Works by Trocóniz, Iñaki F.

Results: 56

Population pharmacokinetic analysis of lanreotide Autogel in healthy subjects : evidence for injection interval of up to 2 months.

Published in:

2009

By:

Trocóniz, Iñaki F.;
Cendrós, Josep-María;
Peraire, Concepción;
Ramis, Joaquim;
Garrido, Maria J.;
Boscani, Paolo F.;
Obach, Rosendo;
Trocóniz, Iñaki F;
Cendrós, Josep-María;
Peraire, Concepción

Publication type:

journal article

Modelling the anti-migraine effects of BIBN 4096 BS: a new calcitonin gene-related peptide receptor antagonist.

Published in:

2006

By:

Trocóniz, Iñaki F.;
Wolters, Jan-Markus;
Tillmann, Christiane;
Schaefer, Hans G.;
Roth, Willy;
Trocóniz, Iñaki F

Publication type:

journal article

Bringing Model-Based Prediction to Oncology Clinical Practice: A Review of Pharmacometrics Principles and Applications.

Published in:

Oncologist, 2016, v. 21, n. 2, p. 220, doi. 10.1634/theoncologist.2015-0322

By:

Buil‐Bruna, Núria;
López‐Picazo, José‐María;
Martín‐Algarra, Salvador;
Trocóniz, Iñaki F.

Publication type:

Article

Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.

Published in:

2010

By:

Vásquez-Bahena, DA;
Salazar-Morales, UE;
Ortiz, MI;
Castañeda-Hernández, G;
Trocóniz, IF;
Vásquez-Bahena, D A;
Salazar-Morales, U E;
Ortiz, M I;
Castañeda-Hernández, G;
Trocóniz, Iñaki F

Publication type:

journal article

Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1.

Published in:

2021

By:

Zalba, Sara;
Belsúe, Virginia;
Topp, Brian;
de Alwis, Dinesh;
Alvarez, Maite;
Trocóniz, Iñaki F.;
Berraondo, Pedro;
Garrido, María J.

Publication type:

journal article

Pharmacokinetic–pharmacodynamic modeling of the influence of chronic phenytoin therapy on the rocuronium bromide response in patients undergoing brain surgery.

Published in:

European Journal of Clinical Pharmacology, 2008, v. 64, n. 8, p. 795, doi. 10.1007/s00228-008-0485-7

By:

Fernández-Candil, Juan;
Gambús, Pedro L.;
Trocóniz, Iñaki F.;
Valero, Ricard;
Carrero, Enrique;
Bueno, Lorea;
Fábregas, Neus

Publication type:

Article

Pharmacodynamic Model of the Hemodynamic Effects of Propofol and Remifentanil and Their Interaction with Noxious Stimulation †.

Published in:

Pharmaceutics, 2024, v. 16, n. 12, p. 1615, doi. 10.3390/pharmaceutics16121615

By:

Garraza-Obaldia, Maite;
Jaramillo, Sebastian;
Parra-Guillen, Zinnia P.;
Valencia, José F.;
Gambús, Pedro L.;
Trocóniz, Iñaki F.

Publication type:

Article

Population Pharmacodynamic Modelling of the CD19+ Suppression Effects of Rituximab in Paediatric Patients with Neurological and Autoimmune Diseases.

Published in:

Pharmaceutics, 2023, v. 15, n. 11, p. 2534, doi. 10.3390/pharmaceutics15112534

By:

Riva, Natalia;
Brstilo, Lucas;
Sancho-Araiz, Aymara;
Molina, Manuel;
Savransky, Andrea;
Roffé, Georgina;
Sanz, Marianela;
Tenembaum, Silvia;
Katsicas, Maria M.;
Trocóniz, Iñaki F.;
Schaiquevich, Paula

Publication type:

Article

The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives.

Published in:

Pharmaceutics, 2021, v. 13, n. 7, p. 1016, doi. 10.3390/pharmaceutics13071016

By:

Sancho-Araiz, Aymara;
Mangas-Sanjuan, Victor;
Trocóniz, Iñaki F.

