Works by Thorson, Jon S.

Results: 67

Preclinical Pharmacokinetic Evaluation of Mithramycin and Mithramycin SA Tryptophan-Conjugated Analog.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 765, doi. 10.3390/pharmaceutics17060765

By:

Niloy, Kumar Kulldeep;
Horn, Jamie;
Bhuiyan, Nazmul H.;
Shaaban, Khaled A.;
Bhosale, Suhas S.;
Prisinzano, Thomas E.;
Thorson, Jon S.;
Rohr, Jurgen;
Leggas, Markos

Publication type:

Article

OleD Loki as a Catalyst for Hydroxamate Glycosylation.

Published in:

ChemBioChem, 2020, v. 21, n. 7, p. 952, doi. 10.1002/cbic.201900601

By:

Hughes, Ryan R.;
Shaaban, Khaled A.;
Ponomareva, Larissa V.;
Horn, Jamie;
Zhang, Chunhui;
Zhan, Chang‐Guo;
Voss, S. Randal;
Leggas, Markos;
Thorson, Jon S.

Publication type:

Article

OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.

Published in:

ChemBioChem, 2017, v. 18, n. 4, p. 363, doi. 10.1002/cbic.201600676

By:

Hughes, Ryan R.;
Shaaban, Khaled A.;
Zhang, Jianjun;
Cao, Hongnan;
Phillips, George N.;
Thorson, Jon S.

Publication type:

Article

Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.

Published in:

ChemBioChem, 2015, v. 16, n. 15, p. 2141, doi. 10.1002/cbic.201500365

By:

Peltier‐Pain, Pauline;
Singh, Shanteri;
Thorson, Jon S.

Publication type:

Article

Characterization of the Calicheamicin Orsellinate C2- O-Methyltransferase CalO6.

Published in:

ChemBioChem, 2014, v. 15, n. 10, p. 1418, doi. 10.1002/cbic.201402119

By:

Singh, Shanteri;
Nandurkar, Nitin S.;
Thorson, Jon S.

Publication type:

Article

A Simple Strategy for Glycosyltransferase-Catalyzed Aminosugar Nucleotide Synthesis.

Published in:

ChemBioChem, 2014, v. 15, n. 5, p. 647, doi. 10.1002/cbic.201300779

By:

Zhang, Jianjun;
Singh, Shanteri;
Hughes, Ryan R.;
Zhou, Maoquan;
Sunkara, Manjula;
Morris, Andrew J.;
Thorson, Jon S.

Publication type:

Article

Substrate Specificity of the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII: Opportunities, Limitations, and Mechanistic HypothesesThis work was supported in part by the National Institutes of Health (grants GM 35 906 and GM 54 346 (H.-w.L.) and AI 52 218, CA 84 374 and GM 70 637) and an NCDDG grant (U19 CA 113 297) from the National Cancer Institute (J.S.T.).

Published in:

Angewandte Chemie, 2006, v. 118, n. 17, p. 2814, doi. 10.1002/ange.200503195

By:

Svetlana A. Borisova;
Changsheng Zhang;
Haruko Takahashi;
Hua Zhang;
Alexander W. Wong;
Jon S. Thorson;
Hung-wen Liu

Publication type:

Article

Die Glycosyltransferase UrdGT2 katalysiert sowohl C- als auch O-glycosidischen Zuckertransfer ( Diese Arbeit wurde durch die Deutsche Forschungsgemeinschaft gefördert (Projektförderung für A.B., Förderkennzeichen 5-1). Wir danken Volker Brecht, Albert-Ludwigs-Universität Freiburg, für die Durchführung der NMR-Experimente. )

Published in:

Angewandte Chemie, 2004, v. 116, n. 22, p. 3022, doi. 10.1002/ange.200453758

By:

Clemens Dürr;
Dirk Hoffmeister;
Sven-Eric Wohlert;
Koji Ichinose;
Monika Weber;
Ursula von Mulert;
Jon S. Thorson;
Andreas Bechthold

Publication type:

Article

Antibiotic optimization via in vitro glycorandomization.

Published in:

Nature Biotechnology, 2003, v. 21, n. 12, p. 1467, doi. 10.1038/nbt909

By:

Jiqing Jiang;
Jianchun Liao, Barry I.;
Changsheng Zhang, Barry I.;
Thorson, Jon S.;
Xun Fu, Jon S.;
Albermann, Christoph

Publication type:

Article

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

Published in:

Nature Biotechnology, 2003, v. 21, n. 2, p. 187, doi. 10.1038/nbt784

By:

Zazopoulos, Emmanuel;
Huang, Kexue;
Staffa, Alfredo;
Liu, Wen;
Bachmann, Brian O.;
Nonaka, Koichi;
Ahlert, Joachim;
Thorson, Jon S.;
Shen, Ben;
Farnet, Chris M.

