Works by Tawfik, Haytham O.

Results: 19

New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 4, p. N.PAG, doi. 10.3390/ph15040481

By:

Tawfik, Haytham O.;
El-Hamaky, Anwar A.;
El-Bastawissy, Eman A.;
Shcherbakov, Kirill A.;
Veselovsky, Alexander V.;
Gladilina, Yulia A.;
Zhdanov, Dmitry D.;
El-Hamamsy, Mervat H.

Publication type:

Article

LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus infected rat skin wound.

Published in:

Natural Product Research, 2023, v. 37, n. 10, p. 1730, doi. 10.1080/14786419.2022.2108421

By:

El-Aasr, Mona;
Nohara, Toshihiro;
Ikeda, Tsuyushi;
Abu-Risha, Sally E.;
Elekhnawy, Engy;
Tawfik, Haytham O.;
Shoeib, Nagwa;
Attia, Ghada

Publication type:

Article

Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R).

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2241674

By:

Abo Al-Hamd, Mahmoud G.;
Tawfik, Haytham O.;
Abdullah, Omeima;
Yamaguchi, Koki;
Sugiura, Masaharu;
Mehany, Ahmed B. M.;
El-Hamamsy, Mervat H.;
El-Moselhy, Tarek F.

Publication type:

Article

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2203389

By:

Shaldam, Moataz A.;
Almahli, Hadia;
Angeli, Andrea;
Badi, Rehab Mustafa;
Khaleel, Eman F.;
Zain-Alabdeen, Abdelrahman I.;
Elsayed, Zainab M.;
Elkaeed, Eslam B.;
Salem, Rofaida;
Supuran, Claudiu T.;
Eldehna, Wagdy M.;
Tawfik, Haytham O.

Publication type:

Article

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2171029

By:

Farouk, Faten;
Elmaaty, Ayman Abo;
Elkamhawy, Ahmed;
Tawfik, Haytham O.;
Alnajjar, Radwan;
Abourehab, Mohammed A. S.;
Saleh, Mohamed A.;
Eldehna, Wagdy M.;
Al‐Karmalawy, Ahmed A.

Publication type:

Article

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1043, doi. 10.1080/14756366.2022.2056734

By:

Tawfik, Haytham O.;
Shaldam, Moataz A.;
Nocentini, Alessio;
Salem, Rofaida;
Almahli, Hadia;
Al-Rashood, Sara T.;
Supuran, Claudiu T.;
Eldehna, Wagdy M.

Publication type:

Article

Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2489, doi. 10.1080/14756366.2022.2120478

By:

Saad, Mohamed H.;
El-Moselhy, Tarek F.;
El-Din, Nabaweya S.;
Mehany, Ahmed B. M.;
Belal, Amany;
Abourehab, Mohammed A. S.;
Tawfik, Haytham O.;
El-Hamamsy, Mervat H.

Publication type:

Article

Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 2765, doi. 10.1080/14756366.2022.2130285

By:

Tawfik, Haytham O.;
Belal, Amany;
Abourehab, Mohammed A. S.;
Angeli, Andrea;
Bonardi, Alessandro;
Supuran, Claudiu T.;
El-Hamamsy, Mervat H.

Publication type:

Article

Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-34189-6

By:

Ghamry, Heba I.;
Belal, Amany;
El-Ashrey, Mohamed Kandeel;
Tawfik, Haytham O.;
Alsantali, Reem I.;
Obaidullah, Ahmad J.;
El-Mansi, Ahmed A.;
Abdelrahman, Doaa

Publication type:

Article

Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies.

Published in:

Metabolites (2218-1989), 2023, v. 13, n. 1, p. 10, doi. 10.3390/metabo13010010

By:

El-Seadawy, Hosam M.;
Abo El-Seoud, Kamilia A.;
El-Aasr, Mona;
Tawfik, Haytham O.;
Eldehna, Wagdy M.;
Ragab, Amany E.

Publication type:

Article

Drosophila melanogaster as a model organism for diabetes II treatment by the ethyl acetate fraction of Atriplex halimus L.

