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HYPOTHESIS: CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES ACTIVATE TARGET CELL ENDONUCLEASES TO TRIGGER APOPTOSIS.
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- Clinical & Experimental Pharmacology & Physiology, 1994, v. 21, n. 1, p. 67, doi. 10.1111/j.1440-1681.1994.tb02438.x
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- Article
The MACPF/CDC family of pore-forming toxins.
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- Cellular Microbiology, 2008, v. 10, n. 9, p. 1765, doi. 10.1111/j.1462-5822.2008.01191.x
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- Publication type:
- Article
Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction.
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- Molecular Human Reproduction, 2001, v. 7, n. 12, p. 1133, doi. 10.1093/molehr/7.12.1133
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- Article
Defining the interaction of perforin with calcium and the phospholipid membrane.
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- Biochemical Journal, 2013, v. 456, n. 3, p. 323, doi. 10.1042/BJ20130999
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- Publication type:
- Article
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21.
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- International Immunology, 2014, v. 26, n. 7, p. 383, doi. 10.1093/intimm/dxu001
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- Publication type:
- Article
Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL.
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- International Immunology, 2006, v. 18, n. 6, p. 837, doi. 10.1093/intimm/dxl020
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- Publication type:
- Article
Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24577-9
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- Article
Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis.
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- British Journal of Haematology, 2020, v. 190, n. 3, p. 458, doi. 10.1111/bjh.16660
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- Article
Forensic Radioimmunoassay--A New Area.
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- Journal of Nuclear Medicine, 1979, v. 20, n. 7, p. 796
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- Article
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.
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- Journal of Cell Biology, 2006, v. 173, n. 1, p. 133, doi. 10.1083/jcb.200510072
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- Publication type:
- Article
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
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- Journal of Cell Biology, 2003, v. 160, n. 2, p. 223, doi. 10.1083/jcb.200210150
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- Publication type:
- Article
Bi-allelic Mutations in stXBp2 Reveal a Complementary Role for stXBp1 in Cytotoxic Lymphocyte Killing.
- Published in:
- Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00529
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- Publication type:
- Article
Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice.
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- PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040357
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- Article
Granzyme H Is a Novel Protease Expressed by Human Mast Cells.
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- International Archives of Allergy & Immunology, 2014, v. 165, n. 1, p. 68, doi. 10.1159/000368403
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- Article
Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H.
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- PLoS Pathogens, 2022, p. 1, doi. 10.1371/journal.ppat.1010325
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- Article
Cloning and characterisation of Ifi206: A new murine HIN-200 family member.
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- Journal of Cellular Biochemistry, 2008, v. 103, n. 4, p. 1270, doi. 10.1002/jcb.21512
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- Article
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin α or β: Modulation by the serpin inhibitor PI‐9.
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- Journal of Cellular Biochemistry, 2005, v. 95, n. 3, p. 598, doi. 10.1002/jcb.20415
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- Article
IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines.
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- Journal of Cellular Biochemistry, 1995, v. 57, n. 1, p. 39, doi. 10.1002/jcb.240570106
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- Publication type:
- Article
Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation.
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- EMBO Reports, 2017, v. 18, n. 10, p. 1775, doi. 10.15252/embr.201744351
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- Article
Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.
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- Genes to Cells, 1996, v. 1, n. 7, p. 673, doi. 10.1046/j.1365-2443.1996.00255.x
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- Article
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.
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- Oncogene, 2003, v. 22, n. 58, p. 9225, doi. 10.1038/sj.onc.1207154
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- Publication type:
- Article
Lipid order and charge protect killer T cells from accidental death.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13385-x
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- Article
Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma.
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- Cancers, 2021, v. 13, n. 18, p. 4704, doi. 10.3390/cancers13184704
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- Article
Words of Advice: choosing the right lab for your post‐doctoral fellowship.
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- FEBS Journal, 2021, v. 288, n. 6, p. 1734, doi. 10.1111/febs.15565
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- Article
Cross‐talk between tumors at anatomically distinct sites.
