Works by Tanila, Heikki

Results: 116

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain energy reserves in Young and Middle-Aged Mice.

Published in:

Frontiers in Aging Neuroscience, 2016, p. 1, doi. 10.3389/fnagi.2016.00041

By:

Koivisto, Hennariikka;
Leinonen, Henri;
Puurula, Mari;
Hafez, Hani Sayed;
Barrera, Glenda Alquicer;
Stridh, Malin H.;
Waagepetersen, Helle S.;
Tiainen, Mika;
Soininen, Pasi;
Zilberter, Yuri;
Tanila, Heikki

Publication type:

Article

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression.

Published in:

Frontiers in Aging Neuroscience, 2015, v. 7, p. 1, doi. 10.3389/fnagi.2015.00077

By:

Grimm, Marcus O. W.;
Mett, Janine;
Stahlmann, Christoph P.;
Grösgen, Sven;
Haupenthal, Viola J.;
Blümel, Tamara;
Hundsdörfer, Benjamin;
Zimmer, Valerie C.;
Mylonas, Nadine T.;
Tanila, Heikki;
Müller, Ulrike;
Grimm, Heike S.;
Hartmann, Tobias

Publication type:

Article

Altered Insulin Signaling in Alzheimer's Disease Brain – Special Emphasis on PI3K-Akt Pathway.

Published in:

Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00629

By:

Gabbouj, Sami;
Ryhänen, Simo;
Marttinen, Mikael;
Wittrahm, Rebekka;
Takalo, Mari;
Kemppainen, Susanna;
Martiskainen, Henna;
Tanila, Heikki;
Haapasalo, Annakaisa;
Hiltunen, Mikko;
Natunen, Teemu

Publication type:

Article

Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease.

Published in:

Neurochemical Research, 2017, v. 42, n. 6, p. 1589, doi. 10.1007/s11064-016-2070-2

By:

Andersen, Jens;
Christensen, Sofie;
Aldana, Blanca;
Nissen, Jakob;
Tanila, Heikki;
Waagepetersen, Helle

Publication type:

Article

Effects of human intravenous immunoglobulins on amyloid pathology and inflammation in a mouse model of Alzheimer's disease

Published in:

2011

By:

Puli, Lakshman;
Pomeshchik, Yuriy;
Tarja, Malm;
Koistinaho, Jari;
Tanila, Heikki

Publication type:

Abstract

Contribution of genetic and dietary insulin resistance to Alzheimer’s phenotype in APP/PS1 transgenic mice

Published in:

2011

By:

Hiltunen, Mikko;
Soininen, Hilkka;
Tanila, Heikki;
Haapasalo, Annakaisa;
Laakso, Markku;
Tusa, Maija;
Mäkinen, Petra;
Krzisch, Marine;
Koivisto, Hennariikka;
Miettinen, Pasi;
Tiilikainen, Tea;
Vepsäläinen, Saila;
Khandelwal, Vinoth;
Kemppainen, Susanna

Publication type:

Abstract

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Published in:

2011

By:

Broersen, Laus;
Koivisto, Hennariikka;
Takalo, M.;
Miettinen, Pasi;
Tanila, Heikki

Publication type:

Abstract

The effect of memantine and rivastigmine on synaptic markers and amyloid processing in cell culture and animal models of Alzheimer's disease

Published in:

2010

By:

Lahiri, Debomoy K.;
Bailey, Jason A.;
Ray, Balmiki;
Tanila, Heikki;
Banerjee, Pradeep;
Long, Justin

Publication type:

Abstract

A low-dose of intravenous immunoglobulin provides protection in focal and global brain ischemia models and abolishes the increased ischemic vulnerability of aged APP/PS1 mice

Published in:

2009

By:

Heikkinen, Riikka;
Malm, Tarja;
Boman, Susanna;
Kuhmonen, Susanna;
Ahtoniemi, Toni;
Muona, Anu;
Tanila, Heikki;
Koistinaho, Jari;
Koistinaho, Milla

Publication type:

Abstract

Effects of memantine and donepezil on object recognition memory in rats with cholinergic lesions

Published in:

2009

By:

Ihalainen, Jouni;
Sarajärvi, Timo;
Kuhmonen, Susanna;
Banerjee, Pradeep K.;
Tanila, Heikki

Publication type:

Abstract

P2-354: Effects of human intravenous immunoglobulin on beta-amyloid in preclinical models

Published in:

2008

By:

Puli, Lakshman K.;
Magga, Johanna;
Kanninen, Katja;
Pihlaja, Rea;
Maier, Elisabeth;
Olas, Katja;
Koistinaho, Milla;
Reipert, Birgit;
Schwarz, Hans-Peter;
Koistinaho, Jari;
Tanila, Heikki

Publication type:

Abstract

P2-023: Discriminating accuracy of entorhinal volumetry exceeds the accuracy of hippocampal fMRI in mild cognitive impairment

Published in:

2008

By:

Jauhiainen, Anne M.;
Pihlajamäki, Maija;
Tervo, Susanna;
Niskanen, Eini;
Hänninen, Tuomo;
Tanila, Heikki;
Vanninen, Ritva L.;
Soininen, Hilkka

Publication type:

Abstract

IC-P2-104: Entorhinal atrophy is related to increased hippocampal fMRI activation during encoding in mild cognitive impairment

Published in:

2008

By:

Jauhiainen, Anne M.;
Pihlajamäki, Maija;
Tervo, Susanna;
Niskanen, Eini;
Hänninen, Tuomo;
Tanila, Heikki;
Vanninen, Ritva L.;
Soininen, Hilkka

Publication type:

Abstract

P-188: Memantine lowers amyloid beta levels in neuronal cells and transgenic mouse models of Alzheimer’s disease

Published in:

2007

By:

Banerjee, Pradeep;
Tanila, Heikki;
Wisniewski, Thomas;
Gupta, Sandeep;
LaFerla, Frank;
Lahiri, Debomoy K.

Publication type:

Abstract

IC-P-052: Increased activation in the fusiform gyrus during picture encoding in subjects with mild cognitive impairment

Published in:

2006

By:

Hämäläinen, Anne;
Pihlajamäki, Maija;
Hänninen, Tuomo;
Tanila, Heikki;
Niskanen, Eini;
Tervo, Susanna;
Karjalainen, Pasi A.;
Vanninen, Ritva L.;
Soininen, Hilkka

Publication type:

Abstract

P3-301: Aβ mediates tau hyperphosphorylation via down-regulating PP2A in Alzheimer’s disease

Published in:

2006

By:

Zhou, Xin-Wen;
Tanila, Heikki;
Liu, Rong;
Winblad, Bengt;
Pei, Jin-Jing

Publication type:

Abstract

P2-307: Increased activation in the fusiform gyrus during picture encoding in subjects with mild cognitive impairment

Published in:

2006

By:

Hämäläinen, Anne;
Pihlajamäki, Maija;
Hänninen, Tuomo;
Tanila, Heikki;
Niskanen, Eini;
Tervo, Susanna;
Karjalainen, Pasi A.;
Vanninen, Ritva L.;
Soininen, Hilkka

Publication type:

Abstract

P1-300: Age and brain region specific alterations in mRNA levels of Aβ-degrading enzymes; IDE and NEP

Published in:

2006

By:

Vepsäläinen, Saila;
Hiltunen, Mikko;
Helisalmi, Seppo;
Tanila, Heikki;
Wang, Jun;
van Groen, Thomas;
Alafuzoff, Irina;
Ojala, Johanna;
Soininen, Hilkka

Publication type:

Abstract

P1-109: Age-dependent changes in hippocampal glutamate levels parallel learning impairment in APP/PS1 transgenic mice

Published in:

2006

By:

Minkeviciene, Rimante;
Ihalainen, Jouni;
Malm, Tarja;
Leguit, N.;
Glennon, J.;
Banerjee, Pradeep K.;
Tanila, Heikki

Publication type:

Abstract

P1-026: Changes in cerebral hemodynamics and Alzheimer’s pathology in aged APP/PS1 mice supplemented with docosahexanoic acid (DHA) and cholesterol enriched diets

Published in:

2006

By:

Hooijmans, Carlijn R.;
Rutters, Femke;
Dederen, Pieter J.;
Heerschap, Arend;
Tanila, Heikki;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Kiliaan, Amanda J.

