Works matching AU Tanus-Santos, Jose E.

Results: 95

The use of probiotics can reduce the severity of experimental periodontitis in rats with metabolic syndrome: An immunoenzymatic and microtomographic study.

Published in:

Journal of Periodontology, 2022, v. 93, n. 2, p. e1, doi. 10.1002/JPER.21-0285

By:

Silva, Giselle A.;
Moreira, André L. G.;
Silva, Pedro H. F.;
Salvador, Sérgio L.;
Casarin, Renato C. V.;
Vicente, Raphael M.;
Ferreira, Graziele C.;
Tanus‐Santos, José E.;
Furlaneto, Flávia A. C.;
Messora, Michel R.;
Tanus-Santos, José E

Publication type:

Article

Facilitating Nitrite-Derived S-Nitrosothiol Formation in the Upper Gastrointestinal Tract in the Therapy of Cardiovascular Diseases.

Published in:

Antioxidants, 2024, v. 13, n. 6, p. 691, doi. 10.3390/antiox13060691

By:

Silva-Cunha, Mila;
Lacchini, Riccardo;
Tanus-Santos, Jose E.

Publication type:

Article

The Skeletal Muscle, the Heart, and the Liver Are the Major Organs of the Accumulation of Nitric Oxide Metabolites after Oral Nitrite Treatment.

Published in:

Antioxidants, 2024, v. 13, n. 3, p. 255, doi. 10.3390/antiox13030255

By:

Lima-Silva, Ana K.;
Rebelo, Macario A.;
Barros, Alessandra C.;
Conde-Tella, Sandra O.;
Tanus-Santos, Jose E.

Publication type:

Article

Transient left bundle branch block during anesthesia.

Published in:

Revista Mexicana de Anestesiología, 1998, v. 21, n. 3, p. 214

By:

Tanus-Santos, Jose E.

Publication type:

Article

Effects of probiotics in rats with experimental metabolic syndrome and periodontitis: An investigation of the intestine–adipose tissue axis.

Published in:

Journal of Periodontology, 2023, v. 94, n. 11, p. 1363, doi. 10.1002/JPER.22-0721

By:

Moreira, André L. G.;
Silva, Pedro H. F.;
Salvador, Sérgio L.;
Ishikawa, Karin H.;
Ferreira, Graziele C.;
Tanus‐Santos, José E.;
Mayer, Marcia P. A.;
de Souza, Sérgio L. S.;
Furlaneto, Flávia A. C.;
Messora, Michel R.

Publication type:

Article

Circulating Interleukin-6 and High-Sensitivity C-Reactive Protein Decrease After Periodontal Therapy in Otherwise Healthy Subjects.

Published in:

Journal of Periodontology, 2009, v. 80, n. 4, p. 594, doi. 10.1902/jop.2009.080561

By:

Marcaccini, Andrea M.;
Meschiari, César A.;
Sorgi, Carlos A.;
Saraiva, Maria C. P.;
de Souza, Ana M.;
Faccioli, Lúcia H.;
Tanus-Santos, José E.;
Novaes Jr., Arthur B.;
Gerlach, Raquel F.

Publication type:

Article

Impaired xanthine oxidoreductase (XOR)-mediated nitrite reductase activity possibly involved in the lack of antihypertensive effects of XOR inhibitors.

Published in:

Hypertension Research, 2017, v. 40, n. 3, p. 301, doi. 10.1038/hr.2016.138

By:

Carvalho, Caio C;
Tanus-Santos, Jose E;
Oliveira-Paula, Gustavo H

Publication type:

Article

Combining drugs to optimize the therapy of hypertension: experimental evidence derived from animal models.

Published in:

Hypertension Research, 2015, v. 38, n. 7, p. 457, doi. 10.1038/hr.2015.52

By:

Guimaraes, Danielle A;
Tanus-Santos, Jose E

Publication type:

Article

Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy.

