Works by Thomas, David Y.

Results: 39

A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.

Published in:

ChemBioChem, 2016, v. 17, n. 9, p. 843, doi. 10.1002/cbic.201500485

By:

Waller, Daniel D.;
Jansen, Gregor;
Golizeh, Makan;
Martel‐Lorion, Chloe;
Dejgaard, Kurt;
Shiao, Tze Chieh;
Mancuso, John;
Tsantrizos, Youla S.;
Roy, René;
Sebag, Michael;
Sleno, Lekha;
Thomas, David Y.

Publication type:

Article

Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme.

Published in:

Glycobiology, 2000, v. 10, n. 4, p. 403, doi. 10.1093/glycob/10.4.403

By:

C.Tessier, Daniel;
Dignard, Daniel;
Zapun, André;
Radominska, Anna;
Parodi, Armando J.;
Bergeron, John J.M.;
Thomas, David Y.

Publication type:

Article

Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase.

Published in:

EMBO Journal, 1997, v. 16, n. 1, p. 83, doi. 10.1093/emboj/16.1.83

By:

Leberer, Ekkehard;
Cunle Wu;
Leeuw, Thomas;
Anne-Fourest-Lieuvin;
Segall, Jeffrey E.;
Thomas, David Y.

Publication type:

Article

Ionocyte-Specific Regulation of Cystic Fibrosis Transmembrane Conductance Regulator.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2023, v. 69, n. 3, p. 281, doi. 10.1165/rcmb.2022-0241oc

By:

Yukiko Sato;
Kim, Dusik;
Turner, Mark J.;
Yishan Luo;
Zehra Zaidi, Syeda Sadaf;
Thomas, David Y.;
Hanrahan, John W.

Publication type:

Article

Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, n. 6, p. 784, doi. 10.33594/000000477

By:

Turner, Mark J.;
Sato, Yukiko;
Thomas, David Y.;
Abbott-Banner, Kathy;
Hanrahan, John W.

Publication type:

Article

Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A.

Published in:

Cells (2073-4409), 2022, v. 11, n. 1, p. 136, doi. 10.3390/cells11010136

By:

Lopes-Pacheco, Miquéias;
Bacalhau, Mafalda;
Ramalho, Sofia S.;
Silva, Iris A. L.;
Ferreira, Filipa C.;
Carlile, Graeme W.;
Thomas, David Y.;
Farinha, Carlos M.;
Hanrahan, John W.;
Amaral, Margarida D.

Publication type:

Article

Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans.

Published in:

Molecular Microbiology, 2001, v. 42, n. 3, p. 673, doi. 10.1046/j.1365-2958.2001.02672.x

By:

Leberer, Ekkehard;
Harcus, Doreen;
Dignard, Daniel;
Johnson, Lyne;
Ushinsky, Sophia;
Thomas, David Y.;
Schröppel, Klaus

Publication type:

Article

A Ste6p/P-glycoprotein homologue from the asexual yeast Candida albicans transports the a-factor...

Published in:

Molecular Microbiology, 1998, v. 27, n. 3, p. 587, doi. 10.1046/j.1365-2958.1998.00704.x

By:

Raymond, Martine;
Dignard, Daniel;
Alarco, Anne-Marie;
Mainville, Norman;
Magee, Beatrice B.;
Thomas, David Y.

Publication type:

Article

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31206-6

By:

Stevers, Loes M.;
Wolter, Madita;
Carlile, Graeme W.;
Macdonald, Dwight;
Richard, Luc;
Gielkens, Frank;
Hanrahan, John W.;
Thomas, David Y.;
Chakka, Sai Kumar;
Peterson, Mark L.;
Thomas, Helmut;
Brunsveld, Luc;
Ottmann, Christian

Publication type:

Article

Molecular cloning of the CRM1 gene from Candida albicans.

Published in:

Yeast, 2000, v. 16, n. 6, p. 531, doi. 10.1002/(SICI)1097-0061(200004)16:6<531::AID-YEA543>3.0.CO;2-J

By:

Raymond, Martine;
Dignard, Daniel;
Alarco, Anne-Marie;
Clark, Karen L.;
Weber, Sandra;
Whiteway, Malcolm;
Leberer, Ekkehard;
Thomas, David Y.