Publication type:

Abstract

IC-P-052: Increased activation in the fusiform gyrus during picture encoding in subjects with mild cognitive impairment

Published in:

2006

By:

Hämäläinen, Anne;
Pihlajamäki, Maija;
Hänninen, Tuomo;
Tanila, Heikki;
Niskanen, Eini;
Tervo, Susanna;
Karjalainen, Pasi A.;
Vanninen, Ritva L.;
Soininen, Hilkka

Publication type:

Abstract

P3-301: Aβ mediates tau hyperphosphorylation via down-regulating PP2A in Alzheimer’s disease

Published in:

2006

By:

Zhou, Xin-Wen;
Tanila, Heikki;
Liu, Rong;
Winblad, Bengt;
Pei, Jin-Jing

Publication type:

Abstract

P2-307: Increased activation in the fusiform gyrus during picture encoding in subjects with mild cognitive impairment

Published in:

2006

By:

Hämäläinen, Anne;
Pihlajamäki, Maija;
Hänninen, Tuomo;
Tanila, Heikki;
Niskanen, Eini;
Tervo, Susanna;
Karjalainen, Pasi A.;
Vanninen, Ritva L.;
Soininen, Hilkka

Publication type:

Abstract

P1-300: Age and brain region specific alterations in mRNA levels of Aβ-degrading enzymes; IDE and NEP

Published in:

2006

By:

Vepsäläinen, Saila;
Hiltunen, Mikko;
Helisalmi, Seppo;
Tanila, Heikki;
Wang, Jun;
van Groen, Thomas;
Alafuzoff, Irina;
Ojala, Johanna;
Soininen, Hilkka

Publication type:

Abstract

P1-109: Age-dependent changes in hippocampal glutamate levels parallel learning impairment in APP/PS1 transgenic mice

Published in:

2006

By:

Minkeviciene, Rimante;
Ihalainen, Jouni;
Malm, Tarja;
Leguit, N.;
Glennon, J.;
Banerjee, Pradeep K.;
Tanila, Heikki

Publication type:

Abstract

P1-026: Changes in cerebral hemodynamics and Alzheimer’s pathology in aged APP/PS1 mice supplemented with docosahexanoic acid (DHA) and cholesterol enriched diets

Published in:

2006

By:

Hooijmans, Carlijn R.;
Rutters, Femke;
Dederen, Pieter J.;
Heerschap, Arend;
Tanila, Heikki;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Kiliaan, Amanda J.

Publication type:

Abstract

Preclinical basis for the efficacy of memantine in Alzheimer’s disease

Published in:

2005

By:

Banerjee, Pradeep K.;
Lahiri, Debomoy K.;
Tanila, Heikki;
Miguel-Hidalgo, Jose Javier;
Iqbal, Khalid

Publication type:

Abstract

PPARβ/δ‐agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.

Published in:

Glia (0894-1491), 2019, v. 67, n. 1, p. 146, doi. 10.1002/glia.23534

By:

Konttinen, Henna;
Gureviciene, Irina;
Oksanen, Minna;
Grubman, Alexandra;
Loppi, Sanna;
Huuskonen, Mikko T.;
Korhonen, Paula;
Lampinen, Riikka;
Keuters, Meike;
Belaya, Irina;
Tanila, Heikki;
Kanninen, Katja M.;
Goldsteins, Gundars;
Landreth, Gary;
Koistinaho, Jari;
Malm, Tarja

Publication type:

Article

Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes.

Published in:

Glia (0894-1491), 2011, v. 59, n. 11, p. 1643, doi. 10.1002/glia.21212

By:

Pihlaja, Rea;
Koistinaho, Jari;
Kauppinen, Riitta;
Sandholm, Jouko;
Tanila, Heikki;
Koistinaho, Milla

Publication type:

Article

WNT signaling in activated microglia is proinflammatory.

Published in:

Glia (0894-1491), 2011, v. 59, n. 1, p. 119, doi. 10.1002/glia.21081

By:

Halleskog, Carina;
Mulder, Jan;
Dahlström, Jenny;
Mackie, Ken;
Hortobágyi, Tibor;
Tanila, Heikki;
Kumar Puli, Lakshman;
Färber, Katrin;
Harkany, Tibor;
Schulte, Gunnar

Publication type:

Article

Genetic ablation of tenascin-C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo.

