Works matching AU Theile, Dirk

Results: 40

The "specific" P-glycoprotein inhibitor zosuquidar (LY335979) also weakly inhibits human organic cation transporters.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2025, v. 398, n. 6, p. 7147, doi. 10.1007/s00210-024-03743-y

By:

Bajraktari-Sylejmani, Gzona;
Kamaraj, Rajamanikkam;
Theile, Dirk;
Pávek, Petr;
Weiss, Johanna

Publication type:

Article

Bortezomib, carfilzomib and ixazomib do not mediate relevant transporter-based drug-drug interactions.

Published in:

Oncology Letters, 2017, v. 14, n. 3, p. 3185, doi. 10.3892/ol.2017.6560

By:

Clemens, Jannick;
Welti, Lukas;
Schäfer, Julia;
Seckinger, Anja;
Burhenne, Jürgen;
Theile, Dirk;
Weiss, Johanna

Publication type:

Article

The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0193242

By:

Rigalli, Juan Pablo;
Reichel, Matthias;
Reuter, Tasmin;
Tocchetti, Guillermo Nicolás;
Dyckhoff, Gerhard;
Herold-Mende, Christel;
Theile, Dirk;
Weiss, Johanna

Publication type:

Article

Impact of drug transporters on cellular resistance towards saquinavir and darunavir.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2010, v. 65, n. 11, p. 2319, doi. 10.1093/jac/dkq324

By:

König, Sonja Katharina;
Herzog, Melanie;
Theile, Dirk;
Zembruski, Nadine;
Haefeli, Walter Emil;
JohannaWeiss

Publication type:

Article

Association of Drug Transporter Expression with Mortality and Progression-Free Survival in Stage IV Head and Neck Squamous Cell Carcinoma.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0108908

By:

Warta, Rolf;
Theile, Dirk;
Mogler, Carolin;
Herpel, Esther;
Grabe, Niels;
Lahrmann, Bernd;
Plinkert, Peter K.;
Herold-Mende, Christel;
Weiss, Johanna;
Dyckhoff, Gerhard

Publication type:

Article

Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo.

Published in:

Archives of Toxicology, 2024, v. 98, n. 8, p. 2541, doi. 10.1007/s00204-024-03763-w

By:

Nilles, Julie;
Theile, Dirk;
Weiss, Johanna;
Haefeli, Walter E.;
Ruez, Stephanie

Publication type:

Article

Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site.

Published in:

Archives of Toxicology, 2024, v. 98, n. 1, p. 223, doi. 10.1007/s00204-023-03618-w

By:

Phondeth, Lottida;
Kamaraj, Rajamanikkam;
Nilles, Julie;
Weiss, Johanna;
Haefeli, Walter E.;
Pávek, Petr;
Theile, Dirk

Publication type:

Article

Comprehensive in vitro analysis evaluating the variable drug–drug interaction risk of rifampicin compared to rifabutin.

Published in:

Archives of Toxicology, 2023, v. 97, n. 8, p. 2219, doi. 10.1007/s00204-023-03531-2

By:

Nilles, Julie;
Weiss, Johanna;
Sauter, Max;
Haefeli, Walter E.;
Ruez, Stephanie;
Theile, Dirk

Publication type:

Article

How to avoid misinterpretation of dual reporter gene assay data affected by cell damage.

Published in:

Archives of Toxicology, 2022, v. 96, n. 9, p. 2501, doi. 10.1007/s00204-022-03323-0

By:

Nilles, Julie;
Weiss, Johanna;
Haefeli, Walter E.;
Ruez, Stephanie;
Theile, Dirk

Publication type:

Article

Antiproliferative efficacies but minor drug transporter inducing effects of paclitaxel, cisplatin, or 5-fluorouracil in a murine xenograft model for head and neck squamous cell carcinoma.

Published in:

Cancer Biology & Therapy, 2014, v. 15, n. 4, p. 436, doi. 10.4161/cbt.27632

By:

Theile, Dirk;
Gal, Zoltan;
Warta, Rolf;
Rigalli, Juan Pablo;
Lahrmann, Bernd;
Grabe, Niels;
Herold-Mende, Christel;
Dyckhoff, Gerhard;
Weiss, Johanna

Publication type:

Article

Cellular effect and efficacy of carfilzomib depends on cellular net concentration gradient.

Published in:

2017

By:

Schäfer, Julia;
Welti, Lukas;
Seckinger, Anja;
Burhenne, Jürgen;
Theile, Dirk;
Weiss, Johanna;
Schäfer, Julia;
Burhenne, Jürgen

Publication type:

journal article

Cellular uptake kinetics of bortezomib in relation to efficacy in myeloma cells and the influence of drug transporters.

Published in:

Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 2, p. 281, doi. 10.1007/s00280-014-2643-1

By:

Clemens, Jannick;
Seckinger, Anja;
Hose, Dirk;
Theile, Dirk;
Longo, Magdalena;
Haefeli, Walter;
Burhenne, Jürgen;
Weiss, Johanna

Publication type:

Article

Minor role of pregnane-x-receptor for acquired multidrug resistance in head and neck squamous cell carcinoma in vitro.

