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Co-targeting BCL-X<sub>L</sub> and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice.
- Published in:
- Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-022-01296-8
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- Article
BCL-X<sub>L</sub> PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRAS<sup>G12C</sup>-mutated cancers.
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- Journal of Hematology & Oncology, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13045-022-01241-3
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- Article
BCL-X<sub>L</sub> PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRAS<sup>G12C</sup>-mutated cancers.
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- Journal of Hematology & Oncology, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13045-022-01241-3
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- Article
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27210-x
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- Article
Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.
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- Biofactors, 2017, v. 43, n. 2, p. 152, doi. 10.1002/biof.1315
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- Article
DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas.
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- Journal of Hematology & Oncology, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13045-020-00928-9
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- Article
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
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- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15838-0
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- Article
Abietic acid attenuates RANKL induced osteoclastogenesis and inflammation associated osteolysis by inhibiting the NF‐KB and MAPK signaling.
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- Journal of Cellular Physiology, 2019, v. 234, n. 1, p. 443, doi. 10.1002/jcp.26575
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- Article
Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling.
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- Journal of Molecular Medicine, 2017, v. 95, n. 10, p. 1065, doi. 10.1007/s00109-017-1553-1
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- Article
Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells.
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- Apoptosis, 2014, v. 19, n. 7, p. 1148, doi. 10.1007/s10495-014-0991-2
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- Article