Works by Tomlinson, Darren C.

Results: 22

Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐x<sub>L</sub> and MCL‐1 through Noncanonical Structural Motifs**.

Published in:

ChemBioChem, 2021, v. 22, n. 1, p. 232, doi. 10.1002/cbic.202000585

By:

Miles, Jennifer A.;
Hobor, Fruzsina;
Trinh, Chi H.;
Taylor, James;
Tiede, Christian;
Rowell, Philip R.;
Jackson, Brian R.;
Nadat, Fatima A.;
Ramsahye, Pallavi;
Kyle, Hannah F.;
Wicky, Basile I. M.;
Clarke, Jane;
Tomlinson, Darren C.;
Wilson, Andrew J.;
Edwards, Thomas A.

Publication type:

Article

Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues.

Published in:

PLoS ONE, 2023, v. 18, n. 3, p. 1, doi. 10.1371/journal.pone.0283044

By:

Liu, Peng;
Roberts, Sophie;
Shoemaker, James T;
Vukasinovic, Jelena;
Tomlinson, Darren C;
Speirs, Valerie

Publication type:

Article

Ortsspezifische Funktionalisierung von Affimeren für die DNA‐PAINT‐Mikroskopie.

Published in:

Angewandte Chemie, 2018, v. 130, n. 34, p. 11226, doi. 10.1002/ange.201804020

By:

Schlichthaerle, Thomas;
Eklund, Alexandra S.;
Schueder, Florian;
Strauss, Maximilian T.;
Tiede, Christian;
Curd, Alistair;
Ries, Jonas;
Peckham, Michelle;
Tomlinson, Darren C.;
Jungmann, Ralf

Publication type:

Article

Generating and validating renewable affimer protein binding reagents targeting SH2 domains.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-79357-4

By:

Heseltine, Sophie J.;
Billenness, Gregory J.;
Martin, Heather L;
Tiede, Christian;
Tang, Anna A.S.;
Foy, Eleanor;
Reddy, Grace;
Gibson, Naomi;
Johnson, Matt;
Webb, Michael E.;
McPherson, Michael J.;
Tomlinson, Darren C.

Publication type:

Article

The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis.

Published in:

Bioscience Reports, 2015, v. 35, n. 5, p. 1, doi. 10.1042/BSR20150171

By:

Smith, Gina A.;
Fearnley, Gareth W.;
Tomlinson, Darren C.;
Harrison, Michael A.;
Ponnambalam, Sreenivasan

Publication type:

Article

Multidrug-resistant breast cancer: current perspectives.

Published in:

Breast Cancer: Targets & Therapy, 2014, v. 6, p. 1, doi. 10.2147/BCTT.S37638

By:

Martin, Heather L.;
Smith, Laura;
Tomlinson, Darren C.

Publication type:

Article

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.

Published in:

Advances in Urology, 2012, p. 1, doi. 10.1155/2012/429213

By:

di Martino, Erica;
Tomlinson, Darren C.;
Knowles, Margaret A.

Publication type:

Article

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.

Published in:

Traffic, 2016, v. 17, n. 1, p. 53, doi. 10.1111/tra.12341

By:

Smith, Gina A.;
Fearnley, Gareth W.;
Abdul‐Zani, Izma;
Wheatcroft, Stephen B.;
Tomlinson, Darren C.;
Harrison, Michael A.;
Ponnambalam, Sreenivasan

Publication type:

Article

Affimer reagents as tools in diagnosing plant virus diseases.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-43945-6

By:

Hesketh, Emma L.;
Tiede, Christian;
Adamson, Hope;
Adams, Thomas L.;
Byrne, Matthew J.;
Meshcheriakova, Yulia;
Kruse, Inga;
McPherson, Michael J.;
Lomonossoff, George P.;
Tomlinson, Darren C.;
Ranson, Neil A.

Publication type:

Article

Structural characterization and inhibition of the interaction between ch-TOG and TACC3.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 6, p. 1, doi. 10.1083/jcb.202407002

By:

Shelford, James;
Burgess, Selena G.;
Rostkova, Elena;
Richards, Mark W.;
Larocque, Gabrielle;
Sampson, Josephina;
Tiede, Christian;
Fielding, Alistair J.;
Daviter, Tina;
Tomlinson, Darren C.;
Calabrese, Antonio N.;
Pfuhl, Mark;
Bayliss, Richard;
Royle, Stephen J.

Publication type:

Article

Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation.

Published in:

Biomolecules (2218-273X), 2024, v. 14, n. 8, p. 1040, doi. 10.3390/biom14081040

By:

Tang, Anna A. S.;
Macdonald, Andrew;
McPherson, Michael J.;
Tomlinson, Darren C.