Publication type:

Article

The native production of the sesquiterpene isopterocarpolone by Streptomyces sp. RM-14-6.

Published in:

Natural Product Research, 2014, v. 28, n. 5, p. 337, doi. 10.1080/14786419.2013.855932

By:

Shaaban, Khaled A.;
Singh, Shanteri;
Elshahawi, Sherif I.;
Wang, Xiachang;
Ponomareva, Larissa V.;
Sunkara, Manjula;
Copley, Gregory C.;
Hower, James C.;
Morris, Andrew J.;
Kharel, Madan K.;
Thorson, Jon S.

Publication type:

Article

Dihydroisocoumarins produced by Diaporthe cf. heveae LGMF1631 inhibiting citrus pathogens.

Published in:

Folia Microbiologica, 2020, v. 65, n. 2, p. 381, doi. 10.1007/s12223-019-00746-8

By:

Savi, Daiani Cristina;
Noriler, Sandriele Aparecida;
Ponomareva, Larissa V.;
Thorson, Jon S.;
Rohr, Jürgen;
Glienke, Chirlei;
Shaaban, Khaled A.

Publication type:

Article

Secondary metabolites produced by Microbacterium sp. LGMB471 with antifungal activity against the phytopathogen Phyllosticta citricarpa.

Published in:

Folia Microbiologica, 2019, v. 64, n. 3, p. 453, doi. 10.1007/s12223-018-00668-x

By:

Savi, Daiani Cristina;
Shaaban, Khaled A.;
Gos, Francielly M. W.;
Thorson, Jon S.;
Glienke, Chirlei;
Rohr, Jürgen

Publication type:

Article

Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds.

Published in:

Folia Microbiologica, 2018, v. 63, n. 4, p. 499, doi. 10.1007/s12223-018-0587-2

By:

de Medeiros, Aliandra G.;
Savi, Daiani C.;
Mitra, Prithiba;
Shaaban, Khaled A.;
Jha, Amit K.;
Thorson, Jon S.;
Rohr, Jürgen;
Glienke, Chirlei

Publication type:

Article

Chemical genetics of regeneration: Contrasting temporal effects of CoCl<sub>2</sub> on axolotl tail regeneration.

Published in:

Developmental Dynamics, 2021, v. 250, n. 6, p. 852, doi. 10.1002/dvdy.294

By:

Baddar, Nour W. Al Haj;
Dwaraka, Varun B.;
Ponomareva, Larissa V.;
Thorson, Jon S.;
Voss, S. Randal

Publication type:

Article

The crystal structure of DynF from the dynemicin‐biosynthesis pathway of Micromonospora chersina.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2022, v. 78, n. 1, p. 1, doi. 10.1107/S2053230X21012322

By:

Kosgei, Abigael J.;
Miller, Mitchell D.;
Bhardwaj, Minakshi;
Xu, Weijun;
Thorson, Jon S.;
Van Lanen, Steven G.;
Phillips, George N.

Publication type:

Article

Structural characterization of DynU16, a START/Bet v1‐like protein involved in dynemicin biosynthesis.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2021, v. 77, n. 10, p. 328, doi. 10.1107/S2053230X21008943

By:

Alvarado, Sarah K.;
Miller, Mitchell D.;
Bhardwaj, Minakshi;
Thorson, Jon S.;
Van Lanen, Steven G.;
Phillips, George N.

Publication type:

Article

Endophytes of Brazilian Medicinal Plants With Activity Against Phytopathogens.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.714750

By:

Iantas, Jucélia;
Savi, Daiani Cristina;
Schibelbein, Renata da Silva;
Noriler, Sandriele Aparecida;
Assad, Beatriz Marques;
Dilarri, Guilherme;
Ferreira, Henrique;
Rohr, Jürgen;
Thorson, Jon S.;
Shaaban, Khaled A.;
Glienke, Chirlei

Publication type:

Article

Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 46, p. 8889, doi. 10.1002/anie.200803508

By:

Gantt, Richard W.;
Goff, Randal D.;
Williams, Gavin J.;
Thorson, Jon S.

