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Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant.
Published in:
European Journal of Endocrinology, 2003, v. 149, n. 6, p. 0521
By:
- W M Drake;
- S V Rowles;
- M E Roberts;
- F K Fode;
- G M Besser;
- J P Monson;
- P J Trainer
Publication type:
Article
Successful treatment of resistant acromegaly with a growth hormone receptor antagonist.
Published in:
European Journal of Endocrinology, 2001, v. 145, n. 4, p. 451, doi. 10.1530/eje.0.1450451
By:
- Drake, W. M.;
- Parkinson, C.;
- Akker, S. A.;
- Monson, J. P.;
- Besser, G. M.;
- Trainer, P. J.
Publication type:
Article
A Follow-Up Study of the Prevalence of Valvular Heart Abnormalities in Hyperprolactinemic Patients Treated With Cabergoline.
Published in:
2016
By:
- Drake, W M;
- Stiles, C E;
- Bevan, J S;
- Karavitaki, N;
- Trainer, P J;
- Rees, D A;
- Richardson, T I;
- Baldeweg, S E;
- Stojanovic, N;
- Murray, R D;
- Toogood, A A;
- Martin, N M;
- Vaidya, B;
- Han, T S;
- Steeds, R P;
- Baldeweg, F C;
- Sheikh, U E;
- Kyriakakis, N;
- Parasuraman, S;
- Taylor, L
Publication type:
journal article
Effective combination treatment with cabergoline and low-dose pegvisomant in active acromegaly: a prospective clinical trial.
Published in:
2012
By:
- Higham CE;
- Atkinson AB;
- Aylwin S;
- Bidlingmaier M;
- Drake WM;
- Lewis A;
- Martin NM;
- Moyes V;
- Newell-Price J;
- Trainer PJ;
- Higham, C E;
- Atkinson, A B;
- Aylwin, S;
- Bidlingmaier, M;
- Drake, W M;
- Lewis, A;
- Martin, N M;
- Moyes, V;
- Newell-Price, J;
- Trainer, P J
Publication type:
journal article
Changes in Arterial Stiffness But Not Carotid Intimal Thickness in Acromegaly.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2011, v. 96, n. 5, p. 1486, doi. 10.1210/jc.2010-2225
By:
- Paisley, A. N.;
- Banerjee, M.;
- Rezai, M.;
- Schofield, R. E.;
- Balakrishnannair, S.;
- Herbert, A.;
- Lawrance, J. A. L.;
- Trainer, P. J.;
- Cruickshank, J. K.
Publication type:
Article
Salivary Cortisone Is a Potential Biomarker for Serum Free Cortisol.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 11, p. 4951, doi. 10.1210/jc.2010-1215
By:
- Perogamvros, I.;
- Keevil, B. G.;
- Ray, D. W.;
- Trainer, P. J.
Publication type:
Article
Novel Corticosteroid-Binding Globulin Variant That Lacks Steroid Binding Activity.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2010, v. 95, n. 10, p. E142, doi. 10.1210/jc.2010-0746
By:
- Perogamvros, I.;
- Underhill, C.;
- Henley, D. E.;
- Hadfield, K. D.;
- Newman, W. G.;
- Ray, D. W.;
- Lightman, S. L.;
- Hammond, G. L.;
- Trainer, P. J.
Publication type:
Article
Pegvisomant improves insulin sensitivity and reduces overnight free fatty acid concentrations in patients with acromegaly.
Published in:
2009
By:
- Higham, C E;
- Rowles, S;
- Russell-Jones, D;
- Umpleby, A M;
- Trainer, P J
Publication type:
journal article
A Subnormal Peak Cortisol Response to Stimulation Testing Does Not Predict a Subnormal Cortisol Production Rate.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2009, v. 94, n. 5, p. 1757, doi. 10.1210/jc.2008-2392
By:
- Paisley, A. N.;
- Rowles, S. V.;
- Brandon, D.;
- Trainer, P. J.
Publication type:
Article
Reductions of circulating matrix metalloproteinase 2 and vascular endothelial growth factor levels after treatment with pegvisomant in subjects with acromegaly.
Published in:
2006
By:
- Paisley, A. N.;
- O'Callaghan, C. J.;
- Lewandowski, K. C.;
- Parkinson, C.;
- Roberts, M. E.;
- Drake, W. M.;
- Monson, J. P.;
- Trainer, P. J.;
- Randeva, H. S.
Publication type:
journal article
Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal.
