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The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model.
- Published in:
- Pediatric Drugs, 2024, v. 26, n. 3, p. 331, doi. 10.1007/s40272-024-00621-1
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- Article
Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 4, p. 638, doi. 10.1002/psp4.13107
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- Article
Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Pain.
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- Pain & Therapy, 2024, v. 13, n. 1, p. 127, doi. 10.1007/s40122-023-00566-2
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- Article
Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?
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- Pain & Therapy, 2024, v. 13, n. 1, p. 145, doi. 10.1007/s40122-023-00569-z
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- Article
Population Pharmacodynamic Modelling of the CD19+ Suppression Effects of Rituximab in Paediatric Patients with Neurological and Autoimmune Diseases.
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- Pharmaceutics, 2023, v. 15, n. 11, p. 2534, doi. 10.3390/pharmaceutics15112534
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- Article
Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment.
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- PLoS Computational Biology, 2023, v. 19, n. 10, p. 1, doi. 10.1371/journal.pcbi.1011507
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- Article
Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria.
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- British Journal of Pharmacology, 2022, v. 179, n. 14, p. 3815, doi. 10.1111/bph.15821
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- Article
Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer.
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- British Journal of Clinical Pharmacology, 2022, v. 88, n. 1, p. 166, doi. 10.1111/bcp.14937
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- Article
Untangling Absorption Mechanisms and Variability in Bioequivalence Studies Using Population Analysis.
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- Pharmaceutical Research, 2021, v. 38, n. 12, p. 2047, doi. 10.1007/s11095-021-03136-3
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- Article
Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.
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- Cancers, 2021, v. 13, n. 20, p. 5049, doi. 10.3390/cancers13205049
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- Article
The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives.
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- Pharmaceutics, 2021, v. 13, n. 7, p. 1016, doi. 10.3390/pharmaceutics13071016
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- Article
Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1.
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- 2021
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- Publication type:
- journal article
Enteric reabsorption processes and their impact on drug pharmacokinetics.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85174-w
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- Article
Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning.
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- British Journal of Clinical Pharmacology, 2020, v. 86, n. 8, p. 1537, doi. 10.1111/bcp.14260
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- Article
Predicting circulating biomarker response and its impact on the survival of advanced melanoma patients treated with adjuvant therapy.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-63441-6
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- Article
Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival.
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- AAPS Journal, 2020, v. 22, n. 3, p. 1, doi. 10.1208/s12248-020-0434-7
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- Article
Drug Exposure to Establish Pharmacokinetic-Response Relationships in Oncology.
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- 2020
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- Publication type:
- journal article
Assessing the impact of the addition of dendritic cell vaccination to neoadjuvant chemotherapy in breast cancer patients: A model‐based characterization approach.
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- British Journal of Clinical Pharmacology, 2019, v. 85, n. 8, p. 1670, doi. 10.1111/bcp.13947
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- Article
Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors.
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- 2019
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- Publication type:
- journal article
Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling.
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- PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0215970
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- Article
Iberoamerican Pharmacometrics Network Congress 2018 Report: Fostering Modeling and Simulation Approaches for Drug Development and Regulatory and Clinical Applications in Latin America.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 4, p. 197, doi. 10.1002/psp4.12387
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- Article
Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.
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- 2019
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- Publication type:
- journal article
Colo-Pro: a pilot randomised controlled trial to compare standard bolus-dosed cefuroxime prophylaxis to bolus-continuous infusion-dosed cefuroxime prophylaxis for the prevention of infections after colorectal surgery.
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- European Journal of Clinical Microbiology & Infectious Diseases, 2019, v. 38, n. 2, p. 357, doi. 10.1007/s10096-018-3435-z
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- Article
Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer.
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- PLoS Computational Biology, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.pcbi.1006087
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- Article
A systems pharmacology model for inflammatory bowel disease.
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- PLoS ONE, 2018, v. 13, n. 3, p. 1, doi. 10.1371/journal.pone.0192949
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- Article
Population Pharmacokinetics of Volasertib Administered in Patients with Acute Myeloid Leukaemia as a Single Agent or in Combination with Cytarabine.
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- 2018
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- Publication type:
- journal article
Advanced Boolean modeling of biological networks applied to systems pharmacology.
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- Bioinformatics, 2017, v. 33, n. 7, p. 1040, doi. 10.1093/bioinformatics/btw747
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- Article
Mechanism-based modeling of the clinical effects of bevacizumab and everolimus on vestibular schwannomas of patients with neurofibromatosis type 2.
