Works by Takashima, Akihiko

Results: 96

Publisher Correction: Essential roles of plexin-B3<sup>+</sup> oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease.

Published in:

2021

By:

Nihonmatsu-Kikuchi, Naomi;
Yu, Xiu-Jun;
Matsuda, Yoshiki;
Ozawa, Nobuyuki;
Ito, Taeko;
Satou, Kazuhito;
Kaname, Tadashi;
Iwasaki, Yasushi;
Akagi, Akio;
Yoshida, Mari;
Toru, Shuta;
Hirokawa, Katsuiku;
Takashima, Akihiko;
Hasegawa, Masato;
Uchihara, Toshiki;
Tatebayashi, Yoshitaka

Publication type:

Correction Notice

Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02404-7

By:

Nihonmatsu-Kikuchi, Naomi;
Yu, Xiu-Jun;
Matsuda, Yoshiki;
Ozawa, Nobuyuki;
Ito, Taeko;
Satou, Kazuhito;
Kaname, Tadashi;
Iwasaki, Yasushi;
Akagi, Akio;
Yoshida, Mari;
Toru, Shuta;
Hirokawa, Katsuiku;
Takashima, Akihiko;
Hasegawa, Masato;
Uchihara, Toshiki;
Tatebayashi, Yoshitaka

Publication type:

Article

Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging.

Published in:

Molecular Brain, 2017, v. 10, p. 1, doi. 10.1186/s13041-016-0282-7

By:

Sosuke Yagishita;
Seiya Suzuki;
Keisuke Yoshikawa;
Keiko Iida;
Ayako Hirata;
Masahiko Suzuki;
Akihiko Takashima;
Kei Maruyama;
Akira Hirasawa;
Takeo Awaji

Publication type:

Article

Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β‐amyloid proteins.

Published in:

Journal of Neuroscience Research, 2006, v. 84, n. 2, p. 427, doi. 10.1002/jnr.20891

By:

Hironori Fujiwara;
Koh Iwasaki;
Katsutoshi Furukawa;
Takashi Seki;
Mei He;
Masahiro Maruyama;
Naoki Tomita;
Yukitsuka Kudo;
Makoto Higuchi;
Takaomi C. Saido;
Sumihiro Maeda;
Akihiko Takashima;
Masahiko Hara;
Yasushi Ohizumi;
Hiroyuki Arai

Publication type:

Article

The Advantages of Structural Equation Modeling to Address the Complexity of Spatial Reference Learning.

Published in:

Frontiers in Behavioral Neuroscience, 2016, p. 1, doi. 10.3389/fnbeh.2016.00018

By:

Moreira, Pedro S.;
Sotiropoulos, Ioannis;
Silva, Joana;
Akihiko Takashima;
Sousa, Nuno;
Leite-Almeida, Hugo;
Costa, Patrício S.

Publication type:

Article

The players on the γ-secretase team.

Published in:

Nature Medicine, 2006, v. 12, n. 7, p. 766, doi. 10.1038/nm0706-766

By:

Takashima, Akihiko;
Shimojo, Masafumi;
Wolozin, Benjamin

Publication type:

Article

Clonal Variability of PC12 Pheochromocytoma Cells with Respect to Catecholamine Biosynthesis.

Published in:

Journal of Neurochemistry, 1984, v. 42, n. 5, p. 1472, doi. 10.1111/j.1471-4159.1984.tb02812.x

By:

Koike, Tatsuro;
Takashima, Akihiko

Publication type:

Article

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.

Published in:

Acta Neuropathologica, 2014, v. 127, n. 5, p. 685, doi. 10.1007/s00401-014-1259-1

By:

Umeda, Tomohiro;
Maekawa, Satomi;
Kimura, Tetsuya;
Takashima, Akihiko;
Tomiyama, Takami;
Mori, Hiroshi

Publication type:

Article

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II.

Published in:

Acta Neuropathologica, 1996, v. 92, n. 3, p. 232, doi. 10.1007/s004010050513

By:

Yamaguchi, Haruyasu;
Ishiguro, Koichi;
Uchida, Tsuneko;
Takashima, Akihiko;
Lemere, Cynthia A.;
Imahori, K.

Publication type:

Article

Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus).