Published in:

Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 5, p. 1335, doi. 10.1007/s00280-013-2133-x

By:

Rigalli, Juan;
Reuter, Tasmin;
Herold-Mende, Christel;
Dyckhoff, Gerhard;
Haefeli, Walter;
Weiss, Johanna;
Theile, Dirk

Publication type:

Article

Methadone against cancer: Lost in translation.

Published in:

International Journal of Cancer, 2018, v. 143, n. 8, p. 1840, doi. 10.1002/ijc.31356

By:

Theile, Dirk;
Mikus, Gerd

Publication type:

Article

Comment on 'Sweat but no gain': Inhibiting proliferation of multidrug resistant cancer cells with 'Ersatzdroges'.

Published in:

International Journal of Cancer, 2015, v. 136, n. 9, p. 2241, doi. 10.1002/ijc.29246

By:

Theile, Dirk;
Weiss, Johanna

Publication type:

Article

Deceptive argumentation against diagnostic microdosing of anticancer drugs.

Published in:

International Journal of Cancer, 2014, v. 135, n. 7, p. 1753, doi. 10.1002/ijc.28806

By:

Theile, Dirk;
Mikus, Gerd

Publication type:

Article

Perfusate Flow Rate: An Overlooked Factor in Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?

Published in:

2024

By:

Theile, Dirk;
Czock, David

Publication type:

Letter

Approaching Sites of Action of Temozolomide for Pharmacological and Clinical Studies in Glioblastoma.

Published in:

Biomedicines, 2022, v. 10, n. 1, p. 1, doi. 10.3390/biomedicines10010001

By:

Fresnais, Margaux;
Turcan, Sevin;
Theile, Dirk;
Ungermann, Johannes;
Abou Zeed, Yasmin;
Lindner, Joshua Raoul;
Breitkopf, Marius;
Burhenne, Jürgen;
Haefeli, Walter E.;
Longuespée, Rémi

Publication type:

Article

Approaching sites of action of drugs in clinical pharmacology: New analytical options and their challenges.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 3, p. 858, doi. 10.1111/bcp.14543

By:

Longuespée, Rémi;
Theile, Dirk;
Fresnais, Margaux;
Burhenne, Jürgen;
Weiss, Johanna;
Haefeli, Walter E.

Publication type:

Article

Molecular prediction of clinical response to anti‐PD‐1/anti‐PD‐L1 immune checkpoint inhibitors: New perspectives for precision medicine and mass spectrometry‐based investigations.

Published in:

International Journal of Cancer, 2023, v. 153, n. 2, p. 252, doi. 10.1002/ijc.34366

By:

Longuespée, Rémi;
Theile, Dirk;
Zörnig, Inka;
Hassel, Jessica C.;
Lindner, Joshua Raoul;
Haefeli, Walter E.;
Fresnais, Margaux

Publication type:

Article

Bosentan enhances in vitro bortezomib's anti‐proliferative potency against multiple myeloma by mechanisms going beyond endothelin receptor blockade.

Published in:

British Journal of Haematology, 2019, v. 184, n. 6, p. 1052, doi. 10.1111/bjh.15241

By:

Schäfer, Julia;
Weiss, Johanna;
Theile, Dirk

Publication type:

Article

The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, v. 397, n. 4, p. 2485, doi. 10.1007/s00210-023-02768-z

By:

Nilles, Julie;
Weiss, Johanna;
Masin, Martin;
Tuffs, Christopher;
Strowitzki, Moritz J.;
Haefeli, Walter E.;
Ruez, Stephanie;
Theile, Dirk

Publication type:

Article

Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection?

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2021, v. 394, n. 8, p. 1621, doi. 10.1007/s00210-021-02112-3

By:

Theile, Dirk;
Wizgall, Pauline

Publication type:

Article

Elucidating the beneficial effects of melphalan, adriamycin, and corticoids in combination with bortezomib against multiple myeloma in vitro.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2019, v. 392, n. 4, p. 461, doi. 10.1007/s00210-018-01602-1

By:

Schäfer, Julia;
Burhenne, Jürgen;
Weiss, Johanna;
Theile, Dirk

Publication type:

Article

Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2017, v. 390, n. 1, p. 49, doi. 10.1007/s00210-016-1304-9

By:

Doricakova, Aneta;
Theile, Dirk;
Weiss, Johanna;
Vrzal, Radim

Publication type:

Article

Proteasome inhibition correlates with intracellular bortezomib concentrations but not with antiproliferative effects after bolus treatment in myeloma cell lines.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2016, v. 389, n. 10, p. 1091, doi. 10.1007/s00210-016-1276-9

By:

Dettmer, Susan;
Theile, Dirk;
Schäfer, Julia;
Seckinger, Anja;
Burhenne, Jürgen;
Weiss, Johanna

Publication type:

Article

Role of NR1I2 (pregnane X receptor) polymorphisms in head and neck squamous cell carcinoma.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, v. 388, n. 11, p. 1141, doi. 10.1007/s00210-015-1150-1

By:

Reuter, Tasmin;
Warta, Rolf;
Theile, Dirk;
Meid, Andreas;
Rigalli, Juan;
Mogler, Carolin;
Herpel, Esther;
Grabe, Niels;
Lahrmann, Bernd;
Plinkert, Peter;
Herold-Mende, Christel;
Dyckhoff, Gerhard;
Haefeli, Walter;
Weiss, Johanna

Publication type:

Article

Physiology‐based pharmacokinetic modelling and experimental data suggest that rifabutin alters dolutegravir kinetics by both P‐glycoprotein induction and concurrent inhibition.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 7, p. 2329, doi. 10.1111/bcp.15740

By:

Theile, Dirk;
Nilles, Julie;
Meid, Andreas D.