Publication type:

Article

Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 5, p. 306, doi. 10.1038/s41429-019-0154-3

By:

Savi, Daiani C.;
Shaaban, Khaled A.;
Mitra, Prithiba;
Ponomareva, Larissa V.;
Thorson, Jon S.;
Glienke, Chirlei;
Rohr, Jürgen

Publication type:

Article

Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 8, p. 571, doi. 10.1038/ja.2014.37

By:

Wang, Xiachang;
Shaaban, Khaled A;
Elshahawi, Sherif I;
Ponomareva, Larissa V;
Sunkara, Manjula;
Copley, Gregory C;
Hower, James C;
Morris, Andrew J;
Kharel, Madan K;
Thorson, Jon S

Publication type:

Article

Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 3, p. 223, doi. 10.1038/ja.2013.113

By:

Shaaban, Khaled A;
Singh, Shanteri;
Elshahawi, Sherif I;
Wang, Xiachang;
Ponomareva, Larissa V;
Sunkara, Manjula;
Copley, Gregory C;
Hower, James C;
Morris, Andrew J;
Kharel, Madan K;
Thorson, Jon S

Publication type:

Article

Antibacterial Activity of Endophytic Actinomycetes Isolated from the Medicinal Plant Vochysia divergens (Pantanal, Brazil).

Published in:

Frontiers in Microbiology, 2017, p. 1, doi. 10.3389/fmicb.2017.01642

By:

Gos, Francielly M. W. R.;
Savi, Daiani C.;
Shaaban, Khaled A.;
Thorson, Jon S.;
Aluizio, Rodrigo;
Possiede, Yvelise M.;
Rohr, Jürgen;
Glienke, Chirlei

Publication type:

Article

Soils and spoils: mineralogy and geochemistry of mining and processing wastes from lead and zinc mining at the Gratz Mine, Owen County, Kentucky.

Published in:

Journal of Soils & Sediments: Protection, Risk Assessment, & Remediation, 2022, v. 22, n. 6, p. 1773, doi. 10.1007/s11368-022-03171-6

By:

Hower, James C.;
Fiket, Željka;
Henke, Kevin R.;
Hiett, John K.;
Thorson, Jon S.;
Kharel, Madan;
Dai, Shifeng;
Silva, Luis F. O.;
Oliveira, Marcos L. S.

Publication type:

Article

Taxonomic and Metabolomics Profiling of Actinobacteria Strains from Himalayan Collection Sites in Pakistan.

Published in:

Current Microbiology, 2021, v. 78, n. 8, p. 3044, doi. 10.1007/s00284-021-02557-y

By:

Cheema, Mohsin T.;
Ponomareva, Larissa V.;
Liu, Tao;
Voss, S. Randal;
Thorson, Jon S.;
Shaaban, Khaled A.;
Sajid, Imran

Publication type:

Article

HDAC Regulates Transcription at the Outset of Axolotl Tail Regeneration.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-43230-6

By:

Voss, S. Randal;
Ponomareva, Larissa V.;
Dwaraka, Varun B.;
Pardue, Kaitlin E.;
Baddar, Nour W. Al Haj;
Rodgers, A. Katherine;
Woodcock, M. Ryan;
Qiu, Qingchao;
Crowner, Anne;
Blichmann, Dana;
Khatri, Shivam;
Thorson, Jon S.

Publication type:

Article

The crystal structure of AbsH3: A putative flavin adenine dinucleotide-dependent reductase in the abyssomicin biosynthesis pathway.

Published in:

Proteins, 2021, v. 89, n. 1, p. 132, doi. 10.1002/prot.25994

By:

Clinger, Jonathan A.;
Xiachang Wang;
Wenlong Cai;
Yanyan Zhu;
Miller, Mitchell D.;
Chang-Guo Zhan;
Van Lanen, Steven G.;
Thorson, Jon S.;
Phillips Jr, George N.

Publication type:

Article

Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.

Published in:

Proteins, 2015, v. 83, n. 8, p. 1547, doi. 10.1002/prot.24844

By:

Singh, Shanteri;
Kim, Youngchang;
Wang, Fengbin;
Bigelow, Lance;
Endres, Michael;
Kharel, Madan K.;
Babnigg, Gyorgy;
Bingman, Craig A.;
Joachimiak, Andrzej;
Thorson, Jon S.;
Phillips, George N.

Publication type:

Article

Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis.

Published in:

Proteins, 2013, v. 81, n. 7, p. 1277, doi. 10.1002/prot.24289

By:

Wang, Fengbin;
Zhou, Maoquan;
Singh, Shanteri;
Yennamalli, Ragothaman M.;
Bingman, Craig A.;
Thorson, Jon S.;
Phillips, George N.