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-020-01104-3

By:

Takaichi, Yuta;
Chambers, James K.;
Takahashi, Kei;
Soeda, Yoshiyuki;
Koike, Riki;
Katsumata, Etsuko;
Kita, Chiaki;
Matsuda, Fuko;
Haritani, Makoto;
Takashima, Akihiko;
Nakayama, Hiroyuki;
Uchida, Kazuyuki

Publication type:

Article

Genetic Diversity on Farm in Japanese Paper Mulberry.

Published in:

Ecology & Evolution (20457758), 2025, v. 15, n. 1, p. 1, doi. 10.1002/ece3.70828

By:

Lam, Dinh Thi;
Tanaka, Katsunori;
Takashima, Akihiko;
Shibutani, Ayako;
Ishikawa, Ryuji

Publication type:

Article

Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3 × Tg-AD mice.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-04777-z

By:

Konishi, Fumiko;
Furusho, Tadasu;
Soeda, Yoshiyuki;
Yamauchi, Jun;
Kobayashi, Shoko;
Ito, Masatoshi;
Araki, Takuma;
Kogure, Sarasa;
Takashima, Akihiko;
Takekoshi, Susumu

Publication type:

Article

Beneficial Effects of Estrogen in a Mouse Model of Cerebrovascular Insufficiency.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005159

By:

Kitamura, Naohito;
Araya, Runa;
Kudoh, Moeko;
Kishida, Haruo;
Kimura, Tetsuya;
Murayama, Miyuki;
Takashima, Akihiko;
Sakamaki, Yuriko;
Hashikawa, Tsutomu;
Ito, Shingo;
Ohtsuki, Sumio;
Terasaki, Tetsuya;
Wess, Jürgen;
Yamada, Masahisa

Publication type:

Article

GSK-3β Is Required for Memory Reconsolidation in Adult Brain.

Published in:

PLoS ONE, 2008, v. 3, n. 10, p. 1, doi. 10.1371/journal.pone.0003540

By:

Kimura, Tetsuya;
Yamashita, Shunji;
Nakao, Shinobu;
Jung-Mi Park;
Murayama, Miyuki;
Mizoroki, Tatsuya;
Yoshiike, Yuji;
Sahara, Naruhiko;
Takashima, Akihiko

Publication type:

Article

Amyloid Oligomer Conformation in a Group of Natively Folded Proteins.

Published in:

PLoS ONE, 2008, v. 3, n. 9, p. 1, doi. 10.1371/journal.pone.0003235

By:

Yoshiike, Yuji;
Minai, Ryoichi;
Matsuo, Yo;
Yun-Ru Chen;
Kimura, Tetsuya;
Takashima, Akihiko

Publication type:

Article

GABA<sub>A</sub> Receptor-Mediated Acceleration of Aging- Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin.

Published in:

PLoS ONE, 2008, v. 3, n. 8, p. 1, doi. 10.1371/journal.pone.0003029

By:

Yoshiike, Yuji;
Kimura, Tetsuya;
Yamashita, Shunji;
Furudate, Hiroyuki;
Mizoroki, Tatsuya;
Murayama, Miyuki;
Takashima, Akihiko

Publication type:

Article

Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 10, p. 2401, doi. 10.1523/JNEUROSCI.5561-03.2004

By:

Planel, Emmanuel;
Miyasaka, Tomohiro;
Launey, Thomas;
De-Hua Chui;
Tanemura, Kentaro;
Sato, Shinji;
Murayama, Ohoshi;
Ishiguro, Koichi;
Tatebayashi, Yoshitaka;
Takashima, Akihiko

Publication type:

Article

c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis.

Published in:

FASEB Journal, 2006, v. 20, n. 6, p. 762, doi. 10.1096/fj.05-4362fje

By:

Tatebayashi, Yoshitaka;
Planel, Emmanuel;
De-Hua Chui;
Sato, Shinji;
Miyasaka, Tomohiro;
Sahara, Naruhiko;
Murayama, Miyuki;
Kikuchi, Naomi;
Yoshioka, Katsuji;
Rivka, Ravid;
Takashima, Akihiko

Publication type:

Article

Role of GSK-3β in Alzheimer's disease pathology.

Published in:

Drug Development Research, 2002, v. 56, n. 3, p. 491, doi. 10.1002/ddr.10100

By:

Planel, Emmanuel;
Sun, Xiaoyan;
Takashima, Akihiko

Publication type:

Article

Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex.