Publication type:

Article

Interaction Potential of the Multitargeted Receptor Tyrosine Kinase Inhibitor Dovitinib with Drug Transporters and Drug Metabolising Enzymes Assessed in Vitro.

Published in:

Pharmaceutics, 2014, v. 6, n. 4, p. 632, doi. 10.3390/pharmaceutics6040632

By:

Weiss, Johanna;
Theile, Dirk;
Dvorak, Zdenek;
Haefeli, Walter Emil

Publication type:

Article

Effects of adrenolytic mitotane on drug elimination pathways assessed in vitro.

Published in:

Endocrine (1355008X), 2015, v. 49, n. 3, p. 842, doi. 10.1007/s12020-014-0517-2

By:

Theile, Dirk;
Haefeli, Walter;
Weiss, Johanna

Publication type:

Article

Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning.

Published in:

Cells (2073-4409), 2021, v. 10, n. 11, p. 3137, doi. 10.3390/cells10113137

By:

Rigalli, Juan Pablo;
Theile, Dirk;
Nilles, Julie;
Weiss, Johanna

Publication type:

Article

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 12, p. 1, doi. 10.1371/journal.pntd.0001951

By:

Rigalli, Juan P.;
Perdomo, Virginia G.;
Luquita, Marcelo G.;
Villanueva, Silvina S. M.;
Arias, Agostina;
Theile, Dirk;
Weiss, Johanna;
Mottino, Aldo D.;
Ruiz, María L.;
Catania, Viviana A.

Publication type:

Article

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 12, p. 1, doi. 10.1371/journal.pntd.0001951

By:

Rigalli, Juan P.;
Perdomo, Virginia G.;
Luquita, Marcelo G.;
Villanueva, Silvina S. M.;
Arias, Agostina;
Theile, Dirk;
Weiss, Johanna;
Mottino, Aldo D.;
Ruiz, María L.;
Catania, Viviana A.

Publication type:

Article

Rifampicin alters the expression of reference genes used to normalize real-time quantitative RT-PCR data.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2012, v. 385, n. 10, p. 1025, doi. 10.1007/s00210-012-0782-7

By:

Weiss, Johanna;
Theile, Dirk;
Haefeli, Walter

Publication type:

Article

Under-Reported Aspects of Platinum Drug Pharmacology.

Published in:

Molecules, 2017, v. 22, n. 3, p. 382, doi. 10.3390/molecules22030382

By:

Theile, Dirk

Publication type:

Article

Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.

Published in:

Journal of Pharmacy & Pharmacology, 2015, v. 67, n. 11, p. 1575, doi. 10.1111/jphp.12455

By:

Theile, Dirk;
Allendorf, David;
Köhler, Bruno Christian;
Jassowicz, Adam;
Weiss, Johanna

Publication type:

Article

In-vitro evaluation of chronic alcohol effects on expression of drug-metabolizing and drug-transporting proteins.

Published in:

Journal of Pharmacy & Pharmacology, 2013, v. 65, n. 10, p. 1518, doi. 10.1111/jphp.12124

By:

Theile, Dirk;
Schmidt, Tobias T.;
Haefeli, Walter E.;
Weiss, Johanna

Publication type:

Article

Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes.

Published in:

Pharmaceutics, 2021, v. 13, n. 6, p. 808, doi. 10.3390/pharmaceutics13060808

By:

Theile, Dirk;
Wagner, Lelia;
Bay, Cindy;
Haefeli, Walter Emil;
Weiss, Johanna

Publication type:

Article

Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma.

Published in:

Head & Neck, 2011, v. 33, n. 7, p. 959, doi. 10.1002/hed.21559

By:

Theile, Dirk;
Ketabi-Kiyanvash, Nahal;
Herold-Mende, Christel;
Dyckhoff, Gerhardt;
Efferth, Thomas;
Bertholet, Vincent;
Haefeli, Walter Emil;
Weiss, Johanna

Publication type:

Article

Impact of enzalutamide and its main metabolite N-desmethyl enzalutamide on pharmacokinetically important drug metabolizing enzymes and drug transporters.

Published in:

Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 9, p. 517, doi. 10.1002/bdd.2103

By:

Weiss, Johanna;
Kocher, Jutta;
Mueller, Corina;
Rosenzweig, Stephanie;
Theile, Dirk

Publication type:

Article