-Panzani, Edda L;
Trocóniz, Iñaki F

Publication type:

journal article

Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy.

Published in:

2008

By:

Isla A;
Rodríguez-Gascón A;
Trocóniz IF;
Bueno L;
Solinís MA;
Maynar J;
Sánchez-Izquierdo JA;
Pedraz JL;
Isla, Arantxazu;
Rodríguez-Gascón, Alicia;
Trocóniz, Iñaki F;
Bueno, Lorea;
Solinís, María Angeles;
Maynar, Javier;
Sánchez-Izquierdo, José Angel;
Pedraz, José Luis

Publication type:

journal article