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- 2016
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- Publication type:
- journal article
Population Pharmacokinetic Analysis of Lanreotide Autogel/Depot in the Treatment of Neuroendocrine Tumors: Pooled Analysis of Four Clinical Trials.
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- 2016
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- Publication type:
- journal article
Bringing Model-Based Prediction to Oncology Clinical Practice: A Review of Pharmacometrics Principles and Applications.
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- Oncologist, 2016, v. 21, n. 2, p. 220, doi. 10.1634/theoncologist.2015-0322
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- Article
Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.
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- British Journal of Clinical Pharmacology, 2015, v. 80, n. 4, p. 630, doi. 10.1111/bcp.12649
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- Article
Pharmacokinetic-pharmacodynamic modelling in anaesthesia.
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- British Journal of Clinical Pharmacology, 2015, v. 79, n. 1, p. 72, doi. 10.1111/bcp.12286
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- Article
A Population Pharmacodynamic Model for Lactate Dehydrogenase and Neuron Specific Enolase to Predict Tumor Progression in Small Cell Lung Cancer Patients.
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- AAPS Journal, 2014, v. 16, n. 3, p. 609, doi. 10.1208/s12248-014-9600-0
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- Article
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis.
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- Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 1, p. 180, doi. 10.1093/jac/dkt304
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- Article
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis.
- Published in:
- 2014
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- Publication type:
- Journal Article
Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats.
- Published in:
- AAPS Journal, 2012, v. 14, n. 4, p. 904, doi. 10.1208/s12248-012-9405-y
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- Article
Pharmacodynamic Modeling of the Effects of Lanreotide Autogel on Growth Hormone and Insulin-Like Growth Factor 1.
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- Journal of Clinical Pharmacology, 2012, v. 52, n. 4, p. 487, doi. 10.1177/0091270011399761
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- Article
Semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the Plk-1 inhibitor BI 2536 and its application in clinical development.
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- Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 4, p. 785, doi. 10.1007/s00280-009-1223-2
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- Article
Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview.
- Published in:
- Pharmaceutical Research, 2010, v. 27, n. 8, p. 1487, doi. 10.1007/s11095-010-0136-4
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- Article
A Semi-physiological-Based Pharmacokinetic/Pharmacodynamic Model to Describe the Effects of Topotecan on B-Lymphocyte Lineage Cells.
- Published in:
- Pharmaceutical Research, 2010, v. 27, n. 3, p. 431, doi. 10.1007/s11095-009-0025-x
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- Article
Population In Vitro- In Vivo Correlation Model for Pramipexole Slow-Release Oral Formulations.
- Published in:
- Pharmaceutical Research, 2010, v. 27, n. 2, p. 340, doi. 10.1007/s11095-009-0027-8
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- Article
Incorporating Physiological and Biochemical Mechanisms into Pharmacokinetic–Pharmacodynamic Models: A Conceptual Framework.
- Published in:
- Basic & Clinical Pharmacology & Toxicology, 2010, v. 106, n. 1, p. 2, doi. 10.1111/j.1742-7843.2009.00456.x
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- Article
Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.
- Published in:
- 2010
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- Publication type:
- journal article
Population pharmacokinetic analysis of lanreotide Autogel in healthy subjects : evidence for injection interval of up to 2 months.
- Published in:
- 2009
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- Publication type:
- journal article
Pharmacokinetic–pharmacodynamic modeling of the influence of chronic phenytoin therapy on the rocuronium bromide response in patients undergoing brain surgery.
- Published in:
- European Journal of Clinical Pharmacology, 2008, v. 64, n. 8, p. 795, doi. 10.1007/s00228-008-0485-7
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- Publication type:
- Article
Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy.
- Published in:
- 2008
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- Publication type:
- journal article
Population Pharmacokinetics of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.
- Published in:
- Clinical Pharmacokinetics, 2008, v. 47, n. 3, p. 173, doi. 10.2165/00003088-200847030-00003
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- Publication type:
- Article
Semi-mechanistic description of the in-vitro antiproliferative effect of different antitumour agents.
- Published in:
- Journal of Pharmacy & Pharmacology, 2008, v. 60, n. 1, p. 77, doi. 10.1211/jpp.60.1.0010
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- Article
Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis.
- Published in:
- British Journal of Clinical Pharmacology, 2006, v. 62, n. 5, p. 527, doi. 10.1111/j.1365-2125.2006.02667.x
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- Article
Modelling the anti-migraine effects of BIBN 4096 BS: a new calcitonin gene-related peptide receptor antagonist.
- Published in:
- 2006
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- Publication type:
- journal article