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Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK.
Published in:
Cellular Physiology & Biochemistry (Karger AG), 2018, v. 49, n. 4, p. 1523, doi. 10.1159/000493456
By:
- Kodai Uematsu;
- Yukiko Enomoto;
- Takashi Onuma;
- Masanori Tsujimoto;
- Tomoaki Doi;
- Rie Matsushima-Nishiwaki;
- Haruhiko Tokuda;
- Shinji Ogura;
- Hiroki Iida;
- Osamu Kozawa;
- Toru Iwama
Publication type:
Article
Atypical drug-induced hypersensitivity syndrome with multiple organ failure rescued by combined acute blood purification therapy: a case report.
Published in:
International Journal of Emergency Medicine, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s12245-023-00511-2
By:
- Oiwa, Hideaki;
- Yoshida, Shozo;
- Okada, Hideshi;
- Yasunishi, Masahiro;
- Kamidani, Ryo;
- Suzuki, Kodai;
- Miyake, Takahito;
- Doi, Tomoaki;
- Shimohata, Takayoshi;
- Ogura, Shinji
Publication type:
Article
Spinal injury with spinal ankylosing disorders as a primary cause of death: report of two cases.
Published in:
International Journal of Emergency Medicine, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s12245-023-00488-y
By:
- Miyake, Takahito;
- Okada, Hideshi;
- Kanda, Norihide;
- Mizuno, Yosuke;
- Suzuki, Kodai;
- Doi, Tomoaki;
- Yoshida, Takahiro;
- Yoshida, Shozo;
- Ogura, Shinji
Publication type:
Article
Synergy by Ristocetin and CXCL12 in Human Platelet Activation: Divergent Regulation by Rho/Rho-Kinase and Rac.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9716, doi. 10.3390/ijms24119716
By:
- Enomoto, Yukiko;
- Onuma, Takashi;
- Hori, Takamitsu;
- Tanabe, Kumiko;
- Ueda, Kyohei;
- Mizutani, Daisuke;
- Doi, Tomoaki;
- Matsushima-Nishiwaki, Rie;
- Ogura, Shinji;
- Iida, Hiroki;
- Iwama, Toru;
- Kozawa, Osamu;
- Tokuda, Haruhiko
Publication type:
Article
Relationship between the Responsiveness of Amyloid β Protein to Platelet Activation by TRAP Stimulation and Brain Atrophy in Patients with Diabetes Mellitus.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 22, p. 14100, doi. 10.3390/ijms232214100
By:
- Hori, Takamitsu;
- Mizutani, Daisuke;
- Onuma, Takashi;
- Okada, Yu;
- Kojima, Kumi;
- Doi, Tomoaki;
- Enomoto, Yukiko;
- Iida, Hiroki;
- Ogura, Shinji;
- Sakurai, Takashi;
- Iwama, Toru;
- Kozawa, Osamu;
- Tokuda, Haruhiko
Publication type:
Article
Leriche syndrome diagnosed due to polytrauma: a case report.
Published in:
International Journal of Emergency Medicine, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s12245-022-00411-x
By:
- Yoshimura, Genki;
- Kamidani, Ryo;
- Miura, Tomotaka;
- Oiwa, Hideaki;
- Mizuno, Yosuke;
- Yasuda, Ryu;
- Kitagawa, Yuichiro;
- Fukuta, Tetsuya;
- Miyake, Takahito;
- Okamoto, Haruka;
- Kanda, Norihide;
- Doi, Tomoaki;
- Okada, Hideshi;
- Yoshida, Takahiro;
- Yoshida, Shozo;
- Ogura, Shinji
Publication type:
Article
Postmortem diagnosis of pulmonary tumor thrombotic microangiopathy with rapid exacerbation in a patient with gastric cancer: a case report.
