Works by Trafalis, Dimitrios T.

Results: 40

The Clinical Relevance of Hypothyroidism in Patients with Solid Non-Thyroid Cancer: A Tantalizing Conundrum.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 12, p. 3417, doi. 10.3390/jcm11123417

By:

Deligiorgi, Maria V.;
Trafalis, Dimitrios T.

Publication type:

Article

Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.

Published in:

European Journal of Nutrition, 2021, v. 60, n. 1, p. 147, doi. 10.1007/s00394-020-02227-y

By:

Mitsiogianni, Melina;
Trafalis, Dimitrios T.;
Franco, Rodrigo;
Zoumpourlis, Vasilis;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma.

Published in:

European Journal of Nutrition, 2020, v. 59, n. 2, p. 557, doi. 10.1007/s00394-019-01925-6

By:

Mitsiogianni, Melina;
Mantso, Theodora;
Trafalis, Dimitrios T.;
Vasantha Rupasinghe, H. P.;
Zoumpourlis, Vasilis;
Franco, Rodrigo;
Botaitis, Sotiris;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Harnessing the versatile role of OPG in bone oncology: counterbalancing RANKL and TRAIL signaling and beyond.

Published in:

Clinical & Experimental Metastasis, 2020, v. 37, n. 1, p. 13, doi. 10.1007/s10585-019-09997-8

By:

Deligiorgi, Maria V.;
Panayiotidis, Mihalis I.;
Griniatsos, John;
Trafalis, Dimitrios T.

Publication type:

Article

The Predictive Value of 8-Hydroxy-Deoxyguanosine (8-OHdG) Serum Concentrations in Irradiated Non-Small Cell Lung Carcinoma (NSCLC) Patients.

Published in:

Biomedicines, 2024, v. 12, n. 1, p. 134, doi. 10.3390/biomedicines12010134

By:

Orfanakos, Kyriakos;
Alifieris, Constantinos E.;
Verigos, Emmanouil K.;
Deligiorgi, Maria V.;
Verigos, Kosmas E.;
Panayiotidis, Mihalis I.;
Nikolaou, Michail;
Trafalis, Dimitrios T.

Publication type:

Article

Cytocidal Antitumor Effects against Human Ovarian Cancer Cells Induced by B-Lactam Steroid Alkylators with Targeted Activity against Poly (ADP-Ribose) Polymerase (PARP) Enzymes in a Cell-Free Assay.

Published in:

Biomedicines, 2021, v. 9, n. 8, p. 1028, doi. 10.3390/biomedicines9081028

By:

Nikoleousakos, Nikolaos;
Dalezis, Panagiotis;
Polonifi, Aikaterini;
Geromichalou, Elena G.;
Sagredou, Sofia;
Alifieris, Constantinos E.;
Deligiorgi, Maria V.;
Sarli, Vasiliki;
Trafalis, Dimitrios T.

Publication type:

Article

Effects of a Novel Thiadiazole Derivative with High Anticancer Activity on Cancer Cell Immunogenic Markers: Mismatch Repair System, PD-L1 Expression, and Tumor Mutation Burden.

Published in:

Pharmaceutics, 2021, v. 13, n. 6, p. 885, doi. 10.3390/pharmaceutics13060885

By:

Sagredou, Sofia;
Dalezis, Panagiotis;
Papadopoulou, Eirini;
Voura, Maria;
Deligiorgi, Maria V.;
Nikolaou, Michail;
Panayiotidis, Mihalis I.;
Nasioulas, George;
Sarli, Vasiliki;
Trafalis, Dimitrios T.

Publication type:

Article

Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation.

Published in:

Pharmaceutics, 2021, v. 13, n. 4, p. 493, doi. 10.3390/pharmaceutics13040493

By:

Trafalis, Dimitrios T.;
Sagredou, Sofia;
Dalezis, Panayiotis;
Voura, Maria;
Fountoulaki, Stella;
Nikoleousakos, Nikolaos;
Almpanakis, Konstantinos;
Deligiorgi, Maria V.;
Sarli, Vasiliki;
Tomašič, Tihomir

Publication type:

Article

Evaluation of Bioactive Properties of Lipophilic Fractions of Edible and Non-Edible Parts of Nasturtium officinale (Watercress) in a Model of Human Malignant Melanoma Cells.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 2, p. 141, doi. 10.3390/ph15020141

By:

Kyriakou, Sotiris;
Tragkola, Venetia;
Alghol, Heba;
Anestopoulos, Ioannis;
Amery, Tom;
Stewart, Kyle;
Winyard, Paul G.;
Trafalis, Dimitrios T.;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Phase II study of bevacizumab plus irinotecan on the treatment of relapsed resistant small cell lung cancer.

