Works matching AU Takors, Ralf

Results: 91

Diversity-Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis.

Published in:

Angewandte Chemie, 2011, v. 123, n. 34, p. 7927, doi. 10.1002/ange.201103261

By:

Bongaerts, Johannes;
Esser, Simon;
Lorbach, Volker;
Al-Momani, Lóay;
Müller, Michael A.;
Franke, Dirk;
Grondal, Christoph;
Kurutsch, Anja;
Bujnicki, Robert;
Takors, Ralf;
Raeven, Leon;
Wubbolts, Marcel;
Bovenberg, Roel;
Nieger, Martin;
Schürmann, Melanie;
Trachtmann, Natalie;
Kozak, Stefan;
Sprenger, Georg A.;
Müller, Michael

Publication type:

Article

Interpretation of metabolic flux maps by limitation potentials and constrained limitation sensitivities.

Published in:

Biotechnology & Bioengineering, 2006, v. 94, n. 2, p. 263, doi. 10.1002/bit.20837

By:

Wahl, S. Aljoscha;
Takors, Ralf;
Wiechert, Wolfgang

Publication type:

Article

Application of model discriminating experimental design for modeling and development of a fermentative fed-batch L-valine production process.

Published in:

Biotechnology & Bioengineering, 2005, v. 91, n. 3, p. 356, doi. 10.1002/bit.20504

By:

Brik Ternbach, Michel;
Bollman, Christian;
Wandrey, Christian;
Takors, Ralf

Publication type:

Article

Process strategies to enhance pyruvate production with recombinant Escherichia coli: From repetitive fed-batch to in situ product recovery with fully integrated electrodialysis.

Published in:

Biotechnology & Bioengineering, 2004, v. 85, n. 6, p. 638, doi. 10.1002/bit.10820

By:

Zelić, Bruno;
Gostović, Srđan;
Vuorilehto, K.;
Vasić-Rac̆ki, Đurđa;
Takors, Ralf

Publication type:

Article

CO/HCO perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum.

Published in:

Applied Microbiology & Biotechnology, 2014, v. 98, n. 20, p. 8563, doi. 10.1007/s00253-014-6014-y

By:

Buchholz, Jens;
Graf, Michaela;
Freund, Andreas;
Busche, Tobias;
Kalinowski, Jörn;
Blombach, Bastian;
Takors, Ralf

Publication type:

Article

Erratum to: CO/HCO perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum.

Published in:

2014

By:

Buchholz, Jens;
Graf, Michaela;
Freund, Andreas;
Busche, Tobias;
Kalinowski, Jörn;
Blombach, Bastian;
Takors, Ralf

Publication type:

Erratum

Real Case Study of 600 m3 Bubble Column Fermentations: Spatially Resolved Simulations Unveil Optimization Potentials for l‐Phenylalanine Production With Escherichia coli.

Published in:

Biotechnology & Bioengineering, 2025, v. 122, n. 2, p. 265, doi. 10.1002/bit.28869

By:

Mast, Yannic;
Ghaderi, Adel;
Takors, Ralf

Publication type:

Article

Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior.

Published in:

Biotechnology & Bioengineering, 2024, v. 121, n. 4, p. 1244, doi. 10.1002/bit.28647

By:

Gaugler, Lena;
Hofmann, Sebastian;
Schlüter, Michael;
Takors, Ralf

Publication type:

Article

Pseudomonas putida KT2440 endures temporary oxygen limitations.

Published in:

Biotechnology & Bioengineering, 2021, v. 118, n. 12, p. 4735, doi. 10.1002/bit.27938

By:

Demling, Philipp;
Ankenbauer, Andreas;
Klein, Bianca;
Noack, Stephan;
Tiso, Till;
Takors, Ralf;
Blank, Lars M.

Publication type:

Article

Balancing glucose and oxygen uptake rates to enable high amorpha‐4,11‐diene production in Escherichia coli via the methylerythritol phosphate pathway.

Published in:

Biotechnology & Bioengineering, 2021, v. 118, n. 3, p. 1317, doi. 10.1002/bit.27655

By:

Patil, Vikas;
Santos, Christine N. S.;
Ajikumar, Parayil K.;
Sarria, Stephen;
Takors, Ralf

Publication type:

Article

Data‐driven in silico prediction of regulation heterogeneity and ATP demands of Escherichia coli in large‐scale bioreactors.