Published in:

Hypertension Research, 2015, v. 38, n. 5, p. 361, doi. 10.1038/hr.2015.15

By:

Luizon, Marcelo R;
Belo, Vanessa A;
Palei, Ana CT;
Amaral, Lorena M;
Lacchini, Riccardo;
Sandrim, Valeria C;
Duarte, Geraldo;
Cavalli, Ricardo C;
Tanus-Santos, Jose E

Publication type:

Article

Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy.

Published in:

Hypertension Research, 2012, v. 35, n. 9, p. 917, doi. 10.1038/hr.2012.60

By:

Luizon, Marcelo R;
Sandrim, Valeria C;
Palei, Ana CT;
Lacchini, Riccardo;
Cavalli, Ricardo C;
Duarte, Geraldo;
Tanus-Santos, Jose E

Publication type:

Article

Imbalanced circulating matrix metalloproteinases in polycystic ovary syndrome.

Published in:

Molecular & Cellular Biochemistry, 2011, v. 353, n. 1/2, p. 251, doi. 10.1007/s11010-011-0793-6

By:

Gomes, Valéria A.;
Vieira, Carolina S.;
Jacob-Ferreira, Anna L.;
Belo, Vanessa A.;
Soares, Gustavo M.;
Fernandes, Janaína B. F.;
Ferriani, Rui A.;
Tanus-Santos, Jose E.

Publication type:

Article

Acute cardiac and hemodynamic effects of sildenafil on resistant hypertension.

Published in:

European Journal of Clinical Pharmacology, 2013, v. 69, n. 12, p. 2027, doi. 10.1007/s00228-013-1571-z

By:

Quinaglia, Thiago;
de Faria, Ana Paula C.;
Fontana, Vanessa;
Barbaro, Natália R.;
Sabbatini, Andréa R.;
Sertório, Jonas T.;
Demacq, Caroline;
Tanus-Santos, José E.;
Moreno, Heitor

Publication type:

Article

Positive correlations between serum and plasma matrix metalloproteinase (MMP)-2 or MMP-9 levels in disease conditions.

Published in:

Clinical Chemistry & Laboratory Medicine, 2009, v. 47, n. 7, p. 888, doi. 10.1515/CCLM.2009.203

By:

Gerlach, Raquel F.;
Meschiari, Cesar A.;
Marcaccini, Andrea M.;
Palei, Ana C.T.;
Sandrim, Valeria C.;
Cavalli, Ricardo C.;
Tanus-Santos, Jose E.

Publication type:

Article

Functional polymorphisms in the promoter of the matrix metalloproteinase-9 ( MMP-9) gene are not linked with significant plasma MMP-9 variations in healthy subjects.

Published in:

Clinical Chemistry & Laboratory Medicine, 2008, v. 46, n. 1, p. 57, doi. 10.1515/CCLM.2008.014

By:

Demacq, Caroline;
Vasconcellos, Vivian B.;
Marcaccini, Andrea M.;
Gerlach, Raquel F.;
Silva Jr., Wilson A.;
Tanus-Santos, Jose E.

Publication type:

Article

Bifidobacterium animalis subspecies lactisHN019 can reduce the sequelae of experimental periodontitis in rats modulating intestinal parameters, expression of lipogenic genes, and levels of hepatic steatosis.

Published in:

Journal of Periodontal Research, 2023, v. 58, n. 5, p. 1006, doi. 10.1111/jre.13163

By:

Moreira, André L. G.;
Silva, Giselle A.;
Silva, Pedro H. F.;
Salvador, Sérgio L.;
Vicente, Raphael M.;
Ferreira, Graziele C.;
Tanus‐Santos, Jose E.;
Mayer, Marcia P. A.;
Ishikawa, Karin H.;
de Souza, Sérgio Luís Scombatti;
Furlaneto, Flávia A. C.;
Messora, Michel R.

Publication type:

Article

Blood transfusions increase circulating plasma free hemoglobin levels and plasma nitric oxide consumption: a prospective observational pilot study.

Published in:

Critical Care, 2012, v. 16, n. 3, p. 1, doi. 10.1186/cc11359

By:

Windsant, Iris C. Vermeulen;
de Wit, Norbert C. J.;
Sertorio, Jonas T. C.;
Beckers, Erik A. M.;
Tanus-Santos, Jose E.;
Jacobs, Michael J.;
Buurman, Wim A.