Publication type:

Article

Untangling Absorption Mechanisms and Variability in Bioequivalence Studies Using Population Analysis.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 12, p. 2047, doi. 10.1007/s11095-021-03136-3

By:

Ameijeiras Rodríguez, Carolina;
Henriques, Sara Carolina;
Sancho-Araiz, Aymara;
Trocóniz, Iñaki F.;
Almeida, Luis;
Silva, Nuno Elvas

Publication type:

Article

Mechanism-based modeling of the clinical effects of bevacizumab and everolimus on vestibular schwannomas of patients with neurofibromatosis type 2.

Published in:

2016

By:

Ouerdani, Aziz;
Goutagny, Stéphane;
Kalamarides, Michel;
Trocóniz, Iñaki;
Ribba, Benjamin;
Goutagny, Stéphane;
Trocóniz, Iñaki F

Publication type:

journal article

Semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the Plk-1 inhibitor BI 2536 and its application in clinical development.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 4, p. 785, doi. 10.1007/s00280-009-1223-2

By:

Soto, Elena;
Staab, Alexander;
Tillmann, Christiane;
Trommeshauser, Dirk;
Fritsch, Holger;
Munzert, Gerd;
Trocóniz, Iñaki F.

Publication type:

Article

Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?

Published in:

Pain & Therapy, 2024, v. 13, n. 1, p. 145, doi. 10.1007/s40122-023-00569-z

By:

Sethi, Vidhu;
Qin, Li;
Cox, Eugène;
Trocóniz, Iñaki F.;
Della Pasqua, Oscar

Publication type:

Article

Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Pain.

Published in:

Pain & Therapy, 2024, v. 13, n. 1, p. 127, doi. 10.1007/s40122-023-00566-2

By:

Sethi, Vidhu;
Qin, Li;
Trocóniz, Iñaki F.;
Van der Laan, Luke;
Cox, Eugène;
Della Pasqua, Oscar

Publication type:

Article

Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 1, p. 166, doi. 10.1111/bcp.14937

By:

Vera‐Yunca, Diego;
Parra‐Guillen, Zinnia P.;
Girard, Pascal;
Trocóniz, Iñaki F.;
Terranova, Nadia

Publication type:

Article

Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning.

Published in:

British Journal of Clinical Pharmacology, 2020, v. 86, n. 8, p. 1537, doi. 10.1111/bcp.14260

By:

Solans, Belén P.;
Chiesa, Robert;
Doncheva, Bilyana;
Prunty, Helen;
Veys, Paul;
Trocóniz, Iñaki F.;
Standing, Joseph F.

Publication type:

Article

Assessing the impact of the addition of dendritic cell vaccination to neoadjuvant chemotherapy in breast cancer patients: A model‐based characterization approach.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 8, p. 1670, doi. 10.1111/bcp.13947

By:

Solans, Belén P.;
López‐Díaz de Cerio, Ascensión;
Elizalde, Arlette;
Pina, Luis Javier;
Inogés, Susana;
Espinós, Jaime;
Salgado, Esteban;
Mejías, Luis Daniel;
Trocóniz, Iñaki F.;
Santisteban, Marta

Publication type:

Article

Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 4, p. 630, doi. 10.1111/bcp.12649

By:

Jacobo‐Cabral, Carlos Orlando;
García‐Roca, Pilar;
Romero‐Tejeda, Elba Margarita;
Reyes, Herlinda;
Medeiros, Mara;
Castañeda‐Hernández, Gilberto;
Trocóniz, Iñaki F.

Publication type:

Article

Pharmacokinetic-pharmacodynamic modelling in anaesthesia.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 79, n. 1, p. 72, doi. 10.1111/bcp.12286

By:

Gambús, Pedro L.;
Trocóniz, Iñaki F.

Publication type:

Article

Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 14, p. 3815, doi. 10.1111/bph.15821

By:

Vera‐Yunca, Diego;
Córdoba, Karol M.;
Parra‐Guillen, Zinnia P.;
Jericó, Daniel;
Fontanellas, Antonio;
Trocóniz, Iñaki F.

Publication type:

Article

Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival.

