Works matching AU Takeki Uehara

Results: 41

The Japanese toxicogenomics project: Application of toxicogenomics.

Published in:

Molecular Nutrition & Food Research, 2010, v. 54, n. 2, p. 218, doi. 10.1002/mnfr.200900169

By:

Uehara, Takeki;
Ono, Atsushi;
Maruyama, Toshiyuki;
Kato, Ikuo;
Yamada, Hiroshi;
Ohno, Yasuo;
Urushidani, Tetsuro

Publication type:

Article

Treatment-Emergent Influenza Variant Viruses With Reduced Baloxavir Susceptibility: Impact on Clinical and Virologic Outcomes in Uncomplicated Influenza.

Published in:

2020

By:

Uehara, Takeki;
Hayden, Frederick G;
Kawaguchi, Keiko;
Omoto, Shinya;
Hurt, Aeron C;
Jong, Menno D De;
Hirotsu, Nobuo;
Sugaya, Norio;
Lee, Nelson;
Baba, Keiko;
Shishido, Takao;
Tsuchiya, Kenji;
Portsmouth, Simon;
Kida, Hiroshi;
De Jong, Menno D

Publication type:

journal article

Comparative Nephrotoxicity of Cisplatin and Nedaplatin: Mechanisms and Histopathological Characteristics.

Published in:

Journal of Toxicologic Pathology, 2011, v. 24, n. 2, p. 87, doi. 10.1293/tox.24.87

By:

Uehara, Takeki;
Yamate, Jyoji;
Torii, Mikinori;
Maruyama, Toshiyuki

Publication type:

Article

Nephrotoxicity of a novel antineoplastic platinum complex, nedaplatin: a comparative study with cisplatin in rats.

Published in:

Archives of Toxicology, 2005, v. 79, n. 8, p. 451, doi. 10.1007/s00204-005-0648-6

By:

Uehara, Takeki;
Watanabe, Hiroshi;
Itoh, Fumio;
Inoue, Satoshi;
Koshida, Hikaru;
Nakamura, Masuhisa;
Yamate, Jyoji;
Maruyama, Toshiyuki

Publication type:

Article

Comparative analysis of gene expression between renal cortex and papilla in nedaplatin-induced nephrotoxicity in rats.

Published in:

Human & Experimental Toxicology, 2007, v. 26, n. 10, p. 767, doi. 10.1177/0960327107084069

By:

Uehara, Takeki;
Miyoshi, Takako;
Tsuchiya, Noriko;
Masuno, Koichi;
Okada, Manabu;
Inoue, Satoshi;
Torii, Mikinori;
Yamate, Jyoji;
Maruyama, Toshiyuki

Publication type:

Article

The DEN and CCl<sub>4</sub>-Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

Published in:

Current Protocols, 2021, v. 1, n. 8, p. 1, doi. 10.1002/cpz1.211

By:

Takeki Uehara;
Pogribny, Igor P.;
Rusyn, Ivan

Publication type:

Article

Diagnostic and predictive performance and standardized threshold of traditional biomarkers for drug-induced liver injury in rats.

Published in:

Journal of Applied Toxicology, 2015, v. 35, n. 2, p. 165, doi. 10.1002/jat.3053

By:

Tonomura, Yutaka;
Kato, Yuki;
Hanafusa, Hiroyuki;
Morikawa, Yuji;
Matsuyama, Keigo;
Uehara, Takeki;
Ueno, Motonobu;
Torii, Mikinori

Publication type:

Article

Plasma miR-208 as a useful biomarker for drug-induced cardiotoxicity in rats.

Published in:

Journal of Applied Toxicology, 2015, v. 35, n. 2, p. 173, doi. 10.1002/jat.3044

By:

Nishimura, Yoko;
Kondo, Chiaki;
Morikawa, Yuji;
Tonomura, Yutaka;
Torii, Mikinori;
Yamate, Jyoji;
Uehara, Takeki

Publication type:

Article

Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats.

Published in:

Journal of Applied Toxicology, 2014, v. 34, n. 10, p. 1087, doi. 10.1002/jat.2933

By:

Uehara, Takeki;
Horinouchi, Akira;
Morikawa, Yuji;
Tonomura, Yutaka;
Minami, Keiichi;
Ono, Atsushi;
Yamate, Jyoji;
Yamada, Hiroshi;
Ohno, Yasuo;
Urushidani, Tetsuro

Publication type:

Article

Toxicogenomics discrimination of potential hepatocarcinogenicity of non-genotoxic compounds in rat liver.

