Works by Taylor, Martin C.

Results: 37

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.

Published in:

Cellular Microbiology, 2016, v. 18, n. 10, p. 1429, doi. 10.1111/cmi.12584

By:

Lewis, Michael D.;
Francisco, Amanda Fortes;
Taylor, Martin C.;
Jayawardhana, Shiromani;
Kelly, John M.

Publication type:

Article

Bioluminescence imaging of chronic T rypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.

Published in:

Cellular Microbiology, 2014, v. 16, n. 9, p. 1285, doi. 10.1111/cmi.12297

By:

Lewis, Michael D.;
Fortes Francisco, Amanda;
Taylor, Martin C.;
Burrell‐Saward, Hollie;
McLatchie, Alex P.;
Miles, Michael A.;
Kelly, John M.

Publication type:

Article

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 4, p. 1, doi. 10.1371/journal.pntd.0007717

By:

Mann, Gurdip Singh;
Francisco, Amanda F.;
Jayawardhana, Shiromani;
Taylor, Martin C.;
Lewis, Michael D.;
Olmo, Francisco;
de Freitas, Elisangela Oliveira;
Leoratti, Fabiana M. S.;
López-Camacho, Cesar;
Reyes-Sandoval, Arturo;
Kelly, John M.

Publication type:

Article

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection.

Published in:

PLoS Neglected Tropical Diseases, 2020, v. 14, n. 3, p. 1, doi. 10.1371/journal.pntd.0008007

By:

Taylor, Martin C.;
Ward, Alexander;
Olmo, Francisco;
Jayawardhana, Shiromani;
Francisco, Amanda F.;
Lewis, Michael D.;
Kelly, John M.

Publication type:

Article

Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population.

Published in:

Journal of Infectious Diseases, 2012, v. 206, n. 2, p. 220, doi. 10.1093/infdis/jis331

By:

Mejia, Ana Maria;
Hall, Belinda S.;
Taylor, Martin C.;
Gómez-Palacio, Andrés;
Wilkinson, Shane R.;
Triana-Chávez, Omar;
Kelly, John M.

Publication type:

Article

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.

Published in:

PLoS Pathogens, 2021, v. 17, n. 8, p. 1, doi. 10.1371/journal.ppat.1009864

By:

Khan, Archie A.;
Langston, Harry C.;
Costa, Fernanda C.;
Olmo, Francisco;
Taylor, Martin C.;
McCann, Conor J.;
Kelly, John M.;
Lewis, Michael D.

Publication type:

Article

Challenges in Chagas Disease Drug Development.

Published in:

Molecules, 2020, v. 25, n. 12, p. 2799, doi. 10.3390/molecules25122799

By:

Francisco, Amanda F.;
Jayawardhana, Shiromani;
Olmo, Francisco;
Lewis, Michael D.;
Wilkinson, Shane R.;
Taylor, Martin C.;
Kelly, John M.;
Tsotinis, Andrew;
Papanastasiou, Ioannis

Publication type:

Article

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

Published in:

Molecules, 2018, v. 23, n. 1, p. 177, doi. 10.3390/molecules23010177

By:

Ghashghaei, Ouldouz;
Kielland, Nicola;
Revés, Marc;
Taylor, Martin C.;
Kelly, John M.;
Di Pietro, Ornella;
Muñoz-Torrero, Diego;
Pérez, Belén;
Lavilla, Rodolfo

Publication type:

Article

Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi.

Published in:

Molbank, 2022, v. 2022, n. 2, p. M1363, doi. 10.3390/M1363

By:

Foscolos, Angeliki Sofia;
Tsotinis, Andrew;
Taylor, Martin C.;
Kelly, John M.;
Papanastasiou, Ioannis P.

Publication type:

Article

Biological factors that impinge on Chagas disease drug development.

Published in:

Parasitology, 2017, v. 144, n. 14, p. 1871, doi. 10.1017/S0031182017001469

By:

FRANCISCO, AMANDA F.;
JAYAWARDHANA, SHIROMANI;
LEWIS, MICHAEL D.;
TAYLOR, MARTIN C.;
KELLY, JOHN M.

