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Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.
Published in:
Brain & Neuroscience Advances, 2022, p. 1, doi. 10.1177/23982128221086464
By:
- Yeap, Jie;
- Sathyaprakash, Chaitra;
- Toombs, Jamie;
- Tulloch, Jane;
- Scutariu, Cristina;
- Rose, Jamie;
- Burr, Karen;
- Davies, Caitlin;
- Colom-Cadena, Marti;
- Chandran, Siddharthan;
- Large, Charles H.;
- Rowan, Matthew J. M.;
- Gunthorpe, Martin J.;
- Spires-Jones, Tara L.
Publication type:
Article
Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.
Published in:
Brain & Neuroscience Advances, 2022, v. 5, p. 1, doi. 10.1177/23982128221086464
By:
- Yeap, Jie;
- Sathyaprakash, Chaitra;
- Toombs, Jamie;
- Tulloch, Jane;
- Scutariu, Cristina;
- Rose, Jamie;
- Burr, Karen;
- Davies, Caitlin;
- Colom-Cadena, Marti;
- Chandran, Siddharthan;
- Large, Charles H.;
- Rowan, Matthew J. M.;
- Gunthorpe, Martin J.;
- Spires-Jones, Tara L.
Publication type:
Article
Correlation between cerebrospinal fluid and plasma neurofilament light protein in treated HIV infection: results from the COBRA study.
Published in:
Journal of NeuroVirology, 2022, v. 28, n. 1, p. 54, doi. 10.1007/s13365-021-01026-3
By:
- Alagaratnam, Jasmini;
- De Francesco, Davide;
- Zetterberg, Henrik;
- Heslegrave, Amanda;
- Toombs, Jamie;
- Kootstra, Neeltje A.;
- Underwood, Jonathan;
- Gisslen, Magnus;
- Reiss, Peter;
- Fidler, Sarah;
- Sabin, Caroline A.;
- Winston, Alan
Publication type:
Article
Neurofilament light predicts neurological outcome after subarachnoid haemorrhage.
Published in:
2021
By:
- Garland, Patrick;
- Morton, Matt;
- Zolnourian, Ardalan;
- Durnford, Andrew;
- Gaastra, Ben;
- Toombs, Jamie;
- Heslegrave, Amanda J;
- More, John;
- Zetterberg, Henrik;
- Bulters, Diederik O;
- Galea, Ian
Publication type:
journal article
Untangling the tau microtubule-binding region.
Published in:
2021
By:
- Toombs, Jamie;
- Zetterberg, Henrik
Publication type:
journal article
Synaptic resilience is associated with maintained cognition during ageing.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 6, p. 2560, doi. 10.1002/alz.12894
By:
- King, Declan;
- Holt, Kris;
- Toombs, Jamie;
- HE, Xin;
- Dando, Owen;
- Okely, Judith A;
- Tzioras, Makis;
- Rose, Jamie;
- Gunn, Ciaran;
- Correia, Adele;
- Montero, Carmen;
- McAlister, Hannah;
- Tulloch, Jane;
- Lamont, Douglas;
- Taylor, Adele M;
- Harris, Sarah E;
- Redmond, Paul;
- Cox, Simon R;
- Henstridge, Christopher M;
- Deary, Ian J
Publication type:
Article
P2‐244: NEUROFILAMENT LIGHT IN ISOPOTENTIAL STEM CELL‐DERIVED NEURONS WITH FAMILIAL AD MUTATIONS AS A MARKER OF NEURODEGENERATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P676, doi. 10.1016/j.jalz.2019.06.2651
By:
- Esteve, Aitana Sogorb;
- Leckey, Claire Alexandra;
- Arber, Charles;
- Toombs, Jamie;
- Wray, Selina;