Publication type:

Article

A structural overview of the PDI family of proteins.

Published in:

FEBS Journal, 2010, v. 277, n. 19, p. 3924, doi. 10.1111/j.1742-4658.2010.07793.x

By:

Kozlov, Guennadi;
Määttänen, Pekka;
Thomas, David Y.;
Gehring, Kalle

Publication type:

Article

Solution structure of the bb′ domains of human protein disulfide isomerase.

Published in:

FEBS Journal, 2009, v. 276, n. 5, p. 1440, doi. 10.1111/j.1742-4658.2009.06884.x

By:

Denisov, Alexey Y.;
Määttänen, Pekka;
Dabrowski, Christian;
Kozlov, Guennadi;
Thomas, David Y.;
Gehring, Kalle

Publication type:

Article

Glycopeptide specificity of the secretory protein folding sensor UDP-glucose glycoprotein:glucosyltransferase.

Published in:

2003

By:

Taylor, Sean C.;
Thibault, Pierre;
Tessier, Daniel C.;
Bergeron, John J. M.;
Thomas, David Y.

Publication type:

Report

Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast.

Published in:

EMBO Reports, 2001, v. 2, n. 5, p. 423, doi. 10.1093/embo-reports/kve089

By:

Jakob, Claude A.;
Bodmer, Daniel;
Spirig, Urs;
Bättig, Patrick;
Marcil, Anne;
Dignard, Daniel;
Bergeron, John J. M.;
Thomas, David Y.;
Aebi, Markus

Publication type:

Article

Nup53p is a Target of Two Mitotic Kinases, Cdk1p and Hrr25p.

Published in:

Traffic, 2007, v. 8, n. 6, p. 647, doi. 10.1111/j.1600-0854.2007.00559.x

By:

Lusk, C. Patrick;
Waller, Daniel D;
Makhnevych, Taras;
Dienemann, Axel;
Whiteway, Malcolm;
Thomas, David Y;
Wozniak, Richard W.

Publication type:

Article

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).

Published in:

2016

By:

Matthes, Elizabeth;
Goepp, Julie;
Carlile, Graeme W;
Luo, Yishan;
Dejgaard, Kurt;
Billet, Arnaud;
Robert, Renaud;
Thomas, David Y;
Hanrahan, John W

Publication type:

journal article

Refining Protein Subcellular Localization.

Published in:

PLoS Computational Biology, 2005, v. 1, n. 6, p. 518, doi. 10.1371/journal.pcbi.0010066

By:

Scott, Michelle S.;
Calafell, Sara J.;
Thomas, David Y.;
Hallett, Michael T.;
Nielsen, Henrik

Publication type:

Article

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines.

Published in:

Orphanet Journal of Rare Diseases, 2013, v. 8, n. 1, p. 1, doi. 10.1186/1750-1172-8-11

By:

Sampson, Heidi M.;
Hung Lam;
Pei-Chun Chen;
Donglei Zhang;
Mottillo, Cristina;
Mirza, Myriam;
Qasim, Karim;
Shrier, Alvin;
Show-Ling Shyng;
Hanrahan, John W.;
Thomas, David Y.

Publication type:

Article

Reverse Genetics in Candida albicans Predicts ARF Cycling Is Essential for Drug Resistance and Virulence.

Published in:

PLoS Pathogens, 2010, v. 6, n. 2, p. 1, doi. 10.1371/journal.ppat.1000753

By:

Epp, Elias;
Vanier, Ghyslaine;
Harcus, Doreen;
Lee, Anna Y.;
Jansen, Gregor;
Hallett, Michael;
Sheppard, Don C.;
Thomas, David Y.;
Munro, Carol A.;
Mullick, Alaka;
Whiteway, Malcolm

Publication type:

Article

Correctors of Protein Trafficking Defects Identified by a Novel High-Throughput Screening Assay.

Published in:

ChemBioChem, 2007, v. 8, n. 9, p. 1012, doi. 10.1002/cbic.200700027

By:

Carlile, Graeme W.;
Robert, Renaud;
Zhang, Donglei;
Teske, Katrina A.;
Luo, Yishan;
Hanrahan, John W.;
Thomas, David Y.

