Works matching AU Tomchick, Diana R.

Results: 27

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer.

Published in:

PLoS Biology, 2008, v. 6, n. 3, p. e50, doi. 10.1371/journal.pbio.0060050

By:

Maojun Yang;
Bing Li;
Chyong-Jy Liu;
Tomchick, Diana R;
Machius, Mischa;
Rizo, Josep;
Hongtao Yu;
Xuelian Luo

Publication type:

Article

Structural Basis for a Munc13-1 Homodimer to Munc13-1/RIM Heterodimer Switch.

Published in:

PLoS Biology, 2006, v. 4, n. 7, p. e192, doi. 10.1371/journal.pbio.0040192

By:

Lu, Jun;
Machius, Mischa;
Dulubova, Irina;
Han Dai;
Südhof, Thomas C.;
Tomchick, Diana R.;
Rizo, Josep

Publication type:

Article

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.

Published in:

Nature, 2005, v. 433, n. 7025, p. 488, doi. 10.1038/nature03251

By:

Otomo, Takanori;
Tomchick, Diana R.;
Otomo, Chinatsu;
Panchal, Sanjay C.;
Machius, Mischa;
Rosen, Michael K.

Publication type:

Article

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Published in:

Science Translational Medicine, 2015, v. 7, n. 296, p. 1, doi. 10.1126/scitranslmed.aaa6645

By:

Phillips, Margaret A.;
Lotharius, Julie;
Marsh, Kennan;
White, John;
Dayan, Anthony;
White, Karen L.;
Njoroge, Jacqueline W.;
El Mazouni, Farah;
Yanbin Lao;
Kokkonda, Sreekanth;
Tomchick, Diana R.;
Xiaoyi Deng;
Laird, Trevor;
Bhatia, Sangeeta N.;
March, Sandra;
Ng, Caroline L.;
Fidock, David A.;
Wittlin, Sergio;
Lafuente-Monasterio, Maria;
Gamo Benito, Francisco Javier

Publication type:

Article

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.

Published in:

Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 4, p. 847, doi. 10.1002/pro.3133

By:

Brautigam, Chad. A.;
Deka, Ranjit K.;
Liu, Wei Z.;
Tomchick, Diana R.;
Norgard, Michael V.

Publication type:

Article

Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.

Published in:

MicrobiologyOpen, 2016, v. 5, n. 1, p. 21, doi. 10.1002/mbo3.306

By:

Deka, Ranjit K.;
Brautigam, Chad A.;
Liu, Wei Z.;
Tomchick, Diana R.;
Norgard, Michael V.

Publication type:

Article

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.

Published in:

PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0213423

By:

Peng, Wei;
de Souza Santos, Marcela;
Li, Yang;
Tomchick, Diana R.;
Orth, Kim

Publication type:

Article

Structural insights for selective disruption of Beclin 1 binding to Bcl-2.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05467-w

By:

Pan, Yun-Zu;
Liang, Qiren;
Tomchick, Diana R.;
De Brabander, Jef K.;
Rizo, Josep

Publication type:

Article

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.

Published in:

EMBO Journal, 2003, v. 22, n. 5, p. 1125, doi. 10.1093/emboj/cdg110

By:

Garrard, Sarah M.;
Capaldo, Christopher T.;
Gao, Lin;
Rosen, Michael K.;
Macara, Ian G.;
Tomchick, Diana R.

Publication type:

Article

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

Published in:

EMBO Journal, 2002, v. 21, n. 23, p. 6387, doi. 10.1093/emboj/cdf651

By:

Michaely, Peter;
Tomchick, Diana R.;
Machius, Mischa;
Anderson, Richard G. W.

Publication type:

Article

Structural and Biochemical Studies on PACSIN.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A994

By:

Panchal, Sanjay C.;
Tomchick, Diana R.;
Machius, Mischa;
Rosen, Michael K.

Publication type:

Article

Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery.

Published in:

PLoS Pathogens, 2024, v. 20, n. 5, p. 1, doi. 10.1371/journal.ppat.1012010

By:

Embry, Aaron;
Baggett, Nina S.;
Heisler, David B.;
White, Addison;
de Jong, Maarten F.;
Kocsis, Benjamin L.;
Tomchick, Diana R.;
Alto, Neal M.;
Gammon, Don B.

Publication type:

Article

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 10, p. 864, doi. 10.1038/nsmb.2880

By:

Hara, Kodai;
Zheng, Ge;
Qu, Qianhui;
Liu, Hong;
Ouyang, Zhuqing;
Chen, Zhe;
Tomchick, Diana R;
Yu, Hongtao

Publication type:

Article

Mechanism of actin filament nucleation by the bacterial effector VopL.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 9, p. 1068, doi. 10.1038/nsmb.2110

By:

Bingke Yu;
Hui-Chun Cheng;
Brautigam, Chad A.;
Tomchick, Diana R.;
Rosen, Michael K.

Publication type:

Article

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 3, p. 280, doi. 10.1038/nsmb.1758

By:

Ok-Ho Shin;
Jun Lu;
Jeong-Seop Rhee;
Tomchick, Diana R.;
Pang, Zhiping P.;
Wojcik, Sonja M.;
Camacho-Perez, Marcial;
Brose, Nils;
Machius, Mischa;
Rizo, Josep;
Rosenmund, Christian;
Südhof, Thomas C.