Published in:

AAPS Journal, 2020, v. 22, n. 3, p. 1, doi. 10.1208/s12248-020-0434-7

By:

Vera-Yunca, Diego;
Girard, Pascal;
Parra-Guillen, Zinnia P.;
Munafo, Alain;
Trocóniz, Iñaki F.;
Terranova, Nadia

Publication type:

Article

A Population Pharmacodynamic Model for Lactate Dehydrogenase and Neuron Specific Enolase to Predict Tumor Progression in Small Cell Lung Cancer Patients.

Published in:

AAPS Journal, 2014, v. 16, n. 3, p. 609, doi. 10.1208/s12248-014-9600-0

By:

Buil-Bruna, Núria;
López-Picazo, José-María;
Moreno-Jiménez, Marta;
Martín-Algarra, Salvador;
Ribba, Benjamin;
Trocóniz, Iñaki F.

Publication type:

Article

Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 904, doi. 10.1208/s12248-012-9405-y

By:

de Mendizábal, Nieves Vélez;
Vásquez-Bahena, Dalia;
Jiménez-Andrade, Juan M.;
Ortiz, Mario I.;
Castañeda-Hernández, Gilberto;
Trocóniz, Iñaki F.

Publication type:

Article

A systems pharmacology model for inflammatory bowel disease.

Published in:

PLoS ONE, 2018, v. 13, n. 3, p. 1, doi. 10.1371/journal.pone.0192949

By:

Balbas-Martinez, Violeta;
Ruiz-Cerdá, Leire;
Irurzun-Arana, Itziar;
González-García, Ignacio;
Vermeulen, An;
Gómez-Mantilla, José David;
Trocóniz, Iñaki F.

Publication type:

Article

Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 8, p. 1487, doi. 10.1007/s11095-010-0136-4

By:

Parra-Guillén, Zinnia P.;
González-Aseguinolaza, Gloria;
Berraondo, Pedro;
Trocóniz, Iñaki F.

Publication type:

Article

A Semi-physiological-Based Pharmacokinetic/Pharmacodynamic Model to Describe the Effects of Topotecan on B-Lymphocyte Lineage Cells.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 3, p. 431, doi. 10.1007/s11095-009-0025-x

By:

De Mendizábal, Nieves Vélez;
Martínez-Forero, Iván;
Garrido, María J.;
Bandrés, Eva;
García-Foncillas, Jesús;
Segura, Cristina;
Trocóniz, Iñaki F.

Publication type:

Article

Population In Vitro- In Vivo Correlation Model for Pramipexole Slow-Release Oral Formulations.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 2, p. 340, doi. 10.1007/s11095-009-0027-8

By:

Soto, Elena;
Haertter, Sebastian;
Koenen-Bergmann, Michael;
Staab, Alexander;
Trocóniz, Iñaki F.

Publication type:

Article

Advanced Boolean modeling of biological networks applied to systems pharmacology.

Published in:

Bioinformatics, 2017, v. 33, n. 7, p. 1040, doi. 10.1093/bioinformatics/btw747

By:

Irurzun-Arana, Itziar;
Martín Pastor, José;
Trocóniz, Iñaki F.;
Gómez-Mantilla, José David

Publication type:

Article

Drug Exposure to Establish Pharmacokinetic-Response Relationships in Oncology.

Published in:

2020

By:

Solans, Belén P.;
Garrido, María Jesús;
Trocóniz, Iñaki F.

Publication type:

journal article

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors.

Published in:

2019

By:

Centanni, Maddalena;
Moes, Dirk Jan A. R.;
Trocóniz, Iñaki F.;
Ciccolini, Joseph;
van Hasselt, J. G. Coen

Publication type:

journal article

Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.

Published in:

2019

By:

Fernandez-Teruel, Carlos;
Gonzalez, Ignacio;
Trocóniz, Iñaki F.;
Lubomirov, Rubin;
Soto, Arturo;
Fudio, Salvador

Publication type:

journal article

Population Pharmacokinetics of Volasertib Administered in Patients with Acute Myeloid Leukaemia as a Single Agent or in Combination with Cytarabine.

