Works by Thorens, Bernard

Results: 112

In vivo effect of murine recombinant interleukin 3 on early hemopoietic progenitors.

Published in:

European Journal of Immunology, 1987, v. 17, n. 10, p. 1511, doi. 10.1002/eji.1830171020

By:

Kindler, Vincent;
Thorens, Bernard;
Vassalli, Pierre

Publication type:

Article

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse.

Published in:

Journal of Comparative Neurology, 2022, v. 530, n. 11, p. 1773, doi. 10.1002/cne.25312

By:

Gaspari, Sevasti;
Quenneville, Simon;
Rodriguez Sanchez‐Archidona, Ana;
Thorens, Bernard;
Croizier, Sophie

Publication type:

Article

Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones.

Published in:

EMBO Journal, 2004, v. 23, n. 3, p. 531, doi. 10.1038/sj.emboj.7600072

By:

Uldry, Marc;
Steiner, Pascal;
Zurich, Marie-Gabrielle;
Beguin, Pascal;
Hirling, Harald;
Dolci, Wanda;
Thorens, Bernard

Publication type:

Article

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.

Published in:

PLoS Biology, 2020, v. 18, n. 11, p. 1, doi. 10.1371/journal.pbio.3000680

By:

Gervais, Manon;
Labouèbe, Gwenaël;
Picard, Alexandre;
Thorens, Bernard;
Croizier, Sophie

Publication type:

Article

α-cell glucokinase suppresses glucose-regulated glucagon secretion.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03034-0

By:

Basco, Davide;
Quan Zhang;
Salehi, Albert;
Tarasov, Andrei;
Dolci, Wanda;
Herrera, Pedro;
Spiliotis, Ioannis;
Berney, Xavier;
Tarussio, David;
Rorsman, Patrik;
Thorens, Bernard

Publication type:

Article

Proteome and transcriptome analyses reveal a role for the liver in hypoglycemia-induced inflammation in diabetes.

Published in:

Nederlands Tijdschrift voor Diabetologie (NTvD), 2023, v. 21, n. 4, p. 26

By:

Hendriksz, Marijn S.;
van Heck, Julia I. P.;
Verhulst, Clementine E. M.;
Castillo-Armengol, Judit;
Thorens, Bernard;
Stienstra, Rinke;
Tack, Cees J.

Publication type:

Article

Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons.

Published in:

FASEB Journal, 2010, v. 24, n. 6, p. 1747, doi. 10.1096/fj.09-144923

By:

Mounien, Lourdes;
Marty, Nell;
Tarussio, David;
Metref, Salima;
Genoux, David;
Preitner, FrÉdÉric;
Foretz1, Marc;
Thorens, Bernard

Publication type:

Article

Recovery of Glucose-Induced Insulin Secretion in a Rat Model of NIDDM Is Not Accompanied by Return of the B-Cell GLUT2 Glucose Transporter.

Published in:

Diabetes, 1992, v. 41, n. 10, p. 1320, doi. 10.2337/diab.41.10.1320

By:

Chuan Chen;
Thorens, Bernard;
Bonner-Weir, Susan;
Weir, Gordon C.;
Leahy, John L.

Publication type:

Article

Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment.

Published in:

1990

By:

Thorens, Bernard;
Flier, Jeffrey S.;
Lodish, Harvey F.;
Kahn, Barbara B.;
Thorens, B;
Flier, J S;
Lodish, H F;
Kahn, B B

Publication type:

journal article

Regulation of adaptive behaviour during fasting by hypothalamic Foxa2.

Published in:

Nature, 2009, v. 462, n. 7273, p. 646, doi. 10.1038/nature08589

By:

Silva, Jose P.;
von Meyenn, Ferdinand;
Howell, Jessica;
Thorens, Bernard;
Wolfrum, Christian;
Stoffel, Markus

Publication type:

Article

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia.

Published in:

EMBO Reports, 2023, v. 24, n. 8, p. 1, doi. 10.15252/embr.202357344

By:

Gaspari, Sevasti;
Labouèbe, Gwenaël;
Picard, Alexandre;
Berney, Xavier;
Rodriguez Sanchez‐Archidona, Ana;
Thorens, Bernard

Publication type:

Article

Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues.

