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Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons.
- Published in:
- Cells (2073-4409), 2023, v. 12, n. 14, p. 1895, doi. 10.3390/cells12141895
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- Article
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment.
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- Cellular & Molecular Life Sciences, 2010, v. 67, n. 21, p. 3589, doi. 10.1007/s00018-010-0486-4
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- Article
Intraluminal vesicle trafficking is involved in the secretion of base excision repair protein APE1.
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- FEBS Journal, 2024, v. 291, n. 13, p. 2849, doi. 10.1111/febs.17088
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- Article
APE1 interacts with the nuclear exosome complex protein MTR4 and is involved in cisplatin‐ and 5‐fluorouracil‐induced RNA damage response.
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- FEBS Journal, 2023, v. 290, n. 7, p. 1740, doi. 10.1111/febs.16671
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- Article
Functional analysis of a novel RUNX2 missense mutation found in a family with cleidocranial dysplasia.
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- Journal of Human Genetics, 2005, v. 50, n. 12, p. 679, doi. 10.1007/s10038-005-0311-3
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- Article
Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
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- Nucleic Acids Research, 2024, v. 52, n. 3, p. 1207, doi. 10.1093/nar/gkad1204
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- Article
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.
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- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00842-8
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- Article
Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker Discovery.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 16, p. 9161, doi. 10.3390/ijms23169161
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- Article
Platinum Salts in Patients with Breast Cancer: A Focus on Predictive Factors.
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- International Journal of Molecular Sciences, 2019, v. 20, n. 14, p. 3390, doi. 10.3390/ijms20143390
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- Article
Nucleophosmin Delocalization in Thyroid Tumour Cells.
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- Endocrine Pathology, 2011, v. 22, n. 1, p. 18, doi. 10.1007/s12022-011-9147-x
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- Article
Brain Exosomes: Friend or Foe in Alzheimer's Disease?
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- Molecular Neurobiology, 2021, v. 58, n. 12, p. 6610, doi. 10.1007/s12035-021-02547-y
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- Article
New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps.
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- Mutagenesis, 2020, v. 35, n. 1, p. 129, doi. 10.1093/mutage/gez051
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- Article
In the TTF-1 Homeodomain the Contribution of Several Amino Acids to DNA Recognition Depends on the Bound Sequence.
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- Nucleic Acids Research, 1996, v. 24, n. 17, p. 3283, doi. 10.1093/nar/24.17.3283
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- Article
Molecular analysis of a human PAX6 homeobox mutant.
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- European Journal of Human Genetics, 2006, v. 14, n. 6, p. 744, doi. 10.1038/sj.ejhg.5201579
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- Article
Integrated multi-omics analyses on patient-derived CRC organoids highlight altered molecular pathways in colorectal cancer progression involving PTEN.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2021, v. 40, n. 1, p. 1, doi. 10.1186/s13046-021-01986-8
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- Article
Unexpected phenotype of a typical NPM1 mutant.
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- 2009
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- Publication type:
- Letter
Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.
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- Molecular Carcinogenesis, 2016, v. 55, n. 5, p. 688, doi. 10.1002/mc.22313
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- Article
The regulatory role of APE1 in epithelial‐to‐mesenchymal transition and in determining EGFR‐TKI responsiveness in non‐small‐cell lung cancer.
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- Cancer Medicine, 2018, v. 7, n. 9, p. 4406, doi. 10.1002/cam4.1717
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- Article
Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-019-56981-z
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- Article
The Redox Function of APE1 Is Involved in the Differentiation Process of Stem Cells toward a Neuronal Cell Fate.
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- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0089232
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- Article
Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070909
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- Article
RbAp48 is a Target of Nuclear Factor-κB Activity in Thyroid Cancer.
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- Journal of Clinical Endocrinology & Metabolism, 2007, v. 92, n. 4, p. 1458, doi. 10.1210/jc.2006-2199
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- Publication type:
- Article
A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein.
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- Proteomics, 2010, v. 10, n. 8, p. 1645, doi. 10.1002/pmic.200900579
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- Article
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.
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- Proteomics, 2009, v. 9, n. 4, p. 1058, doi. 10.1002/pmic.200800638
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- Article
Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation.
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- Proteomics, 2006, v. 6, n. 11, p. 3455, doi. 10.1002/pmic.200500770
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- Article
Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: A proteomics study.
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- Proteomics, 2005, v. 5, n. 7, p. 1827, doi. 10.1002/pmic.200401082
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- Article
Detection of aromatic catabolic gene expression in heterogeneous organic matter used for reduction of volatile organic compounds (VOC) by biofiltration.
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- Biotechnology Letters, 2007, v. 29, n. 1, p. 65, doi. 10.1007/s10529-006-9197-1
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- Publication type:
- Article
Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics.
