Works by Totzke, Frank

Results: 17

Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening.

Published in:

Molecular Informatics, 2011, v. 30, n. 2/3, p. 145, doi. 10.1002/minf.201000138

By:

Lemcke, Thomas;
Dreher, Jan;
Rarey, Matthias;
Totzke, Frank;
Schächtele, Christoph;
Kubbutat, Michael H. G.;
Kunick, Conrad

Publication type:

Article

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2018, v. 33, n. 1, p. 1, doi. 10.1080/14756366.2017.1370583

By:

Fischer, Tim;
Najjar, Abdulkarim;
Totzke, Frank;
Schächtele, Christoph;
Sippl, Wolfgang;
Ritter, Christoph;
Hilgeroth, Andreas

Publication type:

Article

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2017, v. 32, n. 1, p. 271, doi. 10.1080/14756366.2016.1247062

By:

Hempel, Cornelius;
Totzke, Frank;
Schächtele, Christoph;
Najjar, Abdulkarim;
Sippl, Wolfgang;
Ritter, Christoph;
Hilgeroth, Andreas

Publication type:

Article

Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors.

Published in:

Angewandte Chemie International Edition, 2007, v. 46, n. 36, p. 6899, doi. 10.1002/anie.200702406

By:

Dakas, Pierre-Yves;
Barluenga, Sofia;
Totzke, Frank;
Zirrgiebel, Ute;
Winssinger, Nicolas

Publication type:

Article

Decalactone Derivatives from Corynespora cassiicola, an Endophytic Fungus of the Mangrove Plant Laguncularia racemosa.

Published in:

European Journal of Organic Chemistry, 2012, v. 2012, n. 18, p. 3476, doi. 10.1002/ejoc.201200245

By:

Ebrahim, Weaam;
Aly, Amal H.;
Mándi, Attila;
Totzke, Frank;
Kubbutat, Michael H. G.;
Wray, Victor;
Lin, Wen-Han;
Dai, Haofu;
Proksch, Peter;
Kurtán, Tibor;
Debbab, Abdessamad

Publication type:

Article

Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.

Published in:

Molecular Nutrition & Food Research, 2009, v. 53, n. 4, p. 431, doi. 10.1002/mnfr.200700428

By:

Wätjen, Wim;
Debbab, Abdessamad;
Hohlfeld, Anke;
Chovolou, Yvonni;
Kampkötter, Andreas;
Edrada, Ru Angelie;
Ebel, Rainer;
Hakiki, Abdelhak;
Mosaddak, Mahjouba;
Totzke, Frank;
Kubbutat, Michael H. G.;
Proksch, Peter

Publication type:

Article

Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone.

Published in:

ChemBioChem, 2005, v. 6, n. 3, p. 541, doi. 10.1002/cbic.200400099

By:

Conrad Kunick;
Zhihong Zeng;
Rick Gussio;
Daniel Zaharevitz;
Maryse Leost;
Frank Totzke;
Christoph Schächtele;
Michael H. G. Kubbutat;
Laurent Meijer;
Thomas Lemcke

Publication type:

Article

Cytotoxic effects of the anthraquinone derivatives 1′-deoxyrhodoptilometrin and ( S)-(−)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.

Published in:

Archives of Toxicology, 2017, v. 91, n. 3, p. 1485, doi. 10.1007/s00204-016-1787-7

By:

Wätjen, Wim;
Ebada, Sherif;
Bergermann, Anja;
Chovolou, Yvonni;
Totzke, Frank;
Kubbutat, Michael;
Lin, Wenhan;
Proksch, Peter

Publication type:

Article

Discovery of 4-Benzylamino-Substituted α-Carbolines as a Novel Class of Receptor Tyrosine Kinase Inhibitors.