Publication type:

Article

Blood transfusions increase circulating plasma free hemoglobin levels and plasma nitric oxide consumption: a prospective observational pilot study.

Published in:

2012

By:

Vermeulen Windsant, Iris C;
de Wit, Norbert Cj;
Sertorio, Jonas Tc;
Beckers, Erik Am;
Tanus-Santos, Jose E;
Jacobs, Michael J;
Buurman, Wim A;
de Wit, Norbert C J;
Sertorio, Jonas T C;
Beckers, Erik A M

Publication type:

journal article

The potential of stimulating nitric oxide formation in the treatment of hypertension.

Published in:

Expert Opinion on Therapeutic Targets, 2017, v. 21, n. 5, p. 543, doi. 10.1080/14728222.2017.1310840

By:

Pinheiro, Lucas C.;
Tanus-Santos, Jose E.;
Castro, Michele M.

Publication type:

Article

eNOS Tag SNP Haplotypes in Hypertensive Disorders of Pregnancy.

Published in:

DNA & Cell Biology, 2012, v. 31, n. 12, p. 1665, doi. 10.1089/dna.2012.1768

By:

Muniz, Ludmila;
Luizon, Marcelo R.;
Palei, Ana C.T.;
Lacchini, Riccardo;
Duarte, Geraldo;
Cavalli, Ricardo C.;
Tanus-Santos, Jose E.;
Sandrim, Valeria C.

Publication type:

Article

Vascular Endothelial Growth Factor Haplotypes Associated with Childhood Obesity.

Published in:

DNA & Cell Biology, 2011, v. 30, n. 9, p. 709, doi. 10.1089/dna.2011.1260

By:

Belo, Vanessa A.;
Souza-Costa, Debora C.;
Luizon, Marcelo R.;
Izidoro-Toledo, Tatiane C.;
Lanna, Carla M.;
Pinheiro, Lucas C.;
Tanus-Santos, Jose E.

Publication type:

Article

Endothelial Nitric Oxide Synthase Haplotypes Associated with Aura in Patients with Migraine.

Published in:

DNA & Cell Biology, 2011, v. 30, n. 6, p. 363, doi. 10.1089/dna.2010.1152

By:

Gonçalves, Flavia M.;
Martins-Oliveira, Alisson;
Speciali, Jose G.;
Luizon, Marcelo R.;
Izidoro-Toledo, Tatiane C.;
Silva, Pamela S.;
Dach, Fabiola;
Tanus-Santos, Jose E.

Publication type:

Article

Endothelial Nitric Oxide Genotypes and Haplotypes Are Not Associated with End-Stage Renal Disease.

Published in:

DNA & Cell Biology, 2011, v. 30, n. 1, p. 55, doi. 10.1089/dna.2010.1106

By:

Marson, Bernardo P.;
Dickel, Samantha;
Ishizawa, Marília H.;
Metzger, Ingrid F.;
Izidoro-Toledo, Tatiane;
da Costa, Bartira Ercília Pinheiro;
Poli-de-Figueiredo, Carlos E.;
Tanus-Santos, Jose E.

Publication type:

Article

Interethnic Differences in the Distribution of Matrix Metalloproteinases Genetic Polymorphisms Are Consistent with Interethnic Differences in Disease Prevalence.

Published in:

DNA & Cell Biology, 2010, v. 29, n. 11, p. 649, doi. 10.1089/dna.2010.1056

By:

Lacchini, Riccardo;
Metzger, Ingrid F.;
Luizon, Marcelo;
Ishizawa, Marília;
Tanus-Santos, Jose E.

Publication type:

Article

Vascular Endothelial Growth Factor Genetic Polymorphisms and Haplotypes in Women with Migraine.

Published in:

DNA & Cell Biology, 2010, v. 29, n. 7, p. 357, doi. 10.1089/dna.2010.1025

By:

Gonçalves, Flavia M.;
Martins-Oliveira, Alisson;
Speciali, Jose G.;
Izidoro-Toledo, Tatiane C.;
Luizon, Marcelo R.;
Dach, Fabiola;
Tanus-Santos, Jose E.