Published in:
2003
By:
- PARKINSON, C.;
- KASSEM, M.;
- HEICKENDORFF, L.;
- FLYVBJERG, A.;
- TRAINER, P. J.
Publication type:
journal article
A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin, and pancreatic polypeptide responses to oral glucose and a standard mixed meal.
Published in:
2002
By:
- Parkinson, C.;
- Drake, W. M.;
- Roberts, M. E.;
- Meeran, K.;
- Besser, G. M.;
- Trainer, P. J.
Publication type:
journal article
The Relationship between Serum GH and Serum IGF-I in Acromegaly Is Gender-Specific.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2001, v. 86, n. 11, p. 5240, doi. 10.1210/jcem.86.11.8006
By:
- PARKINSON, C.;
- RYDER, W. D. J.;
- TRAINER, P. J.
Publication type:
Article
Modulation of Cortisol Metabolism by the Growth Hormone Receptor Antagonist Pegvisomant in Patients with Acromegaly.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2001, v. 86, n. 7, p. 2989, doi. 10.1210/jc.86.7.2989
By:
- TRAINER, P. J.;
- DRAKE, W. M.;
- PERRY, L. A.;
- TAYLOR, N. F.;
- BESSER, G. M.;
- MONSON, J. P.
Publication type:
Article
Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly.
Published in:
2001
By:
- Trainer, P J;
- Drake, W M;
- Perry, L A;
- Taylor, N F;
- Besser, G M;
- Monson, J P
Publication type:
journal article
Predictors of the Outcome of Surgical Treatment in Acromegaly and the Value of the Mean Growth Hormone Day Curve in Assessing Postoperative Disease Activity.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2001, v. 86, n. 4, p. 1645, doi. 10.1210/jcem.86.4.7398
By:
- KALTSAS, G. A.;
- ISIDORI, A. M.;
- FLORAKIS, D.;
- TRAINER, P. J.;
- CAMACHO-HUBNER, C.;
- AFSHAR, F.;
- SABIN, I.;
- JENKINS, J. P.;
- CHEW, S. L.;
- MONSON, J. P.;
- BESSER, G. M.;
- GROSSMAN, A. B.
Publication type:
Article
Computed Tomography Appearance of the Thymus and Anterior Mediastinum in Active Cushing’s Syndrome.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1999, v. 84, n. 2, p. 602, doi. 10.1210/jc.84.2.602
By:
- HANSON, J. A.;
- SOHAIB, S. A.;
- NEWELL-PRICE, J.;
- ISLAM, N.;
- MONSON, J. P.;
- TRAINER, P. J.;
- GROSSMAN, A.;
- BESSER, G. M.;
- REZNEK, R. H.
Publication type:
Article
A Critical Analysis of the Value of Simultaneous Inferior Petrosal Sinus Sampling in Cushing’s Disease and the Occult Ectopic Adrenocorticotropin Syndrome.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1999, v. 84, n. 2, p. 487, doi. 10.1210/jc.84.2.487
By:
- KALTSAS, G. A.;
- GIANNULIS, M. G.;
- NEWELL-PRICE, J. D. C.;
- DACIE, J. E.;
- THAKKAR, C.;
- AFSHAR, F.;
- MONSON, J. P.;
- GROSSMAN, A. B.;
- BESSER, G. M.;
- TRAINER, P. J.
Publication type:
Article
Optimizing Growth Hormone Replacement Therapy by Dose Titration in Hypopituitary Adults.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1998, v. 83, n. 11, p. 3913, doi. 10.1210/jcem.83.11.5223
By:
- DRAKE, W. M.;
- COYTE, D.;
- CAMACHO-HÜBNER, C.;
- JIVANJI, N. M.;
- KALTSAS, G.;
- WOOD, D. F.;
- TRAINER, P. J.;
- GROSSMAN, A. B.;
- BESSER, G. M.;
- MONSON, J. P.
Publication type:
Article
Menstrual Abnormalities in Women with Cushing’s Disease Are Correlated with Hypercortisolemia Rather Than Raised Circulating Androgen Levels.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1998, v. 83, n. 9, p. 3083, doi. 10.1210/jc.83.9.3083
By:
- LADO-ABEAL, J.;
- RODRIGUEZ-ARNAO, J.;
- NEWELL-PRICE, J. D. C.;
- PERRY, L. A.;
- GROSSMAN, A. B.;
- BESSER, G. M.;
- TRAINER, P. J.