Publication type:

Article

Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48749-5

By:

Khan, Archie A.;
Langston, Harry C.;
Walsh, Louis;
Roscoe, Rebecca;
Jayawardhana, Shiromani;
Francisco, Amanda Fortes;
Taylor, Martin C.;
McCann, Conor J.;
Kelly, John M.;
Lewis, Michael D.

Publication type:

Article

Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction.

Published in:

PLoS Neglected Tropical Diseases, 2024, v. 18, n. 6, p. 1, doi. 10.1371/journal.pntd.0012278

By:

Langston, Harry;
Fortes Francisco, Amanda;
Doidge, Ciaran;
Roberts, Chrissy H.;
Khan, Archie A.;
Jayawardhana, Shiromani;
Taylor, Martin C.;
Kelly, John M.;
Lewis, Michael D.

Publication type:

Article

A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research.

Published in:

PLoS Neglected Tropical Diseases, 2024, v. 18, n. 5, p. 1, doi. 10.1371/journal.pntd.0012106

By:

Olmo, Francisco;
Jayawardhana, Shiromani;
Khan, Archie A.;
Langston, Harry C.;
Francisco, Amanda Fortes;
Atherton, Richard L.;
Ward, Alex I.;
Taylor, Martin C.;
Kelly, John M.;
Lewis, Michael D.

Publication type:

Article

Synthesis and Biological Activity of 2‐Benzo[b]thienyl and 2‐Bithienyl Amidino‐Substituted Benzothiazole and Benzimidazole Derivatives.

Published in:

ChemMedChem, 2023, v. 18, n. 18, p. 1, doi. 10.1002/cmdc.202300261

By:

Racané, Livio;
Zlatić, Katarina;
Cindrić, Maja;
Mehić, Emina;
Karminski‐Zamola, Grace;
Taylor, Martin C.;
Kelly, John M.;
Malić, Silvana Raić;
Stojković, Marijana Radić;
Kralj, Marijeta;
Hranjec, Marijana

Publication type:

Article

Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity.

Published in:

ChemMedChem, 2019, v. 14, n. 13, p. 1227, doi. 10.1002/cmdc.201900165

By:

Foscolos, Angeliki‐Sofia;
Papanastasiou, Ioannis;
Tsotinis, Andrew;
Taylor, Martin C.;
Kelly, John M.

Publication type:

Article

Lipophilic conformationally constrained spiro carbocyclic 2,6‐diketopiperazine‐1‐acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study.

Published in:

Chemical Biology & Drug Design, 2018, v. 91, n. 2, p. 408, doi. 10.1111/cbdd.13088

By:

Zoidis, Grigoris;
Tsotinis, Andrew;
Tsatsaroni, Alexandra;
Fytas, George;
Taylor, Martin C.;
Kelly, John M.;
Efstathiou, Antonia;
Smirlis, Despina

Publication type:

Article

PHEROMONES: SUCCESS OF THE SMELLIEST.

Published in:

Biologist, 2016, v. 63, n. 6, p. 45

By:

TAYLOR, MARTIN C.

Publication type:

Article

Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.875647

By:

Abacha, Yabalu Z.;
Forkuo, Arnold Donkor;
Gbedema, Stephen Y.;
Mittal, Nimisha;
Ottilie, Sabine;
Rocamora, Frances;
Winzeler, Elizabeth A.;
van Schalkwyk, Donelly A.;
Kelly, John M.;
Taylor, Martin C.;
Reader, Janette;
Birkholtz, Lyn-Marie;
Lisgarten, David R.;
Cockcroft, Jeremy K.;
Lisgarten, John N.;
Palmer, Rex A.;
Talbert, Rosemary C.;
Shnyder, Steven D.;
Wright, Colin W.

Publication type:

Article

Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.