Published in:
International Journal of Emergency Medicine, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s12245-021-00377-2
By:
- Kamidani, Ryo;
- Kumada, Keisuke;
- Okada, Hideshi;
- Yoshimura, Genki;
- Kanayama, Tomohiro;
- Tomita, Hiroyuki;
- Miura, Tomotaka;
- Oiwa, Hideaki;
- Mizuno, Yosuke;
- Kitagawa, Yuichiro;
- Yasuda, Ryu;
- Fukuta, Tetsuya;
- Miyake, Takahito;
- Doi, Tomoaki;
- Yoshida, Takahiro;
- Yoshida, Shozo;
- Hara, Akira;
- Ogura, Shinji
Publication type:
Article
Thyrotoxic and pheochromocytoma multisystem crisis: a case report.
Published in:
2017
By:
- Kodai Suzuki;
- Takahito Miyake;
- Hideshi Okada;
- Fuminori Yamaji;
- Yuichiro Kitagawa;
- Tetsuya Fukuta;
- Ryu Yasuda;
- Yoshihito Tanaka;
- Haruka Okamoto;
- Sho Nachi;
- Tomoaki Doi;
- Takahiro Yoshida;
- Keisuke Kumada;
- Shozo Yoshida;
- Hiroaki Ushikoshi;
- Izumi Toyoda;
- Shinji Ogura;
- Suzuki, Kodai;
- Miyake, Takahito;
- Okada, Hideshi
Publication type:
journal article
Blunt cardiac injury due to trauma associated with snowboarding: a case report.
Published in:
2017
By:
- Fuminori Yamaji;
- Hideshi Okada;
- Yasuhiro Nakajima;
- Kodai Suzuki;
- Takahiro Yoshida;
- Yosuke Mizuno;
- Haruka Okamoto;
- Yuichiro Kitagawa;
- Taku Tanaka;
- Shiho Nakano;
- Sho Nachi;
- Tomoaki Doi;
- Keisuke Kumada;
- Shozo Yoshida;
- Narihiro Ishida;
- Katsuya Shimabukuro;
- Hiroaki Ushikoshi;
- Izumi Toyoda;
- Kiyoshi Doi;
- Shinji Ogura
Publication type:
journal article
Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128977
By:
- Tokuda, Haruhiko;
- Kuroyanagi, Gen;
- Tsujimoto, Masanori;
- Enomoto, Yukiko;
- Matsushima-Nishiwaki, Rie;
- Onuma, Takashi;
- Kojima, Akiko;
- Doi, Tomoaki;
- Tanabe, Kumiko;
- Akamatsu, Shigeru;
- Iida, Hiroki;
- Ogura, Shinji;
- Otsuka, Takanobu;
- Iwama, Toru;
- Tanikawa, Takahisa;
- Ishikawa, Kei;
- Kojima, Kumi;
- Kozawa, Osamu
Publication type:
Article
Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation.
Published in:
PLoS ONE, 2020, v. 15, n. 10, p. 1, doi. 10.1371/journal.pone.0241139
By:
- Nakashima, Daiki;
- Onuma, Takashi;
- Tanabe, Kumiko;
- Kito, Yuko;
- Uematsu, Kodai;
- Mizutani, Daisuke;
- Enomoto, Yukiko;
- Tsujimoto, Masanori;
- Doi, Tomoaki;
- Matsushima-Nishiwaki, Rie;
- Tokuda, Haruhiko;
- Ogura, Shinji;
- Iwama, Toru;
- Kozawa, Osamu;
- Iida, Hiroki
Publication type:
Article
Much caution does no harm! Organophosphate poisoning often causes pancreatitis.
Published in:
Journal of Intensive Care, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40560-015-0088-1
By:
- Shozo Yoshida;
- Hideshi Okada;
- Shiho Nakano;
- Kunihiro Shirai;
- Toshiyuki Yuhara;
- Hiromasa Kojima;
- Tomoaki Doi;
- Hisaaki Kato;
- Kodai Suzuki;
- Kentaro Morishita;
- Eiji Murakami;
- Hiroaki Ushikoshi;
- Izumi Toyoda;
- Shinji Ogura
Publication type:
Article
AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: Suppression of HSP27 phosphorylation via p44/p42 MAP kinase.