Publication type:

Article

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

Published in:

Nature, 1998, v. 391, n. 6663, p. 191, doi. 10.1038/34448

By:

Leeuw, Thomas;
Wu, Cunle;
Schrag, Joseph D.;
Whiteway, Malcolm;
Thomas, David Y.;
Leberer, Ekkehard

Publication type:

Article

Reduced pathogenicity of a Candida albicans MAP kinase phosphatase (CPP1) mutant in the murine mastitis model.

Published in:

APMIS, 1998, v. 106, n. 7-12, p. 1049, doi. 10.1111/j.1699-0463.1998.tb00257.x

By:

GUHAD, FAISAL A.;
CSANK, CSILLA;
JENSEN, HENRIK E.;
THOMAS, DAVID Y.;
WHITEWAY, MALCOLM;
HAU, JANN

Publication type:

Article

A novel triple combination of pharmacological chaperones improves F508del-CFTR correction.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-29276-y

By:

Carlile, Graeme W.;
Yang, Qi;
Matthes, Elizabeth;
Liao, Jie;
Radinovic, Stevo;
Miyamoto, Carol;
Robert, Renaud;
Hanrahan, John W.;
Thomas, David Y.

Publication type:

Article

Comment: Canadian Chemical Biology Network: biochemistry back to the future / Commentaire : Réseau canadien de biologie chimique: la biochimie de retour vers le futur.

Published in:

Biochemistry & Cell Biology, 2008, v. 86, n. 2, p. ix, doi. 10.1139/o08-903

By:

Brown, Eric D.;
Thomas, David Y.

Publication type:

Article

Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 7, p. 4002, doi. 10.1093/nar/gkae059

By:

Mubaid, Souad;
Sanchez, Brenda Janice;
Algehani, Rinad A;
Skopenkova, Viktoriia;
Adjibade, Pauline;
Hall, Derek T;
Busque, Sandrine;
Lian, Xian Jin;
Ashour, Kholoud;
Tremblay, Anne-Marie K;
Carlile, Graeme;
Gagné, Jean-Philippe;
Diaz-Gaxiola, Andrea;
Khattak, Shahryar;
Di Marco, Sergio;
Thomas, David Y;
Poirier, Guy G;
Gallouzi, Imed-Eddine

Publication type:

Article

Enhanced Ca<sup>2+</sup> entry due to Orail plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways.

Published in:

FASEB Journal, 2011, v. 25, n. 12, p. 4274, doi. 10.1096/fj.11-187682

By:

Balghi, Haouaria;
Robert, Renaud;
Rappaz, Benjamin;
Xuexin Zhang;
Wohlhuter-Haddad, Adeline;
Evagelidis, Alexandra;
Luo, Yishan;
Goepp, Julie;
Ferraro, Pasquale;
Romto, Philippe;
Trebak, Mohamed;
Wiseman, Paul W.;
Thomas, David Y.;
Hanrahan, John W.

Publication type:

Article

Chemogenomic profiling predicts antifungal synergies.

Published in:

Molecular Systems Biology, 2009, v. 5, n. 1, p. 338, doi. 10.1038/msb.2009.95

By:

Jansen, Gregor;
Lee, Anna Y;
Epp, Elias;
Fredette, Amélie;
Surprenant, Jamie;
Harcus, Doreen;
Scott, Michelle;
Tan, Elaine;
Nishimura, Tamiko;
Whiteway, Malcolm;
Hallett, Michael;
Thomas, David Y

Publication type:

Article

The ER protein folding sensor UDP-glucose glycoprotein-glucosyltransferase modifies substrates distant to local changes in glycoprotein conformation.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 2, p. 128, doi. 10.1038/nsmb715

By:

Taylor, Sean C.;
Ferguson, Andrew D.;
Bergerson, John J.;
Thomas, David Y.

Publication type:

Article

Genetic Analysis of the Interface Between Cdc42p and the CRIB Domain of Ste20p in Saccharomyces cerevisiae.

Published in:

Genetics, 2003, v. 163, n. 1, p. 9, doi. 10.1093/genetics/163.1.9

By:

Ash, Josée;
Cunle Wu;
Larocque, Robert;
Jamal, Maleek;
Stevens, Willem;
Osborne, Mike;
Thomas, David Y.;
Whiteway, Malcolm

Publication type:

Article

Involvement of protein N-glycosyl chain glucosylation and processing in the biosynthesis of...