Published in:

Biotechnology & Bioengineering, 2021, v. 118, n. 1, p. 265, doi. 10.1002/bit.27568

By:

Zieringer, Julia;
Wild, Moritz;
Takors, Ralf

Publication type:

Article

S‐adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese hamster ovary cells.

Published in:

Biotechnology & Bioengineering, 2020, v. 117, n. 11, p. 3239, doi. 10.1002/bit.27484

By:

Verhagen, Natascha;
Teleki, Attila;
Heinrich, Christoph;
Schilling, Martin;
Unsöld, Andreas;
Takors, Ralf

Publication type:

Article

Simulated oxygen and glucose gradients as a prerequisite for predicting industrial scale performance a priori.

Published in:

Biotechnology & Bioengineering, 2020, v. 117, n. 9, p. 2760, doi. 10.1002/bit.27457

By:

Kuschel, Maike;
Takors, Ralf

Publication type:

Article

Perfusion cultures require optimum respiratory ATP supply to maximize cell‐specific and volumetric productivities.

Published in:

Biotechnology & Bioengineering, 2019, v. 116, n. 5, p. 951, doi. 10.1002/bit.26926

By:

Becker, Max;
Junghans, Lisa;
Teleki, Attila;
Bechmann, Jan;
Takors, Ralf

Publication type:

Article

Continuous Adaptive Evolution of a Fast-Growing Corynebacterium glutamicum Strain Independent of Protocatechuate.

Published in:

Frontiers in Microbiology, 2019, p. 1, doi. 10.3389/fmicb.2019.01648

By:

Graf, Michaela;
Haas, Thorsten;
Müller, Felix;
Buchmann, Anina;
Harm-Bekbenbetova, Julia;
Freund, Andreas;
Nieß, Alexander;
Persicke, Marcus;
Kalinowski, Jörn;
Blombach, Bastian;
Takors, Ralf

Publication type:

Article

The knowledge driven DBTL cycle provides mechanistic insights while optimising dopamine production in Escherichia coli.

Published in:

Microbial Cell Factories, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12934-025-02729-6

By:

Hägele, Lorena;
Trachtmann, Natalia;
Takors, Ralf

Publication type:

Article

Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells.

Published in:

Applied Microbiology & Biotechnology, 2024, v. 108, n. 1, p. 1, doi. 10.1007/s00253-024-13363-4

By:

Föller, Stefanie;
Regett, Niklas;
Lataster, Levin;
Radziwill, Gerald;
Takors, Ralf

Publication type:

Article

Investigating the dynamic behavior of biochemical networks using model families.

Published in:

Bioinformatics, 2005, v. 21, n. 8, p. 1617

By:

Marc Daniel Haunschild;
Bernd Freisleben;
Ralf Takors;
Wolfgang Wiechert

Publication type:

Article

Direct Consideration of Process History During Intensified Design of Experiments Planning Eases Interpretation of Mammalian Cell Culture Dynamics.

Published in:

Bioengineering (Basel), 2025, v. 12, n. 3, p. 319, doi. 10.3390/bioengineering12030319

By:

Kienzle, Samuel;
Junghans, Lisa;
Wieschalka, Stefan;
Diem, Katharina;
Takors, Ralf;
Radde, Nicole Erika;
Kunzelmann, Marco;
Presser, Beate;
Nold, Verena

Publication type:

Article

Getting the Right Clones in an Automated Manner: An Alternative to Sophisticated Colony-Picking Robotics.

Published in:

Bioengineering (Basel), 2024, v. 11, n. 9, p. 892, doi. 10.3390/bioengineering11090892

By:

Hägele, Lorena;
Pfleger, Brian F.;
Takors, Ralf

Publication type:

Article

A Two-Compartment Fermentation System to Quantify Strain-Specific Interactions in Microbial Co-Cultures.