Published in:

Journal of Applied Toxicology, 2013, v. 33, n. 11, p. 1284, doi. 10.1002/jat.2790

By:

Yamada, Fumihiro;
Sumida, Kayo;
Uehara, Takeki;
Morikawa, Yuji;
Yamada, Hiroshi;
Urushidani, Tetsuro;
Ohno, Yasuo

Publication type:

Article

Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies.

Published in:

Journal of Applied Toxicology, 2013, v. 33, n. 10, p. 1120, doi. 10.1002/jat.2867

By:

Nishimura, Yoko;
Morikawa, Yuji;
Kondo, Chiaki;
Tonomura, Yutaka;
Fukushima, Ryou;
Torii, Mikinori;
Uehara, Takeki

Publication type:

Article

Time course of the change and amelioration of nedaplatin-induced nephrotoxicity in rats.

Published in:

Journal of Applied Toxicology, 2008, v. 28, n. 3, p. 388, doi. 10.1002/jat.1292

By:

Uehara, Takeki;
Tsuchiya, Noriko;
Masuda, Aki;
Torii, Mikinori;
Nakamura, Masuhisa;
Yamate, Jyoji;
Maruyama, Toshiyuki

Publication type:

Article

Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.

Published in:

Journal of Toxicological Sciences, 2014, v. 39, n. 6, p. 837, doi. 10.2131/jts.39.837

By:

Ko Omura;
Takeki Uehara;
Yuji Morikawa;
Hitomi Hayashi;
Kunitoshi Mitsumori;
Keiichi Minami;
Masayuki Kanki;
Hiroshi Yamada;
Atsushi Ono;
Tetsuro Urushidani

Publication type:

Article

Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.

Published in:

Journal of Toxicological Sciences, 2014, v. 39, n. 5, p. 785, doi. 10.2131/jts.39.785

By:

Ko Omura;
Takeki Uehara;
Yuji Morikawa;
Hitomi Hayashi;
Kunitoshi Mitsumori;
Keiichi Minami;
Masayuki Kanki;
Hiroshi Yamada;
Atsushi Ono;
Tetsuro Urushidani

Publication type:

Article

Predictive genomic biomarkers for drug-induced nephrotoxicity in mice.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 4, p. 723, doi. 10.2131/jts.37.723

By:

Chiaki Kondo;
Miwa Aoki;
Emi Yamamoto;
Yutaka Tonomura;
Minoru Ikeda;
Masako Kaneto;
Jyoji Yamate;
Mikinori Torii;
Takeki Uehara

Publication type:

Article

Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.

Published in:

Journal of Toxicological Sciences, 2009, v. 34, n. 3, p. 281, doi. 10.2131/jts.34.281

By:

Hirode, Mitsuhiro;
Omura, Ko;
Kiyosawa, Naoki;
Uehara, Takeki;
Shimuzu, Toshinobu;
Ono, Atsushi;
Miyagishima, Toshikazu;
Nagao, Taku;
Ohno, Yasuo;
Urushidani, Tetsuro

Publication type:

Article

IDENTIFICATION OF GLUTATHIONE DEPLETION-RESPONSIVE GENES USING PHORONE-TREATED RAT LIVER.

Published in:

Journal of Toxicological Sciences, 2007, v. 32, n. 5, p. 469, doi. 10.2131/jts.32.469

By:

Kiyosawa, Naoki;
Uehara, Takeki;
Weihua Gao;
Omura, Ko;
Hirode, Mitsuhiro;
Shimizu, Toshinobu;
Mizukawa, Yumiko;
Ono, Atsushi;
Miyagishima, Toshikazu;
Nagao, Taku;
Urushidani, Tetsuro

Publication type:

Article

GENE EXPRESSION PROFILING OF RAT LIVER TREATED WITH SERUM TRIGLYCERIDE-DECREASING COMPOUNDS.

Published in:

Journal of Toxicological Sciences, 2007, v. 32, n. 4, p. 387, doi. 10.2131/jts.32.387

By:

Omura, Ko;
Kiyosawa, Naoki;
Uehara, Takeki;
Hirode, Mitsuhiro;
Shimizu, Toshinobu;
Miyagishima, Toshikazu;
Ono, Atsushi;
Nagao, Taku;
Urushidani, Tetsuro

Publication type:

Article

UTILIZATION OF A ONE-DIMENSIONAL SCORE FOR SURVEYING CHEMICAL-INDUCED CHANGES IN EXPRESSION LEVELS OF MULTIPLE BIOMARKER GENE SETS USING A LARGE-SCALE TOXICOGENOMICS DATABASE.