Publication type:

Article

Structural characterization of the mitomycin 7- O-methyltransferase.

Published in:

Proteins, 2011, v. 79, n. 7, p. 2181, doi. 10.1002/prot.23040

By:

Singh, Shanteri;
Chang, Aram;
Goff, Randal D.;
Bingman, Craig A.;
Grüschow, Sabine;
Sherman, David H.;
Phillips, George N.;
Thorson, Jon S.

Publication type:

Article

Structural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway.

Published in:

Proteins, 2009, v. 74, n. 1, p. 50, doi. 10.1002/prot.22131

By:

McCoy, Jason G.;
Johnson, Heather D.;
Singh, Shanteri;
Bingman, Craig A.;
Lei, In-Kyoung;
Thorson, Jon S.;
Phillips, George N.

Publication type:

Article

The structure of flavin-dependent tryptophan 7-halogenase RebH.

Published in:

Proteins, 2008, v. 70, n. 1, p. 289, doi. 10.1002/prot.21627

By:

Bitto, Eduard;
Huang, Yu;
Bingman, Craig A.;
Singh, Shanteri;
Thorson, Jon S.;
Phillips, George N.

Publication type:

Article

Bioprospecting of desert actinobacteria with special emphases on griseoviridin, mitomycin C and a new bacterial metabolite producing Streptomyces sp. PU-KB10–4.

Published in:

BMC Microbiology, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12866-023-02770-8

By:

Saleem, Maira;
Hassan, Ashba;
Li, Feina;
Lu, Qinpei;
Ponomareva, Larissa V.;
Parkin, Sean;
Sun, Chenghang;
Thorson, Jon S.;
Shaaban, Khaled A.;
Sajid, Imran

Publication type:

Article

The in vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI.

Published in:

ChemBioChem, 2008, v. 9, n. 15, p. 2506, doi. 10.1002/cbic.200800349

By:

Zhang, Changsheng;
Moretti, Rocco;
Jiang, Jiqing;
Thorson, Jon S.

Publication type:

Article

Selective Detection of Sugar Phosphates by Capillary Electrophoresis/Mass Spectrometry and Its Application to an Engineered E. coli Host.

Published in:

ChemBioChem, 2007, v. 8, n. 10, p. 1180, doi. 10.1002/cbic.200700116

By:

Hui, Joseph P. M.;
Yang, Jie;
Thorson, Jon S.;
Soo, Evelyn C.

Publication type:

Article

The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification.

Published in:

ChemBioChem, 2007, v. 8, n. 4, p. 385, doi. 10.1002/cbic.200600509

By:

Zhang, Changsheng;
Fu, Qiang;
Albermann, Christoph;
Li, Lingjun;
Thorson, Jon S.

Publication type:

Article

RebG- and RebM-Catalyzed Indolocarbazole Diversification.

Published in:

ChemBioChem, 2006, v. 7, n. 5, p. 795, doi. 10.1002/cbic.200500504

By:

Changsheng Zhang;
Christoph Albermann;
Xun Fu;
Noel R. Peters;
John D. Chisholm;
Guisheng Zhang;
Eric J. Gilbert;
Peng George Wang;
David L. Van Vranken;
Jon S. Thorson

Publication type:

Article

Structure-Based Enhancement of the First Anomeric Glucokinase.

Published in:

ChemBioChem, 2004, v. 5, n. 7, p. 992, doi. 10.1002/cbic.200400041

By:

Jie Yang;
Lesley Liu;
Jon S. Thorson

Publication type:

Article

Mechanistic Implications of Escherichia coli Galactokinase Structure-Based Engineering.

Published in:

ChemBioChem, 2004, v. 5, n. 7, p. 989, doi. 10.1002/cbic.200400003

By:

Dirk Hoffmeister;
Jon S. Thorson

Publication type:

Article

Structure-Based Enzyme Engineering and Its Impact on In Vitro Glycorandomization.

Published in:

ChemBioChem, 2004, v. 5, n. 1, p. 16, doi. 10.1002/cbic.200300620

By:

Jon S. Thorson;
William A. Barton;
Dirk Hoffmeister;
Christoph Albermann;
Dimitar B. Nikolov

Publication type:

Article

Application of the Nucleotidylyltransferase E<sub>p</sub> toward the Chemoenzymatic Synthesis of dTDP-Desosamine Analogues ( dTDP=deoxythymidine diphosphate.).