Publication type:

Article

Endothelial Nitric Oxide Synthase Haplotypes Associated with Hypertension Do Not Predispose to Cardiac Hypertrophy.

Published in:

DNA & Cell Biology, 2010, v. 29, n. 4, p. 171, doi. 10.1089/dna.2009.0955

By:

Vasconcellos, Vivian;
Lacchini, Riccardo;
Jacob-Ferreira, Anna L.B.;
Sales, Maria L.;
Ferreira-Sae, Maria C.;
Schreiber, Roberto;
Nadruz, Wilson;
Tanus-Santos, Jose E.

Publication type:

Article

Interethnic Differences in the Distribution of Clinically Relevant Vascular Endothelial Growth Factor Genetic Polymorphisms.

Published in:

DNA & Cell Biology, 2009, v. 28, n. 11, p. 567, doi. 10.1089/dna.2009.0925

By:

Muniz, Jaqueline J.;
Izidoro-Toledo, Tatiane C.;
Metzger, Ingrid F.;
Sandrim, Valeria C.;
Tanus-Santos, Jose E.

Publication type:

Article

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians.

Published in:

DNA & Cell Biology, 2009, v. 28, n. 7, p. 329, doi. 10.1089/dna.2009.0878

By:

Luizon, Marcelo R.;
Izidoro-Toledo, Tatiane C.;
Simoes, Aguinaldo L.;
Tanus-Santos, Jose E.

Publication type:

Article

Increased activity of MMP-2 in hypertensive obese children is associated with hypoadiponectinemia.

Published in:

Obesity (19307381), 2015, v. 23, n. 1, p. 177, doi. 10.1002/oby.20939

By:

Belo, Vanessa A.;
Lacchini, Riccardo;
Miranda, Josiane A.;
Lanna, Carla M.M.;
Souza‐Costa, Debora C.;
Tanus‐Santos, Jose E.

Publication type:

Article

Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia.

Published in:

Molecular Human Reproduction, 2010, v. 16, n. 7, p. 506, doi. 10.1093/molehr/gaq030

By:

Sandrim, Valeria C.;
Palei, Ana C.T.;
Sertorio, Jonas T.;
Cavalli, Ricardo C.;
Duarte, Geraldo;
Tanus-Santos, Jose E.

Publication type:

Article

Vascular endothelial growth factor genotypes and haplotypes are associated with pre-eclampsia but not with gestational hypertension.

Published in:

Molecular Human Reproduction, 2009, v. 15, n. 2, p. 115

By:

Sandrim, Valeria C.;
Palei, Ana C. T.;
Cavalli, Ricardo C.;
Araújo, Francielle M.;
Ramos, Ester S.;
Duarte, Geraldo;
Tanus-Santos, Jose E.

Publication type:

Article

C-Type Natriuretic Peptide Induces Anti-contractile Effect Dependent on Nitric Oxide, Oxidative Stress, and NPR-B Activation in Sepsis.

Published in:

Frontiers in Physiology, 2016, p. 1, doi. 10.3389/fphys.2016.00226

By:

Pernomian, Laena;
Prado, Alejandro F.;
Silva, Bruno R.;
Azevedo, Aline;
Pinheiro, Lucas C.;
Tanus-Santos, José E.;
Bendhack, Lusiane M.

Publication type:

Article

Targeting matrix metalloproteinases in disease conditions.

Published in:

2014

By:

Castro, Michele M.;
Tanus-Santos, Jose E.

Publication type:

Journal Article

Antioxidant effects of phosphodiesterase-5 inhibitors.

Published in:

Cardiovascular Research, 2013, v. 100, n. 1, p. 170, doi. 10.1093/cvr/cvt189

By:

Tanus-Santos, Jose E.

Publication type:

Article

Plasma from pre-eclamptic patients induces the expression of the anti-angiogenic miR-195-5p in endothelial cells.