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- Mass Spectrometry Reviews, 2005, v. 24, n. 1, p. 55, doi. 10.1002/mas.20006
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- Publication type:
- Article
Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity.
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- Biomolecules (2218-273X), 2020, v. 10, n. 4, p. 531, doi. 10.3390/biom10040531
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- Article
A Potent HIV Protease Inhibitor Identified in an Epimeric Mixture by High-Resolution Protein Crystallography.
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- ChemMedChem, 2006, v. 1, n. 2, p. 186, doi. 10.1002/cmdc.200500063
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- Article
APE1 controls DICER1 expression in NSCLC through miR-33a and miR-130b.
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- Cellular & Molecular Life Sciences, 2022, v. 79, n. 8, p. 1, doi. 10.1007/s00018-022-04443-7
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- Publication type:
- Article
Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).
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- Biochemical Journal, 2013, v. 452, n. 3, p. 545, doi. 10.1042/BJ20121277
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- Article
regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours.
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- Nucleic Acids Research, 2022, v. 50, n. 18, p. 10449, doi. 10.1093/nar/gkac807
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- Article
Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2.
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- Nucleic Acids Research, 2017, v. 45, n. 19, p. 11193, doi. 10.1093/nar/gkx723
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- Article
Mitochondrial translocation of APE1 relies on the MIA pathway.
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- Nucleic Acids Research, 2015, v. 43, n. 11, p. 5451, doi. 10.1093/nar/gkv433
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- Article
The prion protein is critical for DNA repair and cell survival after genotoxic stress.
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- Nucleic Acids Research, 2015, v. 43, n. 2, p. 904, doi. 10.1093/nar/gku1342
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- Publication type:
- Article
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.
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- Nucleic Acids Research, 2010, v. 38, n. 22, p. 8239, doi. 10.1093/nar/gkq691
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- Publication type:
- Article
Expression and Prognostic Significance of APE1/Ref-1 and NPM1 Proteins in High-Grade Ovarian Serous Cancer.
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- American Journal of Clinical Pathology, 2014, v. 141, n. 3, p. 404, doi. 10.1309/AJCPIDKDLSGE26CX
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- Article
Isoforms of the Erythropoietin receptor in dopaminergic neurons of the Substantia Nigra.
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- Journal of Neurochemistry, 2016, v. 139, n. 4, p. 596, doi. 10.1111/jnc.13757
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- Article
Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress.
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- Journal of Cellular Physiology, 2007, v. 212, n. 1, p. 223, doi. 10.1002/jcp.21023
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- Publication type:
- Article
Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: A novel tumorigenic pathway.
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- Journal of Cellular Physiology, 2006, v. 209, n. 1, p. 44, doi. 10.1002/jcp.20704
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- Publication type:
- Article
H<sub>2</sub>O<sub>2</sub> induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line.
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- Journal of Cellular Physiology, 2002, v. 193, n. 2, p. 180, doi. 10.1002/jcp.10159
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- Article
Missense mutations of human homeoboxes: A review.
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- Human Mutation, 2002, v. 19, n. 4, p. 457, doi. 10.1002/humu.10070
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- Article
Missense mutations of human homeoboxes: A review.
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- Human Mutation, 2001, v. 18, n. 5, p. 361, doi. 10.1002/humu.1207
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- Publication type:
- Article
Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP.
- Published in:
- Nucleic Acids Research, 2005, v. 33, n. 14, p. 4379, doi. 10.1093/nar/gki751
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- Publication type:
- Article
Expression and function of the homeodomain-containing protein Hex in thyroid cells.
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- Nucleic Acids Research, 2000, v. 28, n. 13, p. 2503, doi. 10.1093/nar/28.13.2503
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- Publication type:
- Article
An ‘environment to nucleus’ signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation.
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- Nucleic Acids Research, 2000, v. 28, n. 5, p. 1099, doi. 10.1093/nar/28.5.1099
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- Article
Differential capacity of CD90+ cells in autophagy activation following chemotherapy in hepatocellular carcinoma.
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- Annals of Hepatology: Official Journal of the Mexican Association of Hepatology, 2020, v. 19, n. 6, p. 645, doi. 10.1016/j.aohep.2020.07.007
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- Publication type:
- Article
Molecular and functional changes associated with APE1/Ref-1 loss of expression reveal its multifunctional nature in mammalian cells.
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- FASEB Journal, 2008, v. 22, p. 289, doi. 10.1096/fasebj.22.2_supplement.289
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- Article
Biocrystallographic study on drug resistant variants of HIV protease with new inhibitors.
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- FASEB Journal, 2007, v. 21, n. 6, p. A1011, doi. 10.1096/fasebj.21.6.a1011-a
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- Publication type:
- Article