Published in:

Bioengineering (Basel), 2023, v. 10, n. 1, p. 103, doi. 10.3390/bioengineering10010103

By:

Ulmer, Andreas;
Veit, Stefan;
Erdemann, Florian;
Freund, Andreas;
Loesch, Maren;
Teleki, Attila;
Zeidan, Ahmad A.;
Takors, Ralf

Publication type:

Article

Monitoring Intracellular Metabolite Dynamics in Saccharomyces cerevisiae during Industrially Relevant Famine Stimuli.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 3, p. 263, doi. 10.3390/metabo12030263

By:

Minden, Steven;
Aniolek, Maria;
Sarkizi Shams Hajian, Christopher;
Teleki, Attila;
Zerrer, Tobias;
Delvigne, Frank;
van Gulik, Walter;
Deshmukh, Amit;
Noorman, Henk;
Takors, Ralf

Publication type:

Article

Streamlining the Analysis of Dynamic 13 C-Labeling Patterns for the Metabolic Engineering of Corynebacterium glutamicum as l-Histidine Production Host.

Published in:

Metabolites (2218-1989), 2020, v. 10, n. 11, p. 458, doi. 10.3390/metabo10110458

By:

Feith, André;
Schwentner, Andreas;
Teleki, Attila;
Favilli, Lorenzo;
Blombach, Bastian;
Takors, Ralf

Publication type:

Article

HILIC-Enabled 13C Metabolomics Strategies: Comparing Quantitative Precision and Spectral Accuracy of QTOF High- and QQQ Low-Resolution Mass Spectrometry.

Published in:

Metabolites (2218-1989), 2019, v. 9, n. 4, p. 63, doi. 10.3390/metabo9040063

By:

Feith, André;
Teleki, Attila;
Graf, Michaela;
Favilli, Lorenzo;
Takors, Ralf

Publication type:

Article

Mimicked Mixing-Induced Heterogeneities of Industrial Bioreactors Stimulate Long-Lasting Adaption Programs in Ethanol-Producing Yeasts.

Published in:

Genes, 2023, v. 14, n. 5, p. 997, doi. 10.3390/genes14050997

By:

Minden, Steven;
Aniolek, Maria;
Noorman, Henk;
Takors, Ralf

Publication type:

Article

Deciphering the Adaptation of Corynebacterium glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis.

Published in:

Genes, 2018, v. 9, n. 6, p. 297, doi. 10.3390/genes9060297

By:

Lange, Julian;
Münch, Eugenia;
Müller, Jan;
Takors, Ralf;
Blombach, Bastian;
Kalinowski, Jörn;
Busche, Tobias

Publication type:

Article

Food for Thoughts for Prospective Biomanufacturing.

Published in:

Microbial Biotechnology, 2025, v. 18, n. 1, p. 1, doi. 10.1111/1751-7915.70088

By:

Takors, Ralf

Publication type:

Article

Substitute Yeast Extract While Maintaining Performance: Showcase Amorpha‐4,11‐Diene Production.

Published in:

Microbial Biotechnology, 2024, v. 17, n. 11, p. 1, doi. 10.1111/1751-7915.70056

By:

Castillo‐Saldarriaga, Carlos;
Santos, Christine N. S.;
Sarria, Stephen;
Ajikumar, Parayil K.;
Takors, Ralf

Publication type:

Article

Genome reduction improves octanoic acid production in scale down bioreactors.

Published in:

Microbial Biotechnology, 2024, v. 17, n. 11, p. 1, doi. 10.1111/1751-7915.70034

By:

Cordell, William T.;
Avolio, Gennaro;
Takors, Ralf;
Pfleger, Brian F.

Publication type:

Article

Systemic intracellular analysis for balancing complex biosynthesis in a transcriptionally deregulated Escherichia colil‐Methionine producer.

Published in:

Microbial Biotechnology, 2024, v. 17, n. 3, p. 1, doi. 10.1111/1751-7915.14433

By:

Harting, Claudia;
Teleki, Attila;
Braakmann, Marius;
Jankowitsch, Frank;
Takors, Ralf

Publication type:

Article

Performing in spite of starvation: How Saccharomyces cerevisiae maintains robust growth when facing famine zones in industrial bioreactors.

Published in:

Microbial Biotechnology, 2023, v. 16, n. 1, p. 148, doi. 10.1111/1751-7915.14188

By:

Minden, Steven;
Aniolek, Maria;
Noorman, Henk;
Takors, Ralf

Publication type:

Article

Transcriptional profiling of the stringent response mutant strain E. coli SR reveals enhanced robustness to large‐scale conditions.