Publication type:

Article

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 6, p. 535, doi. 10.1038/nsmb1255

By:

Maojun Yang;
Culhane, Jeffrey C.;
Szewczuk, Lawrence M.;
Gocke, Christian B.;
Brautigam, Chad A.;
Tomchick, Diana R.;
Machius, Mischa;
Cole, Philip A.;
Hongtao Yu

Publication type:

Article

Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 9, p. 844, doi. 10.1038/nsmb817

By:

Han Dai;
Ok-Ho Shin;
Machius, Mischa;
Tomchick, Diana R.;
Südhof, Thomas C .;
Rizo, Josep

Publication type:

Article

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation.

Published in:

PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012896

By:

Otomo, Takanori;
Tomchick, Diana R.;
Otomo, Chinatsu;
Machius, Mischa;
Rosen, Michael K.

Publication type:

Article

Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7.

Published in:

PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012544

By:

Mingshan Xue;
Craig, Timothy K.;
Ok-Ho Shin;
Liyi Li;
Brautigam, Chad A.;
Tomchick, Diana R.;
Südhof, Thomas C.;
Rosenmund, Christian;
Rizo, Josep

Publication type:

Article

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 7, p. 555, doi. 10.1038/nsmb.3035

By:

Brewer, Kyle D;
Bacaj, Taulant;
Cavalli, Andrea;
Camilloni, Carlo;
Swarbrick, James D;
Liu, Jin;
Zhou, Amy;
Zhou, Peng;
Barlow, Nicholas;
Xu, Junjie;
Seven, Alpay B;
Prinslow, Eric A;
Voleti, Rashmi;
Häussinger, Daniel;
Bonvin, Alexandre M J J;
Tomchick, Diana R;
Vendruscolo, Michele;
Graham, Bim;
Südhof, Thomas C;
Rizo, Josep

Publication type:

Article

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

Published in:

Nature, 2011, v. 469, n. 7328, p. 107, doi. 10.1038/nature09593

By:

Selyunin, Andrey S.;
Sutton, Sarah E.;
Weigele, Bethany A.;
Reddick, L. Evan;
Orchard, Robert C.;
Bresson, Stefan M.;
Tomchick, Diana R.;
Alto, Neal M.

Publication type:

Article

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.30278

By:

Sung Jun Bae;
Lisheng Ni;
Osinski, Adam;
Tomchick, Diana R.;
Brautigam, Chad A.;
Xuelian Luo

Publication type:

Article

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.22567

By:

Junjie Xu;
Camacho, Marcial;
Yibin Xu;
Esser, Victoria;
Xiaoxia Liu;
Thorsten Trimbuch;
Yun-Zu Pan;
Cong Ma;
Tomchick, Diana R.;
Rosenmund, Christian;
Rizo, Josep

Publication type:

Article

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.20198

By:

Volkov, Oleg A.;
Kinch, Lisa;
Ariagno, Carson;
Xiaoyi Deng;
Shihua Zhong;
Grishin, Nick;
Tomchick, Diana R.;
Zhe Chen;
Phillips, Margaret A.

Publication type:

Article

Bile salt receptor complex activates a pathogenic type III secretion system.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.15718

By:

Peng Li;
Rivera-Cancel, Giomar;
Kinch, Lisa N.;
Salomon, Dor;
Tomchick, Diana R.;
Grishin, Nick V.;
Orth, Kim

Publication type:

Article

Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides.

Published in:

Journal of Biomolecular Structure & Dynamics, 2022, v. 40, n. 20, p. 10300, doi. 10.1080/07391102.2021.1942214

By:

Strand, Arne;
Shen, San-Tai;
Tomchick, Diana R.;
Wang, Junmei;
Wang, Chyung-Ru;
Deisenhofer, Johann

Publication type:

Article

Gain of Function NOTCH3 Variants Cause Familial Partial Lipodystrophy Due to Activation of Senescence Pathways.

Published in:

Diabetes, 2025, v. 74, n. 3, p. 427, doi. 10.2337/db24-0624

By:

Garg, Abhimanyu;
Xing, Chao;
Agarwal, Anil K.;
Westfall, Aundrea K.;
Tomchick, Diana R.;
Zhang, Xunzhi;
Xing, Michelle;
Brown, Rebecca J.

Publication type:

Article

Works matching AU Tomchick, Diana R.

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer.

Structural Basis for a Munc13-1 Homodimer to Munc13-1/RIM Heterodimer Switch.

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.

Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.

Structural insights for selective disruption of Beclin 1 binding to Bcl-2.

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

Structural and Biochemical Studies on PACSIN.

Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery.

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.

Mechanism of actin filament nucleation by the bacterial effector VopL.

Munc13 C<sub>2</sub>B domain is an activity-dependent Ca<sup>2+</sup> regulator of synaptic exocytosis.

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation.

Structural basis for the evolutionary inactivation of Ca<sup>2+</sup> binding to synaptotagmin 4.

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation.

Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7.

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C<sub>1</sub>C<sub>2</sub>BMUN.

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.

Bile salt receptor complex activates a pathogenic type III secretion system.

Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides.

Gain of Function NOTCH3 Variants Cause Familial Partial Lipodystrophy Due to Activation of Senescence Pathways.