Published in:

Journal of Cellular & Molecular Medicine, 2016, v. 20, n. 6, p. 1198, doi. 10.1111/jcmm.12767

By:

Sandrim, Valeria Cristina;
Dias, Mayara Caldeira;
Bovolato, Ana Lívia de Carvalho;
Tanus‐Santos, Jose E;
Deffune, Elenice;
Cavalli, Ricardo C.

Publication type:

Article

Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism.

Published in:

Journal of Cellular & Molecular Medicine, 2013, v. 17, n. 12, p. 1588, doi. 10.1111/jcmm.12163

By:

Neto‐Neves, Evandro M.;
Sousa‐Santos, Ozelia;
Ferraz, Karina C.;
Rizzi, Elen;
Ceron, Carla S.;
Romano, Minna M. D.;
Gali, Luis G.;
Maciel, Benedito C.;
Schulz, Richard;
Gerlach, Raquel F.;
Tanus‐Santos, Jose E.

Publication type:

Article

Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia.

Published in:

Journal of Cellular & Molecular Medicine, 2013, v. 17, n. 10, p. 1300, doi. 10.1111/jcmm.12106

By:

Amaral, Lorena M.;
Pinheiro, Lucas C.;
Guimaraes, Danielle A.;
Palei, Ana C.T.;
Sertório, Jonas T.;
Portella, Rafael L.;
Tanus‐Santos, Jose E.

Publication type:

Article

Hemodynamic Benefits of Matrix Metalloproteinase-9 Inhibition by Doxycycline During Experimental Acute Pulmonary Embolism.

Published in:

Angiology, 2005, v. 56, n. 5, p. 611, doi. 10.1177/000331970505600513

By:

Palei, Ana C. T.;
Zaneti, Rafael A. G.;
Fortuna, Geisa M.;
Gerlach, Raquel F.;
Tanus-Santos, Jose E.

Publication type:

Article

Circulating Total Cell-Free DNA Levels Are Increased in Hypertensive Disorders of Pregnancy and Associated with Prohypertensive Factors and Adverse Clinical Outcomes.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 2, p. 564, doi. 10.3390/ijms22020564

By:

Amaral, Lorena M.;
Sandrim, Valeria C.;
Kutcher, Matthew E.;
Spradley, Frank T.;
Cavalli, Ricardo C.;
Tanus-Santos, Jose E.;
Palei, Ana C.

Publication type:

Article

Inducible Nitric Oxide Synthase Polymorphisms and Nitric Oxide Levels in Individuals with Chronic Periodontitis.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 6, p. 1128, doi. 10.3390/ijms18061128

By:

Scarel-Caminaga, Raquel M.;
Cera, Flávia F.;
Pigossi, Suzane C.;
Finoti, Livia S.;
Kim, Yeon J.;
Viana, Aline C.;
Secolin, Rodrigo;
Montenegro, Marcelo F.;
Tanus-Santos, José E.;
Orrico, Silvana R. P.;
Cirelli, Joni A.

Publication type:

Article

Inhibitors of gastric acid secretion increase oxidative stress and matrix metalloproteinase-2 activity leading to vascular remodeling.

Published in:

Molecular & Cellular Biochemistry, 2024, v. 479, n. 11, p. 3141, doi. 10.1007/s11010-023-04921-x

By:

Nogueira, Renato C.;
Sanches-lopes, Jéssica M.;
Oliveira-Paula, Gustavo H.;
Tanus-Santos, Jose E.

Publication type:

Article

Matrix Metalloproteinases: A Target in In-Stent Restenosis?

Published in:

Cardiology, 2013, v. 124, n. 1, p. 49, doi. 10.1159/000346230

By:

Tanus-Santos, Jose E.

Publication type:

Article

Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2014, v. 41, n. 10, p. 744, doi. 10.1111/1440-1681.12284

By:

Villela, Maria P;
Andrade, Vanessa L;
Eccard, Bryelle;
Jordão, Alceu A;
Sertório, Jonas T;
Tanus‐Santos, Jose E;
Silva, Ieda FO;
Silveira, Josianne N;
Sandrim, Valéria C

Publication type:

Article

Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.