Published in:
Experimental & Therapeutic Medicine, 2016, v. 12, n. 2, p. 1107, doi. 10.3892/etm.2016.3435
By:
- MASANORI TSUJIMOTO;
- HARUHIKO TOKUDA;
- GEN KUROYANAGI;
- NAOHIRO YAMAMOTO;
- SHINGO KAINUMA;
- RIE MATSUSHIMA-NISHIWAKI;
- TAKASHI ONUMA;
- YUKO IIDA;
- AKIKO KOJIMA;
- SHIGENOBU SAWADA;
- TOMOAKI DOI;
- YUKIKO ENOMOTO;
- KUMIKO TANABE;
- SHIGERU AKAMATSU;
- HIROKI IIDA;
- SHINJI OGURA;
- TAKANOBU OTSUKA;
- OSAMU KOZAWA;
- TORU IWAMA
Publication type:
Article
Ristocetin induces phosphorylated-HSP27 (HSPB1) release from the platelets of type 2 DM patients: Anti-platelet agent-effect on the release.
Published in:
Biomedical Reports, 2018, v. 8, n. 4, p. 365, doi. 10.3892/br.2018.1058
By:
- Tokuda, Haruhiko;
- Kuroyanagi, Gen;
- Onuma, Takashi;
- Enomoto, Yukiko;
- Doi, Tomoaki;
- Iida, Hiroki;
- Otsuka, Takanobu;
- Ogura, Shinji;
- Iwama, Toru;
- Kojima, Kumi;
- Kozawa, Osamu
Publication type:
Article
αB-crystallin reduces ristocetin-induced soluble CD40 ligand release in human platelets: Suppression of thromboxane A<sub>2</sub> generation.
Published in:
Molecular Medicine Reports, 2015, v. 12, n. 1, p. 357, doi. 10.3892/mmr.2015.3445
By:
- MASANORI TSUJIMOTO;
- TOMOAKI DOI;
- GEN KUROYANAGI;
- NAOHIRO YAMAMOTO;
- RIE MATSUSHIMA-NISHIWAKI;
- YUKO IIDA;
- YUKIKO ENOMOTO;
- HIROKI IIDA;
- SHINJI OGURA;
- TAKANOBU OTSUKA;
- HARUHIKO TOKUDA;
- OSAMU KOZAWA;
- TORU IWAMA
Publication type:
Article
(-)-Epigallocatechin gallate selectively inhibits adenosine diphosphate-stimulated human platelet activation: Suppression of heat shock protein 27 phosphorylation via p38 mitogen-activated protein kinase.
Published in:
Molecular Medicine Reports, 2014, v. 10, n. 3, p. 1383, doi. 10.3892/mmr.2014.2389
By:
- YUKO IIDA;
- TOMOAKI DOI;
- RIE MATSUSHIMA-NISHIWAKI;
- HARUHIKO TOKUDA;
- SHINJI OGURA;
- OSAMU KOZAWA;
- HIROKI IIDA
Publication type:
Article
Involvement of Rac in thromboxane A<sub>2</sub>-induced human platelet activation: Regulation of sCD40 ligand release and PDGF-AB secretion.
Published in:
Molecular Medicine Reports, 2014, v. 10, n. 1, p. 107, doi. 10.3892/mmr.2014.2143
By:
- YASUNARI KAGEYAMA;
- TOMOAKI DOI;
- RIE MATSUSHIMA-NISHIWAKI;
- YUKO IIDA;
- SHIGERU AKAMATSU;
- AKIRA KONDO;
- GEN KUROYANAGI;
- NAOHIRO YAMAMOTO;
- JUN MIZUTANI;
- TAKANOBU OTSUKA;
- HARUHIKO TOKUDA;
- HIROKI IIDA;
- OSAMU KOZAWA;
- SHINJI OGURA
Publication type:
Article
Hypergranulation over a meshed split-thickness skin graft, a complication of negative-pressure wound therapy: a case report.
