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Editorial: Editors' showcase: molecular signalling and pathways.
- Published in:
- Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1479278
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- Article
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
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- Cells (2073-4409), 2022, v. 11, n. 6, p. 1018, doi. 10.3390/cells11061018
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- Publication type:
- Article
Alpha-Synuclein and Lipids: The Elephant in the Room?
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- Cells (2073-4409), 2021, v. 10, n. 9, p. 2452, doi. 10.3390/cells10092452
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- Article
Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells.
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- Cells (2073-4409), 2021, v. 10, n. 5, p. 981, doi. 10.3390/cells10050981
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- Article
Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience.
- Published in:
- 2021
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- Publication type:
- Editorial
Inhibition of FK506 Binding Proteins Reduces α-Synuclein Aggregation and Parkinson's Disease-Like Pathology.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 7, p. 2454, doi. 10.1523/JNEUROSCI.5983-09.2010
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- Publication type:
- Article
Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis.
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- Journal of Neuroscience, 2009, v. 29, n. 44, p. 13971, doi. 10.1523/JNEUROSCI.3799-09.2009
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- Publication type:
- Article
Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.
- Published in:
- FASEB Journal, 2015, v. 29, n. 7, p. 2980, doi. 10.1096/fj.14-262329
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- Publication type:
- Article
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
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- Journal of Neurochemistry, 2015, v. 135, n. 6, p. 1242, doi. 10.1111/jnc.13369
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- Publication type:
- Article
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
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- Journal of Neurochemistry, 2014, v. 131, n. 2, p. 239, doi. 10.1111/jnc.12798
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- Publication type:
- Article
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
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- Journal of Neurochemistry, 2011, v. 116, n. 2, p. 304, doi. 10.1111/j.1471-4159.2010.07105.x
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- Publication type:
- Article
Distribution of PINK1 and LRRK2 in rat and mouse brain.
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- Journal of Neurochemistry, 2006, v. 98, n. 3, p. 951, doi. 10.1111/j.1471-4159.2006.03919.x
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- Publication type:
- Article
Immunohistochemical detection of transgene expression in the brain using small epitope tags.
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- BMC Biotechnology, 2010, v. 10, p. 1, doi. 10.1186/1472-6750-10-16
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- Publication type:
- Article
MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.
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- Human Molecular Genetics, 2013, v. 22, n. 3, p. 608, doi. 10.1093/hmg/dds470
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- Publication type:
- Article
LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?
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- Biochemical Society Transactions, 2017, v. 45, n. 1, p. 207, doi. 10.1042/BST20160334
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- Publication type:
- Article
Phosphorylation of LRRK2: from kinase to substrate.
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- Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1102, doi. 10.1042/BST20120128
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- Publication type:
- Article
The GTPase function of LRRK2.
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- Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1063, doi. 10.1042/BST20120133
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- Publication type:
- Article
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 6760, doi. 10.3390/ijms22136760
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- Publication type:
- Article
In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants.
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- International Journal of Molecular Sciences, 2014, v. 15, n. 1, p. 1040, doi. 10.3390/ijms15011040
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- Publication type:
- Article
In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins.
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- Proteomics, 2018, v. 18, n. 13, p. 1, doi. 10.1002/pmic.201800103
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- Publication type:
- Article
Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism.
- Published in:
- Frontiers in Genetics, 2014, v. 5, p. 1, doi. 10.3389/fgene.2014.00382
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- Publication type:
- Article
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
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- Molecular Neurodegeneration, 2018, v. 13, p. 1, doi. 10.1186/s13024-018-0235-y
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- Publication type:
- Article
Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions.
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- Journal of Neurochemistry, 2003, v. 84, n. 5, p. 1118, doi. 10.1046/j.1471-4159.2003.01610.x
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- Publication type:
- Article
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
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- Biochemical Journal, 2019, v. 476, n. 19, p. 2797, doi. 10.1042/BCJ20190315
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- Publication type:
- Article
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
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- Biochemical Journal, 2013, v. 456, n. 1, p. 119, doi. 10.1042/BJ20121772
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- Publication type:
- Article
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.
- Published in:
- Bioscience Reports, 2020, v. 40, n. 10, p. 1, doi. 10.1042/BSR20202225
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- Publication type:
- Article
Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.
- Published in:
- Frontiers in Molecular Neuroscience, 2014, p. 1, doi. 10.3389/fnmol.2014.00071
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- Publication type:
- Article
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.
- Published in:
- Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00051
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- Publication type:
- Article
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.
- Published in:
- Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00051
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- Publication type:
- Article
PARKINSON’S DISEASE-ASSOCIATED MUTATIONS IN LRRK2 CAUSE CENTROSOMAL DEFECTS VIA RAB8A PHOSPHORYLATION.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1501, doi. 10.1016/j.jalz.2017.07.604
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- Article
Perspective on the current state of the LRRK2 field.
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- NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00544-7
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- Publication type:
- Article
Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson's disease and pharmacodynamic biomarkers.
- Published in:
- NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00445-9
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- Publication type:
- Article
Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043472
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- Publication type:
- Article
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding.
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- PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023207
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- Publication type:
- Article
The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation.
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- PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008730
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- Publication type:
- Article
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
- Published in:
- Frontiers in Neuroscience, 2020, p. N.PAG, doi. 10.3389/fnins.2020.00865
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- Publication type:
- Article
LRRK2 Phosphorylation, More Than an Epiphenomenon.
- Published in:
- Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00527
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- Publication type:
- Article
Role of LRRK2 in the regulation of dopamine receptor trafficking.
- Published in:
- PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0179082
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- Publication type:
- Article
Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies.
- Published in:
- Frontiers in Molecular Neuroscience, 2024, p. 01, doi. 10.3389/fnmol.2024.1414816
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- Publication type:
- Article
Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time.
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- European Journal of Neuroscience, 2004, v. 19, n. 8, p. 2249, doi. 10.1111/j.0953-816X.2004.03336.x
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- Publication type:
- Article
Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson′s Disease.
- Published in:
- Movement Disorders, 2022, v. 37, n. 8, p. 1761, doi. 10.1002/mds.29124
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- Publication type:
- Article
A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells.
- Published in:
- NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-023-00624-8
- By:
- Publication type:
- Article
Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson's disease and pharmacodynamic biomarkers.
- Published in:
- NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00445-9
- By:
- Publication type:
- Article
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 14, p. 2747, doi. 10.1093/hmg/ddx161
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- Publication type:
- Article
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α-synuclein, and tau.
- Published in:
- BioEssays, 2010, v. 32, n. 3, p. 227, doi. 10.1002/bies.200900163
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- Publication type:
- Article
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
- Published in:
- Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00417
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- Publication type:
- Article
Automated quantitative gait analysis in animal models of movement disorders.
- Published in:
- BMC Neuroscience, 2010, v. 11, p. 92, doi. 10.1186/1471-2202-11-92
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- Publication type:
- Article