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Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.
Published in:
2012
By:
- Agnihotri S;
- Gajadhar AS;
- Ternamian C;
- Gorlia T;
- Diefes KL;
- Mischel PS;
- Kelly J;
- McGown G;
- Thorncroft M;
- Carlson BL;
- Sarkaria JN;
- Margison GP;
- Aldape K;
- Hawkins C;
- Hegi M;
- Guha A;
- Agnihotri, Sameer;
- Gajadhar, Aaron S;
- Ternamian, Christian;
- Gorlia, Thierry
Publication type:
journal article
Characterization of germline TP53 splicing mutations and their genetic and functional analysis.
Published in:
Oncogene, 2001, v. 20, n. 21, p. 2647, doi. 10.1038/sj.onc.1204369
By:
- Varley, J M;
- Attwooll, C;
- White, G;
- McGown, G;
- Thorncroft, M;
- Kelsey, A M;
- Greaves, M;
- Boyle, J;
- Birch, J M
Publication type:
Article
Genetic and functional studies of a germline TP53 splicing mutation in a Li–Fraumeni-like family.
Published in:
Oncogene, 1998, v. 16, n. 25, p. 3291, doi. 10.1038/sj.onc.1201878
By:
- Varley, J M;
- Chapman, P;
- McGown, G;
- Thorncroft, M;
- White, G R M;
- Greaves, M J;
- Scott, D;
- Spreadborough, A;
- Tricker, K J;
- Birch, J M;
- Evans, D G R;
- Reddel, R;
- Camplejohn, R S;
- Burn, J;
- Boyle, J M
Publication type:
Article
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene.
Published in:
Oncogene, 1997, v. 14, n. 7, p. 865, doi. 10.1038/sj.onc.1201041
By:
- Varley, J M;
- Thorncroft, M;
- McGown, G;
- Appleby, J;
- Kelsey, A M;
- Tricker, K J;
- Evans, D G R;
- Birch, J M
Publication type:
Article
A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.
Published in:
2011
By:
- Khan, O. A.;
- Gore, M.;
- Lorigan, P.;
- Stone, J.;
- Greystoke, A.;
- Burke, W.;
- Carmichael, J.;
- Watson, A. J.;
- McGown, G.;
- Thorncroft, M.;
- Margison, G. P.;
- Califano, R.;
- Larkin, J.;
- Wellman, S.;
- Middleton, M. R.
Publication type:
journal article
O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.
Published in:
2009
By:
- Watson, A. J.;
- Middleton, M. R.;
- McGown, G.;
- Thorncroft, M.;
- Ranson, M.;
- Hersey, P.;
- McArthur, G.;
- Davis, I. D.;
- Thomson, D.;
- Beith, J.;
- Haydon, A.;
- Kefford, R.;
- Lorigan, P.;
- Mortimer, P.;
- Sabharwal, A.;
- Hayward, O.;
- Margison, G.P
Publication type:
journal article
Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li–Fraumeni syndrome.
Published in:
British Journal of Cancer, 1999, v. 80, n. 1/2, p. 9, doi. 10.1038/sj.bjc.6690313
By:
- Burt, E C;
- McGown, G;
- Thorncroft, M;
- James, L A;
- Birch, J M;
- Varley, J M
Publication type:
Article

Found: 7

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

Characterization of germline TP53 splicing mutations and their genetic and functional analysis.

Genetic and functional studies of a germline TP53 splicing mutation in a Li–Fraumeni-like family.

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene.

A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.

O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.

Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li–Fraumeni syndrome.