Published in:
2022
By:
- Shiba, Masato;
- Doi, Tomoaki;
- Okada, Hideshi;
- Kamidani, Ryo;
- Yoshimura, Genki;
- Kusuzawa, Keigo;
- Yamaji, Fuminori;
- Miura, Tomotaka;
- Oiwa, Hideaki;
- Mizuno, Yosuke;
- Yasuda, Ryu;
- Fukuta, Tetsuya;
- Kitagawa, Yuichiro;
- Miyake, Takahito;
- Yoshida, Takahiro;
- Yoshida, Shozo;
- Ogura, Shinji
Publication type:
Case Study
Amyloid β protein negatively regulates human platelet activation induced by thrombin receptor-activating protein.
Published in:
Bioscience, Biotechnology & Biochemistry, 2022, v. 86, n. 2, p. 185, doi. 10.1093/bbb/zbab201
By:
- Daisuke Mizutani;
- Haruhiko Tokuda;
- Takashi Onuma;
- Kodai Uematsu;
- Daiki Nakashima;
- Kyohei Ueda;
- Tomoaki Doi;
- Yukiko Enomoto;
- Rie Matsushima-Nishiwaki;
- Shinji Ogura;
- Hiroki Iida;
- Osamu Kozawa;
- Toru Iwama
Publication type:
Article
Olive polyphenol reduces the collagen-elicited release of phosphorylated HSP27 from human platelets.
Published in:
Bioscience, Biotechnology & Biochemistry, 2020, v. 84, n. 3, p. 536, doi. 10.1080/09168451.2019.1697196
By:
- Mizutani, Daisuke;
- Onuma, Takashi;
- Tanabe, Kumiko;
- Kojima, Akiko;
- Uematsu, Kodai;
- Nakashima, Daiki;
- Doi, Tomoaki;
- Enomoto, Yukiko;
- Matsushima-Nishiwaki, Rie;
- Tokuda, Haruhiko;
- Ogura, Shinji;
- Iida, Hiroki;
- Kozawa, Osamu;
- Iwama, Toru
Publication type:
Article
Serum syndecan-1 reflects organ dysfunction in critically ill patients.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88303-7
By:
- Suzuki, Keiko;
- Okada, Hideshi;
- Sumi, Kazuyuki;
- Tomita, Hiroyuki;
- Kobayashi, Ryo;
- Ishihara, Takuma;
- Kakino, Yoshinori;
- Suzuki, Kodai;
- Yoshiyama, Naomasa;
- Yasuda, Ryu;
- Kitagawa, Yuichiro;
- Fukuta, Tetsuya;
- Miyake, Takahito;
- Okamoto, Haruka;
- Doi, Tomoaki;
- Yoshida, Takahiro;
- Yoshida, Shozo;
- Ogura, Shinji;
- Suzuki, Akio
Publication type:
Article
Recombinant thrombomodulin protects against LPS-induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx.
Published in:
2020
By:
- Suzuki, Kodai;
- Okada, Hideshi;
- Takemura, Genzou;
- Takada, Chihiro;
- Tomita, Hiroyuki;
- Yano, Hirohisa;
- Muraki, Isamu;
- Zaikokuji, Ryogen;
- Kuroda, Ayumi;
- Fukuda, Hirotsugu;
- Nishio, Ayane;
- Takashima, Shigeo;
- Suzuki, Akio;
- Miyazaki, Nagisa;
- Fukuta, Tetsuya;
- Yamada, Noriaki;
- Watanabe, Takatomo;
- Doi, Tomoaki;
- Yoshida, Takahiro;
- Kumada, Keisuke
Publication type:
journal article
Intensive granulocyte and monocyte adsorption apheresis for generalized pustular psoriasis.
