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Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury.
- Published in:
- Physiological Reports, 2018, v. 6, n. 12, p. 1, doi. 10.14814/phy2.13753
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- Article
Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios.
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- AAPS Journal, 2021, v. 23, n. 4, p. 1, doi. 10.1208/s12248-021-00609-6
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- Article
Pre‐clinical Characterization of Absorption, Distribution, Metabolism and Excretion Properties of TAK‐063.
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- Basic & Clinical Pharmacology & Toxicology, 2018, v. 122, n. 6, p. 577, doi. 10.1111/bcpt.12964
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- Article
Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.
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- Pharmaceutical Research, 2019, v. 36, n. 5, p. N.PAG, doi. 10.1007/s11095-019-2613-8
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- Article
Utility of Göttingen minipigs for Prediction of Human Pharmacokinetic Profiles After Dermal Drug Application.
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- Pharmaceutical Research, 2017, v. 34, n. 11, p. 2415, doi. 10.1007/s11095-017-2247-7
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- Article
Relationship of MATE1 Inhibition and Cytotoxicity in Nephrotoxicity: Application for Safety Evaluation in Early Drug Discovery.
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- Toxicological Sciences, 2019, v. 170, n. 1, p. 223, doi. 10.1093/toxsci/kfz093
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- Article
Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor.
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- PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0122197
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- Article
Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension.
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- Bioscience, Biotechnology & Biochemistry, 2019, v. 83, n. 6, p. 1000, doi. 10.1080/09168451.2019.1584520
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- Article
Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792.
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- Pharmacology Research & Perspectives, 2019, v. 7, n. 5, p. 1, doi. 10.1002/prp2.517
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- Article
Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate‐salt hypertensive uni‐nephrectomized KKA<sup>y</sup> mice.
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- FASEB Journal, 2020, v. 34, n. 11, p. 14997, doi. 10.1096/fj.202001084R
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- Article
Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 5, p. 900, doi. 10.1002/cpt.1115
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- Article