Publication type:
Article
The Pathophysiology of Circulating CorticotropinReleasing Hormone-Binding Protein Levels in the Human.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1998, v. 83, n. 5, p. 1611
By:
- TRAINER, P. J.;
- WOODS, R. J.;
- KORBONITS, M.;
- POPOVIC, V.;
- STEWART, P. M.;
- LOWRY, P. J.;
- GROSSMAN, A. B.
Publication type:
Article
Clinical, Radiological and Pathological Features of Patients with Rathke’s Cleft Cysts: Tumors That May Recur.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1997, v. 82, n. 7, p. 2357, doi. 10.1210/jc.82.7.2357
By:
- MUKHERJEE, J. J.;
- ISLAM, N.;
- KALTSAS, G.;
- LOWE, D. G.;
- CHARLESWORTH, M.;
- AFSHAR, F.;
- TRAINER, P. J.;
- MONSON, J. P.;
- BESSER, G. M.;
- GROSSMAN, A. B.
Publication type:
Article
Benzodiazepines attenuate the pituitary-adrenal responses to corticotrophin-releasing hormone in healthy volunteers, but not in patients with Cushing's syndrome.
Published in:
Clinical Endocrinology, 1995, v. 43, n. 1, p. 29, doi. 10.1111/j.1365-2265.1995.tb01889.x
By:
- Korbonits, M.;
- Trainer, P. J.;
- Edwards, R.;
- Besser, G. M.;
- Grossman, A. B.
Publication type:
Article
Investigation, management and therapeutic outcome in 12 cases of childhood and adolescent Cushing's syndrome.
Published in:
Clinical Endocrinology, 1995, v. 43, n. 1, p. 19, doi. 10.1111/j.1365-2265.1995.tb01888.x
By:
- Weber, A.;
- Trainer, P. J.;
- Grossman, A. B.;
- Afshar, F.;
- Medbak, S.;
- Perry, L. A.;
- Plowman, P. N.;
- Rees, L. H.;
- Besser, G. M.;
- Savage, M. O.
Publication type:
Article
The effect of recombinant IGF-I on anterior pituitary function in healthy volunteers.
Published in:
Clinical Endocrinology, 1994, v. 41, n. 6, p. 801, doi. 10.1111/j.1365-2265.1994.tb02796.x
By:
- Trainer, P. J.;
- Holly, J.;
- Medbak, S.;
- Rees, L. H.;
- Besser, G. M.
Publication type:
Article
Treatment with GHRH(1-29)NH.
Published in:
Clinical Endocrinology, 1994, v. 41, n. 4, p. 487, doi. 10.1111/j.1365-2265.1994.tb02580.x
By:
- Kirk, J. M. W.;
- Trainer, P. J.;
- Majrowskl, W. H.;
- Murphy, J.;
- Savage, M. O.;
- Besser, G. M.
Publication type:
Article
An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year.
Published in:
Clinical Endocrinology, 1994, v. 41, n. 1, p. 123, doi. 10.1111/j.1365-2265.1994.tb03793.x
By:
- Jones, S. L.;
- Trainer, P. J.;
- Perry, L.;
- Wass, J. A. H.;
- Besser, G. M.;
- Grossman, A.
Publication type:
Article
The relationship between cortisol production rate and serial serum Cortisol estimation in patients on medical therapy for Cushing's syndrome.
Published in:
Clinical Endocrinology, 1993, v. 39, n. 4, p. 441, doi. 10.1111/j.1365-2265.1993.tb02391.x
By:
- Trainer, P. J.;
- Eastment, C.;
- Grossman, A. B.;
- Wheeler, M. J.;
- Perry, L.;
- Besser, G. M.
Publication type:
Article
Malignant prolactinoma with extracranial metastases: a report of three cases.
Published in:
Clinical Endocrinology, 1993, v. 38, n. 4, p. 411, doi. 10.1111/j.1365-2265.1993.tb00523.x
By:
- Walker, J. D.;
- Grossman, A.;
- Anderson, J. V.;
- Ur, E.;
- Trainer, P. J.;
- Benn, J.;
- Lowy, C.;
- Sönksen, P. H.;
- Plowman, P. N.;
- Lowe, D. G.;
- Doniach, I.;
- Wass, J. A. H.;
- Besser, G. M.
Publication type:
Article
Transsphenoidal resection in Cushing's disease: undetectable serum cortisol as the definition of successfuI treatment.