Published in:

Journal of Toxicological Sciences, 2006, v. 31, n. 5, p. 433, doi. 10.2131/jts.31.433

By:

Kiyosawa, Naoki;
Shiwaku, Kouiji;
Hirode, Mitsuhiro;
Omura, Ko;
Uehara, Takeki;
Shimizu, Toshinobu;
Mizukawa, Yumiko;
Miyagishima, Toshikazu;
Ono, Atsushi;
Nagao, Taku;
Urushidani, Tesuro

Publication type:

Article

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model.

Published in:

PLoS Pathogens, 2021, v. 17, n. 5, p. 1, doi. 10.1371/journal.ppat.1009527

By:

Lee, Leo YY;
Zhou, Jie;
Koszalka, Paulina;
Frise, Rebecca;
Farrukee, Rubaiyea;
Baba, Keiko;
Miah, Shahjahan;
Shishido, Takao;
Galiano, Monica;
Hashimoto, Takashi;
Omoto, Shinya;
Uehara, Takeki;
Mifsud, Edin J.;
Collinson, Neil;
Kuhlbusch, Klaus;
Clinch, Barry;
Wildum, Steffen;
Barclay, Wendy S.;
Hurt, Aeron C.

Publication type:

Article

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission.

Published in:

PLoS Pathogens, 2020, v. 16, n. 4, p. 1, doi. 10.1371/journal.ppat.1008395

By:

Lee, Leo Yi Yang;
Zhou, Jie;
Frise, Rebecca;
Goldhill, Daniel H.;
Koszalka, Paulina;
Mifsud, Edin J.;
Baba, Kaoru;
Noda, Takahiro;
Ando, Yoshinori;
Sato, Kenji;
Yuki, Aoe-Ishikawa;
Shishido, Takao;
Uehara, Takeki;
Wildum, Steffen;
Zwanziger, Elke;
Collinson, Neil;
Kuhlbusch, Klaus;
Clinch, Barry;
Hurt, Aeron C.;
Barclay, Wendy S.

Publication type:

Article

ENSITRELVIR FOR MILD-TO-MODERATE COVID-19: PHASE 3 PART OF PHASE 2/3 STUDY.

Published in:

Topics in Antiviral Medicine, 2023, v. 31, n. 2, p. 68

By:

Genki Ichihashi;
Hiroshi Yotsuyanagi;
Norio Ohmagari;
Yohei Doi;
Masaya Yamato;
Takumi Imamura;
Takuhiro Sonoyama;
Takao Sanaki;
Yuko Tsuge;
Takeki Uehara;
Hiroshi Mukae

Publication type:

Article

Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease.

Published in:

Cancer Medicine, 2016, v. 5, n. 3, p. 574, doi. 10.1002/cam4.606

By:

Chappell, Grace;
Silva, Grace O.;
Uehara, Takeki;
Pogribny, Igor P.;
Rusyn, Ivan

Publication type:

Article

Letter to the Editor regarding Response to "Letter to Editor: "Real-World Effectiveness of Ensitrelvir in Reducing Severe Outcomes in Outpatients at High Risk for COVID-19".

Published in:

Infectious Diseases & Therapy, 2024, v. 13, n. 11, p. 2463, doi. 10.1007/s40121-024-01054-6

By:

Takazono, Takahiro;
Fujita, Satoki;
Komeda, Takuji;
Miyazawa, Shogo;
Yoshida, Yuki;
Kitanishi, Yoshitake;
Kinoshita, Masahiro;
Kojima, Satoshi;
Shen, Huilian;
Uehara, Takeki;
Hosogaya, Naoki;
Iwanaga, Naoki;
Mukae, Hiroshi

Publication type:

Article

Real-World Effectiveness of Ensitrelvir in Reducing Severe Outcomes in Outpatients at High Risk for COVID-19.

Published in:

Infectious Diseases & Therapy, 2024, v. 13, n. 8, p. 1821, doi. 10.1007/s40121-024-01010-4

By:

Takazono, Takahiro;
Fujita, Satoki;
Komeda, Takuji;
Miyazawa, Shogo;
Yoshida, Yuki;
Kitanishi, Yoshitake;
Kinoshita, Masahiro;
Kojima, Satoshi;
Shen, Huilian;
Uehara, Takeki;
Hosogaya, Naoki;
Iwanaga, Naoki;
Mukae, Hiroshi

Publication type:

Article

Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.

