Works by Tinti, Michele

Results: 19

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Published in:

Science Translational Medicine, 2025, v. 17, n. 806, p. 1, doi. 10.1126/scitranslmed.adu4564

By:

Tulloch, Lindsay B.;
Tawell, Hugh;
Taylor, Annie E.;
Lima, Marta Lopes;
Dawson, Alice;
Carvalho, Sandra;
Wall, Richard J.;
Corpas-Lopez, Victoriano;
Dey, Gourav;
Duggan, Jack;
Magalhaes, Luma Godoy;
Torrie, Leah S.;
Frame, Laura;
Robinson, David;
Patterson, Stephen;
Tinti, Michele;
Weaver, George W.;
Robinson, William J.;
Cal, Monica;
Kaiser, Marcel

Publication type:

Article

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61480-z

By:

Novotná, Markéta;
Tinti, Michele;
Faria, Joana R. C.;
Horn, David

Publication type:

Article

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52432-0

By:

Trenaman, Anna;
Tinti, Michele;
Wall, Richard J.;
Horn, David

Publication type:

Article

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52432-0

By:

Trenaman, Anna;
Tinti, Michele;
Wall, Richard J.;
Horn, David

Publication type:

Article

VirusMINT: a viral protein interaction database.

Published in:

Nucleic Acids Research, 2009, v. 37, n. suppl_1, p. D669, doi. 10.1093/nar/gkn739

By:

Chatr-aryamontri, Andrew;
Ceol, Arnaud;
Peluso, Daniele;
Nardozza, Aurelio;
Panni, Simona;
Sacco, Francesca;
Tinti, Michele;
Smolyar, Alex;
Castagnoli, Luisa;
Vidal, Marc;
Cusick, Michael E.;
Cesareni, Gianni

Publication type:

Article

Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes.

Published in:

Human Molecular Genetics, 2008, v. 17, n. 13, p. 2018, doi. 10.1093/hmg/ddn099

By:

Martinelli, Simone;
Torreri, Paola;
Tinti, Michele;
Stella, Lorenzo;
Bocchinfuso, Gianfranco;
Flex, Elisabetta;
Grottesi, Alessandro;
Ceccarini, Marina;
Palleschi, Antonio;
Cesareni, Gianni;
Castagnoli, Luisa;
Petrucci, Tamara C.;
Gelb, Bruce D.;
Tartaglia, Marco

Publication type:

Article

Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33109-y

By:

Marques, Catarina A.;
Ridgway, Melanie;
Tinti, Michele;
Cassidy, Andrew;
Horn, David

Publication type:

Article

Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei.

Published in:

PLoS Neglected Tropical Diseases, 2021, v. 15, n. 2, p. 1, doi. 10.1371/journal.pntd.0009132

By:

Sampaio Guther, Maria Lucia;
R. Prescott, Alan;
Kuettel, Sabine;
Tinti, Michele;
Ferguson, Michael A. J.

Publication type:

Article

14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides.

Published in:

Bioinformatics, 2015, v. 31, n. 14, p. 2276, doi. 10.1093/bioinformatics/btv133

By:

Madeira, Fábio;
Tinti, Michele;
Murugesan, Gavuthami;
Berrett, Emily;
Stafford, Margaret;
Toth, Rachel;
Cole, Christian;
MacKintosh, Carol;
Barton, Geoffrey J.

Publication type:

Article

An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-44043-y

By:

Faria, Joana R. C.;
Tinti, Michele;
Marques, Catarina A.;
Zoltner, Martin;
Yoshikawa, Harunori;
Field, Mark C.;
Horn, David

Publication type:

Article

Linear Motif Atlas for Phosphorylation-Dependent Signaling.

Published in:

Science Signaling, 2008, v. 1, n. 35, p. 1, doi. 10.1126/scisignal.1159433

By:

Miller, Martin Lee;
Jensen, Lars Juhl;
Diella, Francesca;
Jørgensen, Claus;
Tinti, Michele;
Lei Li;
Hsiung, Marilyn;
Parker, Sirlester A.;
Bordeaux, Jennifer;
Sicheritz-Ponten, Thomas;
Olhovsky, Marina;
Pasculescu, Adrian;
Alexander, Jes;
Knapp, Stefan;
Blom, Nikolaj;
Bork, Peer;
Shawn Li;
Cesareni, Gianni;
Pawson, Tony;
Turk, Benjamin E.

Publication type:

Article

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei.

Published in:

PLoS ONE, 2018, v. 13, n. 7, p. 1, doi. 10.1371/journal.pone.0201263

By:

Kelner, Anna;
Tinti, Michele;
Guther, Maria Lucia S.;
Foth, Bernardo J.;
Chappell, Lia;
Berriman, Matthew;
Cowling, Victoria Haigh;
Ferguson, Michael A. J.

Publication type:

Article

ProtNet: a tool for stochastic simulations of protein interaction networks dynamics.

Published in:

BMC Bioinformatics, 2007, v. 8, p. S4, doi. 10.1186/1471-2105-8-S1-S4

By:

Bernaschi, Massimo;
Castiglione, Filippo;
Ferranti, Alessandra;
Gavrila, Caius;
Tinti, Michele;
Cesareni, Gianni

Publication type:

Article

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.

Published in:

PLoS Pathogens, 2024, v. 20, n. 7, p. 1, doi. 10.1371/journal.ppat.1012382

By:

Tulloch, Lindsay B.;
Tinti, Michele;
Wall, Richard J.;
Weidt, Stefan K.;
Corpas- Lopez, Victoriano;
Dey, Gourav;
Smith, Terry K.;
Fairlamb, Alan H.;
Barrett, Michael P.;
Wyllie, Susan

Publication type:

Article

Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 14, p. e79, doi. 10.1093/nar/gkac319

By:

Altmann, Simone;
Rico, Eva;
Carvalho, Sandra;
Ridgway, Melanie;
Trenaman, Anna;
Donnelly, Hannah;
Tinti, Michele;
Wyllie, Susan;
Horn, David

Publication type:

Article

Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes.

Published in:

PLoS Pathogens, 2023, v. 19, n. 7, p. 1, doi. 10.1371/journal.ppat.1011530

By:

Escrivani, Douglas O.;
Scheidt, Viktor;
Tinti, Michele;
Faria, Joana;
Horn, David

Publication type:

Article

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome.

Published in:

Database: The Journal of Biological Databases & Curation, 2014, v. 2014, p. 1, doi. 10.1093/database/bat085

By:

Tinti, Michele;
Madeira, Fábio;
Murugesan, Gavuthami;
Hoxhaj, Gerta;
Toth, Rachel;
MacKintosh, Carol

Publication type:

Article

Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.

Published in:

PLoS ONE, 2021, v. 16, n. 3, p. 1, doi. 10.1371/journal.pone.0244699

By:

Ji, Zhe;
Tinti, Michele;
Ferguson, Michael A. J.

Publication type:

Article

Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei.

Published in:

PLoS Pathogens, 2021, v. 17, n. 6, p. 1, doi. 10.1371/journal.ppat.1009696

By:

Gilabert Carbajo, Carla;
Cornell, Lucy J.;
Madbouly, Youssef;
Lai, Zhihao;
Yates, Phillip A.;
Tinti, Michele;
Tiengwe, Calvin

Publication type:

Article