Published in:

2018

By:

P. Solans, Belén;
Fleury, Angèle;
Freiwald, Matthias;
Fritsch, Holger;
Haug, Karin;
Trocóniz, Iñaki F.

Publication type:

journal article

Population Pharmacokinetic Analysis of Lanreotide Autogel/Depot in the Treatment of Neuroendocrine Tumors: Pooled Analysis of Four Clinical Trials.

Published in:

2016

By:

Buil-Bruna, Núria;
Garrido, María;
Dehez, Marion;
Manon, Amandine;
Nguyen, Thi;
Gomez-Panzani, Edda;
Trocóniz, Iñaki;
Buil-Bruna, Núria;
Garrido, María Jesús;
Nguyen, Thi Xuan Quyen;
Gomez-Panzani, Edda L;
Trocóniz, Iñaki F

Publication type:

journal article

Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy.

Published in:

2008

By:

Isla A;
Rodríguez-Gascón A;
Trocóniz IF;
Bueno L;
Solinís MA;
Maynar J;
Sánchez-Izquierdo JA;
Pedraz JL;
Isla, Arantxazu;
Rodríguez-Gascón, Alicia;
Trocóniz, Iñaki F;
Bueno, Lorea;
Solinís, María Angeles;
Maynar, Javier;
Sánchez-Izquierdo, José Angel;
Pedraz, José Luis

Publication type:

journal article

Population Pharmacokinetics of Meropenem inÂ Critically Ill Patients Undergoing ContinuousÂ Renal Replacement Therapy.

Published in:

Clinical Pharmacokinetics, 2008, v. 47, n. 3, p. 173, doi. 10.2165/00003088-200847030-00003

By:

Isla, Arantxazu;
Rodríguez-Gascón, Alicia;
Trocóniz, Iñaki F.;
Bueno, Lorea;
Solinís, María Ángeles;
Maynar, Javier;
Sánchez-Izquierdo, José Ángel;
Pedraz, José Luis

Publication type:

Article

Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2024.1463915

By:

Lefèvre, Apolline;
Parra-Guillen, Zinnia P.;
Trocóniz, Iñaki F.;
Boetsch, Christophe;
Frances, Nicolas

Publication type:

Article

Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling.

Published in:

PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0215970

By:

Martin-Romano, Patricia;
Solans, Belén P.;
Cano, David;
Subtil, Jose Carlos;
Chopitea, Ana;
Arbea, Leire;
Lozano, Maria Dolores;
Castanon, Eduardo;
Baraibar, Iosune;
Salas, Diego;
Hernandez-Lizoain, Jose Luis;
Trocóniz, Iñaki F.;
Rodriguez, Javier

Publication type:

Article

Modeling the Interplay Between Viral and Immune Dynamics in HIV: A Review and Mrgsolve Implementation and Exploration.

Published in:

CTS: Clinical & Translational Science, 2025, v. 18, n. 2, p. 1, doi. 10.1111/cts.70160

By:

Vegas Rodriguez, Alberto;
Velez de Mendizábal, Nieves;
Girish, Sandhya;
Trocóniz, Iñaki F.;
Feigelman, Justin S.

Publication type:

Article

The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model.

Published in:

Pediatric Drugs, 2024, v. 26, n. 3, p. 331, doi. 10.1007/s40272-024-00621-1

By:

Clemente-Bautista, Susana;
Trocóniz, Iñaki F.;
Segarra-Cantón, Óscar;
Salvador-Marín, Sara;
Parramón-Teixidó, Carlos J.;
Álvarez-Beltrán, Marina;
López-Fernández, Luís A.;
Colom, Helena;
Cabañas-Poy, Maria J.;
Gorgas-Torner, Maria Q.;
Miarons, Marta

Publication type:

Article

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.

Published in:

Cancers, 2021, v. 13, n. 20, p. 5049, doi. 10.3390/cancers13205049

By:

Sancho-Araiz, Aymara;
Zalba, Sara;
Garrido, María J.;
Berraondo, Pedro;
Topp, Brian;
de Alwis, Dinesh;
Parra-Guillen, Zinnia P.;
Mangas-Sanjuan, Víctor;
Trocóniz, Iñaki F.

Publication type:

Article

Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer.

Published in:

PLoS Computational Biology, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.pcbi.1006087

By:

Irurzun-Arana, Itziar;
Janda, Alvaro;
Ardanza-Trevijano, Sergio;
Trocóniz, Iñaki F.