Published in:
Journal of Dermatology, 2020, v. 47, n. 11, p. 1326, doi. 10.1111/1346-8138.15569
By:
- Mizutani, Yoko;
- Fujii, Kento;
- Kawamura, Miho;
- Inoue, Madoka;
- Mizutani, Yuki H.;
- Matsuyama, Kanako;
- Doi, Tomoaki;
- Nagaya, Soichiro;
- Seishima, Mariko
Publication type:
Article
Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase.
Published in:
PLoS ONE, 2023, v. 17, n. 1, p. 1, doi. 10.1371/journal.pone.0279011
By:
- Iida, Hiroki;
- Onuma, Takashi;
- Nakashima, Daiki;
- Mizutani, Daisuke;
- Hori, Takamitsu;
- Ueda, Kyohei;
- Hioki, Tomoyuki;
- Kim, Woo;
- Enomoto, Yukiko;
- Doi, Tomoaki;
- Matsushima-Nishiwaki, Rie;
- Yamaguchi, Shinobu;
- Tachi, Junko;
- Tanabe, Kumiko;
- Ogura, Shinji;
- Iwama, Toru;
- Kozawa, Osamu;
- Tokuda, Haruhiko
Publication type:
Article
αB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets
Published in:
FEBS Letters, 2009, v. 583, n. 15, p. 2464, doi. 10.1016/j.febslet.2009.06.036
By:
- Enomoto, Yukiko;
- Adachi, Seiji;
- Matsushima-Nishiwaki, Rie;
- Niwa, Masayuki;
- Tokuda, Haruhiko;
- Akamatsu, Shigeru;
- Doi, Tomoaki;
- Kato, Hisaaki;
- Yoshimura, Shinichi;
- Ogura, Shinji;
- Iwama, Toru;
- Kozawa, Osamu
Publication type:
Article
Brain-Specific Ultrastructure of Capillary Endothelial Glycocalyx and Its Possible Contribution for Blood Brain Barrier.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-35976-2
By:
- Ando, Yoshiaki;
- Okada, Hideshi;
- Takemura, Genzou;
- Suzuki, Kodai;
- Takada, Chihiro;
- Tomita, Hiroyuki;
- Zaikokuji, Ryogen;
- Hotta, Yasuaki;
- Miyazaki, Nagisa;
- Yano, Hirohisa;
- Muraki, Isamu;
- Kuroda, Ayumi;
- Fukuda, Hirotsugu;
- Kawasaki, Yuki;
- Okamoto, Haruka;
- Kawaguchi, Tomonori;
- Watanabe, Takatomo;
- Doi, Tomoaki;
- Yoshida, Takahiro;
- Ushikoshi, Hiroaki
Publication type:
Article
Severe heat stroke complicated by multiple cerebral infarctions: a case report.
Published in:
2021
By:
- Kamidani, Ryo;
- Okada, Hideshi;
- Kitagawa, Yuichiro;
- Kusuzawa, Keigo;
- Ichihashi, Masahiro;
- Kakino, Yoshinori;
- Oiwa, Hideaki;
- Yasuda, Ryu;
- Fukuta, Tetsuya;
- Yoshiyama, Naomasa;
- Miyake, Takahito;
- Okamoto, Haruka;
- Suzuki, Kodai;
- Yamada, Noriaki;
- Doi, Tomoaki;
- Yoshida, Takahiro;
- Ushikoshi, Hiroaki;
- Kumada, Keisuke;
- Yoshida, Shozo;
- Ogura, Shinji
Publication type:
journal article
Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets.
Published in:
International Journal of Molecular Medicine, 2013, v. 32, n. 4, p. 813, doi. 10.3892/ijmm.2013.1455
By:
- YASUNARI KAGEYAMA;
- TOMOAKI DOI;
- SHIGERU AKAMATSU;
- GEN KUROYANAGI;
- AKIRA KONDO;
- JUN MIZUTANI;
- TAKANOBU OTSUKA;
- HARUHIKO TOKUDA;
- OSAMU KOZAWA;
- SHINJI OGURA
Publication type:
Article
Granulocyte and Monocyte Adsorption Apheresis for Generalized Pustular Psoriasis: Therapeutic Outcomes in Three Refractory Patients.