Published in:

Molecular Microbiology, 2013, v. 89, n. 3, p. 420, doi. 10.1111/mmi.12285

By:

Taylor, Martin C.;
McLatchie, Alex P.;
Kelly, John M.

Publication type:

Article

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease.

Published in:

Pathogens, 2023, v. 12, n. 11, p. 1364, doi. 10.3390/pathogens12111364

By:

Francisco, Amanda Fortes;
Sousa, Giovane R.;
Vaughan, Mhairi;
Langston, Harry;
Khan, Archie;
Jayawardhana, Shiromani;
Taylor, Martin C.;
Lewis, Michael D.;
Kelly, John M.

Publication type:

Article

The Viral Thymidine Kinase Gene as a Tool for the Study of Mutagenesis in Trypanosoma Brucei.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 10, p. 1809, doi. 10.1093/nar/24.10.1809

By:

Valdés, Jesús;
Taylor, Martin C.;
Cross, Michael A.;
Ligtenberg, Marjolijn J. L.;
Rudenko, Gloria;
Borst, Piet

Publication type:

Article

In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 8, p. 1, doi. 10.1371/journal.pntd.0002384

By:

Myburgh, Elmarie;
Coles, Jonathan A.;
Ritchie, Ryan;
Kennedy, Peter G. E.;
McLatchie, Alex P.;
Rodgers, Jean;
Taylor, Martin C.;
Barrett, Michael P.;
Brewer, James M.;
Mottram, Jeremy C.

Publication type:

Article

In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 8, p. 1, doi. 10.1371/journal.pntd.0002384

By:

Myburgh, Elmarie;
Coles, Jonathan A.;
Ritchie, Ryan;
Kennedy, Peter G. E.;
McLatchie, Alex P.;
Rodgers, Jean;
Taylor, Martin C.;
Barrett, Michael P.;
Brewer, James M.;
Mottram, Jeremy C.

Publication type:

Article

Imaging the development of chronic Chagas disease after oral transmission.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-29564-7

By:

Lewis, Michael D.;
Francisco, Amanda F.;
Jayawardhana, Shiromani;
Langston, Harry;
Taylor, Martin C.;
Kelly, John M.

Publication type:

Article

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 3, p. 1023, doi. 10.1093/nar/gkq839

By:

Obado, Samson O.;
Bot, Christopher;
Echeverry, Maria C.;
Bayona, Julio C.;
Alvarez, Vanina E.;
Taylor, Martin C.;
Kelly, John M.

Publication type:

Article

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 4, p. 1, doi. 10.1371/journal.pntd.0003707

By:

Taylor, Martin C.;
Lewis, Michael D.;
Francisco, Amanda Fortes;
Wilkinson, Shane R.;
Kelly, John M.

Publication type:

Article

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 4, p. 1, doi. 10.1371/journal.pntd.0003707

By:

Taylor, Martin C.;
Lewis, Michael D.;
Francisco, Amanda Fortes;
Wilkinson, Shane R.;
Kelly, John M.

Publication type:

Article

Highly Sensitive In Vivo Imaging of Trypanosoma brucei Expressing "Red-Shifted" Luciferase.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 11, p. 1, doi. 10.1371/journal.pntd.0002571

By:

McLatchie, Alex P.;
Burrell-Saward, Hollie;
Myburgh, Elmarie;
Lewis, Michael D.;
Ward, Theresa H.;
Mottram, Jeremy C.;
Croft, Simon L.;
Kelly, John M.;
Taylor, Martin C.

Publication type:

Article

Highly Sensitive <i>In Vivo</i> Imaging of <i>Trypanosoma brucei</i> Expressing “Red-Shifted” Luciferase.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 11, p. 1, doi. 10.1371/journal.pntd.0002571

By:

McLatchie, Alex P.;
Burrell-Saward, Hollie;
Myburgh, Elmarie;
Lewis, Michael D.;
Ward, Theresa H.;
Mottram, Jeremy C.;
Croft, Simon L.;
Kelly, John M.;
Taylor, Martin C.