Published in:

Genetics, 1998, v. 149, n. 2, p. 843, doi. 10.1093/genetics/149.2.843

By:

Shahinian, Serge;
Dijkgraaf, Gerrit J.P.;
Sdicu, Anne-Marie;
Thomas, David Y.;
Jakob, Claude A.;
Aebi, Markus;
Bussey, Howard

Publication type:

Article

The Canadian Society of Biochemistry, Molecular & Cellular Biology (CSBMCB) celebrates its 50th birthday in 2007.

Published in:

IUBMB Life, 2007, v. 59, n. 4/5, p. 226, doi. 10.1080/15216540701222898

By:

Thomas, David Y.

Publication type:

Article

Intracellular Eukaryotic Parasites Have a Distinct Unfolded Protein Response.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019118

By:

Gosline, Sara J. C.;
Nascimento, Mirna;
McCall, Laura-Isobel;
Zilberstein, Dan;
Thomas, David Y.;
Matlashewski, Greg;
Hallett, Michael

Publication type:

Article

A Biochemical Genomics Screen for Substrates of Ste20p Kinase Enables the In Silico Prediction of Novel Substrates.

Published in:

PLoS ONE, 2009, v. 4, n. 12, p. 1, doi. 10.1371/journal.pone.0008279

By:

Annan, Robert B.;
Lee, Anna Y.;
Reid, Ian D.;
Sayad, Azin;
Whiteway, Malcolm;
Hallett, Michael;
Thomas, David Y.

Publication type:

Article

Unravelling druggable signalling networks that control F508del-CFTR proteostasis.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.10365

By:

Hegde, Ramanath Narayana;
Parashuraman, Seetharaman;
Iorio, Francesco;
Ciciriello, Fabiana;
Capuani, Fabrizio;
Carissimo, Annamaria;
Carrella, Diego;
Belcastro, Vincenzo;
Subramanian, Advait;
Bounti, Laura;
Persico, Maria;
Carlile, Graeme;
Galietta, Luis;
Thomas, David Y.;
Di Bernardo, Diego;
Luini, Alberto

Publication type:

Article

The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-08661-8

By:

Carlile, Graeme W.;
Yang, Qi;
Matthes, Elizabeth;
Liao, Jie;
Birault, Véronique;
Sneddon, Helen F.;
Poole, Darren L.;
Hall, Callum J.;
Hanrahan, John W.;
Thomas, David Y.

Publication type:

Article

Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-02420-x

By:

Sato, Yukiko;
Mustafina, Kamila R.;
Luo, Yishan;
Martini, Carolina;
Thomas, David Y.;
Wiseman, Paul W.;
Hanrahan, John W.

Publication type:

Article

Cystic Fibrosis: Proteostatic correctors of CFTR trafficking and alternative therapeutic targets.

Published in:

Expert Opinion on Therapeutic Targets, 2019, v. 23, n. 8, p. 711, doi. 10.1080/14728222.2019.1628948

By:

Hanrahan, John W.;
Sato, Yukiko;
Carlile, Graeme W.;
Jansen, Gregor;
Young, Jason C.;
Thomas, David Y.

Publication type:

Article

An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases.

Published in:

2017

By:

Kristof, Arnold S.;
Petrof, Basil J.;
Hamid, Qutayba;
Kolb, Martin;
Landry, Jennifer S.;
MacKenzie, Alex;
McCormack, Francis X.;
Murawski, Inga J.;
Moss, Joel;
Rauch, Frank;
Rosas, Ivan O.;
Shapiro, Adam J.;
Smith, Benjamin M.;
Thomas, David Y.;
Trapnell, Bruce C.;
Young, Lisa R.;
Zariwala, Maimoona A.;
ATS Assembly on Respiratory Cell and Molecular Biology

Publication type:

journal article

N‐glycosylation mediated folding and quality control in serine proteases of the hepsin family.

Published in:

FEBS Journal, 2023, v. 290, n. 16, p. 3963, doi. 10.1111/febs.16779

By:

Bergeron, John J. M.;
Thomas, David Y.

Publication type:

Article