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- FEBS Journal, 2021, v. 288, n. 1, p. 81, doi. 10.1111/febs.15316
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- Article
Antigen‐specific CD4<sup>+</sup>CD25<sup>+</sup> T cells induced by locally expressed ICOS‐Ig: the role of Foxp3, Perforin, Granzyme B and IL‐10 ‐ an experimental study.
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- Transplant International, 2019, v. 32, n. 11, p. 1203, doi. 10.1111/tri.13474
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- Article
The structural basis for membrane binding and pore formation by lymphocyte perforin.
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- Nature, 2010, v. 468, n. 7322, p. 447, doi. 10.1038/nature09518
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- Article
Perforin and granzymes: function, dysfunction and human pathology.
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- Nature Reviews Immunology, 2015, v. 15, n. 6, p. 388, doi. 10.1038/nri3839
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- Article
Endolysosomal proteases and their inhibitors in immunity.
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- 2009
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- Publication type:
- journal article
Perforin-mediated target-cell death and immune homeostasis.
- Published in:
- Nature Reviews Immunology, 2006, v. 6, n. 12, p. 940, doi. 10.1038/nri1983
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- Article
Functional significance of the perforin/granzyme cell death pathway.
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- Nature Reviews Immunology, 2002, v. 2, n. 10, p. 735, doi. 10.1038/nri911
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- Article
Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia.
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- Molecular Therapy, 2013, v. 21, n. 11, p. 2122, doi. 10.1038/mt.2013.154
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- Article
Functional dissection of the granzyme family: cell death and inflammation.
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- Immunological Reviews, 2010, v. 235, n. 1, p. 73, doi. 10.1111/j.0105-2896.2010.00907.x
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- Article
Perforin: structure, function, and role in human immunopathology.
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- Immunological Reviews, 2010, v. 235, n. 1, p. 35, doi. 10.1111/j.0105-2896.2010.00896.x
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- Article
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.
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- Oncogene, 2000, v. 19, n. 52, p. 6033, doi. 10.1038/sj.onc.1204005
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- Article
Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma.
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- Oncogene, 1997, v. 15, n. 4, p. 453, doi. 10.1038/sj.onc.1201206
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- Article
Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.
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- FEBS Journal, 2016, v. 283, n. 5, p. 947, doi. 10.1111/febs.13649
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- Article
Immune profiling of pediatric solid tumors.
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- 2020
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- Publication type:
- journal article
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy.
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- 2017
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- Publication type:
- journal article
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells.
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- Cancer Gene Therapy, 2004, v. 11, n. 5, p. 371, doi. 10.1038/sj.cgt.7700710
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- Article
A fresh look at tumor immunosurveillance and immunotherapy.
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- Nature Immunology, 2001, v. 2, n. 4, p. 293, doi. 10.1038/86297
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- Article
Tumor immune evasion arises through loss of TNF sensitivity.
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- Science Immunology, 2018, v. 3, n. 23, p. 1, doi. 10.1126/sciimmunol.aar3451
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- Article
Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy.
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- Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.589641
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- Article
A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection.
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- PLoS Pathogens, 2014, v. 10, n. 12, p. 1, doi. 10.1371/journal.ppat.1004526
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- Article
Expression of IFI 16 in epithelial cells and lymphoid tissues.
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- Histochemistry & Cell Biology, 2003, v. 119, n. 1, p. 45, doi. 10.1007/s00418-002-0485-0
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- Publication type:
- Article
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.
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- Journal of Cell Biology, 2007, v. 176, n. 4, p. 425, doi. 10.1083/jcb.200609077
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- Article
The major human and mouse granzymes are structurally and functionally divergent.
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- Journal of Cell Biology, 2006, v. 175, n. 4, p. 619, doi. 10.1083/jcb.200606073
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- Publication type:
- Article
Late-onset Non-HLH presentations of Growth arrest, Inflammatory arachnoiditis, and severe Infectious Mononucleosis, in siblings with Hypomorphic Defects in UNC13D.
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- Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.00944
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- Publication type:
- Article
Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
- Published in:
- Cell Death & Differentiation, 1998, v. 5, n. 6, p. 488, doi. 10.1038/sj.cdd.4400373
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- Article
Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer.
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- Cell Death & Disease, 2018, v. 9, n. 5, p. 1, doi. 10.1038/s41419-018-0470-8
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- Article