Works by Toker, Alex

Results: 29

NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer.

Published in:

Molecular Oncology, 2015, v. 9, n. 6, p. 1140, doi. 10.1016/j.molonc.2015.02.004

By:

Kaunisto, Aura;
Henry, Whitney S.;
Montaser-Kouhsari, Laleh;
Jaminet, Shou-Ching;
Oh, Eun-Yeong;
Zhao, Li;
Luo, Hongbo R.;
Beck, Andrew H.;
Toker, Alex

Publication type:

Article

PI 3‐Kinase signaling: A journey in three AKTs.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0I219

By:

Toker, Alex

Publication type:

Article

The PI 3-Kinase and AKT Signaling Pathway in Cell Biology and Disease: From Discovery to Therapeutics.

Published in:

Italian Journal of Anatomy & Embryology / Archivio Italiano di Anatomia Ed Embriologia, 2023, p. 8

By:

Toker, Alex

Publication type:

Article

Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia.

Published in:

PLoS ONE, 2020, v. 15, n. 7, p. 1, doi. 10.1371/journal.pone.0232072

By:

Cohen, Emily B.;
Geck, Renee C.;
Toker, Alex

Publication type:

Article

The biology and biochemistry of diacylglycerol signalling.

Published in:

2005

By:

Toker, Alex

Publication type:

Proceeding

Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.

Published in:

Science Signaling, 2024, v. 17, n. 825, p. 1, doi. 10.1126/scisignal.adf2670

By:

Erickson, Emily C.;
You, Inchul;
Perry, Grace;
Dugourd, Aurelien;
Donovan, Katherine A.;
Crafter, Claire;
Johannes, Jeffrey W.;
Williamson, Stuart;
Moss, Jennifer I.;
Ros, Susana;
Ziegler, Robert E.;
Barry, Simon T.;
Fischer, Eric S.;
Gray, Nathanael S.;
Madsen, Ralitsa R.;
Toker, Alex

Publication type:

Article

Akt/PKB Signaling in Cancer.

Published in:

Cell Cycle, 2006, v. 5, n. 6, p. 603, doi. 10.4161/cc.5.6.2561

By:

Yoeli-Lerner, Merav;
Toker, Alex

Publication type:

Article

NF-κB Signaling.

Published in:

Cell Cycle, 2003, v. 2, n. 1, p. A8

By:

Storz, Peter;
Toker, Alex

Publication type:

Article

Akt isoform-specific signaling in breast cancer.

Published in:

Cell Adhesion & Migration, 2011, v. 5, n. 3, p. 211, doi. 10.4161/cam.5.3.15790

By:

Chin, Y. Rebecca;
Toker, Alex

Publication type:

Article

Akt2 regulates expression of the actin-bundling protein palladin

Published in:

FEBS Letters, 2010, v. 584, n. 23, p. 4769, doi. 10.1016/j.febslet.2010.10.056

By:

Chin, Y. Rebecca;
Toker, Alex

Publication type:

Article

FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases.

Published in:

Molecular & Cellular Biology, 2009, v. 29, n. 18, p. 4906, doi. 10.1128/MCB.00077-09

By:

Storz, Peter;
Döppler, Heike;
Copland, John A.;
Simpson, Kaylene J.;
Toker, Alex

Publication type:

Article

Signalling through the lipid products of phosphoinositide-3-OH kinase.

Published in:

Nature, 1997, v. 387, n. 6634, p. 673, doi. 10.1038/42648

By:

Toker, Alex;
Cantley, Lewis C.

Publication type:

Article

NFAT proteins: emerging roles in cancer progression.

Published in:

2009

By:

Mancini, Maria;
Toker, Alex

Publication type:

journal article

Stimulation of an Insulin Receptor Activates and Down-Regulates the Ca<sup>2+</sup>-Independent Protein Kinase C, Apl II, Through a Wortmannin-Sensitive Signaling Pathway in Aplysia.

Published in:

Journal of Neurochemistry, 1996, v. 67, n. 1, p. 220, doi. 10.1046/j.1471-4159.1996.67010220.x

By:

Sossin, Wayne S.;
Chen, Chin-Sih;
Toker, Alex

Publication type:

Article

Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.

Published in:

PLoS Genetics, 2021, v. 17, n. 11, p. 1, doi. 10.1371/journal.pgen.1009876

By:

Madsen, Ralitsa R.;
Erickson, Emily C.;
Rueda, Oscar M.;
Robin, Xavier;
Caldas, Carlos;
Toker, Alex;
Semple, Robert K.;
Vanhaesebroeck, Bart

Publication type:

Article

Protein kinase D mediates a stress-induced NF-?B activation and survival pathway.

Published in:

EMBO Journal, 2003, v. 22, n. 1, p. 109, doi. 10.1093/emboj/cdg009

By:

Storz, Peter;
Toker, Alex

Publication type:

Article

A rapid method for determining protein kinase phosphorylation specificity.

Published in:

Nature Methods, 2004, v. 1, n. 1, p. 27, doi. 10.1038/nmeth708

By:

Hutti, Jessica E.;
Jarrell, Emily T.;
Chang, James D.;
Abbott, Derek W.;
Storz, Peter;
Toker, Alex;
Cantley, Lewis C.;
Turk, Benjamin E.