Published in:

EMBO Reports, 2020, v. 21, n. 9, p. 1, doi. 10.15252/embr.201949807

By:

Castillo‐Armengol, Judit;
Barquissau, Valentin;
Geller, Sarah;
Ji, Honglei;
Severi, Ilenia;
Venema, Wiebe;
Fenandez, Eric Aria;
Moret, Catherine;
Huber, Katharina;
Leal‐Esteban, Lucia C;
Nasrallah, Anita;
Martinez‐Carreres, Laia;
Niederhäuser, Guy;
Seoane‐Collazo, Patricia;
Lagarrigue, Sylviane;
López, Miguel;
Giordano, Antonio;
Croizier, Sophie;
Thorens, Bernard;
Lopez‐Mejia, Isabel C

Publication type:

Article

Fasting induces metabolic switches and spatial redistributions of lipid processing and neuronal interactions in tanycytes.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50913-w

By:

Brunner, Maxime;
Lopez-Rodriguez, David;
Estrada-Meza, Judith;
Dali, Rafik;
Rohrbach, Antoine;
Deglise, Tamara;
Messina, Andrea;
Thorens, Bernard;
Santoni, Federico;
Langlet, Fanny

Publication type:

Article

Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing.

Published in:

PLoS Biology, 2023, v. 21, n. 9, p. 1, doi. 10.1371/journal.pbio.3002308

By:

Nualart, Francisco;
Cifuentes, Manuel;
Ramírez, Eder;
Martínez, Fernando;
Barahona, María José;
Ferrada, Luciano;
Saldivia, Natalia;
Bongarzone, Ernesto R.;
Thorens, Bernard;
Salazar, Katterine

Publication type:

Article

Correction: Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes.

Published in:

2024

By:

McNeilly, Alison D.;
Gallagher, Jennifer R.;
Evans, Mark L.;
de Galan, Bastiaan E.;
Pedersen-Bjergaard, Ulrik;
Thorens, Bernard;
Dinkova-Kostova, Albena T.;
Huang, Jeffrey-T.;
Ashford, Michael L. J.;
McCrimmon, Rory J.

Publication type:

Correction Notice

Correction: Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia.

Published in:

2024

By:

Vickneson, Keeran;
Blackburn, Jessica;
Gallagher, Jennifer R.;
Evans, Mark L.;
de Galan, Bastiaan E.;
Pedersen-Bjergaard, Ulrik;
Thorens, Bernard;
McNeilly, Alison D.;
McCrimmon, Rory J.

Publication type:

Correction Notice

GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.

Published in:

Diabetologia, 2024, v. 67, n. 3, p. 528, doi. 10.1007/s00125-023-06060-w

By:

Gandasi, Nikhil R.;
Gao, Rui;
Kothegala, Lakshmi;
Pearce, Abigail;
Santos, Cristiano;
Acreman, Samuel;
Basco, Davide;
Benrick, Anna;
Chibalina, Margarita V.;
Clark, Anne;
Guida, Claudia;
Harris, Matthew;
Johnson, Paul R. V.;
Knudsen, Jakob G.;
Ma, Jinfang;
Miranda, Caroline;
Shigeto, Makoto;
Tarasov, Andrei I.;
Yeung, Ho Yan;
Thorens, Bernard

Publication type:

Article

Correction to: Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia.

Published in:

2024

By:

Castillo‑Armengol, Judit;
Marzetta, Flavia;
Sanchez-Archidona, Ana Rodriguez;
Fledelius, Christian;
Evans, Mark;
McNeilly, Alison;
McCrimmon, Rory J.;
Ibberson, Mark;
Thorens, Bernard

Publication type:

Correction Notice

Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia.

Published in:

Diabetologia, 2024, v. 67, n. 2, p. 371, doi. 10.1007/s00125-023-06043-x

By:

Castillo-Armengol, Judit;
Marzetta, Flavia;
Rodriguez Sanchez-Archidona, Ana;
Fledelius, Christian;
Evans, Mark;
McNeilly, Alison;
McCrimmon, Rory J.;
Ibberson, Mark;
Thorens, Bernard

Publication type:

Article

Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes.

Published in:

Diabetologia, 2023, v. 66, n. 7, p. 1340, doi. 10.1007/s00125-023-05907-6

By:

McNeilly, Alison D.;
Gallagher, Jennifer R.;
Evans, Mark L.;
de Galan, Bastiaan E.;
Pedersen-Bjergaard, Ulrik;
Thorens, Bernard;
Dinkova-Kostova, Albena T.;
Huang, Jeffrey-T.;
Ashford, Michael L. J.;
McCrimmon, Rory J.

