Works by Timson, David J.

Results: 62

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model.

Published in:

Biotechnology Letters, 2019, v. 41, n. 11, p. 1309, doi. 10.1007/s10529-019-02737-8

By:

Eardley, Joshua;
Dedi, Cinzia;
Dymond, Marcus;
Hallsworth, John E.;
Timson, David J.

Publication type:

Article

Yeast Cellular Stress: Impacts on Bioethanol Production.

Published in:

Fermentation (Basel), 2020, v. 6, n. 4, p. 1, doi. 10.3390/fermentation6040109

By:

Eardley, Joshua;
Timson, David J.

Publication type:

Article

Four Challenges for Better Biocatalysts.

Published in:

Fermentation (Basel), 2019, v. 5, n. 2, p. 1, doi. 10.3390/fermentation5020039

By:

Timson, David J.

Publication type:

Article

New model for the interaction of IQGAP1 with CDC42 and RAC1.

Published in:

Small GTPases, 2020, v. 11, n. 1, p. 16, doi. 10.1080/21541248.2017.1321169

By:

Nouri, Kazem;
Timson, David J.;
Ahmadian, Mohammad R.

Publication type:

Article

In Silico Prediction of the Effects of Mutations in the Human Mevalonate Kinase Gene: Towards a Predictive Framework for Mevalonate Kinase Deficiency.

Published in:

Annals of Human Genetics, 2015, v. 79, n. 6, p. 451, doi. 10.1111/ahg.12126

By:

Browne, Claire;
Timson, David J.

Publication type:

Article

The biology of habitat dominance; can microbes behave as weeds?

Published in:

Microbial Biotechnology, 2013, v. 6, n. 5, p. 453, doi. 10.1111/1751-7915.12027

By:

Cray, Jonathan A.;
Bell, Andrew N. W.;
Bhaganna, Prashanth;
Mswaka, Allen Y.;
Timson, David J.;
Hallsworth, John E.

Publication type:

Article

Hydrophobic substances induce water stress in microbial cells P. Bhaganna et al. Hydrophobic substances induce cellular water stress.

Published in:

Microbial Biotechnology, 2010, v. 3, n. 6, p. 701, doi. 10.1111/j.1751-7915.2010.00203.x

By:

Bhaganna, Prashanth;
Volkers, Rita J. M.;
Bell, Andrew N. W.;
Kluge, Kathrin;
Timson, David J.;
McGrath, John W.;
Ruijssenaars, Harald J.;
Hallsworth, John E.

Publication type:

Article

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1.

Published in:

Journal of Personalized Medicine, 2022, v. 12, n. 5, p. 747, doi. 10.3390/jpm12050747

By:

Salido, Eduardo;
Timson, David J.;
Betancor-Fernández, Isabel;
Palomino-Morales, Rogelio;
Anoz-Carbonell, Ernesto;
Pacheco-García, Juan Luis;
Medina, Milagros;
Pey, Angel L.

Publication type:

Article

Galactosemia: Towards Pharmacological Chaperones.

Published in:

Journal of Personalized Medicine, 2021, v. 11, n. 2, p. 106, doi. 10.3390/jpm11020106

By:

Banford, Samantha;
McCorvie, Thomas J.;
Pey, Angel L.;
Timson, David J.;
Braun, Ralf

Publication type:

Article

Calmodulin disruption impacts growth and motility in juvenile liver fluke.

Published in:

Parasites & Vectors, 2016, v. 9, p. 1, doi. 10.1186/s13071-016-1324-9

By:

McCammick, Erin M.;
McVeigh, Paul;
McCusker, Paul;
Timson, David J.;
Morphew, Russell M.;
Brophy, Peter M.;
Marks, Nikki J.;
Mousley, Angela;
Maule, Aaron G.

Publication type:

Article

Increased Promiscuity of Human Galactokinase Following Alteration of a Single Amino Acid Residue Distant from the Active Site.

Published in:

ChemBioChem, 2011, v. 12, n. 13, p. 2081, doi. 10.1002/cbic.201100308

By:

Kristiansson, Helena;
Timson, David J.

Publication type:

Article

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.

Published in:

Parasitology, 2015, v. 142, n. 11, p. 1375, doi. 10.1017/S0031182015000736

By:

THOMAS, CHARLOTTE M.;
TIMSON, DAVID J.

Publication type:

Article

UDP-galactose 4′-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors.