Published in:

Journal of Experimental Zoology: Part A Ecological & Integrative Physiology, 2024, v. 341, n. 6, p. 702, doi. 10.1002/jez.2812

By:

Montaser, Omnia;
El‐Aasr, Mona;
Tawfik, Haytham O.;
Meshrif, Wesam S.;
Elbrense, Hanaa

Publication type:

Article

Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di- C -glucoside from Cycas rumphii Miq. Cultivated in Egypt.

Published in:

Plants (2223-7747), 2022, v. 11, n. 21, p. 2867, doi. 10.3390/plants11212867

By:

El-Seadawy, Hosam M.;
Abo El-Seoud, Kamilia A.;
El-Aasr, Mona;
Tawfik, Haytham O.;
Ragab, Amany E.

Publication type:

Article

The Application of CoMFA Approach for the Design of 1,4-Dihydropyridines as Calcium Channel Blockers.

Published in:

Chemistry & Biology Interface, 2016, v. 6, n. 5, p. 350

By:

Shaldam, Moataz A.;
Tawfik, Haytham O.;
El-Bastawissy, Eman A.;
El-Moselhy, Tarek F.

Publication type:

Article

Design and synthesis of novel substituted s‐triazines tethered benzenesulfonamides as potential antimicrobial candidates: Antibiofilm and bacterial protein permeability assessments.

Published in:

Archiv der Pharmazie, 2025, v. 358, n. 3, p. 1, doi. 10.1002/ardp.202400931

By:

Al‐Karmalawy, Ahmed A.;
Tawfik, Haytham O.;
El‐Sayyad, Gharieb S.;
Elmaaty, Ayman Abo;
Abdel‐Fatah, Sobhy S.;
Atiya, Akhtar;
Alzahrani, Abdullah Yahya Abdullah;
Khatib, Arwa Omar Al;
El‐Hamamsy, Mervat H.;
Elsebaie, Heba A.

Publication type:

Article

Identification of 3‐(5‐cyano‐6‐oxo‐pyridin‐2‐yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity.

Published in:

Archiv der Pharmazie, 2024, v. 357, n. 1, p. 1, doi. 10.1002/ardp.202300449

By:

Shaldam, Moataz A.;
Khalil, Ahmed F.;
Almahli, Hadia;
Jaballah, Maiy Y.;
Angeli, Andrea;
Khaleel, Eman F.;
Badi, Rehab Mustafa;
Elkaeed, Eslam B.;
Supuran, Claudiu T.;
Eldehna, Wagdy M.;
Tawfik, Haytham O.

Publication type:

Article

Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors.

Published in:

Archiv der Pharmazie, 2020, v. 353, n. 8, p. 1, doi. 10.1002/ardp.202000060

By:

El‐Hamamsy, Mervat H.;
Sharafeldin, Nabaweya A.;
El‐Moselhy, Tarek F.;
Tawfik, Haytham O.

Publication type:

Article

An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.

Published in:

Molecular Diversity, 2024, v. 28, n. 6, p. 4581, doi. 10.1007/s11030-023-10777-6

By:

Sabt, Ahmed;
Tawfik, Haytham O.;
Khaleel, Eman F.;
Badi, Rehab Mustafa;
Ibrahim, Hoda Atef Abdelsattar;
Elkaeed, Eslam B.;
Eldehna, Wagdy M.

Publication type:

Article

Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease.

Published in:

Frontiers in Chemistry, 2024, p. 01, doi. 10.3389/fchem.2024.1406051

By:

Pengyu Zhao;
Yusen Hou;
Tingting Yan;
Jie Kang;
Ye Tian;
Jiaxin Li;
Chenjuan Zeng;
Funeng Geng;
Qi Liao;
Tawfik, Haytham O.;
Elkady, Hazem

Publication type:

Article

Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening.

Published in:

Molecules, 2023, v. 28, n. 4, p. 1583, doi. 10.3390/molecules28041583

By:

Eliwa, Duaa;
Kabbash, Amal;
El-Aasr, Mona;
Tawfik, Haytham O.;
Batiha, Gaber El-Saber;
Mahmoud, Mohamed H.;
De Waard, Michel;
Eldehna, Wagdy M.;
Ibrahim, Abdel-Rahim S.

Publication type:

Article