Published in:

2016

By:

Trafalis, Dimitrios;
Alifieris, Constantinos;
Stathopoulos, George;
Sitaras, Nikolaos;
Trafalis, Dimitrios T;
Stathopoulos, George P

Publication type:

journal article

The safety profile of denosumab in oncology beyond the safety of denosumab as an anti-osteoporotic agent: still more to learn.

Published in:

Expert Opinion on Drug Safety, 2021, v. 20, n. 2, p. 191, doi. 10.1080/14740338.2021.1861246

By:

Deligiorgi, Maria V.;
Trafalis, Dimitrios T.

Publication type:

Article

Preclinical studies on NSC290205 aza-steroid alkylator activity in combination with adriamycin against lymphoid leukaemia.

Published in:

British Journal of Haematology, 2005, v. 128, n. 3, p. 343, doi. 10.1111/j.1365-2141.2004.05315.x

By:

Trafalis, Dimitrios T. P.;
Tsavdaridis, Dimitrios;
Camoutsis, Charalambos;
Karayiani, Venetia;
Mourelatos, Dionysios;
Chrysogelou, Eleni;
Dalezis, Panayotis;
Athanassiou, Athanasios;
Pangalis, Gerassimos A.;
Papageorgiou, Athanasios

Publication type:

Article

8-Hydroxy-2'-Deoxyguanosine and 8-Nitroguanine Production and Detection in Blood Serum of Breast Cancer Patients in Response to Postoperative Complementary External Ionizing Irradiation of Normal Tissues.

Published in:

Dose-Response, 2020, v. 18, n. 4, p. 1, doi. 10.1177/1559325820982172

By:

Verigos, Kosmas E.;
Sagredou, Sofia;
Orfanakos, Kyriakos;
Dalezis, Panayiotis;
Trafalis, Dimitrios T.

Publication type:

Article

Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis by Modulating the Expression of Apoptotic Genes, Members of Polycomb Repressive Complex 2, and Levels of Tri-Methylating Lysine 27 at Histone 3 in Human Malignant Melanoma Cells.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 5, p. 2745, doi. 10.3390/ijms25052745

By:

Anestopoulos, Ioannis;
Paraskevaidis, Ioannis;
Kyriakou, Sotiris;
Giova, Lambrini E.;
Trafalis, Dimitrios T.;
Botaitis, Sotiris;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

A Concerted Vision to Advance the Knowledge of Diabetes Mellitus Related to Immune Checkpoint Inhibitors.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7630, doi. 10.3390/ijms24087630

By:

Deligiorgi, Maria V.;
Trafalis, Dimitrios T.

Publication type:

Article

The Intriguing Thyroid Hormones–Lung Cancer Association as Exemplification of the Thyroid Hormones–Cancer Association: Three Decades of Evolving Research.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 436, doi. 10.3390/ijms23010436

By:

Deligiorgi, Maria V.;
Trafalis, Dimitrios T.

Publication type:

Article

How Far Are We from Prescribing Fasting as Anticancer Medicine?

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 23, p. 9175, doi. 10.3390/ijms21239175

By:

Deligiorgi, Maria V.;
Liapi, Charis;
Trafalis, Dimitrios T.

Publication type:

Article

Topotecan and pegylated liposomal doxorubicin combination as palliative treatment in patients with pretreated advanced malignant pleural mesothelioma.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2012, v. 50, n. 7, p. 490, doi. 10.5414/CP201688

By:

Trafalis, Dimitrios T.;
Alifieris, Constantinos;
Krikelis, Dimitrios;
Tzogkas, Nikolaos;
Stathopoulos, George P.;
Athanassiou, Athanassios E.;
Sitaras, Nikolaos M.

Publication type:

Article

Effects of homo-aza-steroids on acute non-lymphocytic leukaemia cell proliferation in vitro.

Published in:

British Journal of Haematology, 1995, v. 91, n. 4, p. 907, doi. 10.1111/j.1365-2141.1995.tb05408.x

By:

Trafalis, Dimitrios T. P.;
Sambani, Constantina;
Kapsimali, Violeta;
Economidou, Joanna;
Politis, George;
Catsoulacos, Panayotis

Publication type:

Article

Isothiocyanates Enhance the Anti-Melanoma Effect of Zebularine Through Modulation of Apoptosis and Regulation of DNMTs' Expression, Chromatin Configuration and Histone Posttranslational Modifications Associated with Altered Gene Expression Patterns.