Published in:

Parasitology, 2015, v. 142, n. 3, p. 463, doi. 10.1017/S003118201400136X

By:

ZINSSER, VERONIKA L.;
LINDERT, STEFFEN;
BANFORD, SAMANTHA;
HOEY, ELIZABETH M.;
TRUDGETT, ALAN;
TIMSON, DAVID J.

Publication type:

Article

The Molecular Dynamics of Trypanosoma brucei UDP-Galactose 4′-Epimerase: A Drug Target for African Sleeping Sickness.

Published in:

Chemical Biology & Drug Design, 2012, v. 80, n. 2, p. 173, doi. 10.1111/j.1747-0285.2012.01392.x

By:

Friedman, Aaron J.;
Durrant, Jacob D.;
Pierce, Levi C. T.;
McCorvie, Thomas J.;
Timson, David J.;
McCammon, J. Andrew

Publication type:

Article

Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1).

Published in:

ChemBioChem, 2019, v. 20, n. 22, p. 2841, doi. 10.1002/cbic.201900313

By:

Megarity, Clare F.;
Abdel‐Aal Bettley, Hoda;
Caraher, M. Clare;
Scott, Katherine A.;
Whitehead, Roger C.;
Jowitt, Thomas A.;
Gutierrez, Aldo;
Bryce, Richard A.;
Nolan, Karen A.;
Stratford, Ian J.;
Timson, David J.

Publication type:

Article

Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.

Published in:

ChemBioChem, 2018, v. 19, n. 10, p. 1088, doi. 10.1002/cbic.201800025

By:

McAuley, Margaret;
Mesa‐Torres, Noel;
McFall, Aisling;
Morris, Sarah;
Huang, Meilan;
Pey, Angel L.;
Timson, David J.

Publication type:

Article

Escherichia coli Modulator of Drug Activity B (MdaB) Has Different Enzymological Properties to Eukaryote Quinone Oxidoreductases.

Published in:

Helvetica Chimica Acta, 2019, v. 102, n. 8, p. N.PAG, doi. 10.1002/hlca.201900135

By:

Megarity, Clare F.;
Timson, David J.

Publication type:

Article

Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay

Published in:

Cell Biology International, 2008, v. 32, n. 10, p. 1318, doi. 10.1016/j.cellbi.2008.07.008

By:

Pathmanathan, Sevvel;
Barnard, Emma;
Timson, David J.

Publication type:

Article

Structural and molecular biology of type I galactosemia: Disease-associated mutations.

Published in:

IUBMB Life, 2011, v. 63, n. 11, p. 949, doi. 10.1002/iub.510

By:

McCorvie, Thomas J.;
Timson, David J.

Publication type:

Article

The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase.

Published in:

IUBMB Life, 2011, v. 63, n. 9, p. 694, doi. 10.1002/iub.511

By:

McCorvie, Thomas J.;
Timson, David J.

Publication type:

Article

The structural and molecular biology of type III galactosemia.

Published in:

IUBMB Life, 2006, v. 58, n. 2, p. 83, doi. 10.1080/15216540600644846

By:

Timson, David J.

Publication type:

Article

Antioxidant properties and global metabolite screening of the probiotic yeast Saccharomyces cerevisiae var. boulardii.

Published in:

Journal of the Science of Food & Agriculture, 2017, v. 97, n. 9, p. 3039, doi. 10.1002/jsfa.8147

By:

Datta, Suprama;
Timson, David J;
Annapure, Uday S

Publication type:

Article

A mysterious family of calcium-binding proteins from parasitic worms.

Published in:

Biochemical Society Transactions, 2016, v. 44, n. 4, p. 1005, doi. 10.1042/BST20150270

By:

Thomas, Charlotte M.;
Timson, David J.

Publication type:

Article

Galactokinase promiscuity: a question of flexibility?

Published in:

Biochemical Society Transactions, 2016, v. 44, n. 1, p. 116, doi. 10.1042/BST20150188

By:

McAuley, Megan;
Kristiansson, Helena;
Meilan Huang;
Pey, Angel L.;
Timson, David J.

Publication type:

Article

The roles and applications of chaotropes and kosmotropes in industrial fermentation processes.

Published in:

2020

By:

Timson, David J.

Publication type:

Literature Review

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-59460-y

By:

Ferraro, Florencia;
Corvo, Ileana;
Bergalli, Lucia;
Ilarraz, Andrea;
Cabrera, Mauricio;
Gil, Jorge;
Susuki, Brian M.;
Caffrey, Conor R.;
Timson, David J.;
Robert, Xavier;
Guillon, Christophe;
Freire, Teresa;
Álvarez, Guzmán

Publication type:

Article

Characterisation of two calmodulin-like proteins from the liver fluke, Fasciola hepatica.