Publication type:

Article

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions.

Published in:

Angewandte Chemie, 2015, v. 127, n. 10, p. 3003, doi. 10.1002/ange.201410810

By:

Barnard, Anna;
Long, Kérya;
Martin, Heather L.;
Miles, Jennifer A.;
Edwards, Thomas A.;
Tomlinson, Darren C.;
Macdonald, Andrew;
Wilson, Andrew J.

Publication type:

Article

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 6, p. 1, doi. 10.1371/journal.pntd.0008364

By:

Álvarez-Rodríguez, Beatriz;
Tiede, Christian;
Hoste, Alexis C. R.;
Surtees, Rebecca A.;
Trinh, Chi;
Slack, Gillian S.;
Chamberlain, John;
Hewson, Roger;
Fresco, Alba;
Sastre, Patricia;
Tomlinson, Darren C.;
Millner, Paul A.;
Edwards, Thomas A.;
Barr, John N.

Publication type:

Article

Selection and characterisation of Affimers specific for CEA recognition.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-020-80354-6

By:

Shamsuddin, Shazana Hilda;
Jayne, David G.;
Tomlinson, Darren C.;
McPherson, Michael J.;
Millner, Paul A.

Publication type:

Article

Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection.

Published in:

Science Signaling, 2017, v. 10, n. 505, p. 1, doi. 10.1126/scisignal.aan0868

By:

Tang, Anna Ah-San;
Tiede, Christian;
Hughes, David J.;
McPherson, Michael;
Tomlinson, Darren C.

Publication type:

Article

Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology.

Published in:

Science Signaling, 2017, v. 10, n. 505, p. 1, doi. 10.1126/scisignal.aaj2005

By:

Hughes, David J.;
Tiede, Christian;
Penswick, Natalie;
Tang, Anna A. S.;
Trinh, Chi H.;
Mandal, Upasana;
Zajac, Katarzyna Z.;
Gaule, Thembaninskosi;
Howell, Gareth;
Edwards, Thomas A.;
Jianxin Duan;
Feyfant, Eric;
McPherson, Michael J.;
Tomlinson, Darren C.;
Whitehouse, Adrian

Publication type:

Article

High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0088338

By:

Martin, Heather L.;
Adams, Matthew;
Higgins, Julie;
Bond, Jacquelyn;
Morrison, Ewan E.;
Bell, Sandra M.;
Warriner, Stuart;
Nelson, Adam;
Tomlinson, Darren C.

Publication type:

Article

FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCγ/COX-2-Mediated Mechanisms.

Published in:

PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038972

By:

Tomlinson, Darren C.;
Baxter, Euan W.;
Loadman, Paul M.;
Hull, Mark A.;
Knowles, Margaret A.

Publication type:

Article

Site‐Specific Labeling of Affimers for DNA‐PAINT Microscopy.

Published in:

Angewandte Chemie International Edition, 2018, v. 57, n. 34, p. 11060, doi. 10.1002/anie.201804020

By:

Schlichthaerle, Thomas;
Eklund, Alexandra S.;
Schueder, Florian;
Strauss, Maximilian T.;
Jungmann, Ralf;
Tiede, Christian;
Curd, Alistair;
Peckham, Michelle;
Tomlinson, Darren C.;
Ries, Jonas

Publication type:

Article

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 10, p. 2960, doi. 10.1002/anie.201410810

By:

Barnard, Anna;
Long, Kérya;
Martin, Heather L.;
Miles, Jennifer A.;
Edwards, Thomas A.;
Tomlinson, Darren C.;
Macdonald, Andrew;
Wilson, Andrew J.

Publication type:

Article

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.

Published in:

PEDS: Protein Engineering, Design & Selection, 2014, v. 27, n. 5, p. 145, doi. 10.1093/protein/gzu007

By:

Tiede, Christian;
Tang, Anna A. S.;
Deacon, Sarah E.;
Mandal, Upasana;
Nettleship, Joanne E.;
Owen, Robin L.;
George, Suja E.;
Harrison, David J.;
Owens, Raymond J.;
Tomlinson, Darren C.;
McPherson, Michael J.

Publication type:

Article

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.

Published in:

Oncogene, 2005, v. 24, n. 33, p. 5218, doi. 10.1038/sj.onc.1208705

By:

Jebar, Adel H.;
Hurst, Carolyn D.;
Tomlinson, Darren C.;
Johnston, Colin;
Taylor, Claire F.;
Knowles, Margaret A.

Publication type:

Article