Publication type:

Article

Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia.

Published in:

Diabetologia, 2021, v. 64, n. 6, p. 1436, doi. 10.1007/s00125-021-05425-3

By:

Vickneson, Keeran;
Blackburn, Jessica;
Gallagher, Jennifer R.;
Evans, Mark L.;
de Galan, Bastiaan E.;
Pedersen-Bjergaard, Ulrik;
Thorens, Bernard;
McNeilly, Alison D.;
McCrimmon, Rory J.

Publication type:

Article

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

Published in:

Diabetologia, 2018, v. 61, n. 8, p. 1780, doi. 10.1007/s00125-018-4629-8

By:

Bellini, Lara;
Campana, Mélanie;
Rouch, Claude;
Chacinska, Marta;
Bugliani, Marco;
Meneyrol, Kelly;
Hainault, Isabelle;
Lenoir, Véronique;
Denom, Jessica;
Véret, Julien;
Kassis, Nadim;
Thorens, Bernard;
Ibberson, Mark;
Marchetti, Piero;
Blachnio-Zabielska, Agnieszka;
Cruciani-Guglielmacci, Céline;
Prip-Buus, Carina;
Magnan, Christophe;
Le Stunff, Hervé

Publication type:

Article

Ins1 knock-in mice for beta cell-specific gene recombination.

Published in:

Diabetologia, 2015, v. 58, n. 3, p. 558, doi. 10.1007/s00125-014-3468-5

By:

Thorens, Bernard;
Tarussio, David;
Maestro, Miguel;
Rovira, Meritxell;
Heikkilä, Eija;
Ferrer, Jorge

Publication type:

Article

GLUT2, glucose sensing and glucose homeostasis.

Published in:

Diabetologia, 2015, v. 58, n. 2, p. 221, doi. 10.1007/s00125-014-3451-1

By:

Thorens, Bernard

Publication type:

Article

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.

Published in:

Nature Medicine, 2015, v. 21, n. 4, p. 363, doi. 10.1038/nm.3822

By:

Marquard, Jan;
Otter, Silke;
Welters, Alena;
Stirban, Alin;
Fischer, Annelie;
Eglinger, Jan;
Herebian, Diran;
Kletke, Olaf;
Klemen, Maša Skelin;
Stožer, Andraž;
Wnendt, Stephan;
Piemonti, Lorenzo;
Köhler, Martin;
Ferrer, Jorge;
Thorens, Bernard;
Schliess, Freimut;
Rupnik, Marjan Slak;
Heise, Tim;
Berggren, Per-Olof;
Klöcker, Nikolaj

Publication type:

Article

Molecular physiology of glucose transporters.

Published in:

1990

By:

Thorens, Bernard;
Charron, Maureen J.;
Lodish, Harvey F.;
Thorens, B;
Charron, M J;
Lodish, H F

Publication type:

journal article

Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al.

Published in:

Diabetes, 2024, v. 73, n. 7, p. 1027, doi. 10.2337/dbi24-0025

By:

Thorens, Bernard;
Hodson, David J.

Publication type:

Article

Susumu Seino, MD, DMSci (1948–2021): A Pioneer in the Biology of Insulin Secretion.

Published in:

2022

By:

Accili, Domenico;
Bell, Graeme I.;
Thorens, Bernard

Publication type:

Obituary

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis.

Published in:

2021

By:

Picard, Alexandre;
Metref, Salima;
Tarussio, David;
Dolci, Wanda;
Berney, Xavier;
Croizier, Sophie;
Labouebe, Gwenaël;
Thorens, Bernard

Publication type:

journal article

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes.

Published in:

Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-638-P

By:

BURADE, VINOD S.;
GARCIA-OCANA, ADOLFO;
PRATLEY, RICHARD E.;
RUTTER, GUY A.;
VILSBØLL, TINA;
THORENS, BERNARD;
THENNATI, RAJAMANNAR

Publication type:

Article

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation.