Published in:

Epigenomes, 2025, v. 9, n. 1, p. 7, doi. 10.3390/epigenomes9010007

By:

Anestopoulos, Ioannis;
Paraskevaidis, Ioannis;
Kyriakou, Sotiris;
Potamiti, Louiza;
Trafalis, Dimitrios T.;
Botaitis, Sotiris;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Chemical Characterization and Biological Evaluation of Epilobium parviflorum Extracts in an In Vitro Model of Human Malignant Melanoma.

Published in:

Plants (2223-7747), 2023, v. 12, n. 8, p. 1590, doi. 10.3390/plants12081590

By:

Kyriakou, Sotiris;
Tragkola, Venetia;
Paraskevaidis, Ioannis;
Plioukas, Mihalis;
Trafalis, Dimitrios T.;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Azasteroid Alkylators as Dual Inhibitors of AKT and ERK Signaling for the Treatment of Ovarian Carcinoma.

Published in:

Cancers, 2020, v. 12, n. 5, p. 1263, doi. 10.3390/cancers12051263

By:

Dalezis, Panagiotis;
Geromichalou, Eleni;
Polonifi, Aikaterini;
Sagredou, Sofia;
Nikoleousakos, Nikolaos;
Nikolaou, Michael;
Sarli, Vasiliki;
Panayiotidis, Mihalis I.;
Trafalis, Dimitrios T.

Publication type:

Article

Synthesis and anticancer activity of novel 3,6-disubstituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives.

Published in:

Arabian Journal of Chemistry, 2019, v. 12, n. 8, p. 4784, doi. 10.1016/j.arabjc.2016.09.015

By:

Charitos, Georgios;
Trafalis, Dimitrios T.;
Dalezis, Panayiotis;
Potamitis, Constantinos;
Sarli, Vasiliki;
Zoumpoulakis, Panagiotis;
Camoutsis, Charalambos

Publication type:

Article

Hypophysitis related to immune checkpoint inhibitors: An intriguing adverse event with many faces.

Published in:

Expert Opinion on Biological Therapy, 2021, v. 21, n. 8, p. 1097, doi. 10.1080/14712598.2021.1869211

By:

Deligiorgi, Maria V;
Liapi, Charis;
Trafalis, Dimitrios T

Publication type:

Article

Repurposing denosumab in lung cancer beyond counteracting the skeletal related events: an intriguing perspective.

Published in:

Expert Opinion on Biological Therapy, 2020, v. 20, n. 11, p. 1331, doi. 10.1080/14712598.2020.1790522

By:

Deligiorgi, Maria V.;
Trafalis, Dimitrios T.

Publication type:

Article

Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma.

Published in:

Investigational New Drugs, 2021, v. 39, n. 6, p. 1460, doi. 10.1007/s10637-021-01127-0

By:

Mitsiogianni, Melina;
Anestopoulos, Ioannis;
Kyriakou, Sotiris;
Trafalis, Dimitrios T.;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Chemical and Biological Characterization of the Anticancer Potency of Salvia fruticosa in a Model of Human Malignant Melanoma.

Published in:

Plants (2223-7747), 2021, v. 10, n. 11, p. 2472, doi. 10.3390/plants10112472

By:

Kyriakou, Sotiris;
Tragkola, Venetia;
Plioukas, Michael;
Anestopoulos, Ioannis;
Chatzopoulou, Paschalina S.;
Sarrou, Eirini;
Trafalis, Dimitrios T.;
Deligiorgi, Maria V.;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Polyphenolics, glucosinolates and isothiocyanates profiling of aerial parts of Nasturtium officinale (Watercress).

Published in:

Frontiers in Plant Science, 2022, v. 13, p. 1, doi. 10.3389/fpls.2022.998755

By:

Kyriakou, Sotiris;
Michailidou, Kyriaki;
Amery, Tom;
Stewart, Kyle;
Winyard, Paul G.;
Trafalis, Dimitrios T.;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

3,6-Disubstituted 1,2,4-Triazolo[3,4-b]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 7369, doi. 10.2147/OTT.S254856

By:

Sagredou, Sofia;
Dalezis, Panagiotis;
Nikoleousakos, Nikolaos;
Nikolaou, Michail;
Voura, Maria;
Almpanakis, Konstantinos;
Panayiotidis, Mihalis I;
Sarli, Vasiliki;
Trafalis, Dimitrios T

Publication type:

Article

Assessment of Methodological Pipelines for the Determination of Isothiocyanates Derived from Natural Sources.

Published in:

Antioxidants, 2022, v. 11, n. 4, p. N.PAG, doi. 10.3390/antiox11040642

By:

Kyriakou, Sotiris;
Trafalis, Dimitrios T.;
Deligiorgi, Maria V.;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells.