Published in:
Clinical Endocrinology, 1993, v. 38, n. 1, p. 73, doi. 10.1111/j.1365-2265.1993.tb00975.x
By:
- Trainer, P. J.;
- Lawrie, H. S.;
- Verhelst, J.;
- Howlett, T. A.;
- Lowe, D. G.;
- Grossman, A. B.;
- Savage, M. O.;
- Afshar, F.;
- Besser, G. M.
Publication type:
Article
Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing's syndrome.
Published in:
Clinical Endocrinology, 1991, v. 35, n. 2, p. 169, doi. 10.1111/j.1365-2265.1991.tb03517.x
By:
- Verhelst, J. A.;
- Trainer, P. J.;
- Howlett, T. A.;
- Perry, L.;
- Rees, Lesley H.;
- Grossman, A. B.;
- Wass, J. A. H.;
- Sesser, G. M.
Publication type:
Article
Pyridostigmine fails to increase either spontaneous or GHRH-stimulated GH secretion during day or night in growth hormone-insufficient children.
Published in:
Clinical Endocrinology, 1991, v. 34, n. 5, p. 407, doi. 10.1111/j.1365-2265.1991.tb00313.x
By:
- Kirk, J. M. W.;
- Ross, R. J. M.;
- Trainer, P. J.;
- Froud, A. L. J.;
- Davies, S. C.;
- Savage, M. O.;
- Besser, G. M.
Publication type:
Article
The effects on anterior pituitary hormone secretion of salmon calcitonin in healthy volunteers.
Published in:
Clinical Endocrinology, 1991, v. 34, n. 4, p. 299, doi. 10.1111/j.1365-2265.1991.tb03770.x
By:
- Trainer, P. J.;
- Kirk, J. M. W.;
- McLoughlln, L.;
- Touzel, R. J.;
- Perry, L.;
- Rees, L. H.;
- Besser, G. M.
Publication type:
Article
SUBCUTANEOUS GROWTH HORMONE-RELEASING HORMONE AUGMENTS PULSATILE NOCTURNAL GH RELEASE IN GH-INSUFFICIENT CHILDREN, BUT MAY ALSO RAISE BASAL GH SECRETION.
Published in:
Clinical Endocrinology, 1990, v. 33, n. 2, p. 239, doi. 10.1111/j.1365-2265.1990.tb00488.x
By:
- ROSS, R. J. M.;
- KIRK, J. M. W.;
- TSAGARAKIS, S.;
- TRAINER, P. J.;
- CICCARELLI, E.;
- TOUZEL, R.;
- GROSSMAN, A.;
- SAVAGE, M. O.;
- BESSER, G. M.
Publication type:
Article
Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels.
Published in:
European Journal of Endocrinology, 2017, v. 176, n. 2, p. 221, doi. 10.1530/EJE-16-0779
By:
- Valassi, E.;
- Crespo, I.;
- Keevil, B. G.;
- Aulinas, A.;
- Urgell, E.;
- Santos, A.;
- Trainer, P. J.;
- Webb, S. M.
Publication type:
Article
Successful use of weekly pegvisomant administration in patients with acromegaly.
Published in:
European Journal of Endocrinology, 2009, v. 161, n. 1, p. 21, doi. 10.1530/EJE-08-0990
By:
- Higham, C. E.;
- Thomas, J. D. J.;
- Bidlingmaier, M.;
- Drake, W. M.;
- Trainer, P. J.
Publication type:
Article
Disease activity in acromegaly may be assessed 6 weeks after discontinuation of pegvisomant.
Published in:
European Journal of Endocrinology, 2005, v. 152, n. 1, p. 47, doi. 10.1530/eje.1.01822
By:
- W M Drake;
- R A Loureiro;
- C Parkinson;
- J P Monson;
- G M Besser;
- P J Trainer
Publication type:
Article
Growth hormone excess and the development of growth hormone receptor antagonists.
Published in:
Experimental Physiology, 2008, v. 93, n. 11, p. 1157, doi. 10.1113/expphysiol.2008.042515
By:
- Higham, C. E.;
- Trainer, P. J.
Publication type:
Article
Adrenal enlargement and failure of suppression of circulating cortisol by dexamethasone in patients with malignancy.
Published in:
1999
By:
- Jenkins, P J;
- Sohaib, S A;
- Trainer, P J;
- Lister, T A;
- Besser, G M;
- Reznek, R
Publication type:
journal article
Serum regulates cortisol bioactivity by corticosteroid-binding globulin-dependent and independent mechanisms, as revealed by combined bioassay and physicochemical assay approaches.