Published in:

European Journal of Clinical Pharmacology, 2021, v. 77, n. 6, p. 869, doi. 10.1007/s00228-020-03059-9

By:

Oliveira-Paula, Gustavo H.;
Coeli-Lacchini, Fernanda Borchers;
Ferezin, Letícia Perticarrara;
Ferreira, Graziele C.;
Pinheiro, Lucas C.;
Paula-Garcia, Waynice N.;
Garcia, Luis V.;
Tanus-Santos, Jose E.;
Lacchini, Riccardo

Publication type:

Article

NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature.

Published in:

Alcohol & Alcoholism, 2016, v. 51, n. 5, p. 522, doi. 10.1093/alcalc/agw043

By:

Colombo Marchi, Katia;
Speroni Ceron, Carla;
Muniz, Jaqueline J.;
De Martinis, Bruno S.;
Tanus-Santos, José E.;
Tirapelli, Carlos Renato

Publication type:

Article

Ethanol Consumption Alters the Expression and Reactivity of Adrenomedullin in the Rat Mesenteric Arterial Bed.

Published in:

2012

By:

Rocha, Juliana T.;
Hipólito, Ulisses V.;
Martins-Oliveira, Alisson;
Tirapelli, Daniela P.C.;
Batalhão, Marcelo E.;
Carnio, Evelin C.;
Queiroz, Regina H.;
Coelho, Eduardo B.;
Cunha, Thiago M.;
Tanus-Santos, José E.;
Tirapelli, Carlos R.

Publication type:

Journal Article

Ethanol Consumption Alters the Expression and Reactivity of Adrenomedullin in the Rat Mesenteric Arterial Bed.

Published in:

Alcohol & Alcoholism, 2012, v. 47, n. 1, p. 9, doi. 10.1093/alcalc/agr141

By:

Rocha, Juliana T.;
Hipólito, Ulisses V.;
Martins-Oliveira, Alisson;
Tirapelli, Daniela P.C.;
Batalhão, Marcelo E.;
Carnio, Evelin C.;
Queiroz, Regina H.;
Coelho, Eduardo B.;
Cunha, Thiago M.;
Tanus-Santos, José E.;
Tirapelli, Carlos R.

Publication type:

Article

Serum samples should not be used to assess circulating matrix metalloproteinase-9 levels as a prognostic marker of disease.

Published in:

International Journal of Cancer, 2006, v. 118, n. 3, p. 789, doi. 10.1002/ijc.21405

By:

Tanus-Santos, Jose E.;
Gerlach, Raquel F.

Publication type:

Article

Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage.

Published in:

Frontiers in Physiology, 2014, v. 5, p. 1, doi. 10.3389/fphys.2014.00340

By:

Windsant, Iris C. Vermeulen;
de Wit, Norbert C. J.;
Sertorio, Jonas T. C.;
van Bijnen, Annemarie A.;
Ganushchak, Yuri M.;
Heijmans, John H.;
Tanus-Santos, Jose E.;
Jacobs, Michael J.;
Maessen, Jos G.;
Buurman, Wim A.

Publication type:

Article

Chronic ethanol consumption induces micturition dysfunction and alters the oxidative state of the urinary bladder.

Published in:

Canadian Journal of Physiology & Pharmacology, 2019, v. 97, n. 12, p. 1103, doi. 10.1139/cjpp-2019-0143

By:

do Vale, Gabriel T.;
Sousa, Arthur H.;
Gonzaga, Natália A.;
de Oliveira, Mariana G.;
Justo, Alberto F.O.;
Alexandre, Eduardo C.;
Tanus-Santos, Jose E.;
Antunes, Edson;
Tirapelli, Carlos R.

Publication type:

Article

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.

Published in:

Nature Medicine, 2002, v. 8, n. 12, p. 1383, doi. 10.1038/nm1202-799

By:

Reiter, Christopher D.;
Wang, Xunde;
Tanus-Santos, Jose E.;
Hogg, Neil;
Cannon, Richard O.;
Schechter, Alan N.;
Gladwin, Mark T.

Publication type:

Article