Published in:

2020

By:

Quenneville, Simon;
Labouèbe, Gwenaël;
Basco, Davide;
Metref, Salima;
Viollet, Benoit;
Foretz, Marc;
Thorens, Bernard

Publication type:

journal article

946-P: The GLP-1 Receptor Agonist GL0034 Activates Central Regions Controlling Glucose Homeostasis and Feeding Behavior.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-946-P

By:

PICARD, ALEXANDRE;
TARUSSIO, DAVID;
THENNATI, RAJAMANNAR;
BURADE, VINOD S.;
THORENS, BERNARD

Publication type:

Article

350-OR: A Novel Long-Acting GLP-1 Agonist (GL0034) Demonstrates Remarkable Efficacy on HbA1c, Weight Loss, and Triglycerides in a Model of Type 2 Diabetes, the db/db Mouse.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-350-OR

By:

THENNATI, RAJAMANNAR;
BURADE, VINOD S.;
VILSBØLL, TINA;
THORENS, BERNARD;
RUTTER, GUY A.

Publication type:

Article

Targeting the Brain to Cure Type 2 Diabetes.

Published in:

2019

By:

Thorens, Bernard

Publication type:

journal article

Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.

Published in:

2016

By:

Steinbusch, Laura K. M.;
Picard, Alexandre;
Bonnet, Marion S.;
Basco, Davide;
Labouèbe, Gwenaël;
Thorens, Bernard

Publication type:

journal article

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

Published in:

2016

By:

Marmugi, Alice;
Parnis, Julia;
Xi Chen;
Carmichael, LeAnne;
Hardy, Julie;
Mannan, Naila;
Marchetti, Piero;
Piemonti, Lorenzo;
Bosco, Domenico;
Johnson, Paul;
Shapiro, James A. M.;
Cruciani-Guglielmacci, Céline;
Magnan, Christophe;
Ibberson, Mark;
Thorens, Bernard;
Valdivia, Héctor H.;
Rutter, Guy A.;
Leclerc, Isabelle;
Chen, Xi

Publication type:

journal article

Neurochemical profile of the mouse hypothalamus using in vivo 1H MRS at 14.1T.

Published in:

NMR in Biomedicine, 2010, v. 23, n. 6, p. 578, doi. 10.1002/nbm.1498

By:

Lei, Hongxia;
Poitry-Yamate, Carol;
Preitner, Frédéric;
Thorens, Bernard;
Gruetter, Rolf

Publication type:

Article

SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.

Published in:

Pflügers Archiv: European Journal of Physiology, 2018, v. 470, n. 12, p. 1739, doi. 10.1007/s00424-018-2190-4

By:

Auberson, Muriel;
Stadelmann, Sophie;
Stoudmann, Candice;
Seuwen, Klaus;
Koesters, Robert;
Thorens, Bernard;
Bonny, Olivier

Publication type:

Article

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration.

Published in:

Science Translational Medicine, 2020, v. 12, n. 530, p. 1, doi. 10.1126/scitranslmed.aaw9996

By:

Ackeifi, Courtney;
Wang, Peng;
Karakose, Esra;
Manning Fox, Jocelyn E.;
González, Bryan J.;
Liu, Hongtao;
Wilson, Jessica;
Swartz, Ethan;
Berrouet, Cecilia;
Li, Yansui;
Kumar, Kunal;
MacDonald, Patrick E.;
Sanchez, Roberto;
Thorens, Bernard;
DeVita, Robert;
Homann, Dirk;
Egli, Dieter;
Scott, Donald K.;
Garcia-Ocaña, Adolfo;
Stewart, Andrew F.

Publication type:

Article

Engineering Tolerance into Transplanted β Cell Lines.

Published in:

Annals of the New York Academy of Sciences, 2001, v. 944, n. 1, p. 267, doi. 10.1111/j.1749-6632.2001.tb03838.x

By:

THORENS, BERNARD;
DUPRAZ, PHILIPPE;
COTTET, SANDRA

Publication type:

Article

Encapsulated, Genetically Engineered Cells, Secreting Glucagon-like Peptide-1 for the Treatment of Non-insulin-dependent Diabetes Mellitus.

Published in:

Annals of the New York Academy of Sciences, 1999, v. 875, n. 1, p. 277, doi. 10.1111/j.1749-6632.1999.tb08510.x

By:

BURCELIN, RÉMY;
ROLLAND, ERIC;
DOLCI, WANDA;
GERMAIN, STÉPHANE;
CARREL, VÉRONIQUE;
THORENS, BERNARD

Publication type:

Article

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.