- Heslegrave, Amanda J.;
- De Strooper, Bart;
- Zetterberg, Henrik
Publication type:
Article
O1‐03‐04: CORTICAL NEURONS AND CEREBRAL ORGANOIDS FROM APP AND PSEN1 MUTATION CARRIERS REVEAL MUTATION‐SPECIFIC EFFECTS ON Aβ PRODUCTION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P199, doi. 10.1016/j.jalz.2019.06.4532
By:
- Arber, Charles;
- Toombs, Jamie;
- Lovejoy, Christopher E.J.;
- Paterson, Ross W.;
- Ryan, Natalie S.;
- Willumsen, Nanet;
- Gkanatsiou, Eleni;
- Portelius, Erik;
- Blennow, Kaj;
- Heslegrave, Amanda J.;
- Schott, Jonathan M.;
- Hardy, John;
- Fox, Nick C.;
- Lashley, Tammaryn;
- Zetterberg, Henrik;
- Wray, Selina
Publication type:
Article
P1‐267: CEREBROSPINAL FLUID/PLASMA ALBUMIN RATIO PREDICTS POSTOPERATIVE DELIRIUM IN AN OLDER ELECTIVE ORTHOPAEDIC POPULATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P384, doi. 10.1016/j.jalz.2018.06.273
By:
- Cunningham, Emma L.;
- Passmore, Anthony Peter;
- McAuley, Daniel F.;
- Beverland, David;
- Mawhinney, Tim;
- O'Brien, Seamus;
- Toombs, Jamie;
- Schott, Jonathan M.;
- Zetterberg, Henrik;
- Lunn, Michael;
- McGuinness, Bernadette
Publication type:
Article
P1‐188: MODELLING AMYLOID BETA PROFILES IN IPSC‐DERIVED CORTICAL NEURONS OF MULTIPLE FAMILIAL ALZHEIMER'S DISEASE GENOTYPES, INCLUDING A CASE STUDY OF SAME DONOR CULTURE MEDIA, CSF AND BRAIN TISSUE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P350, doi. 10.1016/j.jalz.2018.06.192
By:
- Toombs, Jamie;
- Arber, Charles;
- James Lovejoy, Christopher Edward;
- Paterson, Ross W.;
- Ryan, Natalie S.;
- Willumsen, Nanet;
- Gkanatsiou, Eleni;
- Portelius, Erik;
- Blennow, Kaj;
- Heslegrave, Amanda;
- Schott, Jonathan M.;
- Hardy, John;
- Lashley, Tammaryn;
- Fox, Nick C.;
- Zetterberg, Henrik;
- Wray, Selina
Publication type:
Article
Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic.
Published in:
Alzheimer's Research & Therapy, 2018, v. 10, p. 1, doi. 10.1186/s13195-018-0361-3
By:
- Paterson, Ross W.;
- Slattery, Catherine F.;
- Poole, Teresa;
- Nicholas, Jennifer M.;
- Magdalinou, Nadia K.;
- Toombs, Jamie;
- Chapman, Miles D.;
- Lunn, Michael P.;
- Heslegrave, Amanda J.;
- Foiani, Martha S;
- Weston, Philip S. J.;
- Keshavan, Ashvini;
- Rohrer, Jonathan D.;
- Rossor, Martin N.;
- Warren, Jason D.;
- Mummery, Catherine J.;
- Blennow, Kaj;
- Fox, Nick C.;
- Zetterberg, Henrik;
- Schott, Jonathan M.
Publication type:
Article
The impact of Tween 20 on repeatability of amyloid β and tau measurements in cerebrospinal fluid.
Published in:
Clinical Chemistry & Laboratory Medicine, 2015, v. 53, n. 12, p. e329, doi. 10.1515/cclm-2015-0414
By:
- Toombs, Jamie;
- Paterson, Ross W.;
- Nicholas, Jennifer M.;
- Petzold, Axel;
- Schott, Jonathan M.;
- Zetterberg, Henrik
Publication type:
Article
Identification of an important potential confound in CSF AD studies: aliquot volume.