Publication type:

Article

Mechanism of genetic exchange in American trypanosomes.

Published in:

Nature, 2003, v. 421, n. 6926, p. 936, doi. 10.1038/nature01438

By:

Gaunt, Michael W.;
Yeo, Matthew;
Frame, Iain A.;
Stothard, J. Russell;
Carrasco, Hernan J.;
Taylor, Martin C.;
Mena, Susana Solis;
Veazey, Paul;
Miles, Graham A. J.;
Acosta, Nidia;
de Arias, Antonieta Rojas;
Miles, Michael A.

Publication type:

Article

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15125-y

By:

Macleod, Olivia J. S.;
Bart, Jean-Mathieu;
MacGregor, Paula;
Peacock, Lori;
Savill, Nicholas J.;
Hester, Svenja;
Ravel, Sophie;
Sunter, Jack D.;
Trevor, Camilla;
Rust, Steven;
Vaughan, Tristan J.;
Minter, Ralph;
Mohammed, Shabaz;
Gibson, Wendy;
Taylor, Martin C.;
Higgins, Matthew K.;
Carrington, Mark

Publication type:

Article

Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 7, p. 1046, doi. 10.3390/ph16071046

By:

Pardali, Vasiliki;
Giannakopoulou, Erofili;
Mpekoulis, George;
Tsopela, Vassilina;
Panos, Georgios;
Taylor, Martin C.;
Kelly, John M.;
Vassilaki, Niki;
Zoidis, Grigoris

Publication type:

Article

Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2021, v. 36, n. 1, p. 1952, doi. 10.1080/14756366.2021.1959572

By:

Racané, Livio;
Rep, Valentina;
Kraljević Pavelić, Sandra;
Grbčić, Petra;
Zonjić, Iva;
Radić Stojković, Marijana;
Taylor, Martin C.;
Kelly, John M.;
Raić-Malić, Silvana

Publication type:

Article

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2018, v. 33, n. 1, p. 1323, doi. 10.1080/14756366.2018.1484733

By:

Bistrović, Andrea;
Krstulović, Luka;
Stolić, Ivana;
Drenjančević, Domagoj;
Talapko, Jasminka;
Taylor, Martin C.;
Kelly, John M.;
Bajić, Miroslav;
Raić-Malić, Silvana

Publication type:

Article

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32728-9

By:

Macleod, Olivia J. S.;
Cook, Alexander D.;
Webb, Helena;
Crow, Mandy;
Burns, Roisin;
Redpath, Maria;
Seisenberger, Stefanie;
Trevor, Camilla E.;
Peacock, Lori;
Schwede, Angela;
Kimblin, Nicola;
Francisco, Amanda F.;
Pepperl, Julia;
Rust, Steve;
Voorheis, Paul;
Gibson, Wendy;
Taylor, Martin C.;
Higgins, Matthew K.;
Carrington, Mark

Publication type:

Article

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2019, v. 13, n. 5, p. 1, doi. 10.1371/journal.pntd.0007373

By:

MacGregor, Paula;
Gonzalez-Munoz, Andrea L.;
Jobe, Fatoumatta;
Taylor, Martin C.;
Rust, Steven;
Sandercock, Alan M.;
Macleod, Olivia J. S.;
Van Bocxlaer, Katrien;
Francisco, Amanda F.;
D’Hooge, Francois;
Tiberghien, Arnaud;
Barry, Conor S.;
Howard, Philip;
Higgins, Matthew K.;
Vaughan, Tristan J.;
Minter, Ralph;
Carrington, Mark

Publication type:

Article

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.

Published in:

PLoS Pathogens, 2023, v. 19, n. 11, p. 1, doi. 10.1371/journal.ppat.1011627

By:

Jayawardhana, Shiromani;
Ward, Alexander I.;
Francisco, Amanda F.;
Lewis, Michael D.;
Taylor, Martin C.;
Kelly, John M.;
Olmo, Francisco

Publication type:

Article