Published in:

ChemBioChem, 2003, v. 4, n. 5, p. 443, doi. 10.1002/cbic.200200566

By:

Jiqing Jiang;
Christoph Albermann;
Jon S. Thorson

Publication type:

Article

The Biosynthesis of Indolocarbazoles in a Heterologous E. coli Host.

Published in:

ChemBioChem, 2003, v. 4, n. 1, p. 114, doi. 10.1002/cbic.200390004

By:

Hyun, Chang-Gu;
Bililign, Tsion;
Liao, Jianchun;
Thorson, Jon S.

Publication type:

Article

On the Origin of Deoxypentoses: Evidence to Support a Glucose Progenitor in the Biosynthesis of Calicheamicin.

Published in:

ChemBioChem, 2002, v. 3, n. 11, p. 1143, doi. 10.1002/1439-7633(20021104)3:11<1143::AID-CBIC1143>3.0.CO;2-W

By:

Bililign, Tsion;
Shepard, Erica M.;
Ahlert, Joachim;
Thorson, Jon S.

Publication type:

Article

Cover Feature: Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics (ChemMedChem 8/2018).

Published in:

ChemMedChem, 2018, v. 13, n. 8, p. 763, doi. 10.1002/cmdc.201800227

By:

Koppermann, Stefan;
Cui, Zheng;
Fischer, Patrick D.;
Wang, Xiachang;
Ludwig, Jannine;
Thorson, Jon S.;
Van Lanen, Steven G.;
Ducho, Christian

Publication type:

Article

Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.

Published in:

ChemMedChem, 2018, v. 13, n. 8, p. 779, doi. 10.1002/cmdc.201700793

By:

Koppermann, Stefan;
Cui, Zheng;
Fischer, Patrick D.;
Wang, Xiachang;
Ludwig, Jannine;
Thorson, Jon S.;
Van Lanen, Steven G.;
Ducho, Christian

Publication type:

Article

Warfarin Glycosylation Invokes a Switch from Anticoagulant to Anticancer Activity.

Published in:

ChemMedChem, 2011, v. 6, n. 8, p. 1347, doi. 10.1002/cmdc.201100178

By:

Peltier-Pain, Pauline;
Timmons, Shannon C.;
Grandemange, Agnès;
Benoit, Etienne;
Thorson, Jon S.

Publication type:

Article

Glycosyloxyamine Neoglycosylation: A Model Study Using Calicheamicin.

Published in:

ChemMedChem, 2011, v. 6, n. 5, p. 774, doi. 10.1002/cmdc.201100028

By:

Goff, Randal D.;
Singh, Shanteri;
Thorson, Jon S.

Publication type:

Article

Substrate Specificity of the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII: Opportunities, Limitations, and Mechanistic HypothesesThis work was supported in part by the National Institutes of Health (grants GM 35 906 and GM 54 346 (H.-w.L.) and AI 52 218, CA 84 374 and GM 70 637) and an NCDDG grant (U19 CA 113 297) from the National Cancer Institute (J.S.T.).

Published in:

Angewandte Chemie International Edition, 2006, v. 45, n. 17, p. 2748, doi. 10.1002/anie.200503195

By:

Svetlana A. Borisova;
Changsheng Zhang;
Haruko Takahashi;
Hua Zhang;
Alexander W. Wong;
Jon S. Thorson;
Hung-wen Liu

Publication type:

Article

The Glycosyltransferase UrdGT2 Catalyzes Both C- and O-Glycosidic Sugar Transfers ( This work was supported by the Deutsche Forschungsgemeinschaft (DFG) grant 5-1 to A.B. We thank Volker Brecht, Albert-Ludwigs-Universität Freiburg, for NMR spectroscopy measurements. )

Published in:

Angewandte Chemie International Edition, 2004, v. 43, n. 22, p. 2962, doi. 10.1002/anie.200453758

By:

Clemens Dürr;
Dirk Hoffmeister;
Sven-Eric Wohlert;
Koji Ichinose;
Monika Weber;
Ursula von Mulert;
Jon S. Thorson;
Andreas Bechthold

Publication type:

Article

Expanding the Pyrimidine Diphosphosugar Repertoire: The Chemoenzymatic Synthesis of Amino- and Acetamidoglucopyranosyl Derivatives.

Published in:

Angewandte Chemie International Edition, 2001, v. 40, n. 8, p. 1502, doi. 10.1002/1521-3773(20010417)40:8<1502::AID-ANIE1502>3.0.CO;2-K

By:

Jiang, Jiqing;
Biggins, John B.;
Thorson, Jon S.

Publication type:

Article