Published in:

Molecular Carcinogenesis, 2016, v. 55, n. 5, p. 808, doi. 10.1002/mc.22323

By:

Marrone, April K.;
Shpyleva, Svitlana;
Chappell, Grace;
Tryndyak, Volodymyr;
Uehara, Takeki;
Tsuchiya, Masato;
Beland, Frederick A.;
Rusyn, Ivan;
Pogribny, Igor P.

Publication type:

Article

Efficacy and Safety of 5-Day Oral Ensitrelvir for Patients With Mild to Moderate COVID-19: The SCORPIO-SR Randomized Clinical Trial.

Published in:

JAMA Network Open, 2024, v. 7, n. 2, p. e2354991, doi. 10.1001/jamanetworkopen.2023.54991

By:

Yotsuyanagi, Hiroshi;
Ohmagari, Norio;
Doi, Yohei;
Yamato, Masaya;
Bac, Nguyen Hoang;
Cha, Bong Ki;
Imamura, Takumi;
Sonoyama, Takuhiro;
Ichihashi, Genki;
Sanaki, Takao;
Tsuge, Yuko;
Uehara, Takeki;
Mukae, Hiroshi

Publication type:

Article

Baloxavir Treatment in Adolescents With Acute Influenza: Subgroup Analysis From the CAPSTONE-1 Trial.

Published in:

Journal of the Pediatric Infectious Diseases Society, 2021, v. 10, n. 4, p. 477, doi. 10.1093/jpids/piaa145

By:

Portsmouth, Simon;
Hayden, Frederick G;
Kawaguchi, Keiko;
Ishibashi, Toru;
Kinoshita, Masahiro;
Shishido, Takao;
Tsuchiya, Kenji;
Uehara, Takeki

Publication type:

Article

Combinatorial Measurement of CDKN1A/p21 and KIF20A Expression for Discrimination of DNA Damage-Induced Clastogenicity.

Published in:

International Journal of Molecular Sciences, 2014, v. 15, n. 10, p. 17256, doi. 10.3390/ijms151017256

By:

Rina Sakai;
Yuji Morikawa;
Chiaki Kondo;
Hiroyuki Oka;
Hirofumi Miyajima;
Kihei Kubo;
Takeki Uehara

Publication type:

Article

Comparative Analysis of the Relationship Between Trichloroethylene Metabolism and Tissue-Specific Toxicity Among Inbred Mouse Strains: Kidney Effects.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2015, v. 78, n. 1, p. 32, doi. 10.1080/15287394.2015.958418

By:

Yoo, Hong Sik;
Bradford, Blair U.;
Kosyk, Oksana;
Uehara, Takeki;
Shymonyak, Svitlana;
Collins, Leonard B.;
Bodnar, Wanda M.;
Ball, Louise M.;
Gold, Avram;
Rusyn, Ivan

Publication type:

Article

Comparative Analysis of the Relationship Between Trichloroethylene Metabolism and Tissue-Specific Toxicity Among Inbred Mouse Strains: Liver Effects.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2015, v. 78, n. 1, p. 15, doi. 10.1080/15287394.2015.958417

By:

Yoo, Hong Sik;
Bradford, Blair U.;
Kosyk, Oksana;
Shymonyak, Svitlana;
Uehara, Takeki;
Collins, Leonard B.;
Bodnar, Wanda M.;
Ball, Louise M.;
Gold, Avram;
Rusyn, Ivan

Publication type:

Article

Efficacy and Safety of Ensitrelvir in Patients With Mild-to-Moderate Coronavirus Disease 2019: The Phase 2b Part of a Randomized, Placebo-Controlled, Phase 2/3 Study.

Published in:

Clinical Infectious Diseases, 2023, v. 76, n. 8, p. 1403, doi. 10.1093/cid/ciac933

By:

Mukae, Hiroshi;
Yotsuyanagi, Hiroshi;
Ohmagari, Norio;
Doi, Yohei;
Sakaguchi, Hiroki;
Sonoyama, Takuhiro;
Ichihashi, Genki;
Sanaki, Takao;
Baba, Keiko;
Tsuge, Yuko;
Uehara, Takeki

Publication type:

Article

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.

Published in:

International Journal of Cancer, 2014, v. 134, n. 12, p. 2778, doi. 10.1002/ijc.28610

By:

Chappell, Grace;
Kutanzi, Kristy;
Uehara, Takeki;
Tryndyak, Volodymyr;
Hong, Hue‐Hua;
Hoenerhoff, Mark;
Beland, Frederick A.;
Rusyn, Ivan;
Pogribny, Igor P.