Published in:
Clinical Chemistry & Laboratory Medicine, 2013, v. 51, n. 12, p. 2311, doi. 10.1515/cclm-2013-0293
By:
- Toombs, Jamie;
- Paterson, Ross W.;
- Lunn, Michael P.;
- Nicholas, Jenifer M.;
- Fox, Nick C.;
- Chapman, Miles D.;
- Schott, Jonathan M.;
- Zetterberg, Henrik
Publication type:
Article
PROBING DEVELOPMENTAL CONSEQUENCES OF PSEN1 MUTATIONS IN IPSC DIFFERENTIATION IN 2D AND 3D.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P327, doi. 10.1016/j.jalz.2017.06.039
By:
- Arber, Charles;
- James Lovejoy, Christopher Edward;
- Ryan, Natalie S.;
- Toombs, Jamie;
- Willumsen, Nanet;
- Fox, Nick C.;
- Hardy, John;
- Wray, Selina
Publication type:
Article
DISTINCT Aβ PRODUCTION IN STEM CELL-DERIVED CORTICAL NEURONS FROM PATIENTS WITH FAD MUTATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P311, doi. 10.1016/j.jalz.2017.06.247
By:
- Toombs, Jamie;
- Arber, Charles;
- Ryan, Natalie S.;
- Heslegrave, Amanda J.;
- Hardy, John;
- De Strooper, Bart;
- Fox, Nick C.;
- Wray, Selina;
- Zetterberg, Henrik
Publication type:
Article
PROBING DEVELOPMENTAL CONSEQUENCES OF PSEN1 MUTATIONS IN IPSC DIFFERENTIATION IN 2D AND 3D.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P242, doi. 10.1016/j.jalz.2017.06.092
By:
- Arber, Charles;
- James Lovejoy, Christopher Edward;
- Ryan, Natalie S.;
- Toombs, Jamie;
- Willumsen, Nanet;
- Fox, Nick C.;
- Hardy, John;
- Wray, Selina
Publication type:
Article
CSF Aβ42 CONCENTRATION INDEPENDENTLY PREDICTS POSTOPERATIVE DELIRIUM IN AN ELDERLY ELECTIVE ARTHROPLASTY POPULATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P390, doi. 10.1016/j.jalz.2017.06.364
By:
- Cunningham, Emma L.;
- McGuinness, Bernadette;
- Beverland, David;
- McAuley, Daniel F.;
- O'Brien, Seamus;
- Mawhinney, Tim;
- Toombs, Jamie;
- Zetterberg, Henrik;
- Schott, Jonathan M.;
- Lunn, Michael;
- Passmore, Anthony Peter
Publication type:
Article
CSF IN THE DIFFERENTIAL DIAGNOSIS OF ALZHEIMER'S DISEASE: CLINICAL UTILITY OF AN EXTENDED PANEL OF BIOMARKERS IN A SPECIALIST COGNITIVE CLINIC.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P203, doi. 10.1016/j.jalz.2016.06.356
By:
- Paterson, Ross W.;
- Slattery, Catherine F.;
- Magdalinou, Nadia K.;
- Toombs, Jamie;
- Chapman, Miles D.;
- Lunn, Michael;
- Blennow, Kaj;
- Fox, Nick C.;
- Zetterberg, Henrik;
- Schott, Jon M.
Publication type:
Article
THE CSF AB42/40 RATIO DOES NOT MITIGATE MISINTERPRETATION OF AB LOSS UPON SERIAL TUBE TRANSFERS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P664, doi. 10.1016/j.jalz.2016.06.1507
By:
- Foiani, Martha;
- Toombs, Jamie;
- Wellington, Henrietta;
- Paterson, Ross W.;
- Arber, Charles;
- Schott, Jon M.;
- Zetterberg, Henrik
Publication type:
Article
Development of a targeted proteomic multiplex CSF assay for neurodegenerative markers.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P645, doi. 10.1016/j.jalz.2015.06.942
By:
- Paterson, Ross W.;
- Heywood, Wendy E.;
- Heslegrave, Amanda J.;
- Magdalinou, Nadia K.;
- Svensson, Johan;
- Johansson, Per M.;
- Toombs, Jamie;
- Fox, Nick C.;
- Zetterberg, Henrik;
- Mills, Kevin;
- Schott, Jonathan M.
Publication type:
Article
Using florbetapir F18 PET to validate CSF cut-points and increase diagnostic certainty in atypical dementias.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P421, doi. 10.1016/j.jalz.2015.06.390
By:
- Weston, Philip S.J.;
- Paterson, Ross W.;
- Lehmann, Manja;
- Modat, Marc;
- Bomanji, Jimmy;
- Kayani, Irfan;
- Dickson, John;
- Barnes, Anna;
- Cash, David M.;
- Ourselin, Sebastien;
- Zetterberg, Henrik;
- Toombs, Jamie;
- Warren, Json;
- Rossor, Martin N.;
- Fox, Nick C.;
- Schott, Jonathan M.
Publication type:
Article
Dissecting IWG-2 typical and atypical Alzheimer's disease: Insights from cerebrospinal fluid analysis.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P254, doi. 10.1016/j.jalz.2015.07.315
By:
- Paterson, Ross W.;
- Toombs, Jamie;
- Slattery, Catherine F.;
- Nicholas, Jennifer;
- Blennow, Kaj;
- Andreasson, Ulf;
- Magdalinou, Nadia K.;
- Warren, Jason D.;
- Mummery, Catherine J.;
- Rossor, Martin N.;
- Lunn, Michael;
- Crutch, Sebastian J.;
- Fox, Nick C.;
- Zetterberg, Henrik;
- Schott, Jonathan M.
Publication type:
Article
Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.