Published in:

ChemMedChem, 2011, v. 6, n. 1, p. 63, doi. 10.1002/cmdc.201000384

By:

Krug, Martin;
Wichapong, Kanin;
Erlenkamp, German;
Sippl, Wolfgang;
Schächtele, Christoph;
Totzke, Frank;
Hilgeroth, Andreas

Publication type:

Article

Probing Novel 1-Aza-9-oxafluorenes as Selective GSK-3β Inhibitors.

Published in:

ChemMedChem, 2008, v. 3, n. 1, p. 120, doi. 10.1002/cmdc.200700175

By:

Voigt, Burkhardt;
Krug, Martin;
Schächtele, Christoph;
Totzke, Frank;
Hilgeroth, Andreas

Publication type:

Article

Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge <italic>Stylissa carteri</italic>.

Published in:

Zeitschrift für Naturforschung. Section C: A Journal of Biosciences, 2018, v. 73, n. 5/6, p. 199, doi. 10.1515/znc-2017-0161

By:

Hamed, Ashraf N.E.;
Schmitz, Roland;
Bergermann, Anja;
Totzke, Frank;
Kubbutat, Michael;
Müller, Werner E.G.;
Youssef, Diaa T.A.;
Bishr, Mokhtar M.;
Kamel, Mohamed S.;
Edrada-Ebel, RuAngelie;
Wätjen, Wim;
Proksch, Peter

Publication type:

Article

Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells.

Published in:

Journal of Pharmacy & Pharmacology, 2013, v. 65, n. 9, p. 1393, doi. 10.1111/jphp.12107

By:

Limper, Christian;
Wang, Yao;
Ruhl, Sven;
Wang, Zhiqiang;
Lou, Yijia;
Totzke, Frank;
Kubbutat, Michael H.G.;
Chovolou, Yvonni;
Proksch, Peter;
Wätjen, Wim

Publication type:

Article

Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarumand Ircinia fasciculatainhibit NF-κB signalling in H4IIE cells.

Published in:

Journal of Pharmacy & Pharmacology, 2009, v. 61, n. 7, p. 919, doi. 10.1211/jpp/61.07.0011

By:

Wim Wätjen;
Annika Putz;
Yvonni Chovolou;
Andreas Kampkötter;
Frank Totzke;
Michael Kubbutat;
Peter Proksch;
Belma Konuklugil

Publication type:

Article

Diversity-Oriented Synthesis of Pochonins and Biological Evaluation against a Panel of Kinases.

Published in:

Chemistry - A European Journal, 2006, v. 12, n. 34, p. 8819, doi. 10.1002/chem.200600553

By:

Moulin, Emilie;
Barluenga, Sofia;
Totzke, Frank;
Winssinger, Nicolas

Publication type:

Article

Marine Derived Hamacanthins as Lead for the Development of Novel PDGFRβ Protein Kinase Inhibitors.

Published in:

Marine Drugs, 2013, v. 11, n. 9, p. 3209, doi. 10.3390/md11093209

By:

Pinchuk, Boris;
Johannes, Eugen;
Gul, Sheraz;
Schlosser, Joachim;
Schaechtele, Christoph;
Totzke, Frank;
Peifer, Christian

Publication type:

Article

7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors.

Published in:

Molecules, 2021, v. 26, n. 6, p. 1611, doi. 10.3390/molecules26061611

By:

Karatas, Mehmet;
Chaikuad, Apirat;
Berger, Bianca;
Kubbutat, Michael H. G.;
Totzke, Frank;
Knapp, Stefan;
Kunick, Conrad;
Chiara, Brullo

Publication type:

Article

Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay.

Published in:

Molecules, 2018, v. 23, n. 9, p. 2335, doi. 10.3390/molecules23092335

By:

Holzer, Max;
Schade, Nico;
Opitz, Ansgar;
Hilbrich, Isabel;
Stieler, Jens;
Vogel, Tim;
Neukel, Valentina;
Oberstadt, Moritz;
Totzke, Frank;
Schächtele, Christoph;
Sippl, Wolfgang;
Hilgeroth, Andreas

Publication type:

Article