Publication type:

Article

Efficacy and Safety of Ensitrelvir for Asymptomatic or Mild COVID‐19: An Exploratory Analysis of a Multicenter, Randomized, Phase 2b/3 Clinical Trial.

Published in:

Influenza & Other Respiratory Viruses, 2024, v. 18, n. 6, p. 1, doi. 10.1111/irv.13338

By:

Ohmagari, Norio;
Yotsuyanagi, Hiroshi;
Doi, Yohei;
Yamato, Masaya;
Imamura, Takumi;
Sakaguchi, Hiroki;
Yamanaka, Hideki;
Imaoka, Ryosuke;
Fukushi, Akimasa;
Ichihashi, Genki;
Sanaki, Takao;
Tsuge, Yuko;
Uehara, Takeki;
Mukae, Hiroshi

Publication type:

Article

Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study.

Published in:

Influenza & Other Respiratory Viruses, 2023, v. 17, n. 1, p. 1, doi. 10.1111/irv.13079

By:

Harding, Joanne;
Bernasconi, Corrado;
Williams, Sarah;
Wildum, Steffen;
Kinoshita, Masahiro;
Uehara, Takeki;
Hurt, Aeron C.

Publication type:

Article

Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus.

Published in:

Influenza & Other Respiratory Viruses, 2020, v. 14, n. 3, p. 353, doi. 10.1111/irv.12721

By:

Baba, Keiko;
Oka, Ryoko;
Shano, Shinya;
Omoto, Shinya;
Noshi, Takeshi;
Shishido, Takao;
Naito, Akira;
Kawaguchi, Keiko;
Ishibashi, Toru;
Uehara, Takeki

Publication type:

Article

Baloxavir safety and clinical and virologic outcomes in influenza virus-infected pediatric patients by age group: age-based pooled analysis of two pediatric studies conducted in Japan.

Published in:

BMC Pediatrics, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12887-023-03841-5

By:

Hirotsu, Nobuo;
Sakaguchi, Hiroki;
Fukao, Keita;
Kojima, Satoshi;
Piedra, Pedro A.;
Tsuchiya, Kenji;
Uehara, Takeki

Publication type:

Article

Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis.

Published in:

Toxicological Sciences, 2013, v. 132, n. 1, p. 53, doi. 10.1093/toxsci/kfs342

By:

Uehara, Takeki;
Ainslie, Garrett R.;
Kutanzi, Kristi;
Pogribny, Igor P.;
Muskhelishvili, Levan;
Izawa, Takeshi;
Yamate, Jyoji;
Kosyk, Oksana;
Shymonyak, Svitlana;
Bradford, Blair U.;
Boorman, Gary A.;
Bataller, Ramon;
Rusyn, Ivan

Publication type:

Article

Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice.

Published in:

Toxicological Sciences, 2011, v. 120, n. 1, p. 206, doi. 10.1093/toxsci/kfq362

By:

Bradford, Blair U.;
Lock, Eric F.;
Kosyk, Oksana;
Kim, Sungkyoon;
Uehara, Takeki;
Harbourt, David;
DeSimone, Michelle;
Threadgill, David W.;
Tryndyak, Volodymyr;
Pogribny, Igor P.;
Bleyle, Lisa;
Koop, Dennis R.;
Rusyn, Ivan

Publication type:

Article

Mechanism for Prevention of Alcohol-Induced Liver Injury by Dietary Methyl Donors.

Published in:

Toxicological Sciences, 2010, v. 115, n. 1, p. 131, doi. 10.1093/toxsci/kfq031

By:

Powell, Christine L.;
Bradford, Blair U.;
Craig, Christopher Patrick;
Tsuchiya, Masato;
Uehara, Takeki;
O'Connell, Thomas M.;
Pogribny, Igor P.;
Melnyk, Stepan;
Koop, Dennis R.;
Bleyle, Lisa;
Threadgill, David W.;
Rusyn, Ivan

Publication type:

Article

Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis.

Published in:

Toxicological Sciences, 2019, v. 170, n. 2, p. 427, doi. 10.1093/toxsci/kfy292

By:

Furuya, Shinji;
Cichocki, Joseph A;
Konganti, Kranti;
Dreval, Kostiantyn;
Uehara, Takeki;
Katou, Yuuki;
Fukushima, Hisataka;
Kono, Hiroshi;
Pogribny, Igor P;
Argemi, Josepmaria;
Bataller, Ramon;
Rusyn, Ivan

Publication type:

Article