Published in:
Scientific Reports, 2016, p. 29200, doi. 10.1038/srep29200
By:
- Bergström, Petra;
- Agholme, Lotta;
- Nazir, Faisal Hayat;
- Satir, Tugce Munise;
- Toombs, Jamie;
- Wellington, Henrietta;
- Strandberg, Joakim;
- Bontell, Thomas Olsson;
- Kvartsberg, Hlin;
- Holmström, Maria;
- Boreström, Cecilia;
- Simonsson, Stina;
- Kunath, Tilo;
- Lindahl, Anders;
- Blennow, Kaj;
- Hanse, Eric;
- Portelius, Erik;
- Wray, Selina;
- Zetterberg, Henrik
Publication type:
Article
Direct Estimates of Natural Selection in Iberia Indicate Calcium Absorption Was Not the Only Driver of Lactase Persistence in Europe.
Published in:
Molecular Biology & Evolution, 2014, v. 31, n. 4, p. 975
By:
- Sverrisdóttir, Oddný Ósk;
- Timpson, Adrian;
- Toombs, Jamie;
- Lecoeur, Cecile;
- Froguel, Philippe;
- Carretero, Jose Miguel;
- Arsuaga Ferreras, Juan Luis;
- Götherström, Anders;
- Thomas, Mark G.
Publication type:
Article
Biomarker Modelling of Early Molecular Changes in Alzheimer's Disease.
Published in:
Molecular Diagnosis & Therapy, 2014, v. 18, n. 2, p. 213, doi. 10.1007/s40291-013-0069-9
By:
- Paterson, Ross;
- Toombs, Jamie;
- Slattery, Catherine;
- Schott, Jonathan;
- Zetterberg, Henrik
Publication type:
Article
Cerebrospinal fluid metallomics in cerebral amyloid angiopathy: an exploratory analysis.
Published in:
Journal of Neurology, 2022, v. 269, n. 3, p. 1470, doi. 10.1007/s00415-021-10711-6
By:
- Banerjee, Gargi;
- Forsgard, Niklas;
- Ambler, Gareth;
- Keshavan, Ashvini;
- Paterson, Ross W.;
- Foiani, Martha S.;
- Toombs, Jamie;
- Heslegrave, Amanda;
- Thompson, Edward J.;
- Lunn, Michael P.;
- Fox, Nick C.;
- Zetterberg, Henrik;
- Schott, Jonathan M.;
- Werring, David J.
Publication type:
Article
Dissecting IWG-2 typical and atypical Alzheimer's disease: insights from cerebrospinal fluid analysis.
Published in:
Journal of Neurology, 2015, v. 262, n. 12, p. 2722, doi. 10.1007/s00415-015-7904-3
By:
- Paterson, Ross;
- Toombs, Jamie;
- Slattery, Catherine;
- Nicholas, Jennifer;
- Andreasson, Ulf;
- Magdalinou, Nadia;
- Blennow, Kaj;
- Warren, Jason;
- Mummery, Cath;
- Rossor, Martin;
- Lunn, Michael;
- Crutch, Sebastian;
- Fox, Nick;
- Zetterberg, Henrik;
- Schott, Jonathan
Publication type:
Article
The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue.
Published in:
Brain Communications, 2023, v. 5, n. 1, p. 1, doi. 10.1093/braincomms/fcac321
By:
- Willumsen, Nanet;
- Arber, Charles;
- Lovejoy, Christopher;
- Toombs, Jamie;
- Alatza, Argyro;
- Weston, Philip S. J.;
- Chávez-Gutiérrez, Lucia;
- Hardy, John;
- Zetterberg, Henrik;
- Fox, Nick C.;
- Ryan, Natalie S.;
- Lashley, Tammaryn;
- Wray, Selina
Publication type:
Article
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease.
Published in:
Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-023-02679-6
By:
- Colom-Cadena, Martí;
- Toombs, Jamie;
- Simzer, Elizabeth;
- Holt, Kristjan;
- McGeachan, Robert;
- Tulloch, Jane;
- Jackson, Rosemary J.;
- Catterson, James H.;
- Spires-Jones, Maxwell P.;
- Rose, Jamie;
- Waybright, Lora;
- Caggiano, Anthony O.;
- King, Declan;
- Gobbo, Francesco;
- Davies, Caitlin;
- Hooley, Monique;
- Dunnett, Sophie;
- Tempelaar, Robert;
- Meftah, Soraya;
- Tzioras, Makis
Publication type:
Article

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