Published in:

Hippocampus, 2009, v. 19, n. 12, p. 1232, doi. 10.1002/hipo.20585

By:

Gurevicius, Kestutis;
Kuang, Fang;
Stoenica, Luminita;
Irintchev, Andrey;
Gureviciene, Irina;
Dityatev, Alexander;
Schachner, Melitta;
Tanila, Heikki

Publication type:

Article

Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment.

Published in:

Hippocampus, 2009, v. 19, n. 2, p. 166, doi. 10.1002/hipo.20494

By:

Jauhiainen, Anne M.;
Pihlajamäki, Maija;
Tervo, Susanna;
Niskanen, Eini;
Tanila, Heikki;
Hänninen, Tuomo;
Vanninen, Ritva L.;
Soininen, Hilkka

Publication type:

Article

Encoding of novel picture pairs activates the perirhinal cortex: An fMRI study.

Published in:

Hippocampus, 2003, v. 13, n. 1, p. 67, doi. 10.1002/hipo.10049

By:

Pihlajamäki, Maija;
Tanila, Heikki;
Hänninen, Tuomo;
Könönen, Mervi;
Mikkonen, Mia;
Jalkanen, Ville;
Partanen, Kaarina;
Aronen, Hannu J.;
Soininen, Hilkka

Publication type:

Article

Cholinergic system regulation of spatial representation by the hippocampus.

Published in:

Hippocampus, 2002, v. 12, n. 3, p. 386, doi. 10.1002/hipo.1109

By:

Ikonen, Sami;
McMahan, Robert;
Gallagher, Michela;
Eichenbaum, Howard;
Tanila, Heikki

Publication type:

Article

Noradrenergic regulation of hippocampal place cells.

Published in:

Hippocampus, 2001, v. 11, n. 6, p. 793, doi. 10.1002/hipo.1095

By:

Tanila, Heikki

Publication type:

Article

Hippocampal place cells can develop distinct representations of two visually identical environments.

Published in:

Hippocampus, 1999, v. 9, n. 3, p. 235, doi. 10.1002/(SICI)1098-1063(1999)9:3<235::AID-HIPO4>3.0.CO;2-3

By:

Tanila, Heikki

Publication type:

Article

Unique features in the processing of spatial information by the aged hippocampus as shown by place cell recording studies: A response to Peter Rapp's commentary 'Representational Organization in the Aged Hippocampus'.

Published in:

Hippocampus, 1998, v. 8, n. 5, p. 436, doi. 10.1002/(SICI)1098-1063(1998)8:5<436::AID-HIPO3>3.0.CO;2-3

By:

Tanila, Heikki

Publication type:

Article

Cues that hippocampal place cells encode: Dynamic and hierarchical representation of local and distal stimuli.

Published in:

Hippocampus, 1997, v. 7, n. 6, p. 624, doi. 10.1002/(SICI)1098-1063(1997)7:6<624::AID-HIPO5>3.0.CO;2-E

By:

Shapiro, Matthew L.;
Tanila, Heikki;
Eichenbaum, Howard

Publication type:

Article

Discordance of spatial representation in ensembles of hippocampal place cells.

Published in:

Hippocampus, 1997, v. 7, n. 6, p. 613, doi. 10.1002/(SICI)1098-1063(1997)7:6<613::AID-HIPO4>3.0.CO;2-F

By:

Tanila, Heikki;
Shapiro, Matthew L.;
Eichenbaum, Howard

Publication type:

Article

Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 4, p. 669, doi. 10.1007/s00401-021-02345-9

By:

Roos, Tomas T.;
Garcia, Megg G.;
Martinsson, Isak;
Mabrouk, Rana;
Israelsson, Bodil;
Deierborg, Tomas;
Kobro-Flatmoen, Asgeir;
Tanila, Heikki;
Gouras, Gunnar K.

Publication type:

Article

Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-68845-y

By:

Jin, Nanxiang;
Ziyatdinova, Sofya;
Gureviciene, Irina;
Tanila, Heikki

Publication type:

Article

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease.

Published in:

Cell Death & Disease, 2021, v. 12, n. 11, p. 1, doi. 10.1038/s41419-021-04237-y

By:

Andersen, Jens V.;
Skotte, Niels H.;
Christensen, Sofie K.;
Polli, Filip S.;
Shabani, Mohammad;
Markussen, Kia H.;
Haukedal, Henriette;
Westi, Emil W.;
Diaz-delCastillo, Marta;
Sun, Ramon C.;
Kohlmeier, Kristi A.;
Schousboe, Arne;
Gentry, Matthew S.;
Tanila, Heikki;
Freude, Kristine K.;
Aldana, Blanca I.;
Mann, Matthias;
Waagepetersen, Helle S.