Published in:

Microbial Biotechnology, 2021, v. 14, n. 3, p. 993, doi. 10.1111/1751-7915.13738

By:

Ziegler, Martin;
Zieringer, Julia;
Takors, Ralf

Publication type:

Article

Electron availability in CO2, CO and H2 mixtures constrains flux distribution, energy management and product formation in Clostridium ljungdahlii.

Published in:

Microbial Biotechnology, 2020, v. 13, n. 6, p. 1831, doi. 10.1111/1751-7915.13625

By:

Hermann, Maria;
Teleki, Attila;
Weitz, Sandra;
Niess, Alexander;
Freund, Andreas;
Bengelsdorf, Frank R.;
Takors, Ralf

Publication type:

Article

Pseudomonas putida KT2440 is naturally endowed to withstand industrial‐scale stress conditions.

Published in:

Microbial Biotechnology, 2020, v. 13, n. 4, p. 1145, doi. 10.1111/1751-7915.13571

By:

Ankenbauer, Andreas;
Schäfer, Richard A.;
Viegas, Sandra C.;
Pobre, Vânia;
Voß, Björn;
Arraiano, Cecília M.;
Takors, Ralf

Publication type:

Article

Using gas mixtures of CO, CO2 and H2 as microbial substrates: the do's and don'ts of successful technology transfer from laboratory to production scale.

Published in:

Microbial Biotechnology, 2018, v. 11, n. 4, p. 606, doi. 10.1111/1751-7915.13270

By:

Takors, Ralf;
Kopf, Michael;
Mampel, Joerg;
Bluemke, Wilfried;
Blombach, Bastian;
Eikmanns, Bernhard;
Bengelsdorf, Frank R.;
Weuster‐botz, Dirk;
Dürre, Peter

Publication type:

Article

Harnessing novel chromosomal integration loci to utilize an organosolv-derived hemicellulose fraction for isobutanol production with engineered Corynebacterium glutamicum.

Published in:

Microbial Biotechnology, 2018, v. 11, n. 1, p. 257, doi. 10.1111/1751-7915.12879

By:

Lange, Julian;
Müller, Felix;
Takors, Ralf;
Blombach, Bastian

Publication type:

Article

Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond.

Published in:

Microbial Biotechnology, 2017, v. 10, n. 5, p. 1267, doi. 10.1111/1751-7915.12803

By:

Delvigne, Frank;
Takors, Ralf;
Mudde, Rob;
Gulik, Walter;
Noorman, Henk

Publication type:

Article

Transcriptional response of Escherichia coli to ammonia and glucose fluctuations.

Published in:

Microbial Biotechnology, 2017, v. 10, n. 4, p. 858, doi. 10.1111/1751-7915.12713

By:

Simen, Joana Danica;
Löffler, Michael;
Freund, Andreas;
Müller, Jan;
Takors, Ralf;
Jäger, Günter;
Schäferhoff, Karin;
Matthes, Jakob

Publication type:

Article

Diversity-Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 34, p. 7781, doi. 10.1002/anie.201103261

By:

Bongaerts, Johannes;
Esser, Simon;
Lorbach, Volker;
Al-Momani, Lóay;
Müller, Michael A.;
Franke, Dirk;
Grondal, Christoph;
Kurutsch, Anja;
Bujnicki, Robert;
Takors, Ralf;
Raeven, Leon;
Wubbolts, Marcel;
Bovenberg, Roel;
Nieger, Martin;
Schürmann, Melanie;
Trachtmann, Natalie;
Kozak, Stefan;
Sprenger, Georg A.;
Müller, Michael

Publication type:

Article

Bio ohne Technik/Technik ohne Bio? – mit interdisziplinärer biotechnologischer Forschung dem Klimawandel begegnen.

Published in:

Chemie Ingenieur Technik (CIT), 2023, v. 95, n. 4, p. 475, doi. 10.1002/cite.202370402

By:

Liese, Andreas;
Müller, Michael;
Noll, Thomas;
Takors, Ralf

Publication type:

Article

Revisiting Basics of kLa Dependency on Aeration in Bubble Columns: a Is Surprisingly Stable.