Published in:
Therapeutic Apheresis & Dialysis, 2015, v. 19, n. 4, p. 336, doi. 10.1111/1744-9987.12342
By:
- Fujisawa, Tomomi;
- Suzuki, Satoko;
- Mizutani, Yoko;
- Doi, Tomoaki;
- Yoshida, Shozo;
- Ogura, Shinji;
- Seishima, Mariko
Publication type:
Article
Efficacy of Granulocyte and Monocyte Adsorption Apheresis for Treatment of Palmoplantar Pustulosis.
Published in:
Therapeutic Apheresis & Dialysis, 2014, v. 18, n. 3, p. 238, doi. 10.1111/1744-9987.12210
By:
- Fujisawa, Tomomi;
- Tawada, Chisato;
- Mizutani, Yoko;
- Doi, Tomoaki;
- Yoshida, Shozo;
- Ogura, Shinji;
- Seishima, Mariko
Publication type:
Article
Generalized Pustular Psoriasis Successfully Treated With Granulocyte and Monocyte Adsorption Apheresis.
Published in:
Therapeutic Apheresis & Dialysis, 2011, v. 15, n. 4, p. 374, doi. 10.1111/j.1744-9987.2011.00961.x
By:
- Fujisawa, Tomomi;
- Murase, Kana;
- Okumura, Yoko;
- Kanoh, Hiroyuki;
- Doi, Tomoaki;
- Yoshida, Shouzo;
- Ogura, Shinji;
- Seishima, Mariko
Publication type:
Article
Thrombopoietin and collagen in low doses cooperatively induce human platelet activation.
Published in:
Acute Medicine & Surgery, 2022, v. 9, n. 1, p. 1, doi. 10.1002/ams2.769
By:
- Doi, Tomoaki;
- Hori, Takamitsu;
- Onuma, Takashi;
- Mizutani, Daisuke;
- Ueda, Kyohei;
- Enomoto, Yukiko;
- Matsushima‐Nishiwaki, Rie;
- Tanabe, Kumiko;
- Hioki, Tomoyuki;
- Tokuda, Haruhiko;
- Iwama, Toru;
- Iida, Hiroki;
- Kozawa, Osamu;
- Ogura, Shinji
Publication type:
Article
Effect of high-flow high-volume-intermittent hemodiafiltration on metformin-associated lactic acidosis with circulatory failure: a case report.
Published in:
2018
By:
- Suzuki, Kodai;
- Okada, Hideshi;
- Yoshida, Shozo;
- Okamoto, Haruka;
- Suzuki, Akio;
- Suzuki, Keiko;
- Yamada, Yuto;
- Hayashi, Hideki;
- Yasuda, Ryu;
- Fukuta, Tetsuya;
- Kitagawa, Yuichiro;
- Miyake, Takahito;
- Kawaguchi, Tomonori;
- Watanabe, Takatomo;
- Doi, Tomoaki;
- Kumada, Keisuke;
- Ushikoshi, Hiroaki;
- Sugiyama, Tadashi;
- Itoh, Yoshinori;
- Ogura, Shinji
Publication type:
journal article
Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions.
Published in:
2017
By:
- Hideshi Okada;
- Genzou Takemura;
- Kodai Suzuki;
- Kazumasa Oda;
- Chihiro Takada;
- Yasuaki Hotta;
- Nagisa Miyazaki;
- Akiko Tsujimoto;
- Isamu Muraki;
- Yoshiaki Ando;
- Ryogen Zaikokuji;
- Atsumu Matsumoto;
- Hiroki Kitagaki;
- Yuto Tamaoki;
- Takahiro Usui;
- Tomoaki Doi;
- Takahiro Yoshida;
- Shozo Yoshida;
- Hiroaki Ushikoshi;
- Izumi Toyoda
Publication type:
journal article

Found: 34