Publication type:

Article

Minimizing Shear Stress in Cell Signaling Studies.

Published in:

Current Protocols, 2024, v. 4, n. 3, p. 1, doi. 10.1002/cpz1.1019

By:

Mendez, Josefina;
Toker, Alex

Publication type:

Article

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

Published in:

Nature Cell Biology, 2009, v. 11, n. 4, p. 397, doi. 10.1038/ncb1847

By:

Gao, Daming;
Inuzuka, Hiroyuki;
Tseng, Alan;
Chin, Rebecca Y.;
Toker, Alex;
Wei, Wenyi

Publication type:

Article

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex.

Published in:

Nature Cell Biology, 2005, v. 7, n. 9, p. 880, doi. 10.1038/ncb1289

By:

Hausser, Angelika;
Storz, Peter;
Märtens, Susanne;
Link, Gisela;
Toker, Alex;
Pfizenmaier, Klaus

Publication type:

Article

The role of NFAT transcription factors in integrin-mediated carcinoma invasion.

Published in:

Nature Cell Biology, 2002, v. 4, n. 7, p. 540, doi. 10.1038/ncb816

By:

Jauliac, Sebastien;
López-Rodriguez, Cristina;
Shaw, Leslie M.;
Brown, Lawrence F.;
Rao, Anjana;
Toker, Alex

Publication type:

Article

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

Published in:

Science Signaling, 2018, v. 11, n. 521, p. 1, doi. 10.1126/scisignal.aao3810

By:

Clement, Emilie;
Inuzuka, Hiroyuki;
Nihira, Naoe T.;
Wei, Wenyi;
Toker, Alex

Publication type:

Article

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.

Published in:

Science Signaling, 2017, v. 10, n. 510, p. 1, doi. 10.1126/scisignal.aao6604

By:

Lien, Evan C.;
Ghisolfi, Laura;
Geck, Renee C.;
Asara, John M.;
Toker, Alex

Publication type:

Article

Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers.

Published in:

Science Signaling, 2017, v. 10, n. 467, p. 1, doi. 10.1126/scisignal.aah4674

By:

Thomas, Clémence;
Henry, Whitney;
Cuiffo, Benjamin G.;
Collmann, Anthony Y.;
Marangoni, Elisabetta;
Benhamo, Vanessa;
Bhasin, Manoj K.;
Cheng Fan;
Fuhrmann, Laetitia;
Baldwin, Albert S.;
Perou, Charles;
Vincent-Salomon, Anne;
Toker, Alex;
Karnoub, Antoine E.

Publication type:

Article

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Published in:

Nature, 2014, v. 508, n. 7497, p. 541, doi. 10.1038/nature13079

By:

Liu, Pengda;
Begley, Michael;
Michowski, Wojciech;
Inuzuka, Hiroyuki;
Ginzberg, Miriam;
Gao, Daming;
Tsou, Peiling;
Gan, Wenjian;
Papa, Antonella;
Kim, Byeong Mo;
Wan, Lixin;
Singh, Amrik;
Zhai, Bo;
Yuan, Min;
Wang, Zhiwei;
Gygi, Steven P.;
Lee, Tae Ho;
Lu, Kun-Ping;
Toker, Alex;
Pandolfi, Pier Paolo

Publication type:

Article

The SCF<sub>β-TRCP</sub> E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Published in:

Science Signaling, 2017, v. 10, n. 460, p. 1, doi. 10.1126/scisignal.aah4117

By:

Kouhei Shimizu;
Hidefumi Fukushima;
Kohei Ogura;
Lien, Evan C.;
Nihira, Naoe Taira;
Jinfang Zhang;
North, Brian J.;
Guo, Ailan;
Katsuyuki Nagashima;
Tadashi Nakagawa;
Seira Hoshikawa;
Asami Watahiki;
Koji Okabe;
Aya Yamada;
Toker, Alex;
Asara, John M.;
Fukumoto, Satoshi;
Nakayama, Keiichi I.;
Nakayama, Keiko;
Hiroyuki Inuzuka

Publication type:

Article

Protein Kinase D Mediates Mitochondrion-to-Nucleus Signaling and Detoxification from Mitochondrial Reactive Oxygen Species.

Published in:

Molecular & Cellular Biology, 2005, v. 25, n. 19, p. 8520, doi. 10.1128/MCB.25.19.8520-8530.2005

By:

Storz, Peter;
Döppler, Heike;
Toker, Alex

Publication type:

Article

Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-ΚB in Oxidative Stress Signaling.

Published in:

Molecular & Cellular Biology, 2004, v. 24, n. 7, p. 2614, doi. 10.1128/MCB.24.7.2614-2626.2004

By:

Storz, Peter;
DÖppler, Heike;
Toker, Alex

Publication type:

Article

Signalling specificity in the Akt pathway in breast cancer.

Published in:

Biochemical Society Transactions, 2014, v. 42, n. 5, p. 1349, doi. 10.1042/BST20140160

By:

Clark, Abbe R.;
Toker, Alex

Publication type:

Article