Published in:

Biological Chemistry, 2007, v. 388, n. 6, p. 593, doi. 10.1515/BC.2007.076

By:

Russell, Sean L.;
McFerran, Neil V.;
Hoey, Elizabeth M.;
Trudgett, Alan;
Timson, David J.

Publication type:

Article

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer.

Published in:

Biomolecules (2218-273X), 2019, v. 9, n. 11, p. 728, doi. 10.3390/biom9110728

By:

Vankova, Pavla;
Salido, Eduardo;
Timson, David J.;
Man, Petr;
Pey, Angel L.

Publication type:

Article

Glycerol enhances fungal germination at the water-activity limit for life.

Published in:

Environmental Microbiology, 2017, v. 19, n. 3, p. 947, doi. 10.1111/1462-2920.13530

By:

Stevenson, Andrew;
Hamill, Philip G.;
Medina, Ángel;
Kminek, Gerhard;
Rummel, John D.;
Dijksterhuis, Jan;
Timson, David J.;
Magan, Naresh;
Leong, Su ‐ Lin L.;
Hallsworth, John E.

Publication type:

Article

Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life.

Published in:

Environmental Microbiology, 2015, v. 17, n. 2, p. 257, doi. 10.1111/1462-2920.12598

By:

Stevenson, Andrew;
Burkhardt, Jürgen;
Cockell, Charles S.;
Cray, Jonathan A.;
Dijksterhuis, Jan;
Fox‐Powell, Mark;
Kee, Terence P.;
Kminek, Gerhard;
McGenity, Terry J.;
Timmis, Kenneth N.;
Timson, David J.;
Voytek, Mary A.;
Westall, Frances;
Yakimov, Michail M.;
Hallsworth, John E.

Publication type:

Article

A universal measure of chaotropicity and kosmotropicity.

Published in:

Environmental Microbiology, 2013, v. 15, n. 1, p. 287, doi. 10.1111/1462-2920.12018

By:

Cray, Jonathan A.;
Russell, John T.;
Timson, David J.;
Singhal, Rekha S.;
Hallsworth, John E.

Publication type:

Article

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places.

Published in:

Bioscience Reports, 2019, v. 39, n. 1, p. 1, doi. 10.1042/BSR20180459

By:

Pey, Angel L.;
Megarity, Clare F.;
Timson, David J.

Publication type:

Article

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var . boulardii.

Published in:

Bioscience Reports, 2017, v. 37, n. 2, p. 1, doi. 10.1042/BSR20160529

By:

Datta, Suprama;
Annapure, Uday S.;
Timson, David J.

Publication type:

Article

IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.

Published in:

Bioscience Reports, 2011, v. 31, n. 5, p. 371, doi. 10.1042/BSR20100123

By:

ATCHESON, Erwan;
HAMILTON, Elaine;
PATHMANATHAN, Sevvel;
GREER, Brett;
HARRIOTT, Pat;
TIMSON, David J.

Publication type:

Article

Interactions of the 67 kDa laminin receptor and its precursor with laminin.

Published in:

Bioscience Reports, 2010, v. 30, n. 2, p. 73, doi. 10.1042/BSR20090023

By:

FATEHULLAH, Aliya;
DOHERTY, Caroline;
PIVATO, Géraldine;
ALLEN, George;
DEVINE, Lynda;
NELSON, John;
TIMSON, David J.

Publication type:

Article

The 67 kDa laminin receptor: structure, function and role in disease.

Published in:

Bioscience Reports, 2008, v. 28, n. 1, p. 33, doi. 10.1042/BSR20070004

By:

NELSON, John;
McFERRAN, Neil V.;
PIVATO, Géraldine;
CHAMBERS, Emma;
DOHERTY, Caroline;
STEELE, David;
TIMSON, David J.

Publication type:

Article

A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1.

Published in:

Molecular & Cellular Biochemistry, 2012, v. 371, n. 1/2, p. 217, doi. 10.1007/s11010-012-1438-0

By:

Andrews, William J.;
Bradley, Conor A.;
Hamilton, Elaine;
Daly, Clare;
Mallon, Thérèse;
Timson, David J.

Publication type:

Article

Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change.

Published in:

Molecular & Cellular Biochemistry, 2011, v. 348, n. 1/2, p. 109, doi. 10.1007/s11010-010-0644-x

By:

Houston, David F.;
Timson, David J.