Published in:

Antioxidants, 2021, v. 10, n. 2, p. 284, doi. 10.3390/antiox10020284

By:

Mitsiogianni, Melina;
Kyriakou, Sotiris;
Anestopoulos, Ioannis;
Trafalis, Dimitrios T.;
Deligiorgi, Maria V.;
Franco, Rodrigo;
Pappa, Aglaia;
Panayiotidis, Mihalis I.;
Napolitano, Alessandra

Publication type:

Article

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.

Published in:

Antioxidants, 2019, v. 8, n. 4, p. 106, doi. 10.3390/antiox8040106

By:

Mitsiogianni, Melina;
Koutsidis, Georgios;
Mavroudis, Nikos;
Trafalis, Dimitrios T.;
Botaitis, Sotiris;
Franco, Rodrigo;
Zoumpourlis, Vasilis;
Amery, Tom;
Galanis, Alex;
Pappa, Aglaia;
Panayiotidis, Mihalis I.

Publication type:

Article

Novel Docosahexaenoic Acid Ester of Phloridzin Inhibits Proliferation and Triggers Apoptosis in an In Vitro Model of Skin Cancer.

Published in:

Antioxidants, 2018, v. 7, n. 12, p. 188, doi. 10.3390/antiox7120188

By:

Mantso, Theodora;
Trafalis, Dimitrios T.;
Botaitis, Sotiris;
Franco, Rodrigo;
Pappa, Aglaia;
Rupasinghe, H. P. Vasantha;
Panayiotidis, Mihalis I.

Publication type:

Article

Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution.

Published in:

Cancers, 2021, v. 13, n. 22, p. 5785, doi. 10.3390/cancers13225785

By:

Deligiorgi, Maria V.;
Siasos, Gerasimos;
Vakkas, Lampros;
Trafalis, Dimitrios T.

Publication type:

Article

The Continuum of Thyroid Disorders Related to Immune Checkpoint Inhibitors: Still Many Pending Queries.

Published in:

Cancers, 2021, v. 13, n. 21, p. 5277, doi. 10.3390/cancers13215277

By:

Deligiorgi, Maria V.;
Sagredou, Sofia;
Vakkas, Lampros;
Trafalis, Dimitrios T.

Publication type:

Article

Efficacy and Safety of Neoadjuvant Treatment with Bevacizumab, Liposomal Doxorubicin, Cyclophosphamide and Paclitaxel Combination in Locally/Regionally Advanced, HER2-Negative, Grade III at Premenopausal Status Breast Cancer: A Phase II Study.

Published in:

Clinical Drug Investigation, 2018, v. 38, n. 7, p. 639, doi. 10.1007/s40261-018-0655-z

By:

Tampaki, Ekaterini C.;
Tampakis, Athanasios;
Alifieris, Constantinos E.;
Krikelis, Dimitrios;
Pazaiti, Anastasia;
Kontos, Michalis;
Trafalis, Dimitrios T.

Publication type:

Article

The continuum of care of anticancer treatment-induced hypothyroidism in patients with solid non-thyroid tumors: time for an intimate collaboration between oncologists and endocrinologists.

Published in:

Expert Review of Clinical Pharmacology, 2022, v. 15, n. 5, p. 531, doi. 10.1080/17512433.2022.2093714

By:

Deligiorgi, Maria V.;
Trafalis, Dimitrios T.

Publication type:

Article

Repurposing denosumab in breast cancer beyond prevention of skeletal related events: Could nonclinical data be translated into clinical practice?

Published in:

Expert Review of Clinical Pharmacology, 2020, v. 13, n. 11, p. 1235, doi. 10.1080/17512433.2020.1839416

By:

Deligiorgi, Maria V.;
Panayiotidis, Mihalis I.;
Trafalis, Dimitrios T.

Publication type:

Article

Inhibition of Cancer Cell Proliferation and Bacterial Growth by Silver(I) Complexes Bearing a CH 3 -Substituted Thiadiazole-Based Thioamide.

Published in:

Molecules, 2023, v. 28, n. 1, p. 336, doi. 10.3390/molecules28010336

By:

Varna, Despoina;
Geromichalou, Elena;
Karlioti, Georgia;
Papi, Rigini;
Dalezis, Panagiotis;
Hatzidimitriou, Antonios G.;
Psomas, George;
Choli-Papadopoulou, Theodora;
Trafalis, Dimitrios T.;
Angaridis, Panagiotis A.

Publication type:

Article

Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells.

Published in:

Chemical Biology & Drug Design, 2017, v. 90, n. 5, p. 854, doi. 10.1111/cbdd.13006

By:

Trafalis, Dimitrios T.;
Polonifi, Aikaterini;
Dalezis, Panayiotis;
Nikoleousakos, Nikolaos;
Katsamakas, Sotirios;
Sarli, Vasiliki

Publication type:

Article