Publication type:

Article

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.

Published in:

Journal of Cellular & Molecular Medicine, 2012, v. 16, n. 6, p. 1206, doi. 10.1111/j.1582-4934.2011.01384.x

By:

Hiltunen, Mikko;
Khandelwal, Vinoth K. M.;
Yaluri, Nagendra;
Tiilikainen, Tea;
Tusa, Maija;
Koivisto, Henna;
Krzisch, Marine;
Vepsäläinen, Saila;
Mäkinen, Petra;
Kemppainen, Susanna;
Miettinen, Pasi;
Haapasalo, Annakaisa;
Soininen, Hilkka;
Laakso, Markku;
Tanila, Heikki

Publication type:

Article

Age-Associated Alterations of Hippocampal Place Cells Are Subregion Specific.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 29, p. 6877, doi. 10.1523/JNEUROSCI.1744-05.2005

By:

Wilson, Iain A.;
Ikonen, Sami;
Gallagher, Michela;
Eichenbaum, Howard;
Tanila, Heikki

Publication type:

Article

Role of α-Synuclein in Presynaptic Dopamine Recruitment.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 49, p. 11165, doi. 10.1523/JNEUROSCI.2559-04.2004

By:

Yavich, Leonid;
Tanila, Heikki;
Vepsäläinen, Saila;
Jäkälä, Pekka

Publication type:

Article

Cognitive Aging and the Hippocampus: How old Rats Represent New Environments.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 15, p. 3870, doi. 10.1523/JNEUROSCI.5205-03.2004

By:

Wilson, Iain A.;
Ikonen, Sami;
Gureviciene, Irina;
McMahan, Robert W.;
Gallagher, Michela;
Eichenbaum, Howard;
Tanila, Heikki

Publication type:

Article

Verbal fluency activates the left medial temporal lobe: A functional magnetic resonance imaging study.

Published in:

Annals of Neurology, 2000, v. 47, n. 4, p. 470, doi. 10.1002/1531-8249(200004)47:4<470::AID-ANA10>3.0.CO;2-M

By:

Pihlajamäki, Maija;
Tanila, Heikki;
Hänninen, Tuomo;
Könönen, Mervi;
Laakso, Mikko;
Partanen, Kaarina;
Soininen, Hilkka;
Aronen, Hannu J.

Publication type:

Article

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 19, p. 3309, doi. 10.1093/hmg/ddz165

By:

Singh, Yajuvinder;
Leinonen, Henri;
Fazaludeen, Feroze;
Jaronen, Merja;
Guest, Debbie;
Buckley, Noel;
Byts, Nadiya;
Oksa, Petra;
Jalkanen, Kari;
Iqbal, Imran;
Huuskonen, Mikko;
Savchenko, Ekaterina;
Keksa-Goldsteine, Velta;
Chew, Sweelin;
Myllyharju, Johanna;
Tanila, Heikki;
Ooi, Lezanne;
Koistinaho, Jari;
Kanninen, Katja M;
Malm, Tarja

Publication type:

Article

Non-fibrillar β-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors.

Published in:

European Journal of Neuroscience, 2006, v. 23, n. 8, p. 2035, doi. 10.1111/j.1460-9568.2006.04733.x

By:

Shemer, Isaac;
Holmgren, Carl;
Min, Rogier;
Fülöp, Livia;
Zilberter, Misha;
Sousa, Kyle M.;
Farkas, Tamás;
Härtig, Wolfgang;
Penke, Botond;
Burnashev, Nail;
Tanila, Heikki;
Zilberter, Yuri;
Harkany, Tibor

Publication type:

Article

Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects.

Published in:

European Journal of Neuroscience, 2005, v. 22, n. 8, p. 2095, doi. 10.1111/j.1460-9568.2005.04380.x

By:

Pihlajamäki, Maija;
Tanila, Heikki;
Könönen, Mervi;
Hänninen, Tuomo;
Aronen, Hannu J.;
Soininen, Hilkka

Publication type:

Article