Published in:

Biomolecules (2218-273X), 2020, v. 10, n. 7, p. 1057, doi. 10.3390/biom10071057

By:

Gausserès, Blandine;
Liu, Junjun;
Foppen, Ewout;
Tourrel-Cuzin, Cécile;
Rodriguez Sanchez-Archidona, Ana;
Delangre, Etienne;
Cruciani-Guglielmacci, Céline;
Pons, Stéphanie;
Maskos, Uwe;
Thorens, Bernard;
Magnan, Christophe;
Movassat, Jamileh;
Maouche, Kamel

Publication type:

Article

Identification of a mammalian H+-myo-inositol symporter expressed predominantly in the brain.

Published in:

EMBO Journal, 2001, v. 20, n. 16, p. 4467, doi. 10.1093/emboj/20.16.4467

By:

Uldry, Marc;
Ibberson, Mark;
Horisberger, Jean-Daniel;
Chatton, Jean-Yves;
Riederer, Beat M.;
Thorens, Bernard

Publication type:

Article

Hypoinsulinaemia, glucose intolerance and diminished Beta-cell size in S6K1-deficient mice.

Published in:

Nature, 2000, v. 408, n. 6815, p. 994, doi. 10.1038/35050135

By:

Pende, Mario;
Kozma, Sara C.;
Jaquet, Muriel;
Oorschot, Viola;
Burcelin, Remy;
Le Marchand-Brustel, Yannick;
Klumperman, Judith;
Thorens, Bernard;
Thomas, George

Publication type:

Article

EuroDia: a beta-cell gene expression resource.

Published in:

Database: The Journal of Biological Databases & Curation, 2010, v. 2010, p. 1, doi. 10.1093/database/baq024

By:

Liechti, Robin;
Csárdi, Gábor;
Bergmann, Sven;
Schütz, Frédéric;
Sengstag, Thierry;
Boj, Sylvia F.;
Servitja, Joan-Marc;
Ferrer, Jorge;
Van Lommel, Leentje;
Schuit, Frans;
Klinger, Sonia;
Thorens, Bernard;
Naamane, Najib;
Eizirik, Decio L.;
Marselli, Lorella;
Bugliani, Marco;
Marchetti, Piero;
Lucas, Stephanie;
Holm, Cecilia;
Jongeneel, C. Victor

Publication type:

Article

No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.

Published in:

Kidney International, 2015, v. 87, n. 5, p. 940, doi. 10.1038/ki.2014.385

By:

Preitner, Frederic;
Pimentel, Anabela;
Metref, Salima;
Berthonneche, Corinne;
Sarre, Alexandre;
Moret, Catherine;
Rotman, Samuel;
Centeno, Gabriel;
Firsov, Dmitri;
Thorens, Bernard

Publication type:

Article

Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction.

Published in:

Scientific Reports, 2016, p. 36937, doi. 10.1038/srep36937

By:

Duszka, Kalina;
Picard, Alexandre;
Ellero-Simatos, Sandrine;
Chen, Jiapeng;
Defernez, Marianne;
Paramalingam, Eeswari;
Pigram, Anna;
Vanoaica, Liviu;
Canlet, Cécile;
Parini, Paolo;
Narbad, Arjan;
Guillou, Hervé;
Thorens, Bernard;
Wahli, Walter

Publication type:

Article

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 5, p. 1390, doi. 10.1093/hmg/ddu553

By:

Mitchell, Ryan K.;
Mondragon, Angeles;
Chen, Lingling;
Mcginty, James A.;
French, Paul M.;
Ferrer, Jorge;
Thorens, Bernard;
Hodson, David J.;
Rutter, Guy A.;
Da Silva Xavier, Gabriela

Publication type:

Article

Gluco-Incretins Regulate Beta-Cell Glucose Competence by Epigenetic Silencing of Fxyd3 Expression.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0103277

By:

Vallois, David;
Niederhäuser, Guy;
Ibberson, Mark;
Nagaray, Vini;
Marselli, Lorella;
Marchetti, Piero;
Chatton, Jean-Yves;
Thorens, Bernard

Publication type:

Article

Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0101005

By:

Vasu, Srividya;
Moffett, R. Charlotte;
Thorens, Bernard;
Flatt, Peter R.

Publication type:

Article