Published in:

Brain Communications, 2024, v. 6, n. 1, p. 1, doi. 10.1093/braincomms/fcad359

By:

Koike, Riki;
Soeda, Yoshiyuki;
Kasai, Atsushi;
Fujioka, Yusuke;
Ishigaki, Shinsuke;
Yamanaka, Akihiro;
Takaichi, Yuta;
Chambers, James K;
Uchida, Kazuyuki;
Watanabe, Hirohisa;
Takashima, Akihiko

Publication type:

Article

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

Published in:

Genes to Cells, 2011, v. 16, n. 6, p. 692, doi. 10.1111/j.1365-2443.2011.01522.x

By:

Kobayashi, Akira;
Tsukide, Takako;
Miyasaka, Tomohiro;
Morita, Tomoko;
Mizoroki, Tatsuya;
Saito, Yoshiro;
Ihara, Yasuo;
Takashima, Akihiko;
Noguchi, Noriko;
Fukamizu, Akiyoshi;
Hirotsu, Yosuke;
Ohtsuji, Makiko;
Katsuoka, Fumiki;
Yamamoto, Masayuki

Publication type:

Article

O-Mannosylation is required for the solubilization of heterologously expressed human β-amyloid precursor protein in Saccharomyces cerevisiae.

Published in:

Genes to Cells, 2009, v. 14, n. 2, p. 205, doi. 10.1111/j.1365-2443.2008.01263.x

By:

Murakami-Sekimata, Akiko;
Sato, Ken;
Takashima, Akihiko;
Nakano, Akihiko

Publication type:

Article

Reconstitution of γ-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of γ-secretase complex.

Published in:

Genes to Cells, 2006, v. 11, n. 1, p. 83, doi. 10.1111/j.1365-2443.2005.00914.x

By:

Shiraishi, Hirohisa;
Marutani, Toshihiro;
Hua-Qin Wang;
Maeda, Yasuhiro;
Kurono, Yukihisa;
Takashima, Akihiko;
Araki, Wataru;
Nishimura, Masaki;
Yanagisawa, Katsuhiko;
Komano, Hiroto

Publication type:

Article

Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo.

Published in:

Human Molecular Genetics, 2021, v. 30, n. 21, p. 1955, doi. 10.1093/hmg/ddab162

By:

Saito, Taro;
Chiku, Tomoki;
Oka, Mikiko;
Wada-Kakuda, Satoko;
Nobuhara, Mika;
Oba, Toshiya;
Shinno, Kanako;
Abe, Saori;
Asada, Akiko;
Sumioka, Akio;
Takashima, Akihiko;
Miyasaka, Tomohiro;
Ando, Kanae

Publication type:

Article

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 17, p. 4879, doi. 10.1093/hmg/ddv212

By:

Etsuro Ohta;
Tomoko Nihira;
Akiko Uchino;
Yoichi Imaizumi;
Yohei Okada;
Wado Akamatsu;
Kayoko Takahashi;
Hideki Hayakawa;
Makiko Nagai;
Manabu Ohyama;
Masafuchi Ryo;
Mieko Ogino;
Shigeo Murayama;
Akihiko Takashima;
Kazutoshi Nishiyama;
Yoshikuni Mizuno;
Hideki Mochizuki;
Fumiya Obata;
Hideyuki Okano

Publication type:

Article

Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.

Published in:

Journal of Neuroscience Research, 2004, v. 75, n. 3, p. 417, doi. 10.1002/jnr.10861

By:

Yuichi Hashimoto;
Emi Tsukamoto;
Takako Niikura;
Yohichi Yamagishi;
Miho Ishizaka;
Sadakazu Aiso;
Akihiko Takashima;
Ikuo Nishimoto

Publication type:

Article

Path integration deficits predict phosphorylated tau accumulation in the entorhinal cortex: Assessment of Braak stage I,II using 3D Virtual reality goggles.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 22, p. 1, doi. 10.1002/alz.072386

By:

Takashima, Akihiko;
Koike, Riki;
Soeda, Yoshiyuki;
Fujioka, Yusuke;
Ishigaki, Shinsuke;
Watanabe, Hirohisa

Publication type:

Article

O5‐10‐05: NOVEL INSIGHTS OF TAU RNA‐PROTEIN BIOLOGY IN THE PRECIPITATING ROLE OF CHRONIC STRESS ON ALZHEIMER'S DISEASE BRAIN PATHOLOGY.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1643, doi. 10.1016/j.jalz.2019.06.4892

By:

Sotiropoulos, Ioannis;
Silva, Joana;
Rodrigues, Sara;
Gomes, Patricia;
Dioli, Chrysoula;
Soares-Cunha, Carina;
Takashima, Akihiko;
Wolozin, Benjamin;
Sousa, Nuno

Publication type:

Article

P1‐087: ISO‐α‐ACIDS, BITTER COMPONENTS IN BEER, IMPROVE HIPPOCAMPUS‐DEPENDENT MEMORY VIA DOPAMINE RELEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P304, doi. 10.1016/j.jalz.2018.06.089

By:

Ano, Yasuhisa;
Hoshi, Ayaka;
Ayabe, Tatsuhiro;
Takashima, Akihiko;
Nakayama, Hiroyuki

Publication type:

Article

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0461-5

By:

Tomohiro Umeda;
Tetsuya Kimura;
Kayo Yoshida;
Keizo Takao;
Yuki Fujita;
Shogo Matsuyama;
Ayumi Sakai;
Minato Yamashita;
Yuki Yamashita;
Kiyouhisa Ohnishi;
Mamiko Suzuki;
Hiroshi Takuma;
Tsuyoshi Miyakawa;
Akihiko Takashima;
Takashi Morita;
Hiroshi Mori;
Takami Tomiyama

Publication type:

Article

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy.

Published in:

Scientific Reports, 2016, p. 33176, doi. 10.1038/srep33176

By:

Huuskonen, Mikko T.;
Loppi, Sanna;
Dhungana, Hiramani;
Keksa-Goldsteine, Velta;
Lemarchant, Sighild;
Korhonen, Paula;
Wojciechowski, Sara;
Pollari, Eveliina;
Valonen, Piia;
Koponen, Juho;
Takashima, Akihiko;
Landreth, Gary;
Goldsteins, Gundars;
Malm, Tarja;
Koistinaho, Jari;
Kanninen, Katja M.

Publication type:

Article

ISO-α-ACIDS, BITTER COMPONENTS OF BEER, PREVENT CEREBRAL INFLAMMATION AND COGNITIVE DECLINE IN A MOUSE MODEL OF ALZHEIMER’S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P619, doi. 10.1016/j.jalz.2017.06.687

By:

Ano, Yasuhisa;
Dohata, Atsushi;
Ayabe, Tatsuhiro;
Uchida, Kazuyuki;
Takashima, Akihiko;
Kondo, Keiji;
Nakayama, Hiroyuki

Publication type:

Article

Granular tau oligomer: Intermediate of tau fibril is involved in neuronal loss

Published in:

2012

By:

Takashima, Akihiko

Publication type:

Abstract

Vitamin A has anti-oligomerization effects on Aβin vitro

Published in:

2012

By:

Ono, Kenjiro;
Takasaki, Jun-ichi;
Yoshiike, Yuji;
Hirohata, Mie;
Ikeda, Tokuhei;
Morinaga, Akiyoshi;
Takashima, Akihiko;
Yamada, Masahito

Publication type:

Abstract

Research consortium of amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan

Published in:

2011

By:

Kokubo, Yasumasa;
Murayama, Shigeo;
Tomiyama, Hiroyuki;
Hirokawa, Yoshihumi;
Hasegawa, Masatho;
Okamoto, Kazushi;
Kihira, Tameko;
Takashima, Akihiko;
Tsuji, Shoji;
Kuzuhara, Shigeki

Publication type:

Abstract

Novel mechanisms of stress-evoked mood and cognitive impairment - the path from depression to Alzheimer's disease

Published in:

2011

By:

Sotiropoulos, Ioannis;
Pinto, Vitor;
Takashima, Akihiko;
Almeida, Osborne;
Sousa, Nuno

Publication type:

Abstract

Spatiotemporally specific alterations of microtubule-associated proteins and memory in alloxan-treated tau transgenic mice

Published in:

2010

By:

Yoshiike, Yuji;
Yamashita, Shunji;
Mizoroki, Tatsuya;
Maeda, Sumihiro;
Murayama, Miyuki;
Kimura, Tetsuya;
Sahara, Naruhiko;
Soeda, Yoshiyuki;
Rolova, Taisia;
Takashima, Akihiko

Publication type:

Abstract

The mechanism for tau aggregation and its relation to neuronal dysfunction

Published in:

2010

By:

Takashima, Akihiko

Publication type:

Abstract

Distinct tau aggregation form involved in synapse loss and neuron loss

Published in:

2009

By:

Takashima, Akihiko

Publication type:

Abstract

Examining the link between synaptosomal accumulation of tau protein and cognitive dysfunction

Published in:

2009

By:

Sahara, Naruhiko;
Kang, Dongcheul;
Yamashita, Shunji;
Kimura, Tatsuya;
Takashima, Akihiko;
Lewis, Jada

Publication type:

Abstract

P4-221: GABA-linked acceleration of aging-associated memory decline in APP/PS1 transgenic mouse and its pharmacological treatment by picrotoxin

Published in:

2008

By:

Yoshiike, Yuji;
Kimura, Tetsuya;
Yamashita, Shunji;
Furudate, Hiroyuki;
Mizoroki, Tatsuya;
Murayama, Miyuki;
Takashima, Akihiko

Publication type:

Abstract

P2-161: Behavioral abnormality in female mice expressing wild-type human tau without neurofibrillary tangles

Published in:

2008

By:

Kambe, Taiki;
Motoi, Yumiko;
Shimada, Kohei;
Wada, Makoto;
Ishiguro, Koichi;
Kimura, Tetsuya;
Yamashita, Shunji;
Sahara, Naruhiko;
Takashima, Akihiko;
Hattori, Nobutaka

Publication type:

Abstract

P2-128: Linkage between spatial memory disturbance and tau protein in JNPL3 male mice

Published in:

2008

By:

Sahara, Naruhiko;
Yamashita, Shunji;
Mizoroki, Tatsuya;
Kimura, Tetsuya;
Takashima, Akihiko

Publication type:

Abstract

O2-05-06: Gender-dependent neurodegenerative potential of chronic stress in P301l Tau transgenic mice

Published in:

2008

By:

Sotiropoulos, Ioannis;
Kimura, Tetsuya;
Sahara, Naruhiko;
Almeida, Osborne F.X.;
Takashima, Akihiko

Publication type:

Abstract

S2-01-06: Granular Tau oligomer: An early diagnostic marker for Alzheimer's disease

Published in:

2008

By:

Takashima, Akihiko

Publication type:

Abstract

P3-314: Molecular chaperone related tau protein metabolism in human brain

Published in:

2006

By:

Sahara, Naruhiko;
Togo, Takashi;
Maeda, Sumihiro;
Mizoroki, Tatsuya;
Murayama, Miyuki;
Hirayasu, Yoshio;
Takashima, Akihiko

Publication type:

Abstract

S3-03-05: Animal models

Published in:

2006

By:

Takashima, Akihiko;
Maeda, Sumihiro;
Sahara, Naruhiko;
Saito, Yuko;
Murayama, Shigeo

Publication type:

Abstract

P3-314: Molecular chaperone related tau protein metabolism in human brain

Published in:

2006

By:

Sahara, Naruhiko;
Togo, Takashi;
Maeda, Sumihiro;
Mizoroki, Tatsuya;
Murayama, Miyuki;
Hirayasu, Yoshio;
Takashima, Akihiko

Publication type:

Abstract

S3-03-05: Animal models

Published in:

2006

By:

Takashima, Akihiko;
Maeda, Sumihiro;
Sahara, Naruhiko;
Saito, Yuko;
Murayama, Shigeo

Publication type:

Abstract

Immunohistochemical analysis of COOH-termini of amyloid beta protein (Aβ) using end-specific antisera for Aβ40 and Aβ42 in Alzheimer's disease and normal aging.

Published in:

Amyloid, 1995, v. 2, n. 1, p. 7, doi. 10.3109/13506129509031882

By:

Yamaguchi, Haruyasu;
Sugihara, Shiro;
Ishiguro, Koji;
Takashima, Akihiko;
Hirai, Shunsaku

Publication type:

Article