Publication type:

Article

In Silico Analysis of the Effects of Point Mutations on α-Globin: Implications for α-Thalassemia.

Published in:

Hemoglobin, 2020, v. 44, n. 2, p. 89, doi. 10.1080/03630269.2020.1739067

By:

Horri-Naceur, Agathe;
Timson, David J.

Publication type:

Article

Purple sweet potato colour - a potential therapy for galactosemia?

Published in:

International Journal of Food Sciences & Nutrition, 2014, v. 65, n. 4, p. 391, doi. 10.3109/09637486.2013.860586

By:

Timson, David J.

Publication type:

Article

The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity.

Published in:

Antioxidants, 2020, v. 9, n. 9, p. 772, doi. 10.3390/antiox9090772

By:

Anoz-Carbonell, Ernesto;
Timson, David J.;
Pey, Angel L.;
Medina, Milagros

Publication type:

Article

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.

Published in:

FEBS Letters, 2014, v. 588, n. 9, p. 1666, doi. 10.1016/j.febslet.2014.02.063

By:

Megarity, Clare F.;
Gill, James R.E.;
Clare Caraher, M.;
Stratford, Ian J.;
Nolan, Karen A.;
Timson, David J.

Publication type:

Article

Triose phosphate isomerase from the blood fluke Schistosoma mansoni: Biochemical characterisation of a potential drug and vaccine target.

Published in:

FEBS Letters, 2013, v. 587, n. 21, p. 3422, doi. 10.1016/j.febslet.2013.09.022

By:

Zinsser, Veronika L.;
Farnell, Edward;
Dunne, David W.;
Timson, David J.

Publication type:

Article

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

Published in:

Scientific Reports, 2017, p. 44532, doi. 10.1038/srep44532

By:

Medina-Carmona, Encarnación;
Neira, Jose L.;
Salido, Eduardo;
Fuchs, Julian E.;
Palomino-Morales, Rogelio;
Timson, David J.;
Pey, Angel L.

Publication type:

Article

Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Published in:

Scientific Reports, 2016, p. 21939, doi. 10.1038/srep21939

By:

Medina-Carmona, Encarnación;
Palomino-Morales, Rogelio J.;
Fuchs, Julian E.;
Padín-Gonzalez, Esperanza;
Mesa-Torres, Noel;
Salido, Eduardo;
Timson, David J.;
Pey, Angel L.

Publication type:

Article

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Published in:

Scientific Reports, 2016, p. 20331, doi. 10.1038/srep20331

By:

Encarnación, Medina-Carmona;
Palomino-Morales, Rogelio J.;
Fuchs, Julian E.;
Esperanza, Padín-Gonzalez;
Noel, Mesa-Torres;
Salido, Eduardo;
Timson, David J.;
Pey, Angel L.

Publication type:

Article

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 18, p. 3531, doi. 10.1093/hmg/ddx238

By:

Medina-Carmona, Encarnación;
Fuchs, Julian E.;
Gavira, Jose A.;
Mesa-Torres, Noel;
Neira, Jose L.;
Salido, Eduardo;
Palomino-Morales, Rogelio;
Burgos, Miguel;
Timson, David J.;
Pey, Angel L.

Publication type:

Article

Galactose epimerase deficiency: lessons from the GalNet registry.

Published in:

2022

By:

Derks, Britt;
Demirbas, Didem;
Arantes, Rodrigo R.;
Banford, Samantha;
Burlina, Alberto B.;
Cabrera, Analía;
Chiesa, Ana;
Couce, M. Luz;
Dionisi-Vici, Carlo;
Gautschi, Matthias;
Grünewald, Stephanie;
Morava, Eva;
Möslinger, Dorothea;
Scholl-Bürgi, Sabine;
Skouma, Anastasia;
Stepien, Karolina M.;
Timson, David J.;
Berry, Gerard T.;
Rubio-Gozalbo, M. Estela

Publication type:

journal article

Functional domains of the human epididymal protease inhibitor, eppin.

Published in:

FEBS Journal, 2008, v. 275, n. 8, p. 1742, doi. 10.1111/j.1742-4658.2008.06333.x

By:

McCrudden, Maelíosa T. C.;
Dafforn, Tim R.;
Houston, David F.;
Turkington, Philip T.;
Timson, David J.

Publication type:

Article

Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase.

Published in:

FEBS Journal, 2005, v. 272, n. 23, p. 6170, doi. 10.1111/j.1742-4658.2005.05017.x

By:

Timson, David J.

Publication type:

Article