Published in:

Chemie Ingenieur Technik (CIT), 2023, v. 95, n. 4, p. 511, doi. 10.1002/cite.202200165

By:

Wild, Moritz;
Mast, Yannic;
Takors, Ralf

Publication type:

Article

Production of 1-Octanol from n-Octane by Pseudomonas putida KT2440.

Published in:

Chemie Ingenieur Technik (CIT), 2013, v. 85, n. 6, p. 841, doi. 10.1002/cite.201200178

By:

Vallon, Tobias;
Glemser, Matthias;
Malca, Sumire Honda;
Scheps, Daniel;
Schmid, Joachim;
Siemann-Herzberg, Martin;
Hauer, Bernhard;
Takors, Ralf

Publication type:

Article

Subpopulation-proteomics reveal growth rate, but not cell cycling, as a major impact on protein composition in Pseudomonas putida KT2440.

Published in:

AMB Express, 2014, v. 4, n. 1, p. 1, doi. 10.1186/s13568-014-0071-6

By:

Lieder, Sarah;
Jahn, Michael;
Seifert, Jana;
von Bergen, Martin;
Müller, Susann;
Takors, Ralf

Publication type:

Article

Growth-rate dependency of ribosome abundance and translation elongation rate in Corynebacterium glutamicum differs from that in Escherichia coli.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41176-y

By:

Matamouros, Susana;
Gensch, Thomas;
Cerff, Martin;
Sachs, Christian C.;
Abdollahzadeh, Iman;
Hendriks, Johnny;
Horst, Lucas;
Tenhaef, Niklas;
Tenhaef, Julia;
Noack, Stephan;
Graf, Michaela;
Takors, Ralf;
Nöh, Katharina;
Bott, Michael

Publication type:

Article

Metabolic engineering of Corynebacterium glutamicum for fatty alcohol production from glucose and wheat straw hydrolysate.

Published in:

Biotechnology for Biofuels & Bioproducts, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13068-023-02367-3

By:

Werner, Felix;
Schwardmann, Lynn S.;
Siebert, Daniel;
Rückert-Reed, Christian;
Kalinowski, Jörn;
Wirth, Marie-Theres;
Hofer, Katharina;
Takors, Ralf;
Wendisch, Volker F.;
Blombach, Bastian

Publication type:

Article

Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein p21.

Published in:

Biology (2079-7737), 2023, v. 12, n. 9, p. 1194, doi. 10.3390/biology12091194

By:

Lataster, Levin;
Huber, Hanna Mereth;
Böttcher, Christina;
Föller, Stefanie;
Takors, Ralf;
Radziwill, Gerald

Publication type:

Article

Subcellular Fractionation Enables Assessment of Nucleotide Sugar Donors Inside the Golgi Apparatus as a Prerequisite for Unraveling Culture Impacts on Glycoforms of Antibodies.

Published in:

Biotechnology Journal, 2025, v. 20, n. 3, p. 1, doi. 10.1002/biot.202400678

By:

Regett, Niklas;
Dieterle, Marcel;
Peters, Fleur;
Deuring, Max;
Stegmaier, Kaja;
Teleki, Attila;
Takors, Ralf

Publication type:

Article

Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression.

Published in:

FEBS Open Bio, 2020, v. 10, n. 12, p. 2791, doi. 10.1002/2211-5463.13019

By:

Verhagen, Natascha;
Zieringer, Julia;
Takors, Ralf

Publication type:

Article

Changes in intracellular ATP-content of CHO cells as response to hyperosmolality.

Published in:

Biotechnology Progress, 2015, v. 31, n. 5, p. 1212, doi. 10.1002/btpr.2143

By:

Pfizenmaier, Jennifer;
Matuszczyk, Jens‐Christoph;
Takors, Ralf

Publication type:

Article

The identification of enzyme targets for the optimization of a valine producing Corynebacterium glutamicum strain using a kinetic model.

Published in:

Biotechnology Progress, 2009, v. 25, n. 3, p. 754, doi. 10.1002/btpr.184

By:

Magnus, Jørgen Barsett;
Oldiges, Marco;
Takors, Ralf

Publication type:

Article