Published in:
Clinical Endocrinology, 2011, v. 75, n. 1, p. 31, doi. 10.1111/j.1365-2265.2011.04003.x
By:
- Perogamvros, I.;
- Kayahara, M.;
- Trainer, P. J.;
- Ray, D. W.
Publication type:
Article
Corticosteroid-binding globulin regulates cortisol pharmacokinetics.
Published in:
Clinical Endocrinology, 2011, v. 74, n. 1, p. 30, doi. 10.1111/j.1365-2265.2010.03897.x
By:
- Perogamvros, I.;
- Aarons, L.;
- Miller, A. G.;
- Trainer, P. J.;
- Ray, D. W.
Publication type:
Article
Long-term experience of pegvisomant therapy as a treatment for acromegaly.
Published in:
Clinical Endocrinology, 2009, v. 71, n. 1, p. 86, doi. 10.1111/j.1365-2265.2008.03469.x
By:
- Higham, C. E.;
- Chung, T. T.;
- Lawrance, J.;
- Drake, W. M.;
- Trainer, P. J.
Publication type:
Article
Use of a GH receptor antagonist (GHRA) to explore the relationship between GH and IGF-I in adults with severe GH deficiency (GHD).
Published in:
Clinical Endocrinology, 2009, v. 70, n. 3, p. 439, doi. 10.1111/j.1365-2265.2008.03481.x
By:
- Berg, C. A.;
- Pokrajac, A.;
- Bidlingmaier, M.;
- Strasburger, C. J.;
- Shalet, S. M.;
- Trainer, P. J.
Publication type:
Article
Surgical debulking of pituitary macroadenomas causing acromegaly improves control by lanreotide.
Published in:
Clinical Endocrinology, 2008, v. 68, n. 6, p. 970, doi. 10.1111/j.1365-2265.2007.03139.x
By:
- Karavitaki, N.;
- Turner, H. E.;
- Adams, C. B. T.;
- Cudlip, S.;
- Byrne, J. V.;
- Fazal-Sanderson, V.;
- Rowlers, S.;
- Trainer, P. J.;
- Wass, J. A. H.
Publication type:
Article
Wide variation in surgical outcomes for acromegaly in the UK.
Published in:
Clinical Endocrinology, 2008, v. 68, n. 1, p. 136, doi. 10.1111/j.1365-2265.2007.03012.x
By:
- Bates, P. R.;
- Carson, M. N.;
- Trainer, P. J.;
- Wass, J. A. H.
Publication type:
Article
Variation in GH and IGF-I assays limits the applicability of international consensus criteria to local practice.
Published in:
Clinical Endocrinology, 2007, v. 67, n. 1, p. 65, doi. 10.1111/j.1365-2265.2007.02836.x
By:
- Pokrajac, A.;
- Wark, G.;
- Ellis, A. R.;
- Wear, J.;
- Wieringa, G. E.;
- Trainer, P. J.
Publication type:
Article
Withdrawal of somatostatin analogue therapy in patients with acromegaly is associated with an increased risk of acute biliary problems.
Published in:
Clinical Endocrinology, 2007, v. 66, n. 5, p. 723, doi. 10.1111/j.1365-2265.2007.02811.x
By:
- Paisley, A. N.;
- Roberts, M. E.;
- Trainer, P. J.
Publication type:
Article
Commentary Growth hormone assay standardization: a biased view?
Published in:
2004
By:
- Wieringa, G. E.;
- Barth, J. H.;
- Trainer, P. J.
Publication type:
Editorial
The effect of pegvisomant-induced serum IGF-I normalization on serum leptin levels in patients with acromegaly.
Published in:
Clinical Endocrinology, 2003, v. 59, n. 2, p. 168, doi. 10.1046/j.1365-2265.2003.01795.x
By:
- Parkinson, C.;
- Whatmore, A. J.;
- Yates, A. P.;
- Drake, W. M.;
- Brabant, G.;
- Clayton, P. E.;
- Trainer, P. J.
Publication type:
Article
Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly.
Published in:
Clinical Endocrinology, 2002, v. 57, n. 1, p. 59, doi. 10.1046/j.1365-2265.2002.01560.x
By:
- Parkinson, C.;
- Renehan, A. G.;
- Ryder, W. D. J.;
- O'Dwyer, S. T.;
- Shalet, S. M.;
- Trainer, P. J.
Publication type:
Article

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