Publication type:

Article

Semi-mechanistic description of the in-vitro antiproliferative effect of different antitumour agents.

Published in:

Journal of Pharmacy & Pharmacology, 2008, v. 60, n. 1, p. 77, doi. 10.1211/jpp.60.1.0010

By:

Daniel Moreno;
Iñaki F. Trocóniz;
Mónica Enguita;
Eva Bandrés;
Jesús García-Foncillas;
María J. Garrido

Publication type:

Article

Enteric reabsorption processes and their impact on drug pharmacokinetics.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85174-w

By:

Ibarra, Manuel;
Trocóniz, Iñaki F.;
Fagiolino, Pietro

Publication type:

Article

Predicting circulating biomarker response and its impact on the survival of advanced melanoma patients treated with adjuvant therapy.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-63441-6

By:

Irurzun-Arana, Itziar;
Asín-Prieto, Eduardo;
Martín-Algarra, Salvador;
Trocóniz, Iñaki F.

Publication type:

Article

Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis.

Published in:

British Journal of Clinical Pharmacology, 2006, v. 62, n. 5, p. 527, doi. 10.1111/j.1365-2125.2006.02667.x

By:

Liesenfeld, Karl-Heinz;
Schäfer, Hans G.;
Trocóniz, Iñaki F.;
Tillmann, Christiane;
Eriksson, Bengt I.;
Stangier, Joachim

Publication type:

Article

Comparison of manual versus ambulatory blood pressure measurements with pharmacokinetic-pharmacodynamic modeling of antihypertensive compounds: Application to moxonidine.

Published in:

Clinical Pharmacology & Therapeutics, 2000, v. 68, n. 1, p. 18, doi. 10.1067/mcp.2000.106907

By:

Trocóniz, Iñaki F.;
de Alwis, Dinesh P.;
Tillmann, Christiane;
Callies, Sophie;
Mitchell, Malcolm;
Schaefer, Hans G.

Publication type:

Article

Population pharmacodynamic modeling of levodopa in patients with Parkinson's disease receiving entacapone.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 1, p. 106, doi. 10.1016/S0009-9236(98)90028-5

By:

Trocóniz, Iñaki F.;
Naukkarinen, Tarja H.;
Ruottinen, Hanna M.;
Rinne, Urpo K.;
Gordin, Ariel;
Karlsson, Mats O.

Publication type:

Article

Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 4, p. 638, doi. 10.1002/psp4.13107

By:

Dias, Bruna Bernar;
Carreño, Fernando;
Helfer, Victória Etges;
Olivo, Laura Ben;
Staudt, Keli Jaqueline;
Paese, Karina;
Barreto, Fabiano;
Meyer, Fabíola Schons;
Herrmann, Ana Paula;
Guterres, Sílvia Stanisçuaski;
Rates, Stela Maris Kuze;
de Araújo, Bibiana Verlindo;
Trocóniz, Iñaki F.;
Dalla Costa, Teresa

Publication type:

Article

Iberoamerican Pharmacometrics Network Congress 2018 Report: Fostering Modeling and Simulation Approaches for Drug Development and Regulatory and Clinical Applications in Latin America.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 4, p. 197, doi. 10.1002/psp4.12387

By:

Ibarra, Manuel;
Dalla Costa, Teresa;
Schaiquevich, Paula;
Cristofoletti, Rodrigo;
Hernández González, Ignacio;
Fajardo‐Robledo, Nicte S.;
Aragón Novoa, Marcela;
Pecchio, Marisín;
Cortinez, Ignacio;
Trocóniz, Iñaki F.;
Romero‐Tejeda, Elba M.

Publication type:

Article

Pharmacodynamic Modeling of the Effects of Lanreotide Autogel on Growth Hormone and Insulin-Like Growth Factor 1.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 4, p. 487, doi. 10.1177/0091270011399761

By:

Garrido, María J.;
Cendrós, Josep-María;
Ramis, Joaquim;
Peraire, Concepción;
Obach, Rosendo;
Trocóniz, Iñaki F.

Publication type:

Article